Cellular Microscopy Phenotype Ontology
type: Ontology
contributor: Bran Herpers
contributor: Jennifer L. Rohn
contributor: James Malone
contributor: Frauke Neff
contributor: Jean-Karim Heriche
contributor: Johan Lundin
contributor: Zvi Kam
contributor: Gabriella Rustici
default-namespace: cmpo
contributor: Thomas Walter
contributor: Simon Jupp
contributor: Beate Neumann
contributor: Claudia Lukas
source: ro
version IRI: cmpo.owl.owl

definition source
IAO_0000114: IAO_0000122

cmpo
type: AnnotationProperty
comment: CMPO subset
sub property of: subset_property

Cross product review
type: AnnotationProperty
comment: Involved_in
sub property of: subset_property

gocheck do not annotate
type: AnnotationProperty
comment: Term not to be used for direct annotation
sub property of: subset_property

gocheck do not manually annotate
type: AnnotationProperty
comment: Term not to be used for direct manual annotation
sub property of: subset_property

goslim aspergillus
type: AnnotationProperty
comment: Aspergillus GO slim
sub property of: subset_property

goslim candida
type: AnnotationProperty
comment: Candida GO slim
sub property of: subset_property

goslim generic
type: AnnotationProperty
comment: Generic GO slim
sub property of: subset_property

goslim metagenomics
type: AnnotationProperty
comment: Metagenomics GO slim
sub property of: subset_property

goslim pir
type: AnnotationProperty
comment: PIR GO slim
sub property of: subset_property

goslim plant
type: AnnotationProperty
comment: Plant GO slim
sub property of: subset_property

goslim pombe
type: AnnotationProperty
comment: Fission yeast GO slim
sub property of: subset_property

goslim yeast
type: AnnotationProperty
comment: Yeast GO slim
sub property of: subset_property

gosubset prok
type: AnnotationProperty
comment: Prokaryotic GO subset
sub property of: subset_property

mf needs review
type: AnnotationProperty
comment: Catalytic activity terms in need of attention
sub property of: subset_property

Systematic synonym
type: AnnotationProperty
sub property of: SynonymTypeProperty
has_scope: has_exact_synonym

termgenie unvetted
type: AnnotationProperty
comment: Terms created by TermGenie that do not follow a template and require additional vetting by editors
sub property of: subset_property

virus checked
type: AnnotationProperty
comment: Viral overhaul terms
sub property of: subset_property

abnormal slim
type: AnnotationProperty
comment: Abnormal/normal slim
sub property of: subset_property

absent slim
type: AnnotationProperty
comment: Absent/present slim
sub property of: subset_property

attribute slim
type: AnnotationProperty
comment: Attribute slim
sub property of: subset_property

cell quality
type: AnnotationProperty
comment: cell_quality
sub property of: subset_property

disposition slim
type: AnnotationProperty
comment: Disposition slim
sub property of: subset_property

mpath slim
type: AnnotationProperty
comment: Pathology slim
sub property of: subset_property

relational slim
type: AnnotationProperty
comment: Relational slim: types of quality that require an additional entity in order to exist
sub property of: subset_property

scalar slim
type: AnnotationProperty
comment: Scalar slim
sub property of: subset_property

value slim
type: AnnotationProperty
comment: Value slim
sub property of: subset_property

subset_property
type: AnnotationProperty

has_alternative_id
type: AnnotationProperty

has_broad_synonym
type: AnnotationProperty

database_cross_reference
type: AnnotationProperty

has_exact_synonym
type: AnnotationProperty

has_narrow_synonym
type: AnnotationProperty

has_obo_namespace
type: AnnotationProperty

has_related_synonym
type: AnnotationProperty

has_scope
type: AnnotationProperty

in_subset
type: AnnotationProperty

shorthand
type: AnnotationProperty

part_of
type: ObjectProperty
type: ReflexiveProperty
type: TransitiveProperty
database_cross_reference: BFO:0000050
database_cross_reference: OBO_REL:part_of
id: part_of
RO_0001900: RO_0001901

has_part
type: ObjectProperty
type: TransitiveProperty
database_cross_reference: BFO:0000051
database_cross_reference: OBO_REL:has_part
IAO_0000115: Q1 has_part Q2 if and only if: every instance of Q1 is a quality_of an entity that has_quality some Q2.
comment: We use the has_part relation to relate complex qualities to more primitive ones. A complex quality is a collection of qualities. The complex quality cannot exist without the sub-qualities. For example, the quality 'swollen' necessarily comes with the qualities of 'protruding' and 'increased size'.
has_obo_namespace: gene_ontology
id: has_part
shorthand: has_part
has_obo_namespace: quality
RO_0001900: RO_0001901
IAO_0000412: go.owl
IAO_0000412: pato.owl

Axiom
database_cross_reference: PATOC:CJM
annotated target: Q1 has_part Q2 if and only if: every instance of Q1 is a quality_of an entity that has_quality some Q2.
annotated source: has_part
annotated property: IAO_0000115

occurs in
type: ObjectProperty
database_cross_reference: BFO:0000066
has_obo_namespace: gene_ontology
id: occurs_in
shorthand: occurs_in
IAO_0000412: go.owl

bearer of
type: ObjectProperty
RO_0001900: RO_0001901

participates in
type: ObjectProperty

located in
RO_0001900: RO_0001901

happens_during
type: ObjectProperty
type: TransitiveProperty
database_cross_reference: RO:0002092
comment: This relation will be used after 2013-05-21.
has_obo_namespace: gene_ontology
shorthand: happens_during
id: happens_during
sub property of: ends_during
IAO_0000412: go.owl

ends_during
type: ObjectProperty
database_cross_reference: RO:0002093
comment: This relation will be used after 2013-05-21.
shorthand: ends_during
id: ends_during
has_obo_namespace: gene_ontology
IAO_0000412: go.owl

regulates
type: ObjectProperty
database_cross_reference: RO:0002211
has_obo_namespace: gene_ontology
id: regulates
shorthand: regulates
IAO_0000114: IAO_0000125
IAO_0000412: go.owl

negatively_regulates
type: ObjectProperty
database_cross_reference: RO:0002212
has_obo_namespace: gene_ontology
shorthand: negatively_regulates
id: negatively_regulates
IAO_0000114: IAO_0000125
sub property of: regulates
IAO_0000412: go.owl

positively_regulates
type: ObjectProperty
database_cross_reference: RO:0002213
has_obo_namespace: gene_ontology
shorthand: positively_regulates
id: positively_regulates
IAO_0000114: IAO_0000125
sub property of: regulates
IAO_0000412: go.owl

transports or maintains localization of
type: ObjectProperty

has target end location
type: ObjectProperty

results_in
type: ObjectProperty
creation date: 2012-03-14T10:35:44Z
comment: This relation is currently used to connect two regulation processes p1 and p2, such that if r1 regulates p1 and r2 regulates p2, and r1 results_in r2 then the regulation of p1 is required for the regulation of p2. For an example of use, see GO:0035958 'regulation of glyoxylate cycle by regulation of transcription from RNA polymerase II promoter'. Note that a precise definition of this relation is under discussion. After it has been formalized it will be added to RO, where it will have a RO ID. Note that the existing identifier and label are subject to change.
created by: cjm
has_obo_namespace: gene_ontology
id: results_in
IAO_0000412: go.owl

decreased_in_magnitude_relative_to
type: ObjectProperty
type: TransitiveProperty
comment: This relation is used to determine the 'directionality' of relative qualities such as 'decreased strength', relative to the parent type, 'strength'.
id: decreased_in_magnitude_relative_to
IAO_0000115: q1 decreased_in_magnitude_relative_to q2 if and only if magnitude(q1) < magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale.
has_obo_namespace: quality
range: quality
domain: quality
IAO_0000412: pato.owl
sub property of: different_in_magnitude_relative_to

Axiom
database_cross_reference: PATOC:CJM
annotated target: q1 decreased_in_magnitude_relative_to q2 if and only if magnitude(q1) < magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale.
annotated property: IAO_0000115
annotated source: decreased_in_magnitude_relative_to

different_in_magnitude_relative_to
type: ObjectProperty
id: different_in_magnitude_relative_to
IAO_0000115: q1 different_in_magnitude_relative_to q2 if and only if magnitude(q1) NOT =~ magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale.
has_obo_namespace: quality
domain: quality
range: quality
IAO_0000412: pato.owl

Axiom
database_cross_reference: PATOC:CJM
annotated target: q1 different_in_magnitude_relative_to q2 if and only if magnitude(q1) NOT =~ magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale.
annotated property: IAO_0000115
annotated source: different_in_magnitude_relative_to

directly_associated_with
type: ObjectProperty
creation date: 2009-08-26T02:50:08Z
comment: Example: 'Lewy bodies increased number related to dystrophic neurite increased number' (from annotation of PMID:8740227 in http://ccdb.ucsd.edu/1.0/NDPO.owl#ndpo_404). Here the increase in the number of lewy bodies is directly_associated_with the increase in the number of dystrophic neurites. Association is weaker than correlation or proportionality. These relations may be later added to PATO.
created by: cjm
id: directly_associated_with
IAO_0000115: q1 directly_associated_with q2 iff q1 is dependent on q2, and the magnitude of q1 increases if the magnitude of q2 is increased, or the magnitude of q1 decreases if the magnitude of q2 is decreased. The relationship is not necessarily linear.
has_obo_namespace: quality
domain: quality
range: quality
IAO_0000412: pato.owl

Axiom
database_cross_reference: PATOC:cjm
database_cross_reference: Wikipedia:Association_(statistics)
annotated target: q1 directly_associated_with q2 iff q1 is dependent on q2, and the magnitude of q1 increases if the magnitude of q2 is increased, or the magnitude of q1 decreases if the magnitude of q2 is decreased. The relationship is not necessarily linear.
annotated property: IAO_0000115
annotated source: directly_associated_with

has_cross_section
type: ObjectProperty
comment: Example: a spherical object has the quality of being spherical, and the spherical quality has_cross_section round.
id: has_cross_section
has_obo_namespace: quality
IAO_0000115: s3 has_cross_section s3 if and only if : there exists some 2d plane that intersects the bearer of s3, and the impression of s3 upon that plane has shape quality s2.
IAO_0000412: pato.owl

Axiom
database_cross_reference: PATOC:CJM
annotated target: s3 has_cross_section s3 if and only if : there exists some 2d plane that intersects the bearer of s3, and the impression of s3 upon that plane has shape quality s2.
annotated property: IAO_0000115
annotated source: has_cross_section

has_dividend_quality
type: ObjectProperty
id: has_dividend_quality
has_obo_namespace: quality
range: quality
IAO_0000412: pato.owl
sub property of: has_ratio_quality

has_divisor_quality
type: ObjectProperty
id: has_divisor_quality
has_obo_namespace: quality
range: quality
IAO_0000412: pato.owl
sub property of: has_ratio_quality

has_ratio_quality
type: ObjectProperty
id: has_ratio_quality
has_obo_namespace: quality
range: quality
IAO_0000412: pato.owl

increased_in_magnitude_relative_to
type: ObjectProperty
type: TransitiveProperty
comment: This relation is used to determine the 'directionality' of relative qualities such as 'increased strength', relative to the parent type, 'strength'.
id: increased_in_magnitude_relative_to
IAO_0000115: q1 increased_in_magnitude_relative_to q2 if and only if magnitude(q1) > magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale.
has_obo_namespace: quality
domain: quality
range: quality
IAO_0000412: pato.owl
sub property of: different_in_magnitude_relative_to

Axiom
database_cross_reference: PATOC:CJM
annotated target: q1 increased_in_magnitude_relative_to q2 if and only if magnitude(q1) > magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale.
annotated property: IAO_0000115
annotated source: increased_in_magnitude_relative_to

inversely_associated_with
type: ObjectProperty
creation date: 2009-08-26T02:50:24Z
comment: Association is weaker than correlation or proportionality. These relations may be later added to PATO.
created by: cjm
id: inversely_associated_with
IAO_0000115: q1 inversely_associated_with q2 iff q1 is dependent on q2, and the magnitude of q1 decreases if the magnitude of q2 is increased, or the magnitude of q1 increases if the magnitude of q2 is decreased. The relationship is not necessarily linear.
has_obo_namespace: quality
domain: quality
range: quality
IAO_0000412: pato.owl

Axiom
database_cross_reference: PATOC:cjm
database_cross_reference: Wikipedia:Association_(statistics)
annotated target: q1 inversely_associated_with q2 iff q1 is dependent on q2, and the magnitude of q1 decreases if the magnitude of q2 is increased, or the magnitude of q1 increases if the magnitude of q2 is decreased. The relationship is not necessarily linear.
annotated property: IAO_0000115
annotated source: inversely_associated_with

reciprocal_of
type: ObjectProperty
comment: There are frequently two ways to state the same thing: we can say 'spermatocyte lacks asters' or 'asters absent from spermatocyte'. In this case the quality is 'lacking all parts of type' - it is a (relational) quality of the spermatocyte, and it is with respect to instances of 'aster'. One of the popular requirements of PATO is that it continue to support 'absent', so we need to relate statements which use this quality to the 'lacking all parts of type' quality.
IAO_0000115: q1 reciprocal_of q2 if and only if : q1 and q2 are relational qualities and a phenotype e q1 e2 mutually implies a phenotype e2 q2 e.
has_obo_namespace: quality
id: reciprocal_of
IAO_0000412: pato.owl

Axiom
database_cross_reference: PATOC:CJM
annotated target: q1 reciprocal_of q2 if and only if : q1 and q2 are relational qualities and a phenotype e q1 e2 mutually implies a phenotype e2 q2 e.
annotated property: IAO_0000115
annotated source: reciprocal_of

similar_in_magnitude_relative_to
type: ObjectProperty
IAO_0000115: q1 similar_in_magnitude_relative_to q2 if and only if magnitude(q1) =~ magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale.
has_obo_namespace: quality
id: similar_in_magnitude_relative_to
range: quality
domain: quality
IAO_0000412: pato.owl

Axiom
database_cross_reference: PATOC:CJM
annotated target: q1 similar_in_magnitude_relative_to q2 if and only if magnitude(q1) =~ magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale.
annotated property: IAO_0000115
annotated source: similar_in_magnitude_relative_to

towards
type: ObjectProperty
comment: Relation binding a relational quality or disposition to the relevant type of entity.
has_obo_namespace: quality
id: towards
IAO_0000412: pato.owl

has accuracy
type: ObjectProperty

has qualifier
type: ObjectProperty

polypeptide
type: Class
subclass of: macromolecule
has_related_synonym: protein

deoxyribonucleic acid
type: Class
subclass of: nucleic acid

molecular entity
type: Class

nucleic acid
type: Class
subclass of: molecular entity

macromolecule
type: Class
subclass of: molecular entity

cto:cell
IAO_0000115: A cell that is maintained or propagated in a controlled artificial environment for use in an investigation.

mitotic sister chromatid segregation
type: Class
equivalent class: Class
  intersection of: chromosome segregation
  intersection of: Restriction
    on property: part_of
    some values from: mitotic cell cycle
subclass of: sister chromatid segregation
subclass of: Restriction
  on property: part_of
  some values from: mitotic cell cycle
subclass of: Restriction
  on property: part_of
  some values from: mitosis
id: GO:0000070
has_alternative_id: GO:0016359
IAO_0000115: The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets.
has_obo_namespace: biological_process
has_exact_synonym: mitotic chromosome segregation
has_narrow_synonym: mitotic sister-chromatid adhesion release
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:ai
annotated target: The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets.
annotated source: mitotic sister chromatid segregation
annotated property: IAO_0000115

G1 phase of mitotic cell cycle
type: Class
equivalent class: Class
  intersection of: G1 phase
  intersection of: Restriction
    on property: part_of
    some values from: mitotic cell cycle
subclass of: G1 phase
subclass of: Restriction
  on property: part_of
  some values from: mitotic cell cycle
subclass of: Restriction
  on property: part_of
  some values from: interphase of mitotic cell cycle
id: GO:0000080
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct process is 'regulation of x/y phase transition'.
database_cross_reference: Reactome:REACT_101162
database_cross_reference: Reactome:REACT_1590
database_cross_reference: Reactome:REACT_29795
database_cross_reference: Reactome:REACT_34060
database_cross_reference: Reactome:REACT_78665
database_cross_reference: Reactome:REACT_78866
database_cross_reference: Reactome:REACT_83686
database_cross_reference: Reactome:REACT_91654
database_cross_reference: Reactome:REACT_93384
database_cross_reference: Reactome:REACT_93574
IAO_0000115: The cell cycle 'gap' phase which is the interval between the completion of DNA segregation by mitosis and the beginning of DNA synthesis.
has_obo_namespace: biological_process
IAO_0000412: go.owl
in_subset: gocheck do not annotate

Axiom
database_cross_reference: GOC:mtg_cell_cycle
annotated target: The cell cycle 'gap' phase which is the interval between the completion of DNA segregation by mitosis and the beginning of DNA synthesis.
annotated source: G1 phase of mitotic cell cycle
annotated property: IAO_0000115

G1 Phase, Sus scrofa
type: Axiom
annotated target: Reactome:REACT_78866
annotated source: G1 phase of mitotic cell cycle
annotated property: database_cross_reference

G1 Phase, Canis familiaris
type: Axiom
annotated target: Reactome:REACT_34060
annotated source: G1 phase of mitotic cell cycle
annotated property: database_cross_reference

G1 Phase, Taeniopygia guttata
type: Axiom
annotated target: Reactome:REACT_29795
annotated source: G1 phase of mitotic cell cycle
annotated property: database_cross_reference

G1 Phase, Gallus gallus
type: Axiom
annotated target: Reactome:REACT_78665
annotated source: G1 phase of mitotic cell cycle
annotated property: database_cross_reference

G1 Phase, Mus musculus
type: Axiom
annotated target: Reactome:REACT_91654
annotated source: G1 phase of mitotic cell cycle
annotated property: database_cross_reference

G1 Phase, Xenopus tropicalis
type: Axiom
annotated target: Reactome:REACT_93574
annotated source: G1 phase of mitotic cell cycle
annotated property: database_cross_reference

G1 Phase, Rattus norvegicus
type: Axiom
annotated target: Reactome:REACT_93384
annotated source: G1 phase of mitotic cell cycle
annotated property: database_cross_reference

G1 Phase, Danio rerio
type: Axiom
annotated target: Reactome:REACT_83686
annotated source: G1 phase of mitotic cell cycle
annotated property: database_cross_reference

G1 Phase, Bos taurus
type: Axiom
annotated target: Reactome:REACT_101162
annotated source: G1 phase of mitotic cell cycle
annotated property: database_cross_reference

G1 Phase, Homo sapiens
type: Axiom
annotated target: Reactome:REACT_1590
annotated source: G1 phase of mitotic cell cycle
annotated property: database_cross_reference

S phase of mitotic cell cycle
type: Class
equivalent class: Class
  intersection of: S phase
  intersection of: Restriction
    on property: part_of
    some values from: mitotic cell cycle
subclass of: S phase
subclass of: Restriction
  on property: part_of
  some values from: interphase of mitotic cell cycle
subclass of: Restriction
  on property: part_of
  some values from: mitotic cell cycle
id: GO:0000084
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct process is 'regulation of x/y phase transition'.
database_cross_reference: Reactome:REACT_105829
database_cross_reference: Reactome:REACT_108550
database_cross_reference: Reactome:REACT_110039
database_cross_reference: Reactome:REACT_28988
database_cross_reference: Reactome:REACT_32013
database_cross_reference: Reactome:REACT_34043
database_cross_reference: Reactome:REACT_78838
database_cross_reference: Reactome:REACT_78845
database_cross_reference: Reactome:REACT_81914
database_cross_reference: Reactome:REACT_82813
database_cross_reference: Reactome:REACT_85811
database_cross_reference: Reactome:REACT_89318
database_cross_reference: Reactome:REACT_899
database_cross_reference: Reactome:REACT_92500
database_cross_reference: Reactome:REACT_92759
database_cross_reference: Reactome:REACT_95174
database_cross_reference: Reactome:REACT_96081
database_cross_reference: Reactome:REACT_97603
database_cross_reference: Reactome:REACT_99645
has_exact_synonym: S-phase of mitotic cell cycle
IAO_0000115: The cell cycle phase, following G1, during which DNA synthesis takes place as part of a mitotic cell cycle.
has_obo_namespace: biological_process
IAO_0000412: go.owl
in_subset: gocheck do not annotate

Axiom
database_cross_reference: GOC:mtg_cell_cycle
annotated target: The cell cycle phase, following G1, during which DNA synthesis takes place as part of a mitotic cell cycle.
annotated source: S phase of mitotic cell cycle
annotated property: IAO_0000115

S Phase, Mus musculus
type: Axiom
annotated target: Reactome:REACT_92500
annotated source: S phase of mitotic cell cycle
annotated property: database_cross_reference

S Phase, Caenorhabditis elegans
type: Axiom
annotated target: Reactome:REACT_105829
annotated source: S phase of mitotic cell cycle
annotated property: database_cross_reference

S Phase, Canis familiaris
type: Axiom
annotated target: Reactome:REACT_92759
annotated source: S phase of mitotic cell cycle
annotated property: database_cross_reference

S Phase, Xenopus tropicalis
type: Axiom
annotated target: Reactome:REACT_78845
annotated source: S phase of mitotic cell cycle
annotated property: database_cross_reference

S Phase, Bos taurus
type: Axiom
annotated target: Reactome:REACT_99645
annotated source: S phase of mitotic cell cycle
annotated property: database_cross_reference

S Phase, Arabidopsis thaliana
type: Axiom
annotated target: Reactome:REACT_82813
annotated source: S phase of mitotic cell cycle
annotated property: database_cross_reference

S Phase, Rattus norvegicus
type: Axiom
annotated target: Reactome:REACT_108550
annotated source: S phase of mitotic cell cycle
annotated property: database_cross_reference

S Phase, Danio rerio
type: Axiom
annotated target: Reactome:REACT_97603
annotated source: S phase of mitotic cell cycle
annotated property: database_cross_reference

S Phase, Sus scrofa
type: Axiom
annotated target: Reactome:REACT_85811
annotated source: S phase of mitotic cell cycle
annotated property: database_cross_reference

S Phase, Saccharomyces cerevisiae
type: Axiom
annotated target: Reactome:REACT_81914
annotated source: S phase of mitotic cell cycle
annotated property: database_cross_reference

S Phase, Plasmodium falciparum
type: Axiom
annotated target: Reactome:REACT_78838
annotated source: S phase of mitotic cell cycle
annotated property: database_cross_reference

S Phase, Drosophila melanogaster
type: Axiom
annotated target: Reactome:REACT_89318
annotated source: S phase of mitotic cell cycle
annotated property: database_cross_reference

S Phase, Oryza sativa
type: Axiom
annotated target: Reactome:REACT_34043
annotated source: S phase of mitotic cell cycle
annotated property: database_cross_reference

S Phase, Taeniopygia guttata
type: Axiom
annotated target: Reactome:REACT_28988
annotated source: S phase of mitotic cell cycle
annotated property: database_cross_reference

S Phase, Mycobacterium tuberculosis
type: Axiom
annotated target: Reactome:REACT_32013
annotated source: S phase of mitotic cell cycle
annotated property: database_cross_reference

S Phase, Dictyostelium discoideum
type: Axiom
annotated target: Reactome:REACT_96081
annotated source: S phase of mitotic cell cycle
annotated property: database_cross_reference

S Phase, Homo sapiens
type: Axiom
annotated target: Reactome:REACT_899
annotated source: S phase of mitotic cell cycle
annotated property: database_cross_reference

S Phase, Schizosaccharomyces pombe
type: Axiom
annotated target: Reactome:REACT_110039
annotated source: S phase of mitotic cell cycle
annotated property: database_cross_reference

S Phase, Gallus gallus
type: Axiom
annotated target: Reactome:REACT_95174
annotated source: S phase of mitotic cell cycle
annotated property: database_cross_reference

G2 phase of mitotic cell cycle
type: Class
equivalent class: Class
  intersection of: G2 phase
  intersection of: Restriction
    on property: part_of
    some values from: mitotic cell cycle
subclass of: G2 phase
subclass of: Restriction
  on property: part_of
  some values from: interphase of mitotic cell cycle
subclass of: Restriction
  on property: part_of
  some values from: mitotic cell cycle
id: GO:0000085
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct process is 'regulation of x/y phase transition'.
database_cross_reference: Reactome:REACT_105223
database_cross_reference: Reactome:REACT_105307
database_cross_reference: Reactome:REACT_106415
database_cross_reference: Reactome:REACT_106836
database_cross_reference: Reactome:REACT_1915
database_cross_reference: Reactome:REACT_28975
database_cross_reference: Reactome:REACT_85928
database_cross_reference: Reactome:REACT_96332
IAO_0000115: The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation by mitosis.
has_obo_namespace: biological_process
IAO_0000412: go.owl

G2 Phase, Sus scrofa
type: Axiom
annotated target: Reactome:REACT_85928
annotated source: G2 phase of mitotic cell cycle
annotated property: database_cross_reference

G2 Phase, Mus musculus
type: Axiom
annotated target: Reactome:REACT_105223
annotated source: G2 phase of mitotic cell cycle
annotated property: database_cross_reference

G2 Phase, Rattus norvegicus
type: Axiom
annotated target: Reactome:REACT_28975
annotated source: G2 phase of mitotic cell cycle
annotated property: database_cross_reference

Axiom
database_cross_reference: GOC:mtg_cell_cycle
annotated target: The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation by mitosis.
annotated source: G2 phase of mitotic cell cycle
annotated property: IAO_0000115

G2 Phase, Xenopus tropicalis
type: Axiom
annotated target: Reactome:REACT_106415
annotated source: G2 phase of mitotic cell cycle
annotated property: database_cross_reference

G2 Phase, Homo sapiens
type: Axiom
annotated target: Reactome:REACT_1915
annotated source: G2 phase of mitotic cell cycle
annotated property: database_cross_reference

G2 Phase, Canis familiaris
type: Axiom
annotated target: Reactome:REACT_105307
annotated source: G2 phase of mitotic cell cycle
annotated property: database_cross_reference

G2 Phase, Danio rerio
type: Axiom
annotated target: Reactome:REACT_96332
annotated source: G2 phase of mitotic cell cycle
annotated property: database_cross_reference

G2 Phase, Bos taurus
type: Axiom
annotated target: Reactome:REACT_106836
annotated source: G2 phase of mitotic cell cycle
annotated property: database_cross_reference

G2/M transition of mitotic cell cycle
type: Class
subclass of: mitotic cell cycle phase transition
id: GO:0000086
database_cross_reference: Reactome:REACT_100942
database_cross_reference: Reactome:REACT_103766
database_cross_reference: Reactome:REACT_107882
database_cross_reference: Reactome:REACT_114616
database_cross_reference: Reactome:REACT_2203
database_cross_reference: Reactome:REACT_28929
database_cross_reference: Reactome:REACT_30388
database_cross_reference: Reactome:REACT_34062
database_cross_reference: Reactome:REACT_77778
database_cross_reference: Reactome:REACT_83880
database_cross_reference: Reactome:REACT_87036
database_cross_reference: Reactome:REACT_87230
database_cross_reference: Reactome:REACT_87807
database_cross_reference: Reactome:REACT_88018
database_cross_reference: Reactome:REACT_88369
database_cross_reference: Reactome:REACT_92702
IAO_0000115: The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex.
has_obo_namespace: biological_process
IAO_0000412: go.owl

G2/M Transition, Saccharomyces cerevisiae
type: Axiom
annotated target: Reactome:REACT_87036
annotated source: G2/M transition of mitotic cell cycle
annotated property: database_cross_reference

G2/M Transition, Caenorhabditis elegans
type: Axiom
annotated target: Reactome:REACT_88018
annotated source: G2/M transition of mitotic cell cycle
annotated property: database_cross_reference

G2/M Transition, Bos taurus
type: Axiom
annotated target: Reactome:REACT_92702
annotated source: G2/M transition of mitotic cell cycle
annotated property: database_cross_reference

G2/M Transition, Arabidopsis thaliana
type: Axiom
annotated target: Reactome:REACT_114616
annotated source: G2/M transition of mitotic cell cycle
annotated property: database_cross_reference

G2/M Transition, Mus musculus
type: Axiom
annotated target: Reactome:REACT_34062
annotated source: G2/M transition of mitotic cell cycle
annotated property: database_cross_reference

G2/M Transition, Rattus norvegicus
type: Axiom
annotated target: Reactome:REACT_88369
annotated source: G2/M transition of mitotic cell cycle
annotated property: database_cross_reference

G2/M Transition, Sus scrofa
type: Axiom
annotated target: Reactome:REACT_107882
annotated source: G2/M transition of mitotic cell cycle
annotated property: database_cross_reference

G2/M Transition, Gallus gallus
type: Axiom
annotated target: Reactome:REACT_30388
annotated source: G2/M transition of mitotic cell cycle
annotated property: database_cross_reference

G2/M Transition, Dictyostelium discoideum
type: Axiom
annotated target: Reactome:REACT_87807
annotated source: G2/M transition of mitotic cell cycle
annotated property: database_cross_reference

G2/M Transition, Xenopus tropicalis
type: Axiom
annotated target: Reactome:REACT_28929
annotated source: G2/M transition of mitotic cell cycle
annotated property: database_cross_reference

Axiom
database_cross_reference: GOC:mtg_cell_cycle
annotated target: The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex.
annotated source: G2/M transition of mitotic cell cycle
annotated property: IAO_0000115

G2/M Transition, Schizosaccharomyces pombe
type: Axiom
annotated target: Reactome:REACT_103766
annotated source: G2/M transition of mitotic cell cycle
annotated property: database_cross_reference

G2/M Transition, Homo sapiens
type: Axiom
annotated target: Reactome:REACT_2203
annotated source: G2/M transition of mitotic cell cycle
annotated property: database_cross_reference

G2/M Transition, Taeniopygia guttata
type: Axiom
annotated target: Reactome:REACT_77778
annotated source: G2/M transition of mitotic cell cycle
annotated property: database_cross_reference

G2/M Transition, Danio rerio
type: Axiom
annotated target: Reactome:REACT_100942
annotated source: G2/M transition of mitotic cell cycle
annotated property: database_cross_reference

G2/M Transition, Drosophila melanogaster
type: Axiom
annotated target: Reactome:REACT_83880
annotated source: G2/M transition of mitotic cell cycle
annotated property: database_cross_reference

G2/M Transition, Canis familiaris
type: Axiom
annotated target: Reactome:REACT_87230
annotated source: G2/M transition of mitotic cell cycle
annotated property: database_cross_reference

M phase of mitotic cell cycle
type: Class
equivalent class: Class
  intersection of: M phase
  intersection of: Restriction
    on property: part_of
    some values from: mitotic cell cycle
subclass of: M phase
subclass of: Restriction
  on property: part_of
  some values from: mitotic cell cycle
IAO_0000115: A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase and occurs as part of a mitotic cell cycle.
id: GO:0000087
has_exact_synonym: M-phase of mitotic cell cycle
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct process is 'regulation of x/y phase transition'.
database_cross_reference: Reactome:REACT_105412
database_cross_reference: Reactome:REACT_107095
database_cross_reference: Reactome:REACT_109059
database_cross_reference: Reactome:REACT_29488
database_cross_reference: Reactome:REACT_33490
database_cross_reference: Reactome:REACT_82055
database_cross_reference: Reactome:REACT_87132
database_cross_reference: Reactome:REACT_88263
database_cross_reference: Reactome:REACT_910
database_cross_reference: Reactome:REACT_92998
database_cross_reference: Reactome:REACT_93131
database_cross_reference: Reactome:REACT_93566
database_cross_reference: Reactome:REACT_93720
database_cross_reference: Reactome:REACT_94536
has_obo_namespace: biological_process
IAO_0000412: go.owl
in_subset: gocheck do not annotate

M Phase, Homo sapiens
type: Axiom
annotated target: Reactome:REACT_910
annotated source: M phase of mitotic cell cycle
annotated property: database_cross_reference

Axiom
annotated target: A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase and occurs as part of a mitotic cell cycle.
database_cross_reference: GOC:mtg_cell_cycle
annotated source: M phase of mitotic cell cycle
annotated property: IAO_0000115

M Phase, Bos taurus
type: Axiom
annotated target: Reactome:REACT_87132
annotated source: M phase of mitotic cell cycle
annotated property: database_cross_reference

M Phase, Schizosaccharomyces pombe
type: Axiom
annotated target: Reactome:REACT_93131
annotated source: M phase of mitotic cell cycle
annotated property: database_cross_reference

M Phase, Danio rerio
type: Axiom
annotated target: Reactome:REACT_92998
annotated source: M phase of mitotic cell cycle
annotated property: database_cross_reference

M Phase, Rattus norvegicus
type: Axiom
annotated target: Reactome:REACT_82055
annotated source: M phase of mitotic cell cycle
annotated property: database_cross_reference

M Phase, Canis familiaris
type: Axiom
annotated target: Reactome:REACT_29488
annotated source: M phase of mitotic cell cycle
annotated property: database_cross_reference

M Phase, Drosophila melanogaster
type: Axiom
annotated target: Reactome:REACT_93720
annotated source: M phase of mitotic cell cycle
annotated property: database_cross_reference

M Phase, Caenorhabditis elegans
type: Axiom
annotated target: Reactome:REACT_33490
annotated source: M phase of mitotic cell cycle
annotated property: database_cross_reference

M Phase, Mus musculus
type: Axiom
annotated target: Reactome:REACT_105412
annotated source: M phase of mitotic cell cycle
annotated property: database_cross_reference

M Phase, Xenopus tropicalis
type: Axiom
annotated target: Reactome:REACT_88263
annotated source: M phase of mitotic cell cycle
annotated property: database_cross_reference

M Phase, Dictyostelium discoideum
type: Axiom
annotated target: Reactome:REACT_107095
annotated source: M phase of mitotic cell cycle
annotated property: database_cross_reference

M Phase, Gallus gallus
type: Axiom
annotated target: Reactome:REACT_93566
annotated source: M phase of mitotic cell cycle
annotated property: database_cross_reference

M Phase, Taeniopygia guttata
type: Axiom
annotated target: Reactome:REACT_94536
annotated source: M phase of mitotic cell cycle
annotated property: database_cross_reference

M Phase, Saccharomyces cerevisiae
type: Axiom
annotated target: Reactome:REACT_109059
annotated source: M phase of mitotic cell cycle
annotated property: database_cross_reference

mitotic prophase
type: Class
equivalent class: Class
  intersection of: prophase
  intersection of: Restriction
    on property: part_of
    some values from: mitotic cell cycle
subclass of: prophase
subclass of: Restriction
  on property: part_of
  some values from: mitotic cell cycle
id: GO:0000088
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct process is 'regulation of x/y phase transition'.
database_cross_reference: Reactome:REACT_100605
database_cross_reference: Reactome:REACT_102122
database_cross_reference: Reactome:REACT_105127
database_cross_reference: Reactome:REACT_106058
database_cross_reference: Reactome:REACT_28443
database_cross_reference: Reactome:REACT_28607
database_cross_reference: Reactome:REACT_32677
database_cross_reference: Reactome:REACT_765
database_cross_reference: Reactome:REACT_79474
database_cross_reference: Reactome:REACT_80300
database_cross_reference: Reactome:REACT_83888
database_cross_reference: Reactome:REACT_90347
database_cross_reference: Reactome:REACT_90481
IAO_0000115: The cell cycle phase which is the first stage of M phase of mitosis and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell.
has_obo_namespace: biological_process
IAO_0000412: go.owl
in_subset: gocheck do not annotate

Mitotic Prophase, Xenopus tropicalis
type: Axiom
annotated target: Reactome:REACT_32677
annotated source: mitotic prophase
annotated property: database_cross_reference

Mitotic Prophase, Schizosaccharomyces pombe
type: Axiom
annotated target: Reactome:REACT_90481
annotated source: mitotic prophase
annotated property: database_cross_reference

Mitotic Prophase, Drosophila melanogaster
type: Axiom
annotated target: Reactome:REACT_106058
annotated source: mitotic prophase
annotated property: database_cross_reference

Mitotic Prophase, Dictyostelium discoideum
type: Axiom
annotated target: Reactome:REACT_83888
annotated source: mitotic prophase
annotated property: database_cross_reference

Mitotic Prophase, Taeniopygia guttata
type: Axiom
annotated target: Reactome:REACT_28443
annotated source: mitotic prophase
annotated property: database_cross_reference

Mitotic Prophase, Gallus gallus
type: Axiom
annotated target: Reactome:REACT_80300
annotated source: mitotic prophase
annotated property: database_cross_reference

Mitotic Prophase, Homo sapiens
type: Axiom
annotated target: Reactome:REACT_765
annotated source: mitotic prophase
annotated property: database_cross_reference

Mitotic Prophase, Mus musculus
type: Axiom
annotated target: Reactome:REACT_102122
annotated source: mitotic prophase
annotated property: database_cross_reference

Mitotic Prophase, Caenorhabditis elegans
type: Axiom
annotated target: Reactome:REACT_79474
annotated source: mitotic prophase
annotated property: database_cross_reference

Axiom
database_cross_reference: GOC:mtg_cell_cycle
annotated target: The cell cycle phase which is the first stage of M phase of mitosis and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell.
annotated source: mitotic prophase
annotated property: IAO_0000115

Mitotic Prophase, Saccharomyces cerevisiae
type: Axiom
annotated target: Reactome:REACT_100605
annotated source: mitotic prophase
annotated property: database_cross_reference

Mitotic Prophase, Rattus norvegicus
type: Axiom
annotated target: Reactome:REACT_28607
annotated source: mitotic prophase
annotated property: database_cross_reference

Mitotic Prophase, Danio rerio
type: Axiom
annotated target: Reactome:REACT_105127
annotated source: mitotic prophase
annotated property: database_cross_reference

Mitotic Prophase, Canis familiaris
type: Axiom
annotated target: Reactome:REACT_90347
annotated source: mitotic prophase
annotated property: database_cross_reference

mitotic metaphase
type: Class
equivalent class: Class
  intersection of: metaphase
  intersection of: Restriction
    on property: part_of
    some values from: mitotic cell cycle
subclass of: metaphase
subclass of: Restriction
  on property: part_of
  some values from: mitotic cell cycle
id: GO:0000089
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct process is 'regulation of x/y phase transition'.
database_cross_reference: Reactome:REACT_434
IAO_0000115: The cell cycle phase, following prophase, during which chromosomes become aligned on the equatorial plate of the cell as part of a mitotic cell cycle.
has_obo_namespace: biological_process
IAO_0000412: go.owl
in_subset: gocheck do not annotate

Axiom
database_cross_reference: GOC:mtg_cell_cycle
annotated target: The cell cycle phase, following prophase, during which chromosomes become aligned on the equatorial plate of the cell as part of a mitotic cell cycle.
annotated source: mitotic metaphase
annotated property: IAO_0000115

Mitotic Metaphase, Homo sapiens
type: Axiom
annotated target: Reactome:REACT_434
annotated source: mitotic metaphase
annotated property: database_cross_reference

microtubule cytoskeleton organization
type: Class
subclass of: cytoskeleton organization
subclass of: microtubule-based process
IAO_0000115: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
id: GO:0000226
has_obo_namespace: biological_process
has_exact_synonym: microtubule cytoskeleton organisation
has_related_synonym: microtubule cytoskeleton organization and biogenesis
has_exact_synonym: microtubule dynamics
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:mah
annotated target: microtubule cytoskeleton organisation
annotated source: microtubule cytoskeleton organization
annotated property: has_exact_synonym

Axiom
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
database_cross_reference: GOC:mah
annotated source: microtubule cytoskeleton organization
annotated property: IAO_0000115

Axiom
database_cross_reference: GOC:mah
annotated target: microtubule cytoskeleton organization and biogenesis
annotated source: microtubule cytoskeleton organization
annotated property: has_related_synonym

Axiom
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb
annotated target: microtubule dynamics
annotated source: microtubule cytoskeleton organization
annotated property: has_exact_synonym

mitotic prometaphase
type: Class
subclass of: cell cycle phase
id: GO:0000236
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct process is 'regulation of x/y phase transition'.
database_cross_reference: Reactome:REACT_102823
database_cross_reference: Reactome:REACT_104270
database_cross_reference: Reactome:REACT_105082
database_cross_reference: Reactome:REACT_114704
database_cross_reference: Reactome:REACT_118069
database_cross_reference: Reactome:REACT_118526
database_cross_reference: Reactome:REACT_118539
database_cross_reference: Reactome:REACT_31336
database_cross_reference: Reactome:REACT_31385
database_cross_reference: Reactome:REACT_682
database_cross_reference: Reactome:REACT_79351
database_cross_reference: Reactome:REACT_83126
database_cross_reference: Reactome:REACT_98905
database_cross_reference: Reactome:REACT_99376
IAO_0000115: The cell cycle phase in higher eukaryotes which follows mitotic prophase and during which the nuclear envelope is disrupted and breaks into membrane vesicles, and the spindle microtubules enter the nuclear region. Kinetochores mature on each centromere and attach to some of the spindle microtubules. Kinetochore microtubules begin the process of aligning chromosomes in one plane halfway between the poles.
has_obo_namespace: biological_process
IAO_0000412: go.owl
in_subset: gocheck do not annotate

Mitotic Prometaphase, Bos taurus
type: Axiom
annotated target: Reactome:REACT_104270
annotated source: mitotic prometaphase
annotated property: database_cross_reference

Mitotic Prometaphase, Saccharomyces cerevisiae
type: Axiom
annotated target: Reactome:REACT_118526
annotated source: mitotic prometaphase
annotated property: database_cross_reference

Mitotic Prometaphase, Drosophila melanogaster
type: Axiom
annotated target: Reactome:REACT_83126
annotated source: mitotic prometaphase
annotated property: database_cross_reference

Mitotic Prometaphase, Rattus norvegicus
type: Axiom
annotated target: Reactome:REACT_79351
annotated source: mitotic prometaphase
annotated property: database_cross_reference

Mitotic Prometaphase, Canis familiaris
type: Axiom
annotated target: Reactome:REACT_99376
annotated source: mitotic prometaphase
annotated property: database_cross_reference

Mitotic Prometaphase, Danio rerio
type: Axiom
annotated target: Reactome:REACT_31336
annotated source: mitotic prometaphase
annotated property: database_cross_reference

Mitotic Prometaphase, Mus musculus
type: Axiom
annotated target: Reactome:REACT_102823
annotated source: mitotic prometaphase
annotated property: database_cross_reference

Mitotic Prometaphase, Homo sapiens
type: Axiom
annotated target: Reactome:REACT_682
annotated source: mitotic prometaphase
annotated property: database_cross_reference

Mitotic Prometaphase, Xenopus tropicalis
type: Axiom
annotated target: Reactome:REACT_98905
annotated source: mitotic prometaphase
annotated property: database_cross_reference

Mitotic Prometaphase, Schizosaccharomyces pombe
type: Axiom
annotated target: Reactome:REACT_114704
annotated source: mitotic prometaphase
annotated property: database_cross_reference

Mitotic Prometaphase, Gallus gallus
type: Axiom
annotated target: Reactome:REACT_118069
annotated source: mitotic prometaphase
annotated property: database_cross_reference

Mitotic Prometaphase, Caenorhabditis elegans
type: Axiom
annotated target: Reactome:REACT_31385
annotated source: mitotic prometaphase
annotated property: database_cross_reference

Mitotic Prometaphase, Dictyostelium discoideum
type: Axiom
annotated target: Reactome:REACT_105082
annotated source: mitotic prometaphase
annotated property: database_cross_reference

Axiom
database_cross_reference: GOC:mtg_cell_cycle
annotated target: The cell cycle phase in higher eukaryotes which follows mitotic prophase and during which the nuclear envelope is disrupted and breaks into membrane vesicles, and the spindle microtubules enter the nuclear region. Kinetochores mature on each centromere and attach to some of the spindle microtubules. Kinetochore microtubules begin the process of aligning chromosomes in one plane halfway between the poles.
annotated source: mitotic prometaphase
annotated property: IAO_0000115

Mitotic Prometaphase, Taeniopygia guttata
type: Axiom
annotated target: Reactome:REACT_118539
annotated source: mitotic prometaphase
annotated property: database_cross_reference

mitotic cell cycle
type: Class
equivalent class: Class
  intersection of: cell cycle
  intersection of: Restriction
    on property: has_part
    some values from: mitosis
subclass of: cell cycle
subclass of: Restriction
  on property: has_part
  some values from: mitosis
id: GO:0000278
IAO_0000115: Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
database_cross_reference: Reactome:REACT_100451
database_cross_reference: Reactome:REACT_104035
database_cross_reference: Reactome:REACT_104195
database_cross_reference: Reactome:REACT_105856
database_cross_reference: Reactome:REACT_108233
database_cross_reference: Reactome:REACT_152
database_cross_reference: Reactome:REACT_28464
database_cross_reference: Reactome:REACT_28953
database_cross_reference: Reactome:REACT_33388
database_cross_reference: Reactome:REACT_53493
database_cross_reference: Reactome:REACT_79085
database_cross_reference: Reactome:REACT_84794
database_cross_reference: Reactome:REACT_85137
database_cross_reference: Reactome:REACT_85950
database_cross_reference: Reactome:REACT_90332
database_cross_reference: Reactome:REACT_90846
database_cross_reference: Reactome:REACT_96281
database_cross_reference: Reactome:REACT_97744
database_cross_reference: Reactome:REACT_98208
has_obo_namespace: biological_process
IAO_0000412: go.owl
in_subset: goslim yeast

Cell Cycle, Mitotic, Rattus norvegicus
type: Axiom
annotated target: Reactome:REACT_33388
annotated source: mitotic cell cycle
annotated property: database_cross_reference

Cell Cycle, Mitotic, Mycobacterium tuberculosis
type: Axiom
annotated target: Reactome:REACT_98208
annotated source: mitotic cell cycle
annotated property: database_cross_reference

Axiom
database_cross_reference: GOC:mah
database_cross_reference: ISBN:0815316194
annotated target: Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
database_cross_reference: Reactome:69278
annotated source: mitotic cell cycle
annotated property: IAO_0000115

Cell Cycle, Mitotic, Sus scrofa
type: Axiom
annotated target: Reactome:REACT_104035
annotated source: mitotic cell cycle
annotated property: database_cross_reference

Cell Cycle, Mitotic, Schizosaccharomyces pombe
type: Axiom
annotated target: Reactome:REACT_79085
annotated source: mitotic cell cycle
annotated property: database_cross_reference

Cell Cycle, Mitotic, Oryza sativa
type: Axiom
annotated target: Reactome:REACT_90846
annotated source: mitotic cell cycle
annotated property: database_cross_reference

Cell Cycle, Mitotic, Homo sapiens
type: Axiom
annotated target: Reactome:REACT_152
annotated source: mitotic cell cycle
annotated property: database_cross_reference

Cell Cycle, Mitotic, Xenopus tropicalis
type: Axiom
annotated target: Reactome:REACT_28464
annotated source: mitotic cell cycle
annotated property: database_cross_reference

Cell Cycle, Mitotic, Caenorhabditis elegans
type: Axiom
annotated target: Reactome:REACT_84794
annotated source: mitotic cell cycle
annotated property: database_cross_reference

Cell Cycle, Mitotic, Canis familiaris
type: Axiom
annotated target: Reactome:REACT_104195
annotated source: mitotic cell cycle
annotated property: database_cross_reference

Cell Cycle, Mitotic, Saccharomyces cerevisiae
type: Axiom
annotated target: Reactome:REACT_108233
annotated source: mitotic cell cycle
annotated property: database_cross_reference

Cell Cycle, Mitotic, Arabidopsis thaliana
type: Axiom
annotated target: Reactome:REACT_85950
annotated source: mitotic cell cycle
annotated property: database_cross_reference

Cell Cycle, Mitotic, Drosophila melanogaster
type: Axiom
annotated target: Reactome:REACT_96281
annotated source: mitotic cell cycle
annotated property: database_cross_reference

Cell Cycle, Mitotic, Bos taurus
type: Axiom
annotated target: Reactome:REACT_28953
annotated source: mitotic cell cycle
annotated property: database_cross_reference

Cell Cycle, Mitotic, Dictyostelium discoideum
type: Axiom
annotated target: Reactome:REACT_97744
annotated source: mitotic cell cycle
annotated property: database_cross_reference

Cell Cycle, Mitotic, Danio rerio
type: Axiom
annotated target: Reactome:REACT_105856
annotated source: mitotic cell cycle
annotated property: database_cross_reference

Cell Cycle, Mitotic, Plasmodium falciparum
type: Axiom
annotated target: Reactome:REACT_53493
annotated source: mitotic cell cycle
annotated property: database_cross_reference

Cell Cycle, Mitotic, Gallus gallus
type: Axiom
annotated target: Reactome:REACT_85137
annotated source: mitotic cell cycle
annotated property: database_cross_reference

Cell Cycle, Mitotic, Taeniopygia guttata
type: Axiom
annotated target: Reactome:REACT_100451
annotated source: mitotic cell cycle
annotated property: database_cross_reference

Cell Cycle, Mitotic, Mus musculus
type: Axiom
annotated target: Reactome:REACT_90332
annotated source: mitotic cell cycle
annotated property: database_cross_reference

M phase
type: Class
subclass of: cell cycle phase
IAO_0000115: A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase.
id: GO:0000279
has_exact_synonym: M-phase
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct process is 'regulation of x/y phase transition'.
database_cross_reference: Wikipedia:M_phase
has_obo_namespace: biological_process
IAO_0000412: go.owl
in_subset: gocheck do not annotate

Axiom
annotated target: A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase.
database_cross_reference: GOC:mtg_cell_cycle
annotated source: M phase
annotated property: IAO_0000115

nuclear division
type: Class
subclass of: organelle fission
id: GO:0000280
IAO_0000115: The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei.
has_obo_namespace: biological_process
has_related_synonym: karyokinesis
IAO_0000412: go.owl
in_subset: goslim pir

Axiom
database_cross_reference: GOC:mah
annotated target: The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei.
annotated source: nuclear division
annotated property: IAO_0000115

DNA catabolic process, endonucleolytic
type: Class
subclass of: DNA catabolic process
subclass of: nucleic acid phosphodiester bond hydrolysis
has_exact_synonym: DNA breakdown, endonucleolytic
has_exact_synonym: DNA degradation, endonucleolytic
id: GO:0000737
IAO_0000115: The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides.
has_obo_namespace: biological_process
has_exact_synonym: endonucleolytic DNA catabolism
has_exact_synonym: endonucleolytic degradation of DNA
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:elh
database_cross_reference: GOC:mah
annotated target: The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides.
annotated source: DNA catabolic process, endonucleolytic
annotated property: IAO_0000115

sister chromatid segregation
type: Class
subclass of: chromosome segregation
subclass of: cell cycle process
subclass of: chromosome organization
id: GO:0000819
IAO_0000115: The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets.
has_obo_namespace: biological_process
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:ai
database_cross_reference: GOC:elh
annotated target: The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets.
annotated source: sister chromatid segregation
annotated property: IAO_0000115

cell morphogenesis
type: Class
subclass of: cellular component morphogenesis
id: GO:0000902
has_alternative_id: GO:0007148
has_alternative_id: GO:0045790
has_alternative_id: GO:0045791
IAO_0000115: The developmental process in which the size or shape of a cell is generated and organized.
has_obo_namespace: biological_process
has_exact_synonym: cellular morphogenesis
IAO_0000412: go.owl
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim yeast
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:clt
database_cross_reference: GOC:dph
database_cross_reference: GOC:go_curators
database_cross_reference: GOC:tb
annotated target: The developmental process in which the size or shape of a cell is generated and organized.
annotated source: cell morphogenesis
annotated property: IAO_0000115

cell morphogenesis involved in differentiation
type: Class
equivalent class: Class
  intersection of: cell morphogenesis
  intersection of: Restriction
    on property: part_of
    some values from: cell development
subclass of: cell morphogenesis
subclass of: Restriction
  on property: part_of
  some values from: cell development
id: GO:0000904
IAO_0000115: The change in form (cell shape and size) that occurs when relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history.
has_obo_namespace: biological_process
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:go_curators
annotated target: The change in form (cell shape and size) that occurs when relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history.
annotated source: cell morphogenesis involved in differentiation
annotated property: IAO_0000115

cytokinesis
type: Class
subclass of: cell cycle process
subclass of: Restriction
  on property: part_of
  some values from: cell division
id: GO:0000910
has_alternative_id: GO:0007104
has_alternative_id: GO:0016288
has_alternative_id: GO:0033205
database_cross_reference: Reactome:REACT_101918
database_cross_reference: Reactome:REACT_108805
database_cross_reference: Reactome:REACT_1932
database_cross_reference: Reactome:REACT_30667
database_cross_reference: Reactome:REACT_32636
database_cross_reference: Reactome:REACT_78494
database_cross_reference: Reactome:REACT_84722
database_cross_reference: Reactome:REACT_87726
database_cross_reference: Reactome:REACT_92849
database_cross_reference: Reactome:REACT_93374
database_cross_reference: Reactome:REACT_94382
database_cross_reference: Reactome:REACT_98952
database_cross_reference: Reactome:REACT_99118
IAO_0000115: The division of the cytoplasm and the plasma membrane of a cell and its separation into two daughter cells.
database_cross_reference: Wikipedia:Cytokinesis
has_obo_namespace: biological_process
has_exact_synonym: cell cycle cytokinesis
has_exact_synonym: cytokinesis involved in cell cycle
IAO_0000412: go.owl
in_subset: gocheck do not manually annotate
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim pombe
in_subset: goslim yeast
in_subset: gosubset prok

Mitotic Telophase /Cytokinesis, Taeniopygia guttata
type: Axiom
annotated target: Reactome:REACT_92849
annotated source: cytokinesis
annotated property: database_cross_reference

Mitotic Telophase /Cytokinesis, Caenorhabditis elegans
type: Axiom
annotated target: Reactome:REACT_99118
annotated source: cytokinesis
annotated property: database_cross_reference

Mitotic Telophase /Cytokinesis, Drosophila melanogaster
type: Axiom
annotated target: Reactome:REACT_94382
annotated source: cytokinesis
annotated property: database_cross_reference

Mitotic Telophase /Cytokinesis, Rattus norvegicus
type: Axiom
annotated target: Reactome:REACT_98952
annotated source: cytokinesis
annotated property: database_cross_reference

Axiom
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb
annotated target: cytokinesis involved in cell cycle
annotated source: cytokinesis
annotated property: has_exact_synonym

Mitotic Telophase /Cytokinesis, Gallus gallus
type: Axiom
annotated target: Reactome:REACT_84722
annotated source: cytokinesis
annotated property: database_cross_reference

Mitotic Telophase /Cytokinesis, Dictyostelium discoideum
type: Axiom
annotated target: Reactome:REACT_108805
annotated source: cytokinesis
annotated property: database_cross_reference

Mitotic Telophase /Cytokinesis, Xenopus tropicalis
type: Axiom
annotated target: Reactome:REACT_87726
annotated source: cytokinesis
annotated property: database_cross_reference

Mitotic Telophase /Cytokinesis, Schizosaccharomyces pombe
type: Axiom
annotated target: Reactome:REACT_30667
annotated source: cytokinesis
annotated property: database_cross_reference

Mitotic Telophase /Cytokinesis, Bos taurus
type: Axiom
annotated target: Reactome:REACT_32636
annotated source: cytokinesis
annotated property: database_cross_reference

Axiom
database_cross_reference: GOC:mtg_cell_cycle
annotated target: The division of the cytoplasm and the plasma membrane of a cell and its separation into two daughter cells.
annotated source: cytokinesis
annotated property: IAO_0000115

Mitotic Telophase /Cytokinesis, Homo sapiens
type: Axiom
annotated target: Reactome:REACT_1932
annotated source: cytokinesis
annotated property: database_cross_reference

Mitotic Telophase /Cytokinesis, Danio rerio
type: Axiom
annotated target: Reactome:REACT_78494
annotated source: cytokinesis
annotated property: database_cross_reference

Mitotic Telophase /Cytokinesis, Mus musculus
type: Axiom
annotated target: Reactome:REACT_101918
annotated source: cytokinesis
annotated property: database_cross_reference

Mitotic Telophase /Cytokinesis, Canis familiaris
type: Axiom
annotated target: Reactome:REACT_93374
annotated source: cytokinesis
annotated property: database_cross_reference

regulatory region DNA binding
type: Class
subclass of: regulatory region nucleic acid binding
subclass of: DNA binding
creation date: 2010-08-10T10:56:24Z
id: GO:0000975
IAO_0000115: Interacting selectively and non-covalently with a DNA region that regulates a DNA-based process. Such processes include transcription, DNA replication, and DNA repair.
created by: kchris
has_obo_namespace: molecular_function
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:txnOH
annotated target: Interacting selectively and non-covalently with a DNA region that regulates a DNA-based process. Such processes include transcription, DNA replication, and DNA repair.
annotated source: regulatory region DNA binding
annotated property: IAO_0000115

transcription regulatory region sequence-specific DNA binding
type: Class
subclass of: sequence-specific DNA binding
subclass of: transcription regulatory region DNA binding
creation date: 2010-08-10T11:00:02Z
id: GO:0000976
IAO_0000115: Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
comment: The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding".
created by: kchris
has_obo_namespace: molecular_function
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:txnOH
annotated target: Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
annotated source: transcription regulatory region sequence-specific DNA binding
annotated property: IAO_0000115

regulatory region nucleic acid binding
type: Class
subclass of: nucleic acid binding
creation date: 2010-10-21T04:08:56Z
id: GO:0001067
IAO_0000115: Interacting selectively and non-covalently with a nucleic acid region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair.
created by: kchris
has_obo_namespace: molecular_function
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:txnOH
annotated target: Interacting selectively and non-covalently with a nucleic acid region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair.
annotated source: regulatory region nucleic acid binding
annotated property: IAO_0000115

nucleic acid binding transcription factor activity
type: Class
subclass of: molecular_function
subclass of: Restriction
  on property: part_of
  some values from: regulation of RNA biosynthetic process
subclass of: Restriction
  on property: has_part
  some values from: nucleic acid binding
creation date: 2010-10-21T04:37:54Z
id: GO:0001071
IAO_0000115: Interacting selectively and non-covalently with a DNA or RNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. This term does not provide specificity with respect to the type of nucleic acid binding, e.g. RNA or DNA. Please use a child term that provides that specificity or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
created by: kchris
has_obo_namespace: molecular_function
has_broad_synonym: transcription factor activity
IAO_0000412: go.owl
in_subset: gocheck do not manually annotate
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim yeast

Axiom
database_cross_reference: GOC:txnOH
annotated target: Interacting selectively and non-covalently with a DNA or RNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
annotated source: nucleic acid binding transcription factor activity
annotated property: IAO_0000115

stress fiber
type: Class
subclass of: actin filament bundle
subclass of: actomyosin
IAO_0000115: A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.
id: GO:0001725
has_related_synonym: actin cable
has_obo_namespace: cellular_component
has_exact_synonym: stress fibre
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:mah
annotated target: actin cable
annotated source: stress fiber
annotated property: has_related_synonym

Axiom
annotated target: A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.
database_cross_reference: PMID:16651381
annotated source: stress fiber
annotated property: IAO_0000115

podosome
type: Class
subclass of: intracellular non-membrane-bounded organelle
subclass of: protein complex
subclass of: cytoskeletal part
subclass of: Restriction
  on property: part_of
  some values from: actin cytoskeleton
IAO_0000115: An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm.
id: GO:0002102
comment: Note that podosomes can be distinguished from other F-actin-rich structures or from other matrix contacts. For example, focal adhesions and focal contacts do not display a core structure of F-actin. Unlike focal adhesions, podosome assembly does not require de novo protein synthesis. However, most of the podosome ring components are found in focal adhesions and other cell-matrix contacts. Podosomes are typically found in cells that cross tissue boundaries, recruited to the leading edge of migrating cells, and are often sites of extracellular matrix degradation.
database_cross_reference: Wikipedia:Podosome
has_obo_namespace: cellular_component
IAO_0000412: go.owl

Axiom
annotated target: An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm.
database_cross_reference: PMID:12837608
database_cross_reference: PMID:15890982
annotated source: podosome
annotated property: IAO_0000115

molecular_function
type: Class
disjoint with: cellular_component
disjoint with: biological_process
IAO_0000115: Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
id: GO:0003674
has_alternative_id: GO:0005554
comment: Note that, in addition to forming the root of the molecular function ontology, this term is recommended for use for the annotation of gene products whose molecular function is unknown. Note that when this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this.
has_exact_synonym: molecular function
has_narrow_synonym: molecular function unknown
has_obo_namespace: molecular_function
IAO_0000412: go.owl
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim yeast
in_subset: gosubset prok

Axiom
annotated target: Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
database_cross_reference: GOC:go_curators
annotated source: molecular_function
annotated property: IAO_0000115

nucleic acid binding
type: Class
subclass of: organic cyclic compound binding
subclass of: heterocyclic compound binding
id: GO:0003676
IAO_0000115: Interacting selectively and non-covalently with any nucleic acid.
has_obo_namespace: molecular_function
IAO_0000412: go.owl
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:jl
annotated target: Interacting selectively and non-covalently with any nucleic acid.
annotated source: nucleic acid binding
annotated property: IAO_0000115

DNA binding
type: Class
subclass of: nucleic acid binding
IAO_0000115: Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
id: GO:0003677
has_related_synonym: microtubule/chromatin interaction
has_obo_namespace: molecular_function
has_narrow_synonym: plasmid binding
IAO_0000412: go.owl
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim generic
in_subset: goslim plant
in_subset: goslim yeast
in_subset: gosubset prok

Axiom
annotated target: Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
database_cross_reference: GOC:dph
database_cross_reference: GOC:jl
database_cross_reference: GOC:tb
database_cross_reference: GOC:vw
annotated source: DNA binding
annotated property: IAO_0000115

sequence-specific DNA binding transcription factor activity
type: Class
subclass of: nucleic acid binding transcription factor activity
subclass of: Restriction
  on property: has_part
  some values from: transcription regulatory region sequence-specific DNA binding
subclass of: Restriction
  on property: part_of
  some values from: regulation of transcription, DNA-dependent
has_alternative_id: GO:0000130
id: GO:0003700
IAO_0000115: Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
has_obo_namespace: molecular_function
has_broad_synonym: transcription factor activity
IAO_0000412: go.owl
in_subset: goslim plant
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:curators
database_cross_reference: GOC:txnOH
annotated target: Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
annotated source: sequence-specific DNA binding transcription factor activity
annotated property: IAO_0000115

telomerase activity
type: Class
subclass of: RNA-directed DNA polymerase activity
IAO_0000115: Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence.
database_cross_reference: EC:2.7.7.-
id: GO:0003720
database_cross_reference: Reactome:REACT_104705
database_cross_reference: Reactome:REACT_106476
database_cross_reference: Reactome:REACT_108407
database_cross_reference: Reactome:REACT_109443
database_cross_reference: Reactome:REACT_113385
database_cross_reference: Reactome:REACT_114466
database_cross_reference: Reactome:REACT_115824
database_cross_reference: Reactome:REACT_116122
database_cross_reference: Reactome:REACT_28249
database_cross_reference: Reactome:REACT_30494
database_cross_reference: Reactome:REACT_30995
database_cross_reference: Reactome:REACT_31549
database_cross_reference: Reactome:REACT_33436
database_cross_reference: Reactome:REACT_77280
database_cross_reference: Reactome:REACT_7985
database_cross_reference: Reactome:REACT_8019
database_cross_reference: Reactome:REACT_80834
database_cross_reference: Reactome:REACT_81691
database_cross_reference: Reactome:REACT_83982
database_cross_reference: Reactome:REACT_85286
database_cross_reference: Reactome:REACT_86666
database_cross_reference: Reactome:REACT_90823
database_cross_reference: Reactome:REACT_93232
database_cross_reference: Reactome:REACT_94534
database_cross_reference: Reactome:REACT_94768
database_cross_reference: Reactome:REACT_95176
database_cross_reference: Reactome:REACT_96912
database_cross_reference: Reactome:REACT_97770
has_obo_namespace: molecular_function
IAO_0000412: go.owl

Elongation of Extended Telomeric Chromosome End, Saccharomyces cerevisiae
type: Axiom
annotated target: Reactome:REACT_104705
annotated source: telomerase activity
annotated property: database_cross_reference

Elongation of Extended Telomeric Chromosome End, Schizosaccharomyces pombe
type: Axiom
annotated target: Reactome:REACT_94768
annotated source: telomerase activity
annotated property: database_cross_reference

Elongation of Extended Telomeric Chromosome End, Arabidopsis thaliana
type: Axiom
annotated target: Reactome:REACT_77280
annotated source: telomerase activity
annotated property: database_cross_reference

Elongation of Extended Telomeric Chromosome End, Gallus gallus
type: Axiom
annotated target: Reactome:REACT_28249
annotated source: telomerase activity
annotated property: database_cross_reference

Elongation Of The Telomeric Chromosome End, Schizosaccharomyces pombe
type: Axiom
annotated target: Reactome:REACT_93232
annotated source: telomerase activity
annotated property: database_cross_reference

Elongation of Extended Telomeric Chromosome End, Oryza sativa
type: Axiom
annotated target: Reactome:REACT_108407
annotated source: telomerase activity
annotated property: database_cross_reference

Axiom
annotated target: Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence.
database_cross_reference: GOC:krc
annotated source: telomerase activity
annotated property: IAO_0000115

Elongation Of The Telomeric Chromosome End, Homo sapiens
type: Axiom
annotated target: Reactome:REACT_8019
annotated source: telomerase activity
annotated property: database_cross_reference

Elongation of Extended Telomeric Chromosome End, Taeniopygia guttata
type: Axiom
annotated target: Reactome:REACT_96912
annotated source: telomerase activity
annotated property: database_cross_reference

Elongation of Extended Telomeric Chromosome End, Xenopus tropicalis
type: Axiom
annotated target: Reactome:REACT_114466
annotated source: telomerase activity
annotated property: database_cross_reference

Elongation Of The Telomeric Chromosome End, Bos taurus
type: Axiom
annotated target: Reactome:REACT_106476
annotated source: telomerase activity
annotated property: database_cross_reference

Elongation Of The Telomeric Chromosome End, Oryza sativa
type: Axiom
annotated target: Reactome:REACT_83982
annotated source: telomerase activity
annotated property: database_cross_reference

Elongation and translocation of the telomeric chromosome end, Gallus gallus
type: Axiom
annotated target: Reactome:REACT_116122
annotated source: telomerase activity
annotated property: database_cross_reference

Elongation of Extended Telomeric Chromosome End, Danio rerio
type: Axiom
annotated target: Reactome:REACT_33436
annotated source: telomerase activity
annotated property: database_cross_reference

Elongation of Extended Telomeric Chromosome End, Homo sapiens
type: Axiom
annotated target: Reactome:REACT_7985
annotated source: telomerase activity
annotated property: database_cross_reference

Elongation Of The Telomeric Chromosome End, Gallus gallus
type: Axiom
annotated target: Reactome:REACT_95176
annotated source: telomerase activity
annotated property: database_cross_reference

Elongation Of The Telomeric Chromosome End, Saccharomyces cerevisiae
type: Axiom
annotated target: Reactome:REACT_31549
annotated source: telomerase activity
annotated property: database_cross_reference

Elongation Of The Telomeric Chromosome End, Arabidopsis thaliana
type: Axiom
annotated target: Reactome:REACT_97770
annotated source: telomerase activity
annotated property: database_cross_reference

Elongation of Extended Telomeric Chromosome End, Sus scrofa
type: Axiom
annotated target: Reactome:REACT_86666
annotated source: telomerase activity
annotated property: database_cross_reference

Elongation Of The Telomeric Chromosome End, Xenopus tropicalis
type: Axiom
annotated target: Reactome:REACT_113385
annotated source: telomerase activity
annotated property: database_cross_reference

Elongation Of The Telomeric Chromosome End, Mus musculus
type: Axiom
annotated target: Reactome:REACT_80834
annotated source: telomerase activity
annotated property: database_cross_reference

Elongation of Extended Telomeric Chromosome End, Mus musculus
type: Axiom
annotated target: Reactome:REACT_90823
annotated source: telomerase activity
annotated property: database_cross_reference

Elongation and translocation of the extended telomeric chromosome end, Gallus gallus
type: Axiom
annotated target: Reactome:REACT_115824
annotated source: telomerase activity
annotated property: database_cross_reference

Elongation Of The Telomeric Chromosome End, Sus scrofa
type: Axiom
annotated target: Reactome:REACT_30494
annotated source: telomerase activity
annotated property: database_cross_reference

Elongation Of The Telomeric Chromosome End, Canis familiaris
type: Axiom
annotated target: Reactome:REACT_30995
annotated source: telomerase activity
annotated property: database_cross_reference

Elongation Of The Telomeric Chromosome End, Taeniopygia guttata
type: Axiom
annotated target: Reactome:REACT_94534
annotated source: telomerase activity
annotated property: database_cross_reference

Elongation Of The Telomeric Chromosome End, Danio rerio
type: Axiom
annotated target: Reactome:REACT_109443
annotated source: telomerase activity
annotated property: database_cross_reference

Elongation of Extended Telomeric Chromosome End, Canis familiaris
type: Axiom
annotated target: Reactome:REACT_81691
annotated source: telomerase activity
annotated property: database_cross_reference

Elongation of Extended Telomeric Chromosome End, Bos taurus
type: Axiom
annotated target: Reactome:REACT_85286
annotated source: telomerase activity
annotated property: database_cross_reference

catalytic activity
type: Class
subclass of: molecular_function
subclass of: Restriction
  on property: part_of
  some values from: metabolic process
IAO_0000115: Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
id: GO:0003824
database_cross_reference: Wikipedia:Enzyme
has_exact_synonym: enzyme activity
has_obo_namespace: molecular_function
IAO_0000412: go.owl
in_subset: goslim pir
in_subset: goslim plant
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb
annotated target: enzyme activity
annotated source: catalytic activity
annotated property: has_exact_synonym

Axiom
annotated target: Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
database_cross_reference: ISBN:0198506732
annotated source: catalytic activity
annotated property: IAO_0000115

RNA-directed DNA polymerase activity
type: Class
subclass of: DNA polymerase activity
IAO_0000115: Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time.
has_exact_synonym: DNA nucleotidyltransferase (RNA-directed) activity
database_cross_reference: EC:2.7.7.49
id: GO:0003964
database_cross_reference: MetaCyc:RNA-DIRECTED-DNA-POLYMERASE-RXN
has_exact_synonym: RNA revertase activity
has_exact_synonym: RNA-dependent DNA polymerase activity
has_exact_synonym: RNA-dependent deoxyribonucleate nucleotidyltransferase activity
has_narrow_synonym: RNA-directed DNA polymerase, group II intron encoded
has_narrow_synonym: RNA-directed DNA polymerase, transposon encoded
has_exact_synonym: RNA-instructed DNA polymerase activity
has_related_synonym: RT
database_cross_reference: Reactome:REACT_9039
database_cross_reference: Reactome:REACT_9049
has_exact_synonym: deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed) activity
has_obo_namespace: molecular_function
has_exact_synonym: reverse transcriptase activity
has_related_synonym: revertase activity
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
database_cross_reference: EC:2.7.7.49
annotated target: RNA-dependent DNA polymerase activity
annotated source: RNA-directed DNA polymerase activity
annotated property: has_exact_synonym

Axiom
database_cross_reference: EC:2.7.7.49
annotated target: revertase activity
annotated source: RNA-directed DNA polymerase activity
annotated property: has_related_synonym

Axiom
database_cross_reference: EC:2.7.7.49
annotated target: RT
annotated source: RNA-directed DNA polymerase activity
annotated property: has_related_synonym

Axiom
annotated target: Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time.
database_cross_reference: EC:2.7.7.49
annotated source: RNA-directed DNA polymerase activity
annotated property: IAO_0000115

Minus strand DNA synthesis resumes, Homo sapiens
type: Axiom
annotated target: Reactome:REACT_9049
annotated source: RNA-directed DNA polymerase activity
annotated property: database_cross_reference

Axiom
database_cross_reference: EC:2.7.7.49
annotated target: deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed) activity
annotated source: RNA-directed DNA polymerase activity
annotated property: has_exact_synonym

Axiom
database_cross_reference: EC:2.7.7.49
annotated target: RNA revertase activity
annotated source: RNA-directed DNA polymerase activity
annotated property: has_exact_synonym

Axiom
annotated target: DNA nucleotidyltransferase (RNA-directed) activity
database_cross_reference: EC:2.7.7.49
annotated source: RNA-directed DNA polymerase activity
annotated property: has_exact_synonym

Axiom
database_cross_reference: EC:2.7.7.49
annotated target: reverse transcriptase activity
annotated source: RNA-directed DNA polymerase activity
annotated property: has_exact_synonym

Axiom
database_cross_reference: EC:2.7.7.49
annotated target: RNA-instructed DNA polymerase activity
annotated source: RNA-directed DNA polymerase activity
annotated property: has_exact_synonym

Axiom
database_cross_reference: EC:2.7.7.49
annotated target: RNA-dependent deoxyribonucleate nucleotidyltransferase activity
annotated source: RNA-directed DNA polymerase activity
annotated property: has_exact_synonym

Synthesis of minus strand strong stop DNA (-sssDNA), Homo sapiens
type: Axiom
annotated target: Reactome:REACT_9039
annotated source: RNA-directed DNA polymerase activity
annotated property: database_cross_reference

binding
type: Class
subclass of: molecular_function
comment: For ligands that bind to signal transducing receptors, consider the molecular function term 'receptor binding ; GO:0005102' and its children.
id: GO:0005488
IAO_0000115: The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.
database_cross_reference: Wikipedia:Binding_(molecular)
has_narrow_synonym: ligand
has_obo_namespace: molecular_function
IAO_0000412: go.owl
in_subset: goslim pir
in_subset: goslim plant
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:ceb
database_cross_reference: GOC:mah
database_cross_reference: ISBN:0198506732
annotated target: The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.
annotated source: binding
annotated property: IAO_0000115

cellular_component
type: Class
disjoint with: biological_process
id: GO:0005575
has_alternative_id: GO:0008372
database_cross_reference: NIF_Subcellular:sao1337158144
comment: Note that, in addition to forming the root of the cellular component ontology, this term is recommended for use for the annotation of gene products whose cellular component is unknown. Note that when this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this.
IAO_0000115: The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.
has_exact_synonym: cellular component
has_narrow_synonym: cellular component unknown
has_obo_namespace: cellular_component
IAO_0000412: go.owl
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim yeast
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:go_curators
annotated target: The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.
annotated source: cellular_component
annotated property: IAO_0000115

intracellular
type: Class
subclass of: intracellular part
id: GO:0005622
IAO_0000115: The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
database_cross_reference: Wikipedia:Intracellular
has_obo_namespace: cellular_component
has_exact_synonym: internal to cell
has_related_synonym: nucleocytoplasm
has_exact_synonym: protoplasm
has_related_synonym: protoplast
IAO_0000412: go.owl
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim plant
in_subset: gosubset prok

Axiom
database_cross_reference: ISBN:0198506732
annotated target: The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
annotated source: intracellular
annotated property: IAO_0000115

Axiom
database_cross_reference: GOC:mah
annotated target: nucleocytoplasm
annotated source: intracellular
annotated property: has_related_synonym

Axiom
database_cross_reference: GOC:mah
annotated target: protoplast
annotated source: intracellular
annotated property: has_related_synonym

cell
type: Class
subclass of: cell part
id: GO:0005623
database_cross_reference: NIF_Subcellular:sao1813327414
IAO_0000115: The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
database_cross_reference: Wikipedia:Cell_(biology)
has_obo_namespace: cellular_component
IAO_0000412: go.owl
in_subset: goslim generic
in_subset: goslim plant
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:go_curators
annotated target: The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
annotated source: cell
annotated property: IAO_0000115

nucleus
type: Class
subclass of: intracellular membrane-bounded organelle
subclass of: nuclear part
IAO_0000115: A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
id: GO:0005634
database_cross_reference: NIF_Subcellular:sao1702920020
database_cross_reference: Wikipedia:Cell_nucleus
has_exact_synonym: cell nucleus
has_obo_namespace: cellular_component
IAO_0000412: go.owl
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim yeast

Axiom
annotated target: A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
database_cross_reference: GOC:go_curators
annotated source: nucleus
annotated property: IAO_0000115

nucleoplasm
type: Class
subclass of: nucleoplasm part
subclass of: Restriction
  on property: part_of
  some values from: nuclear lumen
id: GO:0005654
database_cross_reference: NIF_Subcellular:sao661522542
IAO_0000115: That part of the nuclear content other than the chromosomes or the nucleolus.
database_cross_reference: Wikipedia:Nucleoplasm
has_obo_namespace: cellular_component
IAO_0000412: go.owl
in_subset: goslim generic
in_subset: goslim plant

Axiom
database_cross_reference: GOC:ma
database_cross_reference: ISBN:0124325653
annotated target: That part of the nuclear content other than the chromosomes or the nucleolus.
annotated source: nucleoplasm
annotated property: IAO_0000115

chromosome
type: Class
subclass of: intracellular non-membrane-bounded organelle
subclass of: chromosomal part
IAO_0000115: A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
id: GO:0005694
database_cross_reference: Wikipedia:Chromosome
has_obo_namespace: cellular_component
has_related_synonym: chromatid
has_narrow_synonym: interphase chromosome
has_narrow_synonym: prophase chromosome
IAO_0000412: go.owl
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim yeast
in_subset: gosubset prok

Axiom
annotated target: A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
database_cross_reference: ISBN:0198547684
annotated source: chromosome
annotated property: IAO_0000115

nucleolus
type: Class
subclass of: intracellular non-membrane-bounded organelle
subclass of: nuclear part
subclass of: Restriction
  on property: part_of
  some values from: nuclear lumen
IAO_0000115: A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
id: GO:0005730
database_cross_reference: NIF_Subcellular:sao1820400233
database_cross_reference: Wikipedia:Nucleolus
has_obo_namespace: cellular_component
IAO_0000412: go.owl
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim yeast

Axiom
annotated target: A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
database_cross_reference: ISBN:0198506732
annotated source: nucleolus
annotated property: IAO_0000115

cytoplasm
type: Class
subclass of: cytoplasmic part
IAO_0000115: All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
id: GO:0005737
database_cross_reference: Wikipedia:Cytoplasm
has_obo_namespace: cellular_component
IAO_0000412: go.owl
in_subset: goslim candida
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim plant
in_subset: goslim yeast
in_subset: gosubset prok

Axiom
annotated target: All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
database_cross_reference: ISBN:0198547684
annotated source: cytoplasm
annotated property: IAO_0000115

mitochondrion
type: Class
subclass of: intracellular membrane-bounded organelle
subclass of: mitochondrial part
IAO_0000115: A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
id: GO:0005739
database_cross_reference: NIF_Subcellular:sao1860313010
database_cross_reference: Wikipedia:Mitochondrion
has_obo_namespace: cellular_component
has_exact_synonym: mitochondria
IAO_0000412: go.owl
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim yeast

Axiom
annotated target: A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
database_cross_reference: ISBN:0198506732
annotated source: mitochondrion
annotated property: IAO_0000115

endoplasmic reticulum
type: Class
subclass of: intracellular membrane-bounded organelle
subclass of: endoplasmic reticulum part
has_exact_synonym: ER
id: GO:0005783
database_cross_reference: NIF_Subcellular:sao1036339110
IAO_0000115: The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
database_cross_reference: Wikipedia:Endoplasmic_reticulum
has_obo_namespace: cellular_component
IAO_0000412: go.owl
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim yeast

Axiom
database_cross_reference: ISBN:0198506732
annotated target: The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
annotated source: endoplasmic reticulum
annotated property: IAO_0000115

Golgi apparatus
type: Class
subclass of: intracellular membrane-bounded organelle
subclass of: Golgi apparatus part
IAO_0000115: A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
id: GO:0005794
has_broad_synonym: Golgi
has_exact_synonym: Golgi complex
has_narrow_synonym: Golgi ribbon
database_cross_reference: NIF_Subcellular:sao451912436
comment: Note that the Golgi apparatus can be located in various places in the cytoplasm. In plants and lower animal cells, the Golgi apparatus exists as many copies of discrete stacks dispersed throughout the cytoplasm, while the Golgi apparatus of interphase mammalian cells is a juxtanuclear, often pericentriolar reticulum, where the discrete Golgi stacks are stitched together to form a compact and interconnected ribbon, sometimes called the Golgi ribbon.
database_cross_reference: Wikipedia:Golgi_apparatus
has_obo_namespace: cellular_component
IAO_0000412: go.owl
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim yeast

Axiom
annotated target: A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
database_cross_reference: ISBN:0198506732
annotated source: Golgi apparatus
annotated property: IAO_0000115

cytosol
type: Class
subclass of: cytoplasmic part
id: GO:0005829
database_cross_reference: NIF_Subcellular:sao101633890
IAO_0000115: The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
database_cross_reference: Wikipedia:Cytosol
has_obo_namespace: cellular_component
IAO_0000412: go.owl
in_subset: goslim aspergillus
in_subset: goslim generic
in_subset: goslim plant
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:hgd
database_cross_reference: GOC:jl
annotated target: The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
annotated source: cytosol
annotated property: IAO_0000115

cytoskeleton
type: Class
subclass of: intracellular non-membrane-bounded organelle
subclass of: cytoskeletal part
IAO_0000115: Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
id: GO:0005856
database_cross_reference: Wikipedia:Cytoskeleton
has_obo_namespace: cellular_component
IAO_0000412: go.owl
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim yeast
in_subset: gosubset prok

Axiom
annotated target: Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
database_cross_reference: GOC:mah
database_cross_reference: ISBN:0198547684
database_cross_reference: PMID:16959967
annotated source: cytoskeleton
annotated property: IAO_0000115

microtubule
type: Class
subclass of: protein complex
subclass of: cytoskeletal part
subclass of: Restriction
  on property: part_of
  some values from: microtubule cytoskeleton
IAO_0000115: Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
id: GO:0005874
database_cross_reference: NIF_Subcellular:sao1846835077
database_cross_reference: Wikipedia:Microtubule
has_obo_namespace: cellular_component
has_exact_synonym: microtubuli
has_exact_synonym: microtubulus
has_narrow_synonym: neurotubule
IAO_0000412: go.owl

Axiom
annotated target: Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
database_cross_reference: ISBN:0879693568
annotated source: microtubule
annotated property: IAO_0000115

Axiom
database_cross_reference: NIF_Subcellular:sao248349196
annotated target: neurotubule
annotated source: microtubule
annotated property: has_narrow_synonym

actin filament
type: Class
subclass of: protein complex
subclass of: cytoskeletal part
subclass of: Restriction
  on property: part_of
  some values from: actin cytoskeleton
IAO_0000115: A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane.
database_cross_reference: FMA:63850
id: GO:0005884
database_cross_reference: NIF_Subcellular:sao1588493326
database_cross_reference: Wikipedia:Actin
has_obo_namespace: cellular_component
has_exact_synonym: microfilament
IAO_0000412: go.owl

Axiom
annotated target: A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane.
database_cross_reference: GOC:mah
database_cross_reference: ISBN:0198506732
database_cross_reference: PMID:10666339
annotated source: actin filament
annotated property: IAO_0000115

adherens junction
type: Class
subclass of: anchoring junction
IAO_0000115: A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments.
id: GO:0005912
has_obo_namespace: cellular_component
IAO_0000412: go.owl

Axiom
annotated target: A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments.
database_cross_reference: GOC:mah
database_cross_reference: ISBN:0198506732
database_cross_reference: http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html
annotated source: adherens junction
annotated property: IAO_0000115

cell-substrate adherens junction
type: Class
subclass of: adherens junction
subclass of: cell-substrate junction
IAO_0000115: An adherens junction which connects a cell to the extracellular matrix.
id: GO:0005924
has_obo_namespace: cellular_component
has_related_synonym: hemi-adherens junction
IAO_0000412: go.owl

Axiom
annotated target: An adherens junction which connects a cell to the extracellular matrix.
database_cross_reference: GOC:hb
annotated source: cell-substrate adherens junction
annotated property: IAO_0000115

focal adhesion
type: Class
subclass of: cell-substrate adherens junction
id: GO:0005925
has_alternative_id: GO:0008357
IAO_0000115: Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
database_cross_reference: Wikipedia:Focal_adhesion
has_obo_namespace: cellular_component
has_exact_synonym: focal contact
has_related_synonym: hemi-adherens junction
IAO_0000412: go.owl

Axiom
database_cross_reference: ISBN:0124325653
database_cross_reference: ISBN:0815316208
annotated target: Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
annotated source: focal adhesion
annotated property: IAO_0000115

cilium
type: Class
subclass of: cell projection
subclass of: intracellular membrane-bounded organelle
subclass of: cilium part
IAO_0000115: A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
id: GO:0005929
database_cross_reference: NIF_Subcellular:sao787716553
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent.
database_cross_reference: Wikipedia:Cilium
has_obo_namespace: cellular_component
has_exact_synonym: eukaryotic flagellum
has_related_synonym: flagellum
has_exact_synonym: microtubule-based flagellum
IAO_0000412: go.owl
in_subset: goslim generic
in_subset: goslim pir

Axiom
annotated target: A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
database_cross_reference: GOC:kmv
database_cross_reference: ISBN:0198547684
annotated source: cilium
annotated property: IAO_0000115

cell cortex
type: Class
subclass of: cell cortex part
subclass of: Restriction
  on property: part_of
  some values from: cell periphery
id: GO:0005938
IAO_0000115: The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
database_cross_reference: Wikipedia:Cell_cortex
has_related_synonym: cell periphery
has_obo_namespace: cellular_component
has_related_synonym: peripheral cytoplasm
IAO_0000412: go.owl
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim yeast

Axiom
database_cross_reference: GOC:mah
database_cross_reference: ISBN:0815316194
annotated target: The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
annotated source: cell cortex
annotated property: IAO_0000115

nucleobase-containing compound metabolic process
type: Class
subclass of: cellular aromatic compound metabolic process
subclass of: cellular nitrogen compound metabolic process
subclass of: primary metabolic process
subclass of: heterocycle metabolic process
subclass of: organic cyclic compound metabolic process
IAO_0000115: Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.
id: GO:0006139
has_alternative_id: GO:0055134
has_obo_namespace: biological_process
has_exact_synonym: cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
has_exact_synonym: cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolism
has_related_synonym: nucleobase, nucleoside and nucleotide metabolic process
has_related_synonym: nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
has_exact_synonym: nucleobase, nucleoside, nucleotide and nucleic acid metabolism
IAO_0000412: go.owl
in_subset: goslim pir
in_subset: goslim plant
in_subset: gosubset prok

Axiom
annotated target: Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.
database_cross_reference: GOC:ai
annotated source: nucleobase-containing compound metabolic process
annotated property: IAO_0000115

Axiom
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb
annotated target: nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
annotated source: nucleobase-containing compound metabolic process
annotated property: has_related_synonym

DNA metabolic process
type: Class
subclass of: cellular macromolecule metabolic process
subclass of: nucleic acid metabolic process
IAO_0000115: Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.
has_exact_synonym: DNA metabolism
id: GO:0006259
has_alternative_id: GO:0055132
has_obo_namespace: biological_process
has_exact_synonym: cellular DNA metabolism
IAO_0000412: go.owl
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: gosubset prok

Axiom
annotated target: Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.
database_cross_reference: ISBN:0198506732
annotated source: DNA metabolic process
annotated property: IAO_0000115

DNA amplification
type: Class
subclass of: DNA biosynthetic process
id: GO:0006277
IAO_0000115: The process in which the number of copies of a gene is increased in certain cells as extra copies of DNA are made in response to certain signals of cell development or of stress from the environment.
has_obo_namespace: biological_process
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
database_cross_reference: ISBN:0721601464
annotated target: The process in which the number of copies of a gene is increased in certain cells as extra copies of DNA are made in response to certain signals of cell development or of stress from the environment.
annotated source: DNA amplification
annotated property: IAO_0000115

DNA catabolic process
type: Class
subclass of: DNA metabolic process
subclass of: nucleobase-containing compound catabolic process
subclass of: cellular macromolecule catabolic process
has_exact_synonym: DNA breakdown
has_exact_synonym: DNA catabolism
has_exact_synonym: DNA degradation
id: GO:0006308
IAO_0000115: The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one.
has_obo_namespace: biological_process
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:go_curators
database_cross_reference: ISBN:0198506732
annotated target: The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one.
annotated source: DNA catabolic process
annotated property: IAO_0000115

apoptotic DNA fragmentation
type: Class
equivalent class: Class
  intersection of: DNA catabolic process, endonucleolytic
  intersection of: Restriction
    on property: part_of
    some values from: apoptotic nuclear changes
subclass of: DNA catabolic process, endonucleolytic
subclass of: Restriction
  on property: part_of
  some values from: apoptotic nuclear changes
has_exact_synonym: DNA catabolic process during apoptosis
has_exact_synonym: DNA catabolism during apoptosis
has_broad_synonym: DNA fragmentation
has_exact_synonym: DNA fragmentation involved in apoptotic nuclear change
id: GO:0006309
has_alternative_id: GO:0008178
database_cross_reference: Reactome:REACT_102783
database_cross_reference: Reactome:REACT_105342
database_cross_reference: Reactome:REACT_110358
database_cross_reference: Reactome:REACT_113418
database_cross_reference: Reactome:REACT_1213
database_cross_reference: Reactome:REACT_28808
database_cross_reference: Reactome:REACT_33113
database_cross_reference: Reactome:REACT_92967
database_cross_reference: Reactome:REACT_94135
database_cross_reference: Reactome:REACT_98713
database_cross_reference: Reactome:REACT_99275
database_cross_reference: Reactome:REACT_99925
IAO_0000115: The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments.
has_obo_namespace: biological_process
has_broad_synonym: chromatinolysis
has_exact_synonym: endonucleolytic DNA catabolic process involved in apoptosis
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:mtg_apoptosis
annotated target: chromatinolysis
annotated source: apoptotic DNA fragmentation
annotated property: has_broad_synonym

Apoptosis induced DNA fragmentation, Taeniopygia guttata
type: Axiom
annotated target: Reactome:REACT_94135
annotated source: apoptotic DNA fragmentation
annotated property: database_cross_reference

Apoptosis induced DNA fragmentation, Drosophila melanogaster
type: Axiom
annotated target: Reactome:REACT_92967
annotated source: apoptotic DNA fragmentation
annotated property: database_cross_reference

Apoptosis induced DNA fragmentation, Plasmodium falciparum
type: Axiom
annotated target: Reactome:REACT_113418
annotated source: apoptotic DNA fragmentation
annotated property: database_cross_reference

Apoptosis induced DNA fragmentation, Canis familiaris
type: Axiom
annotated target: Reactome:REACT_98713
annotated source: apoptotic DNA fragmentation
annotated property: database_cross_reference

Apoptosis induced DNA fragmentation, Bos taurus
type: Axiom
annotated target: Reactome:REACT_102783
annotated source: apoptotic DNA fragmentation
annotated property: database_cross_reference

Apoptosis induced DNA fragmentation, Sus scrofa
type: Axiom
annotated target: Reactome:REACT_105342
annotated source: apoptotic DNA fragmentation
annotated property: database_cross_reference

Apoptosis induced DNA fragmentation, Gallus gallus
type: Axiom
annotated target: Reactome:REACT_99275
annotated source: apoptotic DNA fragmentation
annotated property: database_cross_reference

Apoptosis induced DNA fragmentation, Mus musculus
type: Axiom
annotated target: Reactome:REACT_33113
annotated source: apoptotic DNA fragmentation
annotated property: database_cross_reference

Axiom
annotated target: DNA fragmentation involved in apoptotic nuclear change
database_cross_reference: GOC:cjm
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb
annotated source: apoptotic DNA fragmentation
annotated property: has_exact_synonym

Apoptosis induced DNA fragmentation, Rattus norvegicus
type: Axiom
annotated target: Reactome:REACT_28808
annotated source: apoptotic DNA fragmentation
annotated property: database_cross_reference

Apoptosis induced DNA fragmentation, Xenopus tropicalis
type: Axiom
annotated target: Reactome:REACT_110358
annotated source: apoptotic DNA fragmentation
annotated property: database_cross_reference

Axiom
database_cross_reference: GOC:dph
database_cross_reference: GOC:mah
database_cross_reference: GOC:tb
database_cross_reference: ISBN:0721639976
annotated target: The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments.
annotated source: apoptotic DNA fragmentation
annotated property: IAO_0000115

Apoptosis induced DNA fragmentation, Danio rerio
type: Axiom
annotated target: Reactome:REACT_99925
annotated source: apoptotic DNA fragmentation
annotated property: database_cross_reference

Apoptosis induced DNA fragmentation, Homo sapiens
type: Axiom
annotated target: Reactome:REACT_1213
annotated source: apoptotic DNA fragmentation
annotated property: database_cross_reference

DNA packaging
type: Class
subclass of: cellular component organization
subclass of: DNA conformation change
IAO_0000115: Any process in which DNA and associated proteins are formed into a compact, orderly structure.
has_exact_synonym: DNA organisation
has_exact_synonym: DNA organization
id: GO:0006323
has_obo_namespace: biological_process
IAO_0000412: go.owl
in_subset: goslim pir

Axiom
annotated target: Any process in which DNA and associated proteins are formed into a compact, orderly structure.
database_cross_reference: GOC:mah
database_cross_reference: ISBN:0815316194
annotated source: DNA packaging
annotated property: IAO_0000115

Axiom
annotated target: DNA organization
database_cross_reference: GOC:curators
annotated source: DNA packaging
annotated property: has_exact_synonym

Axiom
annotated target: DNA organisation
database_cross_reference: GOC:curators
annotated source: DNA packaging
annotated property: has_exact_synonym

transcription, DNA-dependent
type: Class
subclass of: RNA biosynthetic process
subclass of: cellular macromolecule biosynthetic process
subclass of: Restriction
  on property: part_of
  some values from: gene expression
has_exact_synonym: DNA-dependent transcription
has_alternative_id: GO:0006350
id: GO:0006351
has_alternative_id: GO:0061018
has_alternative_id: GO:0061022
IAO_0000115: The cellular synthesis of RNA on a template of DNA.
database_cross_reference: Wikipedia:Transcription_(genetics)
has_obo_namespace: biological_process
has_broad_synonym: cellular transcription
has_exact_synonym: cellular transcription, DNA-dependent
has_broad_synonym: transcription
has_related_synonym: transcription regulator activity
IAO_0000412: go.owl
in_subset: goslim aspergillus
in_subset: goslim metagenomics
in_subset: goslim pombe
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:jl
database_cross_reference: GOC:txnOH
annotated target: The cellular synthesis of RNA on a template of DNA.
annotated source: transcription, DNA-dependent
annotated property: IAO_0000115

regulation of transcription, DNA-dependent
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: regulates
    some values from: transcription, DNA-dependent
subclass of: regulation of gene expression
subclass of: regulation of cellular macromolecule biosynthetic process
subclass of: regulation of RNA biosynthetic process
subclass of: Restriction
  on property: regulates
  some values from: transcription, DNA-dependent
IAO_0000115: Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription.
id: GO:0006355
has_alternative_id: GO:0032583
has_alternative_id: GO:0045449
has_alternative_id: GO:0061019
has_obo_namespace: biological_process
has_exact_synonym: regulation of cellular transcription, DNA-dependent
has_related_synonym: regulation of gene-specific transcription
has_broad_synonym: transcriptional control
IAO_0000412: go.owl
in_subset: goslim pombe
in_subset: gosubset prok

Axiom
annotated target: Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription.
database_cross_reference: GOC:go_curators
database_cross_reference: GOC:txnOH
annotated source: regulation of transcription, DNA-dependent
annotated property: IAO_0000115

protein targeting
type: Class
subclass of: intracellular protein transport
subclass of: single-organism transport
id: GO:0006605
comment: Note that protein targeting encompasses the transport of the protein to the specified location, and may also include additional steps such as protein processing.
IAO_0000115: The process of targeting specific proteins to particular membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif.
database_cross_reference: Wikipedia:Protein_targeting
has_obo_namespace: biological_process
has_related_synonym: nascent polypeptide association
has_narrow_synonym: protein sorting along secretory pathway
IAO_0000412: go.owl
in_subset: goslim generic
in_subset: goslim pombe
in_subset: goslim yeast
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:ma
annotated target: The process of targeting specific proteins to particular membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif.
annotated source: protein targeting
annotated property: IAO_0000115

protein import into nucleus
type: Class
subclass of: intracellular protein transport
subclass of: protein import
subclass of: nuclear import
subclass of: Restriction
  on property: part_of
  some values from: protein targeting to nucleus
subclass of: Restriction
  on property: part_of
  some values from: protein localization to nucleus
id: GO:0006606
IAO_0000115: The directed movement of a protein from the cytoplasm to the nucleus.
has_obo_namespace: biological_process
has_exact_synonym: establishment of protein localization to nucleus
has_exact_synonym: protein import into cell nucleus
has_exact_synonym: protein nucleus import
has_exact_synonym: protein transport from cytoplasm to nucleus
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:mah
annotated target: establishment of protein localization to nucleus
annotated source: protein import into nucleus
annotated property: has_exact_synonym

Axiom
database_cross_reference: GOC:jl
annotated target: The directed movement of a protein from the cytoplasm to the nucleus.
annotated source: protein import into nucleus
annotated property: IAO_0000115

cellular aromatic compound metabolic process
type: Class
subclass of: cellular metabolic process
id: GO:0006725
IAO_0000115: The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells.
has_exact_synonym: aromatic compound metabolism
has_narrow_synonym: aromatic hydrocarbon metabolic process
has_narrow_synonym: aromatic hydrocarbon metabolism
has_obo_namespace: biological_process
IAO_0000412: go.owl
in_subset: goslim pir
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:ai
database_cross_reference: ISBN:0198506732
annotated target: The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells.
annotated source: cellular aromatic compound metabolic process
annotated property: IAO_0000115

nitrogen compound metabolic process
type: Class
subclass of: metabolic process
id: GO:0006807
comment: Note that amino acid and derivative metabolism should not be annotated here. Instead use the 'amino acid and derivative metabolism' node.
IAO_0000115: The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen, including (but not limited to) nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium.
has_obo_namespace: biological_process
has_exact_synonym: nitrogen compound metabolism
IAO_0000412: go.owl
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: gosubset prok

Axiom
database_cross_reference: CHEBI:51143
database_cross_reference: GOC:go_curators
database_cross_reference: GOC:jl
database_cross_reference: ISBN:0198506732
annotated target: The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen, including (but not limited to) nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium.
annotated source: nitrogen compound metabolic process
annotated property: IAO_0000115

transport
type: Class
subclass of: establishment of localization
id: GO:0006810
has_alternative_id: GO:0015457
has_alternative_id: GO:0015460
IAO_0000115: The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore.
has_related_synonym: auxiliary transport protein activity
has_obo_namespace: biological_process
has_narrow_synonym: small molecule transport
has_narrow_synonym: solute:solute exchange
has_related_synonym: transport accessory protein activity
IAO_0000412: go.owl
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:mah
annotated target: transport accessory protein activity
annotated source: transport
annotated property: has_related_synonym

Axiom
database_cross_reference: GOC:mah
annotated target: auxiliary transport protein activity
annotated source: transport
annotated property: has_related_synonym

Axiom
database_cross_reference: GOC:dph
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah
annotated target: The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore.
annotated source: transport
annotated property: IAO_0000115

intracellular protein transport
type: Class
equivalent class: Class
  intersection of: protein transport
  intersection of: Restriction
    on property: occurs in
    some values from: intracellular
subclass of: protein transport
subclass of: intracellular transport
subclass of: Restriction
  on property: part_of
  some values from: cellular protein localization
subclass of: Restriction
  on property: occurs in
  some values from: intracellular
id: GO:0006886
has_alternative_id: GO:0032779
IAO_0000115: The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
has_obo_namespace: biological_process
has_related_synonym: copper-induced intracellular protein transport
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:mah
annotated target: The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
annotated source: intracellular protein transport
annotated property: IAO_0000115

Axiom
database_cross_reference: GOC:al
annotated target: copper-induced intracellular protein transport
annotated source: intracellular protein transport
annotated property: has_related_synonym

nucleocytoplasmic transport
type: Class
subclass of: nuclear transport
has_alternative_id: GO:0000063
id: GO:0006913
comment: Note that transport through the nuclear pore complex is not transmembrane because the nuclear membrane is a double membrane, and is not traversed.
IAO_0000115: The directed movement of molecules between the nucleus and the cytoplasm.
has_obo_namespace: biological_process
has_narrow_synonym: nucleocytoplasmic shuttling
IAO_0000412: go.owl
in_subset: goslim generic
in_subset: goslim pombe

Axiom
database_cross_reference: GOC:go_curators
annotated target: The directed movement of molecules between the nucleus and the cytoplasm.
annotated source: nucleocytoplasmic transport
annotated property: IAO_0000115

apoptotic process
type: Class
subclass of: programmed cell death
IAO_0000115: A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathways) which typically lead to rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. The process ends when the cell has died. The process is divided into a signaling pathway phase, and an execution phase, which is triggered by the former.
id: GO:0006915
has_alternative_id: GO:0008632
database_cross_reference: Reactome:REACT_100045
database_cross_reference: Reactome:REACT_100962
database_cross_reference: Reactome:REACT_101249
database_cross_reference: Reactome:REACT_104187
database_cross_reference: Reactome:REACT_105149
database_cross_reference: Reactome:REACT_106405
database_cross_reference: Reactome:REACT_106672
database_cross_reference: Reactome:REACT_107264
database_cross_reference: Reactome:REACT_108651
database_cross_reference: Reactome:REACT_109165
database_cross_reference: Reactome:REACT_110081
database_cross_reference: Reactome:REACT_111964
database_cross_reference: Reactome:REACT_13526
database_cross_reference: Reactome:REACT_13638
database_cross_reference: Reactome:REACT_13643
database_cross_reference: Reactome:REACT_28087
database_cross_reference: Reactome:REACT_28795
database_cross_reference: Reactome:REACT_28816
database_cross_reference: Reactome:REACT_30266
database_cross_reference: Reactome:REACT_30361
database_cross_reference: Reactome:REACT_30371
database_cross_reference: Reactome:REACT_30548
database_cross_reference: Reactome:REACT_30763
database_cross_reference: Reactome:REACT_31349
database_cross_reference: Reactome:REACT_34139
database_cross_reference: Reactome:REACT_578
database_cross_reference: Reactome:REACT_77132
database_cross_reference: Reactome:REACT_77313
database_cross_reference: Reactome:REACT_77415
database_cross_reference: Reactome:REACT_78287
database_cross_reference: Reactome:REACT_78802
database_cross_reference: Reactome:REACT_79809
database_cross_reference: Reactome:REACT_82724
database_cross_reference: Reactome:REACT_83328
database_cross_reference: Reactome:REACT_85877
database_cross_reference: Reactome:REACT_86749
database_cross_reference: Reactome:REACT_86873
database_cross_reference: Reactome:REACT_87570
database_cross_reference: Reactome:REACT_88740
database_cross_reference: Reactome:REACT_88784
database_cross_reference: Reactome:REACT_89196
database_cross_reference: Reactome:REACT_90267
database_cross_reference: Reactome:REACT_91011
database_cross_reference: Reactome:REACT_91243
database_cross_reference: Reactome:REACT_93937
database_cross_reference: Reactome:REACT_94099
database_cross_reference: Reactome:REACT_95069
database_cross_reference: Reactome:REACT_95675
database_cross_reference: Reactome:REACT_97627
database_cross_reference: Reactome:REACT_99784
database_cross_reference: Reactome:REACT_99799
database_cross_reference: Wikipedia:Apoptosis
has_narrow_synonym: apoptosis
has_exact_synonym: apoptotic cell death
has_narrow_synonym: apoptotic program
has_exact_synonym: apoptotic programmed cell death
has_obo_namespace: biological_process
has_broad_synonym: cell suicide
has_broad_synonym: cellular suicide
has_exact_synonym: programmed cell death by apoptosis
has_related_synonym: signaling (initiator) caspase activity
has_narrow_synonym: type I programmed cell death
IAO_0000412: go.owl

Apoptosis, Sus scrofa
type: Axiom
annotated target: Reactome:REACT_83328
annotated source: apoptotic process
annotated property: database_cross_reference

NRAGE signals death through JNK, Saccharomyces cerevisiae
type: Axiom
annotated target: Reactome:REACT_30371
annotated source: apoptotic process
annotated property: database_cross_reference

NRAGE signals death through JNK, Drosophila melanogaster
type: Axiom
annotated target: Reactome:REACT_77132
annotated source: apoptotic process
annotated property: database_cross_reference

Apoptosis, Caenorhabditis elegans
type: Axiom
annotated target: Reactome:REACT_91011
annotated source: apoptotic process
annotated property: database_cross_reference

Axiom
database_cross_reference: GOC:add
annotated target: apoptotic program
annotated source: apoptotic process
annotated property: has_narrow_synonym

Apoptosis, Xenopus tropicalis
type: Axiom
annotated target: Reactome:REACT_95069
annotated source: apoptotic process
annotated property: database_cross_reference

Apoptosis, Plasmodium falciparum
type: Axiom
annotated target: Reactome:REACT_95675
annotated source: apoptotic process
annotated property: database_cross_reference

Apoptosis, Gallus gallus
type: Axiom
annotated target: Reactome:REACT_78287
annotated source: apoptotic process
annotated property: database_cross_reference

Apoptosis, Danio rerio
type: Axiom
annotated target: Reactome:REACT_28816
annotated source: apoptotic process
annotated property: database_cross_reference

NRIF signals cell death from the nucleus, Homo sapiens
type: Axiom
annotated target: Reactome:REACT_13643
annotated source: apoptotic process
annotated property: database_cross_reference

NRAGE signals death through JNK, Xenopus tropicalis
type: Axiom
annotated target: Reactome:REACT_106405
annotated source: apoptotic process
annotated property: database_cross_reference

NRIF signals cell death from the nucleus, Canis familiaris
type: Axiom
annotated target: Reactome:REACT_77415
annotated source: apoptotic process
annotated property: database_cross_reference

Apoptosis, Taeniopygia guttata
type: Axiom
annotated target: Reactome:REACT_82724
annotated source: apoptotic process
annotated property: database_cross_reference

NRAGE signals death through JNK, Oryza sativa
type: Axiom
annotated target: Reactome:REACT_30763
annotated source: apoptotic process
annotated property: database_cross_reference

NRAGE signals death through JNK, Dictyostelium discoideum
type: Axiom
annotated target: Reactome:REACT_111964
annotated source: apoptotic process
annotated property: database_cross_reference

Axiom
annotated target: A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathways) which typically lead to rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. The process ends when the cell has died. The process is divided into a signaling pathway phase, and an execution phase, which is triggered by the former.
database_cross_reference: GOC:dhl
database_cross_reference: GOC:ecd
database_cross_reference: GOC:go_curators
database_cross_reference: GOC:mtg_apoptosis
database_cross_reference: GOC:tb
database_cross_reference: ISBN:0198506732
database_cross_reference: PMID:18846107
database_cross_reference: PMID:21494263
annotated source: apoptotic process
annotated property: IAO_0000115

Apoptosis, Homo sapiens
type: Axiom
annotated target: Reactome:REACT_578
annotated source: apoptotic process
annotated property: database_cross_reference

Apoptosis, Schizosaccharomyces pombe
type: Axiom
annotated target: Reactome:REACT_79809
annotated source: apoptotic process
annotated property: database_cross_reference

NRAGE signals death through JNK, Schizosaccharomyces pombe
type: Axiom
annotated target: Reactome:REACT_110081
annotated source: apoptotic process
annotated property: database_cross_reference

NRIF signals cell death from the nucleus, Mus musculus
type: Axiom
annotated target: Reactome:REACT_88784
annotated source: apoptotic process
annotated property: database_cross_reference

NADE modulates death signalling, Rattus norvegicus
type: Axiom
annotated target: Reactome:REACT_105149
annotated source: apoptotic process
annotated property: database_cross_reference

Apoptosis, Mus musculus
type: Axiom
annotated target: Reactome:REACT_100962
annotated source: apoptotic process
annotated property: database_cross_reference

Apoptosis, Dictyostelium discoideum
type: Axiom
annotated target: Reactome:REACT_89196
annotated source: apoptotic process
annotated property: database_cross_reference

NRAGE signals death through JNK, Bos taurus
type: Axiom
annotated target: Reactome:REACT_99784
annotated source: apoptotic process
annotated property: database_cross_reference

Apoptosis, Rattus norvegicus
type: Axiom
annotated target: Reactome:REACT_86749
annotated source: apoptotic process
annotated property: database_cross_reference

NRIF signals cell death from the nucleus, Xenopus tropicalis
type: Axiom
annotated target: Reactome:REACT_107264
annotated source: apoptotic process
annotated property: database_cross_reference

NADE modulates death signalling, Bos taurus
type: Axiom
annotated target: Reactome:REACT_77313
annotated source: apoptotic process
annotated property: database_cross_reference

Apoptosis, Canis familiaris
type: Axiom
annotated target: Reactome:REACT_30361
annotated source: apoptotic process
annotated property: database_cross_reference

NRAGE signals death through JNK, Arabidopsis thaliana
type: Axiom
annotated target: Reactome:REACT_109165
annotated source: apoptotic process
annotated property: database_cross_reference

NRAGE signals death through JNK, Gallus gallus
type: Axiom
annotated target: Reactome:REACT_34139
annotated source: apoptotic process
annotated property: database_cross_reference

NRIF signals cell death from the nucleus, Bos taurus
type: Axiom
annotated target: Reactome:REACT_97627
annotated source: apoptotic process
annotated property: database_cross_reference

NRIF signals cell death from the nucleus, Sus scrofa
type: Axiom
annotated target: Reactome:REACT_88740
annotated source: apoptotic process
annotated property: database_cross_reference

NRAGE signals death through JNK, Rattus norvegicus
type: Axiom
annotated target: Reactome:REACT_85877
annotated source: apoptotic process
annotated property: database_cross_reference

NRAGE signals death through JNK, Caenorhabditis elegans
type: Axiom
annotated target: Reactome:REACT_30548
annotated source: apoptotic process
annotated property: database_cross_reference

Axiom
database_cross_reference: GOC:sl
annotated target: apoptotic cell death
annotated source: apoptotic process
annotated property: has_exact_synonym

NRIF signals cell death from the nucleus, Taeniopygia guttata
type: Axiom
annotated target: Reactome:REACT_90267
annotated source: apoptotic process
annotated property: database_cross_reference

NRAGE signals death through JNK, Mus musculus
type: Axiom
annotated target: Reactome:REACT_108651
annotated source: apoptotic process
annotated property: database_cross_reference

NRAGE signals death through JNK, Homo sapiens
type: Axiom
annotated target: Reactome:REACT_13638
annotated source: apoptotic process
annotated property: database_cross_reference

Apoptosis, Arabidopsis thaliana
type: Axiom
annotated target: Reactome:REACT_30266
annotated source: apoptotic process
annotated property: database_cross_reference

NRIF signals cell death from the nucleus, Rattus norvegicus
type: Axiom
annotated target: Reactome:REACT_87570
annotated source: apoptotic process
annotated property: database_cross_reference

NADE modulates death signalling, Mus musculus
type: Axiom
annotated target: Reactome:REACT_91243
annotated source: apoptotic process
annotated property: database_cross_reference

Apoptosis, Oryza sativa
type: Axiom
annotated target: Reactome:REACT_28795
annotated source: apoptotic process
annotated property: database_cross_reference

NRIF signals cell death from the nucleus, Gallus gallus
type: Axiom
annotated target: Reactome:REACT_86873
annotated source: apoptotic process
annotated property: database_cross_reference

Apoptosis, Saccharomyces cerevisiae
type: Axiom
annotated target: Reactome:REACT_28087
annotated source: apoptotic process
annotated property: database_cross_reference

NRAGE signals death through JNK, Canis familiaris
type: Axiom
annotated target: Reactome:REACT_31349
annotated source: apoptotic process
annotated property: database_cross_reference

Apoptosis, Bos taurus
type: Axiom
annotated target: Reactome:REACT_93937
annotated source: apoptotic process
annotated property: database_cross_reference

NADE modulates death signalling, Sus scrofa
type: Axiom
annotated target: Reactome:REACT_106672
annotated source: apoptotic process
annotated property: database_cross_reference

NRAGE signals death through JNK, Taeniopygia guttata
type: Axiom
annotated target: Reactome:REACT_104187
annotated source: apoptotic process
annotated property: database_cross_reference

Apoptosis, Drosophila melanogaster
type: Axiom
annotated target: Reactome:REACT_100045
annotated source: apoptotic process
annotated property: database_cross_reference

NRIF signals cell death from the nucleus, Danio rerio
type: Axiom
annotated target: Reactome:REACT_101249
annotated source: apoptotic process
annotated property: database_cross_reference

NADE modulates death signalling, Canis familiaris
type: Axiom
annotated target: Reactome:REACT_78802
annotated source: apoptotic process
annotated property: database_cross_reference

NADE modulates death signalling, Homo sapiens
type: Axiom
annotated target: Reactome:REACT_13526
annotated source: apoptotic process
annotated property: database_cross_reference

NRAGE signals death through JNK, Sus scrofa
type: Axiom
annotated target: Reactome:REACT_99799
annotated source: apoptotic process
annotated property: database_cross_reference

NRAGE signals death through JNK, Danio rerio
type: Axiom
annotated target: Reactome:REACT_94099
annotated source: apoptotic process
annotated property: database_cross_reference

cellular component disassembly involved in execution phase of apoptosis
type: Class
equivalent class: Class
  intersection of: cellular component disassembly
  intersection of: Restriction
    on property: part_of
    some values from: execution phase of apoptosis
subclass of: cellular component disassembly
subclass of: Restriction
  on property: part_of
  some values from: execution phase of apoptosis
id: GO:0006921
database_cross_reference: Reactome:REACT_100800
database_cross_reference: Reactome:REACT_108463
database_cross_reference: Reactome:REACT_29660
database_cross_reference: Reactome:REACT_77151
database_cross_reference: Reactome:REACT_78666
database_cross_reference: Reactome:REACT_79472
database_cross_reference: Reactome:REACT_79859
database_cross_reference: Reactome:REACT_80493
database_cross_reference: Reactome:REACT_81021
database_cross_reference: Reactome:REACT_81052
database_cross_reference: Reactome:REACT_84120
database_cross_reference: Reactome:REACT_89424
database_cross_reference: Reactome:REACT_90988
database_cross_reference: Reactome:REACT_92689
database_cross_reference: Reactome:REACT_93576
database_cross_reference: Reactome:REACT_94230
database_cross_reference: Reactome:REACT_97703
database_cross_reference: Reactome:REACT_995
IAO_0000115: The breakdown of structures such as organelles, proteins, or other macromolecular structures during apoptosis.
has_obo_namespace: biological_process
has_narrow_synonym: cellular component disassembly involved in apoptosis
has_broad_synonym: cellular component disassembly involved in apoptotic process
has_broad_synonym: disassembly of cell structures
IAO_0000412: go.owl

Apoptotic execution phase, Drosophila melanogaster
type: Axiom
annotated target: Reactome:REACT_81021
annotated source: cellular component disassembly involved in execution phase of apoptosis
annotated property: database_cross_reference

Apoptotic execution phase, Homo sapiens
type: Axiom
annotated target: Reactome:REACT_995
annotated source: cellular component disassembly involved in execution phase of apoptosis
annotated property: database_cross_reference

Apoptotic execution phase, Danio rerio
type: Axiom
annotated target: Reactome:REACT_100800
annotated source: cellular component disassembly involved in execution phase of apoptosis
annotated property: database_cross_reference

Apoptotic execution phase, Arabidopsis thaliana
type: Axiom
annotated target: Reactome:REACT_89424
annotated source: cellular component disassembly involved in execution phase of apoptosis
annotated property: database_cross_reference

Apoptotic execution phase, Mus musculus
type: Axiom
annotated target: Reactome:REACT_97703
annotated source: cellular component disassembly involved in execution phase of apoptosis
annotated property: database_cross_reference

Apoptotic execution phase, Bos taurus
type: Axiom
annotated target: Reactome:REACT_94230
annotated source: cellular component disassembly involved in execution phase of apoptosis
annotated property: database_cross_reference

Apoptotic execution phase, Xenopus tropicalis
type: Axiom
annotated target: Reactome:REACT_84120
annotated source: cellular component disassembly involved in execution phase of apoptosis
annotated property: database_cross_reference

Apoptotic execution phase, Taeniopygia guttata
type: Axiom
annotated target: Reactome:REACT_108463
annotated source: cellular component disassembly involved in execution phase of apoptosis
annotated property: database_cross_reference

Apoptotic execution phase, Plasmodium falciparum
type: Axiom
annotated target: Reactome:REACT_90988
annotated source: cellular component disassembly involved in execution phase of apoptosis
annotated property: database_cross_reference

Apoptotic execution phase, Dictyostelium discoideum
type: Axiom
annotated target: Reactome:REACT_80493
annotated source: cellular component disassembly involved in execution phase of apoptosis
annotated property: database_cross_reference

Apoptotic execution phase, Caenorhabditis elegans
type: Axiom
annotated target: Reactome:REACT_92689
annotated source: cellular component disassembly involved in execution phase of apoptosis
annotated property: database_cross_reference

Apoptotic execution phase, Oryza sativa
type: Axiom
annotated target: Reactome:REACT_29660
annotated source: cellular component disassembly involved in execution phase of apoptosis
annotated property: database_cross_reference

Axiom
database_cross_reference: GOC:dph
database_cross_reference: GOC:mah
database_cross_reference: GOC:mtg_apoptosis
database_cross_reference: GOC:tb
annotated target: The breakdown of structures such as organelles, proteins, or other macromolecular structures during apoptosis.
annotated source: cellular component disassembly involved in execution phase of apoptosis
annotated property: IAO_0000115

Apoptotic execution phase, Schizosaccharomyces pombe
type: Axiom
annotated target: Reactome:REACT_79472
annotated source: cellular component disassembly involved in execution phase of apoptosis
annotated property: database_cross_reference

Apoptotic execution phase, Gallus gallus
type: Axiom
annotated target: Reactome:REACT_93576
annotated source: cellular component disassembly involved in execution phase of apoptosis
annotated property: database_cross_reference

Apoptotic execution phase, Canis familiaris
type: Axiom
annotated target: Reactome:REACT_81052
annotated source: cellular component disassembly involved in execution phase of apoptosis
annotated property: database_cross_reference

Apoptotic execution phase, Saccharomyces cerevisiae
type: Axiom
annotated target: Reactome:REACT_78666
annotated source: cellular component disassembly involved in execution phase of apoptosis
annotated property: database_cross_reference

Apoptotic execution phase, Rattus norvegicus
type: Axiom
annotated target: Reactome:REACT_79859
annotated source: cellular component disassembly involved in execution phase of apoptosis
annotated property: database_cross_reference

Apoptotic execution phase, Sus scrofa
type: Axiom
annotated target: Reactome:REACT_77151
annotated source: cellular component disassembly involved in execution phase of apoptosis
annotated property: database_cross_reference

cellular component movement
type: Class
subclass of: single-organism cellular process
id: GO:0006928
comment: Note that in GO cellular components include whole cells (cell is_a cellular component).
IAO_0000115: The directed, self-propelled movement of a cellular component without the involvement of an external agent such as a transporter or a pore.
has_obo_namespace: biological_process
has_related_synonym: cell movement
has_exact_synonym: cellular component motion
IAO_0000412: go.owl
in_subset: goslim pir
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:dgh
database_cross_reference: GOC:dph
database_cross_reference: GOC:jl
database_cross_reference: GOC:mlg
annotated target: The directed, self-propelled movement of a cellular component without the involvement of an external agent such as a transporter or a pore.
annotated source: cellular component movement
annotated property: IAO_0000115

Axiom
database_cross_reference: GOC:dph
database_cross_reference: GOC:jl
annotated target: cellular component motion
annotated source: cellular component movement
annotated property: has_exact_synonym

substrate-dependent cell migration
type: Class
subclass of: cell migration
id: GO:0006929
IAO_0000115: The orderly movement of a cell from one site to another along a substrate such as the extracellular matrix; the migrating cell forms a protrusion that attaches to the substrate.
has_obo_namespace: biological_process
has_exact_synonym: substrate-bound cell migration
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:curators
annotated target: substrate-bound cell migration
annotated source: substrate-dependent cell migration
annotated property: has_exact_synonym

Axiom
database_cross_reference: ISBN:0815316194
database_cross_reference: PMID:11944043
database_cross_reference: PMID:14657486
annotated target: The orderly movement of a cell from one site to another along a substrate such as the extracellular matrix; the migrating cell forms a protrusion that attaches to the substrate.
annotated source: substrate-dependent cell migration
annotated property: IAO_0000115

substrate-dependent cell migration, cell extension
type: Class
subclass of: cell projection assembly
subclass of: Restriction
  on property: part_of
  some values from: substrate-dependent cell migration
id: GO:0006930
IAO_0000115: The formation of a cell surface protrusion, such as a lamellipodium or filopodium, at the leading edge of a migrating cell.
has_obo_namespace: biological_process
has_exact_synonym: substrate-bound cell migration, cell extension
IAO_0000412: go.owl

Axiom
database_cross_reference: ISBN:0815316194
database_cross_reference: PMID:11944043
database_cross_reference: PMID:14657486
annotated target: The formation of a cell surface protrusion, such as a lamellipodium or filopodium, at the leading edge of a migrating cell.
annotated source: substrate-dependent cell migration, cell extension
annotated property: IAO_0000115

Axiom
database_cross_reference: GOC:curators
annotated target: substrate-bound cell migration, cell extension
annotated source: substrate-dependent cell migration, cell extension
annotated property: has_exact_synonym

cellular membrane fusion
type: Class
subclass of: cellular membrane organization
subclass of: membrane fusion
id: GO:0006944
IAO_0000115: The cellular process that joins two lipid bilayers to form a single membrane.
database_cross_reference: Wikipedia:Lipid_bilayer_fusion
has_obo_namespace: biological_process
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:mah
annotated target: The cellular process that joins two lipid bilayers to form a single membrane.
annotated source: cellular membrane fusion
annotated property: IAO_0000115

organelle organization
type: Class
subclass of: cellular component organization
subclass of: single-organism cellular process
IAO_0000115: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
id: GO:0006996
has_obo_namespace: biological_process
has_exact_synonym: organelle organisation
has_related_synonym: organelle organization and biogenesis
IAO_0000412: go.owl
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim pir
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:dph
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah
annotated target: organelle organization and biogenesis
annotated source: organelle organization
annotated property: has_related_synonym

Axiom
database_cross_reference: GOC:curators
annotated target: organelle organisation
annotated source: organelle organization
annotated property: has_exact_synonym

Axiom
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
database_cross_reference: GOC:mah
annotated source: organelle organization
annotated property: IAO_0000115

cytoskeleton organization
type: Class
subclass of: organelle organization
IAO_0000115: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.
id: GO:0007010
has_obo_namespace: biological_process
has_related_synonym: cytoskeletal organization and biogenesis
has_related_synonym: cytoskeletal regulator activity
has_exact_synonym: cytoskeleton organisation
has_related_synonym: cytoskeleton organization and biogenesis
IAO_0000412: go.owl
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim generic
in_subset: goslim pombe
in_subset: goslim yeast
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:curators
annotated target: cytoskeleton organisation
annotated source: cytoskeleton organization
annotated property: has_exact_synonym

Axiom
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.
database_cross_reference: GOC:dph
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah
annotated source: cytoskeleton organization
annotated property: IAO_0000115

Axiom
database_cross_reference: GOC:mah
annotated target: cytoskeleton organization and biogenesis
annotated source: cytoskeleton organization
annotated property: has_related_synonym

Axiom
database_cross_reference: GOC:mah
annotated target: cytoskeletal organization and biogenesis
annotated source: cytoskeleton organization
annotated property: has_related_synonym

microtubule-based process
type: Class
subclass of: single-organism cellular process
IAO_0000115: Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins.
id: GO:0007017
has_obo_namespace: biological_process
IAO_0000412: go.owl

Axiom
annotated target: Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins.
database_cross_reference: GOC:mah
annotated source: microtubule-based process
annotated property: IAO_0000115

endoplasmic reticulum organization
type: Class
subclass of: organelle organization
IAO_0000115: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum.
has_exact_synonym: ER organisation
has_related_synonym: ER organization and biogenesis
id: GO:0007029
has_obo_namespace: biological_process
has_related_synonym: endoplasmic reticulum morphology
has_exact_synonym: endoplasmic reticulum organisation
has_related_synonym: endoplasmic reticulum organization and biogenesis
IAO_0000412: go.owl
in_subset: goslim pir

Axiom
annotated target: ER organisation
database_cross_reference: GOC:curators
annotated source: endoplasmic reticulum organization
annotated property: has_exact_synonym

Axiom
database_cross_reference: GOC:curators
annotated target: endoplasmic reticulum organisation
annotated source: endoplasmic reticulum organization
annotated property: has_exact_synonym

Axiom
database_cross_reference: GOC:mah
annotated target: endoplasmic reticulum organization and biogenesis
annotated source: endoplasmic reticulum organization
annotated property: has_related_synonym

Axiom
annotated target: ER organization and biogenesis
database_cross_reference: GOC:mah
annotated source: endoplasmic reticulum organization
annotated property: has_related_synonym

Axiom
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum.
database_cross_reference: GOC:dph
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah
annotated source: endoplasmic reticulum organization
annotated property: IAO_0000115

cell cycle
type: Class
subclass of: cell cycle process
id: GO:0007049
IAO_0000115: The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
database_cross_reference: Wikipedia:Cell_cycle
has_obo_namespace: biological_process
has_exact_synonym: cell-division cycle
IAO_0000412: go.owl
in_subset: gocheck do not manually annotate
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim plant
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:go_curators
database_cross_reference: GOC:mtg_cell_cycle
annotated target: The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
annotated source: cell cycle
annotated property: IAO_0000115

chromosome segregation
type: Class
subclass of: single-organism cellular process
id: GO:0007059
IAO_0000115: The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the alignment of chromosomes at the metaphase plate, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
database_cross_reference: Wikipedia:Chromosome_segregation
has_obo_namespace: biological_process
has_exact_synonym: chromosome division
has_related_synonym: chromosome transmission
IAO_0000412: go.owl
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim pombe
in_subset: goslim yeast
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:ai
database_cross_reference: GOC:mah
annotated target: The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the alignment of chromosomes at the metaphase plate, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
annotated source: chromosome segregation
annotated property: IAO_0000115

mitosis
type: Class
subclass of: nuclear division
subclass of: cell cycle process
subclass of: Restriction
  on property: part_of
  some values from: mitotic cell cycle
IAO_0000115: A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.
id: GO:0007067
database_cross_reference: Wikipedia:Mitosis
has_obo_namespace: biological_process
IAO_0000412: go.owl
in_subset: goslim generic

Axiom
annotated target: A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.
database_cross_reference: GOC:dph
database_cross_reference: GOC:ma
database_cross_reference: GOC:mah
database_cross_reference: ISBN:0198547684
annotated source: mitosis
annotated property: IAO_0000115

mitotic chromosome condensation
type: Class
equivalent class: Class
  intersection of: chromosome condensation
  intersection of: Restriction
    on property: part_of
    some values from: mitotic cell cycle
subclass of: cell cycle process
subclass of: chromosome condensation
subclass of: Restriction
  on property: part_of
  some values from: mitotic sister chromatid segregation
subclass of: Restriction
  on property: part_of
  some values from: mitotic cell cycle
id: GO:0007076
IAO_0000115: The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells.
has_obo_namespace: biological_process
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:mah
database_cross_reference: ISBN:0815316194
annotated target: The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells.
annotated source: mitotic chromosome condensation
annotated property: IAO_0000115

mitotic metaphase plate congression
type: Class
equivalent class: Class
  intersection of: metaphase plate congression
  intersection of: Restriction
    on property: part_of
    some values from: mitotic cell cycle
subclass of: cell cycle process
subclass of: metaphase plate congression
subclass of: Restriction
  on property: part_of
  some values from: mitotic sister chromatid segregation
subclass of: Restriction
  on property: part_of
  some values from: mitotic cell cycle
id: GO:0007080
IAO_0000115: The cell cycle process in which chromosomes are aligned at the metaphase plate, a plane halfway between the poles of the mitotic spindle, during mitosis.
has_obo_namespace: biological_process
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:mah
database_cross_reference: ISBN:0815316194
annotated target: The cell cycle process in which chromosomes are aligned at the metaphase plate, a plane halfway between the poles of the mitotic spindle, during mitosis.
annotated source: mitotic metaphase plate congression
annotated property: IAO_0000115

mitotic chromosome decondensation
type: Class
equivalent class: Class
  intersection of: chromosome decondensation
  intersection of: Restriction
    on property: part_of
    some values from: mitotic cell cycle
subclass of: cell cycle process
subclass of: chromosome decondensation
subclass of: Restriction
  on property: part_of
  some values from: mitotic sister chromatid segregation
subclass of: Restriction
  on property: part_of
  some values from: mitotic cell cycle
id: GO:0007083
IAO_0000115: The cell cycle process in which chromosome structure is altered from the condensed form taken on during mitosis to the relaxed disperse form held in resting cells.
has_obo_namespace: biological_process
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:ai
annotated target: The cell cycle process in which chromosome structure is altered from the condensed form taken on during mitosis to the relaxed disperse form held in resting cells.
annotated source: mitotic chromosome decondensation
annotated property: IAO_0000115

centrosome cycle
type: Class
subclass of: cell cycle process
subclass of: centrosome organization
id: GO:0007098
IAO_0000115: The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle.
has_obo_namespace: biological_process
IAO_0000412: go.owl

Axiom
database_cross_reference: ISBN:0815316194
annotated target: The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle.
annotated source: centrosome cycle
annotated property: IAO_0000115

centriole replication
type: Class
subclass of: microtubule-based process
subclass of: cell cycle process
subclass of: centrosome organization
subclass of: Restriction
  on property: part_of
  some values from: centrosome duplication
id: GO:0007099
IAO_0000115: The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type.
has_obo_namespace: biological_process
has_exact_synonym: centriole duplication
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:kmv
database_cross_reference: ISBN:0815316194
annotated target: The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type.
annotated source: centriole replication
annotated property: IAO_0000115

cell communication
type: Class
subclass of: single-organism cellular process
IAO_0000115: Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
id: GO:0007154
database_cross_reference: Wikipedia:Cell_signaling
has_obo_namespace: biological_process
IAO_0000412: go.owl
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: gosubset prok

Axiom
annotated target: Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
database_cross_reference: GOC:mah
annotated source: cell communication
annotated property: IAO_0000115

cell adhesion
type: Class
subclass of: biological adhesion
subclass of: single-organism cellular process
id: GO:0007155
IAO_0000115: The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
database_cross_reference: Wikipedia:Cell_adhesion
has_obo_namespace: biological_process
has_related_synonym: cell adhesion molecule activity
IAO_0000412: go.owl
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim pombe
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:hb
database_cross_reference: GOC:pf
annotated target: The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
annotated source: cell adhesion
annotated property: IAO_0000115

cell-matrix adhesion
type: Class
subclass of: cell-substrate adhesion
id: GO:0007160
IAO_0000115: The binding of a cell to the extracellular matrix via adhesion molecules.
has_obo_namespace: biological_process
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:hb
annotated target: The binding of a cell to the extracellular matrix via adhesion molecules.
annotated source: cell-matrix adhesion
annotated property: IAO_0000115

establishment or maintenance of cell polarity
type: Class
subclass of: single-organism cellular process
IAO_0000115: Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.
id: GO:0007163
has_alternative_id: GO:0030012
has_alternative_id: GO:0030467
has_obo_namespace: biological_process
has_related_synonym: cell polarity
has_related_synonym: establishment and/or maintenance of cell polarity
has_related_synonym: establishment and/or maintenance of cell polarization
IAO_0000412: go.owl
in_subset: goslim pombe

Axiom
annotated target: Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.
database_cross_reference: GOC:mah
annotated source: establishment or maintenance of cell polarity
annotated property: IAO_0000115

Axiom
database_cross_reference: GOC:mah
database_cross_reference: GOC:vw
annotated target: cell polarity
annotated source: establishment or maintenance of cell polarity
annotated property: has_related_synonym

signal transduction
type: Class
subclass of: regulation of cellular process
subclass of: cellular response to stimulus
subclass of: Restriction
  on property: part_of
  some values from: cell communication
subclass of: Restriction
  on property: part_of
  some values from: single organism signaling
id: GO:0007165
has_alternative_id: GO:0023033
comment: Note that signal transduction is defined broadly to include a ligand interacting with a receptor, downstream signaling steps and a response being triggered. A change in form of the signal in every step is not necessary. Note that in many cases the end of this process is regulation of the initiation of transcription. Note that specific transcription factors may be annotated to this term, but core/general transcription machinery such as RNA polymerase should not.
database_cross_reference: Reactome:REACT_100624
database_cross_reference: Reactome:REACT_102354
database_cross_reference: Reactome:REACT_112130
database_cross_reference: Reactome:REACT_112549
database_cross_reference: Reactome:REACT_113151
database_cross_reference: Reactome:REACT_113601
database_cross_reference: Reactome:REACT_113964
database_cross_reference: Reactome:REACT_114657
database_cross_reference: Reactome:REACT_114690
database_cross_reference: Reactome:REACT_114820
database_cross_reference: Reactome:REACT_114910
database_cross_reference: Reactome:REACT_115037
database_cross_reference: Reactome:REACT_115147
database_cross_reference: Reactome:REACT_12478
database_cross_reference: Reactome:REACT_31232
database_cross_reference: Reactome:REACT_78535
database_cross_reference: Reactome:REACT_89740
database_cross_reference: Reactome:REACT_93680
database_cross_reference: Reactome:REACT_98872
IAO_0000115: The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
database_cross_reference: Wikipedia:Signal_transduction
has_obo_namespace: biological_process
has_narrow_synonym: signaling cascade
has_related_synonym: signaling pathway
has_narrow_synonym: signalling cascade
has_related_synonym: signalling pathway
IAO_0000412: go.owl
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim plant
in_subset: gosubset prok

EGFR interacts with phospholipase C-gamma, Drosophila melanogaster
type: Axiom
annotated target: Reactome:REACT_113601
annotated source: signal transduction
annotated property: database_cross_reference

EGFR interacts with phospholipase C-gamma, Xenopus tropicalis
type: Axiom
annotated target: Reactome:REACT_78535
annotated source: signal transduction
annotated property: database_cross_reference

EGFR interacts with phospholipase C-gamma, Sus scrofa
type: Axiom
annotated target: Reactome:REACT_114820
annotated source: signal transduction
annotated property: database_cross_reference

EGFR interacts with phospholipase C-gamma, Taeniopygia guttata
type: Axiom
annotated target: Reactome:REACT_89740
annotated source: signal transduction
annotated property: database_cross_reference

EGFR interacts with phospholipase C-gamma, Plasmodium falciparum
type: Axiom
annotated target: Reactome:REACT_115037
annotated source: signal transduction
annotated property: database_cross_reference

EGFR interacts with phospholipase C-gamma, Caenorhabditis elegans
type: Axiom
annotated target: Reactome:REACT_114910
annotated source: signal transduction
annotated property: database_cross_reference

EGFR interacts with phospholipase C-gamma, Oryza sativa
type: Axiom
annotated target: Reactome:REACT_112130
annotated source: signal transduction
annotated property: database_cross_reference

EGFR interacts with phospholipase C-gamma, Dictyostelium discoideum
type: Axiom
annotated target: Reactome:REACT_114657
annotated source: signal transduction
annotated property: database_cross_reference

EGFR interacts with phospholipase C-gamma, Saccharomyces cerevisiae
type: Axiom
annotated target: Reactome:REACT_114690
annotated source: signal transduction
annotated property: database_cross_reference

EGFR interacts with phospholipase C-gamma, Schizosaccharomyces pombe
type: Axiom
annotated target: Reactome:REACT_115147
annotated source: signal transduction
annotated property: database_cross_reference

EGFR interacts with phospholipase C-gamma, Homo sapiens
type: Axiom
annotated target: Reactome:REACT_12478
annotated source: signal transduction
annotated property: database_cross_reference

EGFR interacts with phospholipase C-gamma, Canis familiaris
type: Axiom
annotated target: Reactome:REACT_102354
annotated source: signal transduction
annotated property: database_cross_reference

EGFR interacts with phospholipase C-gamma, Bos taurus
type: Axiom
annotated target: Reactome:REACT_113964
annotated source: signal transduction
annotated property: database_cross_reference

EGFR interacts with phospholipase C-gamma, Arabidopsis thaliana
type: Axiom
annotated target: Reactome:REACT_112549
annotated source: signal transduction
annotated property: database_cross_reference

EGFR interacts with phospholipase C-gamma, Mycobacterium tuberculosis
type: Axiom
annotated target: Reactome:REACT_113151
annotated source: signal transduction
annotated property: database_cross_reference

EGFR interacts with phospholipase C-gamma, Gallus gallus
type: Axiom
annotated target: Reactome:REACT_100624
annotated source: signal transduction
annotated property: database_cross_reference

Axiom
database_cross_reference: GOC:mah
annotated target: signalling pathway
annotated source: signal transduction
annotated property: has_related_synonym

Axiom
database_cross_reference: GOC:go_curators
database_cross_reference: GOC:mtg_signaling_feb11
annotated target: The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
annotated source: signal transduction
annotated property: IAO_0000115

EGFR interacts with phospholipase C-gamma, Mus musculus
type: Axiom
annotated target: Reactome:REACT_98872
annotated source: signal transduction
annotated property: database_cross_reference

EGFR interacts with phospholipase C-gamma, Danio rerio
type: Axiom
annotated target: Reactome:REACT_93680
annotated source: signal transduction
annotated property: database_cross_reference

EGFR interacts with phospholipase C-gamma, Rattus norvegicus
type: Axiom
annotated target: Reactome:REACT_31232
annotated source: signal transduction
annotated property: database_cross_reference

intracellular protein kinase cascade
type: Class
subclass of: intracellular signal transduction
IAO_0000115: A series of reactions in which a signal is passed on to downstream proteins within the cell by sequential protein phosphorylation and activation of the cascade components.
id: GO:0007243
database_cross_reference: Reactome:REACT_100795
database_cross_reference: Reactome:REACT_102462
database_cross_reference: Reactome:REACT_104200
database_cross_reference: Reactome:REACT_108216
database_cross_reference: Reactome:REACT_1525
database_cross_reference: Reactome:REACT_80030
database_cross_reference: Reactome:REACT_83068
database_cross_reference: Reactome:REACT_83869
database_cross_reference: Reactome:REACT_87453
database_cross_reference: Reactome:REACT_89085
database_cross_reference: Reactome:REACT_89983
database_cross_reference: Reactome:REACT_90740
database_cross_reference: Reactome:REACT_99938
has_obo_namespace: biological_process
has_exact_synonym: protein kinase cascade
IAO_0000412: go.owl

Axiom
annotated target: A series of reactions in which a signal is passed on to downstream proteins within the cell by sequential protein phosphorylation and activation of the cascade components.
database_cross_reference: GOC:bf
database_cross_reference: GOC:jl
database_cross_reference: GOC:signaling
annotated source: intracellular protein kinase cascade
annotated property: IAO_0000115

PKA-mediated phosphorylation of key metabolic factors, Taeniopygia guttata
type: Axiom
annotated target: Reactome:REACT_104200
annotated source: intracellular protein kinase cascade
annotated property: database_cross_reference

PKA-mediated phosphorylation of key metabolic factors, Danio rerio
type: Axiom
annotated target: Reactome:REACT_89983
annotated source: intracellular protein kinase cascade
annotated property: database_cross_reference

PKA-mediated phosphorylation of key metabolic factors, Rattus norvegicus
type: Axiom
annotated target: Reactome:REACT_89085
annotated source: intracellular protein kinase cascade
annotated property: database_cross_reference

PKA-mediated phosphorylation of key metabolic factors, Homo sapiens
type: Axiom
annotated target: Reactome:REACT_1525
annotated source: intracellular protein kinase cascade
annotated property: database_cross_reference

PKA-mediated phosphorylation of key metabolic factors, Dictyostelium discoideum
type: Axiom
annotated target: Reactome:REACT_108216
annotated source: intracellular protein kinase cascade
annotated property: database_cross_reference

PKA-mediated phosphorylation of key metabolic factors, Bos taurus
type: Axiom
annotated target: Reactome:REACT_87453
annotated source: intracellular protein kinase cascade
annotated property: database_cross_reference

PKA-mediated phosphorylation of key metabolic factors, Canis familiaris
type: Axiom
annotated target: Reactome:REACT_102462
annotated source: intracellular protein kinase cascade
annotated property: database_cross_reference

PKA-mediated phosphorylation of key metabolic factors, Gallus gallus
type: Axiom
annotated target: Reactome:REACT_83068
annotated source: intracellular protein kinase cascade
annotated property: database_cross_reference

PKA-mediated phosphorylation of key metabolic factors, Saccharomyces cerevisiae
type: Axiom
annotated target: Reactome:REACT_100795
annotated source: intracellular protein kinase cascade
annotated property: database_cross_reference

PKA-mediated phosphorylation of key metabolic factors, Mus musculus
type: Axiom
annotated target: Reactome:REACT_99938
annotated source: intracellular protein kinase cascade
annotated property: database_cross_reference

PKA-mediated phosphorylation of key metabolic factors, Schizosaccharomyces pombe
type: Axiom
annotated target: Reactome:REACT_90740
annotated source: intracellular protein kinase cascade
annotated property: database_cross_reference

PKA-mediated phosphorylation of key metabolic factors, Sus scrofa
type: Axiom
annotated target: Reactome:REACT_80030
annotated source: intracellular protein kinase cascade
annotated property: database_cross_reference

PKA-mediated phosphorylation of key metabolic factors, Xenopus tropicalis
type: Axiom
annotated target: Reactome:REACT_83869
annotated source: intracellular protein kinase cascade
annotated property: database_cross_reference

I-kappaB kinase/NF-kappaB cascade
type: Class
subclass of: intracellular protein kinase cascade
subclass of: Restriction
  on property: has_part
  some values from: positive regulation of NF-kappaB transcription factor activity
id: GO:0007249
has_broad_synonym: NF-kappaB cascade
database_cross_reference: Reactome:REACT_13696.1
database_cross_reference: Reactome:REACT_25351
IAO_0000115: The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
has_related_synonym: activation of the inhibitor of kappa kinase
has_obo_namespace: biological_process
has_exact_synonym: canonical NF-kappaB signaling cascade
has_related_synonym: p50-dependent NF-kappaB signaling
IAO_0000412: go.owl

NF-kB is activated and signals survival, Homo sapiens
type: Axiom
annotated target: Reactome:REACT_13696.1
annotated source: I-kappaB kinase/NF-kappaB cascade
annotated property: database_cross_reference

Axiom
database_cross_reference: PMID:18292232
annotated target: p50-dependent NF-kappaB signaling
annotated source: I-kappaB kinase/NF-kappaB cascade
annotated property: has_related_synonym

Axiom
database_cross_reference: GOC:bf
database_cross_reference: GOC:jl
database_cross_reference: PMID:12773372
database_cross_reference: Reactome:REACT_13696.1
annotated target: The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
annotated source: I-kappaB kinase/NF-kappaB cascade
annotated property: IAO_0000115

TRAF6 mediated induction of TAK1 complex, Homo sapiens
type: Axiom
annotated target: Reactome:REACT_25351
annotated source: I-kappaB kinase/NF-kappaB cascade
annotated property: database_cross_reference

Axiom
database_cross_reference: GOC:bf
annotated target: canonical NF-kappaB signaling cascade
annotated source: I-kappaB kinase/NF-kappaB cascade
annotated property: has_exact_synonym

cytoplasmic sequestering of NF-kappaB
type: Class
subclass of: negative regulation of NF-kappaB import into nucleus
subclass of: cytoplasmic sequestering of transcription factor
subclass of: Restriction
  on property: part_of
  some values from: negative regulation of I-kappaB kinase/NF-kappaB cascade
id: GO:0007253
IAO_0000115: The selective interaction of the transcription factor NF-kappaB with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus.
has_obo_namespace: biological_process
has_exact_synonym: cytoplasmic NF-kappaB retention
has_exact_synonym: cytoplasmic NF-kappaB sequestration
has_exact_synonym: cytoplasmic NF-kappaB storage
has_exact_synonym: cytoplasmic retention of NF-kappaB
has_exact_synonym: cytoplasmic sequestration of NF-kappaB
has_exact_synonym: cytoplasmic storage of NF-kappaB
has_exact_synonym: maintenance of NF-kappaB location in cytoplasm
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:jl
annotated target: The selective interaction of the transcription factor NF-kappaB with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus.
annotated source: cytoplasmic sequestering of NF-kappaB
annotated property: IAO_0000115

Axiom
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb
annotated target: maintenance of NF-kappaB location in cytoplasm
annotated source: cytoplasmic sequestering of NF-kappaB
annotated property: has_exact_synonym

protein localization
type: Class
subclass of: macromolecule localization
IAO_0000115: Any process in which a protein is transported to, or maintained in, a specific location.
id: GO:0008104
has_obo_namespace: biological_process
has_exact_synonym: establishment and maintenance of protein localization
has_exact_synonym: protein localisation
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:mah
annotated target: protein localisation
annotated source: protein localization
annotated property: has_exact_synonym

Axiom
annotated target: Any process in which a protein is transported to, or maintained in, a specific location.
database_cross_reference: GOC:ai
annotated source: protein localization
annotated property: IAO_0000115

biological_process
type: Class
IAO_0000115: Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
has_alternative_id: GO:0000004
has_alternative_id: GO:0007582
id: GO:0008150
comment: Note that, in addition to forming the root of the biological process ontology, this term is recommended for use for the annotation of gene products whose biological process is unknown. Note that when this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this.
database_cross_reference: Wikipedia:Biological_process
has_exact_synonym: biological process
has_narrow_synonym: biological process unknown
has_obo_namespace: biological_process
has_exact_synonym: physiological process
IAO_0000412: go.owl
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: goslim pombe
in_subset: goslim yeast
in_subset: gosubset prok

Axiom
annotated target: Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
database_cross_reference: GOC:go_curators
database_cross_reference: GOC:isa_complete
annotated source: biological_process
annotated property: IAO_0000115

metabolic process
type: Class
subclass of: biological_process
id: GO:0008152
comment: Note that metabolic processes do not include single functions or processes such as protein-protein interactions, protein-nucleic acids, nor receptor-ligand interactions.
IAO_0000115: The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
database_cross_reference: Wikipedia:Metabolism
has_obo_namespace: biological_process
has_narrow_synonym: metabolic process resulting in cell growth
has_exact_synonym: metabolism
has_narrow_synonym: metabolism resulting in cell growth
IAO_0000412: go.owl
in_subset: goslim pir
in_subset: goslim plant
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:go_curators
database_cross_reference: ISBN:0198547684
annotated target: The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
annotated source: metabolic process
annotated property: IAO_0000115

cell death
type: Class
subclass of: death
subclass of: single-organism cellular process
IAO_0000115: Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as "apoptotic bodies"); and/or (3) its corpse (or its fragments) have been engulfed by an adjacent cell in vivo.
id: GO:0008219
has_related_synonym: accidental cell death
has_obo_namespace: biological_process
has_related_synonym: necrosis
IAO_0000412: go.owl
in_subset: goslim generic
in_subset: goslim plant
in_subset: gosubset prok

Axiom
annotated target: Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as "apoptotic bodies"); and/or (3) its corpse (or its fragments) have been engulfed by an adjacent cell in vivo.
database_cross_reference: GOC:mah
database_cross_reference: GOC:mtg_apoptosis
annotated source: cell death
annotated property: IAO_0000115

release of cytoplasmic sequestered NF-kappaB
type: Class
subclass of: positive regulation of NF-kappaB import into nucleus
subclass of: negative regulation of cellular process
subclass of: Restriction
  on property: negatively_regulates
  some values from: cytoplasmic sequestering of NF-kappaB
subclass of: Restriction
  on property: part_of
  some values from: I-kappaB kinase/NF-kappaB cascade
id: GO:0008588
IAO_0000115: The release of NF-kappaB from specific molecules in the cytoplasm to which it was bound, thereby allowing its translocation into the nucleus.
has_related_synonym: activation of NF-kappa B
has_obo_namespace: biological_process
has_related_synonym: negative regulation of cytoplasmic NF-kappaB retention
has_related_synonym: negative regulation of cytoplasmic NF-kappaB sequestering
has_related_synonym: negative regulation of cytoplasmic NF-kappaB sequestration
has_related_synonym: negative regulation of cytoplasmic NF-kappaB storage
has_exact_synonym: release of NF-kappaB sequestered in cytoplasm
has_exact_synonym: release of NF-kappaB stored in cytoplasm
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:jl
annotated target: The release of NF-kappaB from specific molecules in the cytoplasm to which it was bound, thereby allowing its translocation into the nucleus.
annotated source: release of cytoplasmic sequestered NF-kappaB
annotated property: IAO_0000115

catabolic process
type: Class
subclass of: metabolic process
id: GO:0009056
IAO_0000115: The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism.
database_cross_reference: Wikipedia:Catabolism
has_obo_namespace: biological_process
has_exact_synonym: breakdown
has_exact_synonym: catabolism
has_exact_synonym: degradation
IAO_0000412: go.owl
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim plant
in_subset: gosubset prok

Axiom
database_cross_reference: ISBN:0198547684
annotated target: The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism.
annotated source: catabolic process
annotated property: IAO_0000115

macromolecule catabolic process
type: Class
subclass of: macromolecule metabolic process
subclass of: organic substance catabolic process
id: GO:0009057
has_alternative_id: GO:0043285
IAO_0000115: The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
has_obo_namespace: biological_process
has_exact_synonym: biopolymer catabolic process
has_exact_synonym: macromolecule breakdown
has_exact_synonym: macromolecule catabolism
has_exact_synonym: macromolecule degradation
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
database_cross_reference: CHEBI:33694
database_cross_reference: GOC:mah
annotated target: The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
annotated source: macromolecule catabolic process
annotated property: IAO_0000115

Axiom
database_cross_reference: GOC:mtg_chebi_dec09
annotated target: biopolymer catabolic process
annotated source: macromolecule catabolic process
annotated property: has_exact_synonym

biosynthetic process
type: Class
subclass of: metabolic process
id: GO:0009058
IAO_0000115: The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.
database_cross_reference: Wikipedia:Anabolism
has_exact_synonym: anabolism
has_obo_namespace: biological_process
has_exact_synonym: biosynthesis
has_exact_synonym: formation
has_exact_synonym: synthesis
IAO_0000412: go.owl
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim plant
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:curators
database_cross_reference: ISBN:0198547684
annotated target: The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.
annotated source: biosynthetic process
annotated property: IAO_0000115

macromolecule biosynthetic process
type: Class
subclass of: macromolecule metabolic process
subclass of: organic substance biosynthetic process
id: GO:0009059
has_alternative_id: GO:0043284
IAO_0000115: The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
has_obo_namespace: biological_process
has_exact_synonym: biopolymer biosynthetic process
has_exact_synonym: macromolecule anabolism
has_exact_synonym: macromolecule biosynthesis
has_exact_synonym: macromolecule formation
has_exact_synonym: macromolecule synthesis
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:mtg_chebi_dec09
annotated target: biopolymer biosynthetic process
annotated source: macromolecule biosynthetic process
annotated property: has_exact_synonym

Axiom
database_cross_reference: CHEBI:33694
database_cross_reference: GOC:mah
annotated target: The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
annotated source: macromolecule biosynthetic process
annotated property: IAO_0000115

protein secretion
type: Class
subclass of: protein transport
subclass of: secretion by cell
id: GO:0009306
has_alternative_id: GO:0045166
has_alternative_id: GO:0045731
IAO_0000115: The controlled release of proteins from a cell.
has_obo_namespace: biological_process
has_narrow_synonym: glycoprotein secretion
has_narrow_synonym: protein secretion during cell fate commitment
has_narrow_synonym: protein secretion resulting in cell fate commitment
IAO_0000412: go.owl
in_subset: goslim metagenomics
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:ai
annotated target: The controlled release of proteins from a cell.
annotated source: protein secretion
annotated property: IAO_0000115

anatomical structure morphogenesis
type: Class
subclass of: developmental process
subclass of: Restriction
  on property: part_of
  some values from: anatomical structure development
id: GO:0009653
IAO_0000115: The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.
database_cross_reference: Wikipedia:Morphogenesis
has_exact_synonym: anatomical structure organization
has_obo_namespace: biological_process
has_broad_synonym: embryogenesis and morphogenesis
has_exact_synonym: morphogenesis
IAO_0000412: go.owl
in_subset: goslim plant
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:go_curators
database_cross_reference: ISBN:0521436125
annotated target: The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.
annotated source: anatomical structure morphogenesis
annotated property: IAO_0000115

unidimensional cell growth
type: Class
subclass of: cell morphogenesis
subclass of: cell growth
subclass of: developmental growth involved in morphogenesis
id: GO:0009826
IAO_0000115: The process in which a cell irreversibly increases in size in one [spatial] dimension or along one axis, resulting in the morphogenesis of the cell.
comment: Unidimensional cell growth refers to a change in both cell size and cell shape. For cell shape changes where cell size is not affected, consider instead the term 'regulation of cell shape ; GO:0008360' and its children.
has_obo_namespace: biological_process
has_narrow_synonym: cell elongation
has_exact_synonym: cell growth along one axis
has_exact_synonym: cell growth in one dimension
has_exact_synonym: cell morphogenesis by unidimensional growth
has_exact_synonym: polar cell growth
has_exact_synonym: polarized cell growth
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb
annotated target: cell morphogenesis by unidimensional growth
annotated source: unidimensional cell growth
annotated property: has_exact_synonym

Axiom
database_cross_reference: ISBN:0943088399
annotated target: The process in which a cell irreversibly increases in size in one [spatial] dimension or along one axis, resulting in the morphogenesis of the cell.
annotated source: unidimensional cell growth
annotated property: IAO_0000115

regulation of biosynthetic process
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: regulates
    some values from: biosynthetic process
subclass of: regulation of metabolic process
subclass of: Restriction
  on property: regulates
  some values from: biosynthetic process
IAO_0000115: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.
id: GO:0009889
has_obo_namespace: biological_process
has_exact_synonym: regulation of anabolism
has_exact_synonym: regulation of biosynthesis
has_exact_synonym: regulation of formation
has_exact_synonym: regulation of synthesis
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
annotated target: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.
database_cross_reference: GOC:go_curators
annotated source: regulation of biosynthetic process
annotated property: IAO_0000115

regulation of signal transduction
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: regulates
    some values from: signal transduction
subclass of: regulation of cell communication
subclass of: regulation of signaling
subclass of: regulation of response to stimulus
subclass of: Restriction
  on property: regulates
  some values from: signal transduction
IAO_0000115: Any process that modulates the frequency, rate or extent of signal transduction.
id: GO:0009966
has_alternative_id: GO:0035466
has_obo_namespace: biological_process
has_related_synonym: regulation of signaling pathway
has_related_synonym: regulation of signalling pathway
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
annotated target: Any process that modulates the frequency, rate or extent of signal transduction.
database_cross_reference: GOC:sm
annotated source: regulation of signal transduction
annotated property: IAO_0000115

Axiom
database_cross_reference: GOC:mah
annotated target: regulation of signalling pathway
annotated source: regulation of signal transduction
annotated property: has_related_synonym

negative regulation of signal transduction
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: negatively_regulates
    some values from: signal transduction
subclass of: regulation of signal transduction
subclass of: negative regulation of cell communication
subclass of: negative regulation of signaling
subclass of: negative regulation of response to stimulus
subclass of: Restriction
  on property: negatively_regulates
  some values from: signal transduction
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction.
id: GO:0009968
has_alternative_id: GO:0035467
database_cross_reference: Reactome:REACT_6334
has_obo_namespace: biological_process
has_exact_synonym: down regulation of signal transduction
has_exact_synonym: down-regulation of signal transduction
has_exact_synonym: downregulation of signal transduction
has_narrow_synonym: inhibition of signal transduction
has_related_synonym: negative regulation of signaling pathway
has_related_synonym: negative regulation of signalling pathway
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:mah
annotated target: negative regulation of signalling pathway
annotated source: negative regulation of signal transduction
annotated property: has_related_synonym

Axiom
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction.
database_cross_reference: GOC:sm
annotated source: negative regulation of signal transduction
annotated property: IAO_0000115

DTSC1 AND DTSC2 form a complex, Drosophila melanogaster
type: Axiom
annotated target: Reactome:REACT_6334
annotated source: negative regulation of signal transduction
annotated property: database_cross_reference

cellular process
type: Class
subclass of: biological_process
IAO_0000115: Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
has_alternative_id: GO:0008151
id: GO:0009987
has_alternative_id: GO:0050875
has_obo_namespace: biological_process
has_narrow_synonym: cell growth and/or maintenance
has_exact_synonym: cell physiology
has_exact_synonym: cellular physiological process
IAO_0000412: go.owl
in_subset: goslim pir
in_subset: goslim plant
in_subset: gosubset prok

Axiom
annotated target: Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
database_cross_reference: GOC:go_curators
database_cross_reference: GOC:isa_complete
annotated source: cellular process
annotated property: IAO_0000115

exit from mitosis
type: Class
subclass of: cell cycle process
subclass of: Restriction
  on property: part_of
  some values from: mitosis
id: GO:0010458
IAO_0000115: The cell cycle process where a cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place.
has_obo_namespace: biological_process
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb
annotated target: The cell cycle process where a cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place.
annotated source: exit from mitosis
annotated property: IAO_0000115

gene expression
type: Class
subclass of: macromolecule metabolic process
id: GO:0010467
database_cross_reference: Reactome:REACT_100537
database_cross_reference: Reactome:REACT_101147
database_cross_reference: Reactome:REACT_101952
database_cross_reference: Reactome:REACT_105649
database_cross_reference: Reactome:REACT_108313
database_cross_reference: Reactome:REACT_29068
database_cross_reference: Reactome:REACT_34240
database_cross_reference: Reactome:REACT_71
database_cross_reference: Reactome:REACT_78136
database_cross_reference: Reactome:REACT_78959
database_cross_reference: Reactome:REACT_79662
database_cross_reference: Reactome:REACT_85241
database_cross_reference: Reactome:REACT_85359
database_cross_reference: Reactome:REACT_86357
database_cross_reference: Reactome:REACT_89816
database_cross_reference: Reactome:REACT_91657
database_cross_reference: Reactome:REACT_91965
database_cross_reference: Reactome:REACT_93586
database_cross_reference: Reactome:REACT_93968
database_cross_reference: Reactome:REACT_94814
database_cross_reference: Reactome:REACT_98256
IAO_0000115: The process in which a gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.
database_cross_reference: Wikipedia:Gene_expression
has_obo_namespace: biological_process
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb
annotated target: The process in which a gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.
annotated source: gene expression
annotated property: IAO_0000115

Gene Expression, Taeniopygia guttata
type: Axiom
annotated target: Reactome:REACT_78959
annotated source: gene expression
annotated property: database_cross_reference

Gene Expression, Plasmodium falciparum
type: Axiom
annotated target: Reactome:REACT_79662
annotated source: gene expression
annotated property: database_cross_reference

Gene Expression, Drosophila melanogaster
type: Axiom
annotated target: Reactome:REACT_105649
annotated source: gene expression
annotated property: database_cross_reference

Gene Expression, Canis familiaris
type: Axiom
annotated target: Reactome:REACT_86357
annotated source: gene expression
annotated property: database_cross_reference

Gene Expression, Schizosaccharomyces pombe
type: Axiom
annotated target: Reactome:REACT_94814
annotated source: gene expression
annotated property: database_cross_reference

Gene Expression, Oryza sativa
type: Axiom
annotated target: Reactome:REACT_85241
annotated source: gene expression
annotated property: database_cross_reference

Gene Expression, Mus musculus
type: Axiom
annotated target: Reactome:REACT_78136
annotated source: gene expression
annotated property: database_cross_reference

Gene Expression, Danio rerio
type: Axiom
annotated target: Reactome:REACT_101147
annotated source: gene expression
annotated property: database_cross_reference

Gene Expression, Saccharomyces cerevisiae
type: Axiom
annotated target: Reactome:REACT_98256
annotated source: gene expression
annotated property: database_cross_reference

Gene Expression, Mycobacterium tuberculosis
type: Axiom
annotated target: Reactome:REACT_89816
annotated source: gene expression
annotated property: database_cross_reference

Gene Expression, Dictyostelium discoideum
type: Axiom
annotated target: Reactome:REACT_93586
annotated source: gene expression
annotated property: database_cross_reference

Gene Expression, Arabidopsis thaliana
type: Axiom
annotated target: Reactome:REACT_91657
annotated source: gene expression
annotated property: database_cross_reference

Gene Expression, Caenorhabditis elegans
type: Axiom
annotated target: Reactome:REACT_108313
annotated source: gene expression
annotated property: database_cross_reference

Gene Expression, Sus scrofa
type: Axiom
annotated target: Reactome:REACT_101952
annotated source: gene expression
annotated property: database_cross_reference

Gene Expression, Staphylococcus aureus N315
type: Axiom
annotated target: Reactome:REACT_34240
annotated source: gene expression
annotated property: database_cross_reference

Gene Expression, Homo sapiens
type: Axiom
annotated target: Reactome:REACT_71
annotated source: gene expression
annotated property: database_cross_reference

Gene Expression, Gallus gallus
type: Axiom
annotated target: Reactome:REACT_85359
annotated source: gene expression
annotated property: database_cross_reference

Gene Expression, Xenopus tropicalis
type: Axiom
annotated target: Reactome:REACT_100537
annotated source: gene expression
annotated property: database_cross_reference

Gene Expression, Rattus norvegicus
type: Axiom
annotated target: Reactome:REACT_91965
annotated source: gene expression
annotated property: database_cross_reference

Gene Expression, Escherichia coli
type: Axiom
annotated target: Reactome:REACT_29068
annotated source: gene expression
annotated property: database_cross_reference

Gene Expression, Bos taurus
type: Axiom
annotated target: Reactome:REACT_93968
annotated source: gene expression
annotated property: database_cross_reference

regulation of gene expression
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: regulates
    some values from: gene expression
subclass of: regulation of macromolecule metabolic process
subclass of: Restriction
  on property: regulates
  some values from: gene expression
IAO_0000115: Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.
id: GO:0010468
database_cross_reference: Wikipedia:Regulation_of_gene_expression
has_obo_namespace: biological_process
has_related_synonym: regulation of gene product expression
has_narrow_synonym: regulation of protein expression
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
annotated target: Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb
annotated source: regulation of gene expression
annotated property: IAO_0000115

Axiom
database_cross_reference: GOC:curators
annotated target: regulation of protein expression
annotated source: regulation of gene expression
annotated property: has_narrow_synonym

Axiom
database_cross_reference: GOC:curators
annotated target: regulation of gene product expression
annotated source: regulation of gene expression
annotated property: has_related_synonym

regulation of macromolecule biosynthetic process
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: regulates
    some values from: macromolecule biosynthetic process
subclass of: regulation of biosynthetic process
subclass of: regulation of macromolecule metabolic process
subclass of: Restriction
  on property: regulates
  some values from: macromolecule biosynthetic process
IAO_0000115: Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
id: GO:0010556
has_obo_namespace: biological_process
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
annotated target: Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb
annotated source: regulation of macromolecule biosynthetic process
annotated property: IAO_0000115

regulation of intracellular protein kinase cascade
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: regulates
    some values from: intracellular protein kinase cascade
subclass of: regulation of signal transduction
subclass of: Restriction
  on property: regulates
  some values from: intracellular protein kinase cascade
IAO_0000115: Any process that modulates the rate, frequency or extent of a series of reactions, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound.
id: GO:0010627
has_obo_namespace: biological_process
IAO_0000412: go.owl

Axiom
annotated target: Any process that modulates the rate, frequency or extent of a series of reactions, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb
annotated source: regulation of intracellular protein kinase cascade
annotated property: IAO_0000115

regulation of cell communication
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: regulates
    some values from: cell communication
subclass of: regulation of cellular process
subclass of: Restriction
  on property: regulates
  some values from: cell communication
IAO_0000115: Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
id: GO:0010646
has_obo_namespace: biological_process
IAO_0000412: go.owl

Axiom
annotated target: Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb
annotated source: regulation of cell communication
annotated property: IAO_0000115

negative regulation of cell communication
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: negatively_regulates
    some values from: cell communication
subclass of: regulation of cell communication
subclass of: negative regulation of cellular process
subclass of: Restriction
  on property: negatively_regulates
  some values from: cell communication
IAO_0000115: Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
id: GO:0010648
has_obo_namespace: biological_process
IAO_0000412: go.owl

Axiom
annotated target: Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb
annotated source: negative regulation of cell communication
annotated property: IAO_0000115

negative regulation of intracellular protein kinase cascade
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: negatively_regulates
    some values from: intracellular protein kinase cascade
subclass of: negative regulation of signal transduction
subclass of: regulation of intracellular protein kinase cascade
subclass of: Restriction
  on property: negatively_regulates
  some values from: intracellular protein kinase cascade
IAO_0000115: Any process that decreases the rate, frequency or extent of a series of reactions, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound.
id: GO:0010741
has_obo_namespace: biological_process
IAO_0000412: go.owl

Axiom
annotated target: Any process that decreases the rate, frequency or extent of a series of reactions, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb
annotated source: negative regulation of intracellular protein kinase cascade
annotated property: IAO_0000115

programmed cell death
type: Class
subclass of: cell death
IAO_0000115: A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell.
id: GO:0012501
has_alternative_id: GO:0016244
comment: Note that this term should be used to annotate gene products in the organism undergoing the programmed cell death. To annotate genes in another organism whose products modulate programmed cell death in a host organism, consider the term 'modulation by symbiont of host programmed cell death ; GO:0052040'.
has_exact_synonym: PCD
database_cross_reference: Wikipedia:Programmed_cell_death
has_obo_namespace: biological_process
has_narrow_synonym: non-apoptotic programmed cell death
has_narrow_synonym: nonapoptotic programmed cell death
has_related_synonym: regulated cell death
IAO_0000412: go.owl

Axiom
annotated target: A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell.
database_cross_reference: GOC:lr
database_cross_reference: GOC:mtg_apoptosis
annotated source: programmed cell death
annotated property: IAO_0000115

protein transport
type: Class
subclass of: establishment of protein localization
subclass of: organic substance transport
id: GO:0015031
has_alternative_id: GO:0015831
IAO_0000115: The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
has_obo_namespace: biological_process
has_narrow_synonym: enzyme transport
IAO_0000412: go.owl
in_subset: goslim pir
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:ai
annotated target: The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
annotated source: protein transport
annotated property: IAO_0000115

actin cytoskeleton
type: Class
subclass of: cytoskeleton
id: GO:0015629
IAO_0000115: The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
has_obo_namespace: cellular_component
IAO_0000412: go.owl
in_subset: goslim aspergillus

Axiom
database_cross_reference: GOC:jl
database_cross_reference: ISBN:0395825172
database_cross_reference: ISBN:0815316194
annotated target: The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
annotated source: actin cytoskeleton
annotated property: IAO_0000115

microtubule cytoskeleton
type: Class
subclass of: cytoskeleton
id: GO:0015630
IAO_0000115: The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.
has_obo_namespace: cellular_component
IAO_0000412: go.owl
in_subset: goslim aspergillus

Axiom
database_cross_reference: GOC:jl
database_cross_reference: ISBN:0395825172
annotated target: The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.
annotated source: microtubule cytoskeleton
annotated property: IAO_0000115

cytoplasmic membrane-bounded vesicle
type: Class
equivalent class: Class
  intersection of: membrane-bounded vesicle
  intersection of: Restriction
    on property: part_of
    some values from: cytoplasm
subclass of: cytoplasmic vesicle
subclass of: membrane-bounded vesicle
subclass of: intracellular membrane-bounded organelle
subclass of: Restriction
  on property: part_of
  some values from: cytoplasm
IAO_0000115: A membrane-bounded vesicle found in the cytoplasm of the cell.
id: GO:0016023
has_obo_namespace: cellular_component
has_exact_synonym: cytoplasmic membrane bounded vesicle
has_exact_synonym: cytoplasmic membrane-enclosed vesicle
IAO_0000412: go.owl
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim generic
in_subset: goslim yeast
in_subset: gosubset prok

Axiom
annotated target: A membrane-bounded vesicle found in the cytoplasm of the cell.
database_cross_reference: GOC:ai
database_cross_reference: GOC:mah
annotated source: cytoplasmic membrane-bounded vesicle
annotated property: IAO_0000115

cellular component organization
type: Class
subclass of: cellular component organization or biogenesis
IAO_0000115: A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component.
id: GO:0016043
has_alternative_id: GO:0044235
has_alternative_id: GO:0071842
has_obo_namespace: biological_process
has_exact_synonym: cell organisation
has_related_synonym: cell organization and biogenesis
has_exact_synonym: cellular component organisation at cellular level
has_exact_synonym: cellular component organisation in other organism
has_exact_synonym: cellular component organization at cellular level
has_exact_synonym: cellular component organization in other organism
IAO_0000412: go.owl
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:mah
annotated target: cellular component organisation in other organism
annotated source: cellular component organization
annotated property: has_exact_synonym

Axiom
database_cross_reference: GOC:mah
annotated target: cell organization and biogenesis
annotated source: cellular component organization
annotated property: has_related_synonym

Axiom
database_cross_reference: GOC:mah
annotated target: cellular component organisation at cellular level
annotated source: cellular component organization
annotated property: has_exact_synonym

Axiom
annotated target: A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component.
database_cross_reference: GOC:ai
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah
annotated source: cellular component organization
annotated property: IAO_0000115

cellular membrane organization
type: Class
subclass of: single-organism cellular process
subclass of: membrane organization
IAO_0000115: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
id: GO:0016044
database_cross_reference: Reactome:REACT_101524
database_cross_reference: Reactome:REACT_103082
database_cross_reference: Reactome:REACT_11123
database_cross_reference: Reactome:REACT_29278
database_cross_reference: Reactome:REACT_32337
database_cross_reference: Reactome:REACT_33741
database_cross_reference: Reactome:REACT_34084
database_cross_reference: Reactome:REACT_78213
database_cross_reference: Reactome:REACT_78288
database_cross_reference: Reactome:REACT_83546
database_cross_reference: Reactome:REACT_86557
database_cross_reference: Reactome:REACT_87431
database_cross_reference: Reactome:REACT_88307
database_cross_reference: Reactome:REACT_91154
database_cross_reference: Reactome:REACT_93714
database_cross_reference: Reactome:REACT_95586
database_cross_reference: Reactome:REACT_96516
database_cross_reference: Reactome:REACT_97881
has_obo_namespace: biological_process
has_exact_synonym: cellular membrane organisation
has_related_synonym: membrane organization and biogenesis
IAO_0000412: go.owl
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim pir
in_subset: gosubset prok

Membrane Trafficking, Arabidopsis thaliana
type: Axiom
annotated target: Reactome:REACT_86557
annotated source: cellular membrane organization
annotated property: database_cross_reference

Membrane Trafficking, Gallus gallus
type: Axiom
annotated target: Reactome:REACT_95586
annotated source: cellular membrane organization
annotated property: database_cross_reference

Membrane Trafficking, Plasmodium falciparum
type: Axiom
annotated target: Reactome:REACT_78213
annotated source: cellular membrane organization
annotated property: database_cross_reference

Membrane Trafficking, Sus scrofa
type: Axiom
annotated target: Reactome:REACT_29278
annotated source: cellular membrane organization
annotated property: database_cross_reference

Membrane Trafficking, Dictyostelium discoideum
type: Axiom
annotated target: Reactome:REACT_101524
annotated source: cellular membrane organization
annotated property: database_cross_reference

Membrane Trafficking, Drosophila melanogaster
type: Axiom
annotated target: Reactome:REACT_87431
annotated source: cellular membrane organization
annotated property: database_cross_reference

Membrane Trafficking, Bos taurus
type: Axiom
annotated target: Reactome:REACT_33741
annotated source: cellular membrane organization
annotated property: database_cross_reference

Membrane Trafficking, Caenorhabditis elegans
type: Axiom
annotated target: Reactome:REACT_34084
annotated source: cellular membrane organization
annotated property: database_cross_reference

Axiom
database_cross_reference: GOC:curators
annotated target: cellular membrane organisation
annotated source: cellular membrane organization
annotated property: has_exact_synonym

Membrane Trafficking, Saccharomyces cerevisiae
type: Axiom
annotated target: Reactome:REACT_91154
annotated source: cellular membrane organization
annotated property: database_cross_reference

Axiom
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
database_cross_reference: GOC:ai
database_cross_reference: GOC:dph
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah
annotated source: cellular membrane organization
annotated property: IAO_0000115

Membrane Trafficking, Rattus norvegicus
type: Axiom
annotated target: Reactome:REACT_97881
annotated source: cellular membrane organization
annotated property: database_cross_reference

Membrane Trafficking, Xenopus tropicalis
type: Axiom
annotated target: Reactome:REACT_78288
annotated source: cellular membrane organization
annotated property: database_cross_reference

Membrane Trafficking, Danio rerio
type: Axiom
annotated target: Reactome:REACT_93714
annotated source: cellular membrane organization
annotated property: database_cross_reference

Axiom
database_cross_reference: GOC:mah
annotated target: membrane organization and biogenesis
annotated source: cellular membrane organization
annotated property: has_related_synonym

Membrane Trafficking, Schizosaccharomyces pombe
type: Axiom
annotated target: Reactome:REACT_103082
annotated source: cellular membrane organization
annotated property: database_cross_reference

Membrane Trafficking, Homo sapiens
type: Axiom
annotated target: Reactome:REACT_11123
annotated source: cellular membrane organization
annotated property: database_cross_reference

Membrane Trafficking, Canis familiaris
type: Axiom
annotated target: Reactome:REACT_96516
annotated source: cellular membrane organization
annotated property: database_cross_reference

Membrane Trafficking, Taeniopygia guttata
type: Axiom
annotated target: Reactome:REACT_32337
annotated source: cellular membrane organization
annotated property: database_cross_reference

Membrane Trafficking, Mus musculus
type: Axiom
annotated target: Reactome:REACT_88307
annotated source: cellular membrane organization
annotated property: database_cross_reference

Membrane Trafficking, Oryza sativa
type: Axiom
annotated target: Reactome:REACT_83546
annotated source: cellular membrane organization
annotated property: database_cross_reference

cell growth
type: Class
subclass of: growth
subclass of: single-organism cellular process
id: GO:0016049
has_alternative_id: GO:0048591
IAO_0000115: The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.
has_obo_namespace: biological_process
has_related_synonym: cell expansion
has_exact_synonym: cellular growth
has_exact_synonym: growth of cell
has_related_synonym: metabolic process resulting in cell growth
has_related_synonym: metabolism resulting in cell growth
has_related_synonym: non-developmental cell growth
has_related_synonym: non-developmental growth of a unicellular organism
IAO_0000412: go.owl
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:ai
annotated target: The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.
annotated source: cell growth
annotated property: IAO_0000115

Axiom
database_cross_reference: GOC:mah
annotated target: non-developmental cell growth
annotated source: cell growth
annotated property: has_related_synonym

Axiom
database_cross_reference: GOC:mah
annotated target: non-developmental growth of a unicellular organism
annotated source: cell growth
annotated property: has_related_synonym

RNA metabolic process
type: Class
subclass of: cellular macromolecule metabolic process
subclass of: nucleic acid metabolic process
id: GO:0016070
has_exact_synonym: RNA metabolism
database_cross_reference: Reactome:REACT_107259
database_cross_reference: Reactome:REACT_107652
database_cross_reference: Reactome:REACT_110289
database_cross_reference: Reactome:REACT_21257
database_cross_reference: Reactome:REACT_30579
database_cross_reference: Reactome:REACT_31367
database_cross_reference: Reactome:REACT_33720
database_cross_reference: Reactome:REACT_80071
database_cross_reference: Reactome:REACT_83630
database_cross_reference: Reactome:REACT_84169
database_cross_reference: Reactome:REACT_85788
database_cross_reference: Reactome:REACT_88316
database_cross_reference: Reactome:REACT_89992
database_cross_reference: Reactome:REACT_91556
database_cross_reference: Reactome:REACT_92152
database_cross_reference: Reactome:REACT_94876
database_cross_reference: Reactome:REACT_99403
database_cross_reference: Reactome:REACT_99885
IAO_0000115: The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
has_obo_namespace: biological_process
IAO_0000412: go.owl
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: gosubset prok

Metabolism of RNA, Plasmodium falciparum
type: Axiom
annotated target: Reactome:REACT_33720
annotated source: RNA metabolic process
annotated property: database_cross_reference

Axiom
database_cross_reference: ISBN:0198506732
annotated target: The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
annotated source: RNA metabolic process
annotated property: IAO_0000115

Metabolism of RNA, Danio rerio
type: Axiom
annotated target: Reactome:REACT_110289
annotated source: RNA metabolic process
annotated property: database_cross_reference

Metabolism of RNA, Dictyostelium discoideum
type: Axiom
annotated target: Reactome:REACT_31367
annotated source: RNA metabolic process
annotated property: database_cross_reference

Metabolism of RNA, Oryza sativa
type: Axiom
annotated target: Reactome:REACT_85788
annotated source: RNA metabolic process
annotated property: database_cross_reference

Metabolism of RNA, Homo sapiens
type: Axiom
annotated target: Reactome:REACT_21257
annotated source: RNA metabolic process
annotated property: database_cross_reference

Metabolism of RNA, Bos taurus
type: Axiom
annotated target: Reactome:REACT_91556
annotated source: RNA metabolic process
annotated property: database_cross_reference

Metabolism of RNA, Caenorhabditis elegans
type: Axiom
annotated target: Reactome:REACT_80071
annotated source: RNA metabolic process
annotated property: database_cross_reference

Metabolism of RNA, Sus scrofa
type: Axiom
annotated target: Reactome:REACT_107259
annotated source: RNA metabolic process
annotated property: database_cross_reference

Metabolism of RNA, Gallus gallus
type: Axiom
annotated target: Reactome:REACT_99885
annotated source: RNA metabolic process
annotated property: database_cross_reference

Metabolism of RNA, Xenopus tropicalis
type: Axiom
annotated target: Reactome:REACT_30579
annotated source: RNA metabolic process
annotated property: database_cross_reference

Metabolism of RNA, Rattus norvegicus
type: Axiom
annotated target: Reactome:REACT_99403
annotated source: RNA metabolic process
annotated property: database_cross_reference

Metabolism of RNA, Schizosaccharomyces pombe
type: Axiom
annotated target: Reactome:REACT_107652
annotated source: RNA metabolic process
annotated property: database_cross_reference

Metabolism of RNA, Mus musculus
type: Axiom
annotated target: Reactome:REACT_88316
annotated source: RNA metabolic process
annotated property: database_cross_reference

Metabolism of RNA, Canis familiaris
type: Axiom
annotated target: Reactome:REACT_84169
annotated source: RNA metabolic process
annotated property: database_cross_reference

Metabolism of RNA, Arabidopsis thaliana
type: Axiom
annotated target: Reactome:REACT_94876
annotated source: RNA metabolic process
annotated property: database_cross_reference

Metabolism of RNA, Taeniopygia guttata
type: Axiom
annotated target: Reactome:REACT_83630
annotated source: RNA metabolic process
annotated property: database_cross_reference

Metabolism of RNA, Saccharomyces cerevisiae
type: Axiom
annotated target: Reactome:REACT_89992
annotated source: RNA metabolic process
annotated property: database_cross_reference

Metabolism of RNA, Drosophila melanogaster
type: Axiom
annotated target: Reactome:REACT_92152
annotated source: RNA metabolic process
annotated property: database_cross_reference

death
type: Class
subclass of: single-organism process
IAO_0000115: A permanent cessation of all vital functions: the end of life; can be applied to a whole organism or to a part of an organism.
id: GO:0016265
comment: See also the biological process term 'apoptosis ; GO:0006915'.
database_cross_reference: Wikipedia:Death
has_obo_namespace: biological_process
IAO_0000412: go.owl
in_subset: goslim plant
in_subset: gosubset prok

Axiom
annotated target: A permanent cessation of all vital functions: the end of life; can be applied to a whole organism or to a part of an organism.
database_cross_reference: GOC:mah
database_cross_reference: ISBN:0877797099
annotated source: death
annotated property: IAO_0000115

cell migration
type: Class
subclass of: cell motility
id: GO:0016477
IAO_0000115: The orderly movement of a cell from one site to another, often during the development of a multicellular organism or multicellular structure.
database_cross_reference: Wikipedia:Cell_migration
has_obo_namespace: biological_process
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:ems
database_cross_reference: GOC:pf
annotated target: The orderly movement of a cell from one site to another, often during the development of a multicellular organism or multicellular structure.
annotated source: cell migration
annotated property: IAO_0000115

cytoplasmic transport
type: Class
subclass of: intracellular transport
id: GO:0016482
IAO_0000115: The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, or within the cytoplasm of a cell.
has_obo_namespace: biological_process
has_narrow_synonym: cytoplasmic streaming
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:ai
annotated target: The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, or within the cytoplasm of a cell.
annotated source: cytoplasmic transport
annotated property: IAO_0000115

nuclear body
type: Class
subclass of: nucleoplasm part
IAO_0000115: Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
id: GO:0016604
database_cross_reference: NIF_Subcellular:sao505137457
has_obo_namespace: cellular_component
IAO_0000412: go.owl

Axiom
annotated target: Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
database_cross_reference: GOC:ma
database_cross_reference: PMID:10330182
annotated source: nuclear body
annotated property: IAO_0000115

transferase activity
type: Class
subclass of: catalytic activity
IAO_0000115: Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
database_cross_reference: EC:2
id: GO:0016740
database_cross_reference: Reactome:REACT_25050
has_obo_namespace: molecular_function
IAO_0000412: go.owl
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: goslim plant
in_subset: gosubset prok

Molybdenum ion transfer onto molybdopterin, Homo sapiens
type: Axiom
annotated target: Reactome:REACT_25050
annotated source: transferase activity
annotated property: database_cross_reference

Axiom
annotated target: Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
database_cross_reference: ISBN:0198506732
annotated source: transferase activity
annotated property: IAO_0000115

transferase activity, transferring phosphorus-containing groups
type: Class
subclass of: transferase activity
IAO_0000115: Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor).
database_cross_reference: EC:2.7
id: GO:0016772
comment: Note that this term encompasses all kinase activities, as well as activities that transfer other phosphorus-containing groups such as diphosphate or nucleotides.
has_obo_namespace: molecular_function
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
annotated target: Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor).
database_cross_reference: GOC:jl
database_cross_reference: ISBN:0198506732
annotated source: transferase activity, transferring phosphorus-containing groups
annotated property: IAO_0000115

nucleotidyltransferase activity
type: Class
subclass of: transferase activity, transferring phosphorus-containing groups
IAO_0000115: Catalysis of the transfer of a nucleotidyl group to a reactant.
database_cross_reference: EC:2.7.7
id: GO:0016779
has_obo_namespace: molecular_function
IAO_0000412: go.owl
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: goslim generic
in_subset: goslim yeast
in_subset: gosubset prok

Axiom
annotated target: Catalysis of the transfer of a nucleotidyl group to a reactant.
database_cross_reference: ISBN:0198506732
annotated source: nucleotidyltransferase activity
annotated property: IAO_0000115

protein import
type: Class
subclass of: protein transport
subclass of: single-organism transport
id: GO:0017038
IAO_0000115: The directed movement of proteins into a cell or organelle.
has_obo_namespace: biological_process
has_exact_synonym: protein uptake
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:ai
annotated target: The directed movement of proteins into a cell or organelle.
annotated source: protein import
annotated property: IAO_0000115

heterocycle biosynthetic process
type: Class
subclass of: cellular biosynthetic process
subclass of: heterocycle metabolic process
id: GO:0018130
IAO_0000115: The chemical reactions and pathways resulting in the formation of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings).
has_obo_namespace: biological_process
has_exact_synonym: heterocycle anabolism
has_exact_synonym: heterocycle biosynthesis
has_exact_synonym: heterocycle formation
has_exact_synonym: heterocycle synthesis
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
database_cross_reference: ISBN:0198547684
annotated target: The chemical reactions and pathways resulting in the formation of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings).
annotated source: heterocycle biosynthetic process
annotated property: IAO_0000115

regulation of nucleobase-containing compound metabolic process
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: regulates
    some values from: nucleobase-containing compound metabolic process
subclass of: regulation of cellular metabolic process
subclass of: regulation of nitrogen compound metabolic process
subclass of: regulation of primary metabolic process
subclass of: Restriction
  on property: regulates
  some values from: nucleobase-containing compound metabolic process
IAO_0000115: Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.
id: GO:0019219
has_obo_namespace: biological_process
has_related_synonym: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
has_exact_synonym: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb
annotated target: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
annotated source: regulation of nucleobase-containing compound metabolic process
annotated property: has_related_synonym

Axiom
annotated target: Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.
database_cross_reference: GOC:go_curators
annotated source: regulation of nucleobase-containing compound metabolic process
annotated property: IAO_0000115

regulation of metabolic process
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: regulates
    some values from: metabolic process
subclass of: regulation of biological process
subclass of: Restriction
  on property: regulates
  some values from: metabolic process
IAO_0000115: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
id: GO:0019222
has_obo_namespace: biological_process
has_exact_synonym: regulation of metabolism
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
annotated target: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
database_cross_reference: GOC:go_curators
annotated source: regulation of metabolic process
annotated property: IAO_0000115

aromatic compound biosynthetic process
type: Class
subclass of: cellular aromatic compound metabolic process
subclass of: cellular biosynthetic process
id: GO:0019438
IAO_0000115: The chemical reactions and pathways resulting in the formation of aromatic compounds, any substance containing an aromatic carbon ring.
has_exact_synonym: aromatic compound anabolism
has_exact_synonym: aromatic compound biosynthesis
has_exact_synonym: aromatic compound formation
has_exact_synonym: aromatic compound synthesis
has_narrow_synonym: aromatic hydrocarbon biosynthesis
has_narrow_synonym: aromatic hydrocarbon biosynthetic process
has_obo_namespace: biological_process
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:ai
annotated target: The chemical reactions and pathways resulting in the formation of aromatic compounds, any substance containing an aromatic carbon ring.
annotated source: aromatic compound biosynthetic process
annotated property: IAO_0000115

aromatic compound catabolic process
type: Class
subclass of: cellular aromatic compound metabolic process
subclass of: cellular catabolic process
id: GO:0019439
IAO_0000115: The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring.
has_exact_synonym: aromatic compound breakdown
has_exact_synonym: aromatic compound catabolism
has_exact_synonym: aromatic compound degradation
has_narrow_synonym: aromatic hydrocarbon catabolic process
has_narrow_synonym: aromatic hydrocarbon catabolism
has_obo_namespace: biological_process
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:ai
annotated target: The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring.
annotated source: aromatic compound catabolic process
annotated property: IAO_0000115

cell cycle process
type: Class
equivalent class: Class
  intersection of: single-organism cellular process
  intersection of: Restriction
    on property: part_of
    some values from: cell cycle
subclass of: single-organism cellular process
subclass of: Restriction
  on property: part_of
  some values from: cell cycle
id: GO:0022402
IAO_0000115: The cellular process that ensures successive accurate and complete genome replication and chromosome segregation.
has_obo_namespace: biological_process
IAO_0000412: go.owl
in_subset: gocheck do not manually annotate
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:isa_complete
database_cross_reference: GOC:mtg_cell_cycle
annotated target: The cellular process that ensures successive accurate and complete genome replication and chromosome segregation.
annotated source: cell cycle process
annotated property: IAO_0000115

cell cycle phase
type: Class
subclass of: cell cycle process
id: GO:0022403
IAO_0000115: One of the distinct periods or stages into which the cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events.
has_obo_namespace: biological_process
IAO_0000412: go.owl
in_subset: gocheck do not annotate

Axiom
database_cross_reference: GOC:mtg_cell_cycle
annotated target: One of the distinct periods or stages into which the cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events.
annotated source: cell cycle phase
annotated property: IAO_0000115

cellular component disassembly
type: Class
subclass of: cellular component organization
subclass of: single-organism cellular process
IAO_0000115: A cellular process that results in the breakdown of a cellular component.
id: GO:0022411
has_alternative_id: GO:0071845
has_obo_namespace: biological_process
has_exact_synonym: cell structure disassembly
has_exact_synonym: cellular component disassembly at cellular level
IAO_0000412: go.owl
in_subset: goslim pir
in_subset: gosubset prok

Axiom
annotated target: A cellular process that results in the breakdown of a cellular component.
database_cross_reference: GOC:isa_complete
annotated source: cellular component disassembly
annotated property: IAO_0000115

cellular component assembly
type: Class
subclass of: cellular component organization
subclass of: Restriction
  on property: part_of
  some values from: cellular component biogenesis
id: GO:0022607
has_alternative_id: GO:0071844
IAO_0000115: The aggregation, arrangement and bonding together of a cellular component.
has_obo_namespace: biological_process
has_exact_synonym: cell structure assembly
has_exact_synonym: cellular component assembly at cellular level
IAO_0000412: go.owl
in_subset: goslim generic
in_subset: goslim pir
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:isa_complete
annotated target: The aggregation, arrangement and bonding together of a cellular component.
annotated source: cellular component assembly
annotated property: IAO_0000115

biological adhesion
type: Class
subclass of: biological_process
id: GO:0022610
IAO_0000115: The attachment of a cell or organism to a substrate or other organism.
has_obo_namespace: biological_process
IAO_0000412: go.owl
in_subset: goslim pir
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:isa_complete
annotated target: The attachment of a cell or organism to a substrate or other organism.
annotated source: biological adhesion
annotated property: IAO_0000115

regulation of signaling
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: regulates
    some values from: signaling
subclass of: regulation of biological process
subclass of: Restriction
  on property: regulates
  some values from: single organism signaling
subclass of: Restriction
  on property: regulates
  some values from: signaling
creation date: 2010-02-16T09:30:50Z
IAO_0000115: Any process that modulates the frequency, rate or extent of a signaling process.
id: GO:0023051
has_obo_namespace: biological_process
has_related_synonym: regulation of signaling process
has_related_synonym: regulation of signalling process
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:bf
annotated target: regulation of signaling process
annotated source: regulation of signaling
annotated property: has_related_synonym

Axiom
annotated target: Any process that modulates the frequency, rate or extent of a signaling process.
database_cross_reference: GOC:mtg_signal
annotated source: regulation of signaling
annotated property: IAO_0000115

Axiom
database_cross_reference: GOC:mah
annotated target: regulation of signalling process
annotated source: regulation of signaling
annotated property: has_related_synonym

signaling
type: Class
subclass of: biological_process
creation date: 2010-02-16T09:30:50Z
has_alternative_id: GO:0023046
id: GO:0023052
comment: Note that a signal is any variable property or parameter that serves to convey information, and may be a physical entity such as a gene product or small molecule, a photon, or a change in state such as movement or voltage change.
IAO_0000115: The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered.
has_exact_synonym: biological signaling
has_obo_namespace: biological_process
has_exact_synonym: signaling process
has_exact_synonym: signalling
has_related_synonym: signalling process
IAO_0000412: go.owl
in_subset: goslim pombe
in_subset: goslim yeast

Axiom
database_cross_reference: GOC:mtg_signal
database_cross_reference: GOC:mtg_signaling_feb11
database_cross_reference: GOC:signaling
annotated target: The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered.
annotated source: signaling
annotated property: IAO_0000115

Axiom
database_cross_reference: GOC:mah
annotated target: signalling process
annotated source: signaling
annotated property: has_related_synonym

negative regulation of signaling
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: negatively_regulates
    some values from: signaling
subclass of: regulation of signaling
subclass of: negative regulation of biological process
subclass of: Restriction
  on property: negatively_regulates
  some values from: single organism signaling
subclass of: Restriction
  on property: negatively_regulates
  some values from: signaling
creation date: 2010-02-16T09:30:50Z
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process.
id: GO:0023057
has_obo_namespace: biological_process
has_related_synonym: negative regulation of signaling process
has_related_synonym: negative regulation of signalling process
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:mah
annotated target: negative regulation of signalling process
annotated source: negative regulation of signaling
annotated property: has_related_synonym

Axiom
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process.
database_cross_reference: GOC:mtg_signal
annotated source: negative regulation of signaling
annotated property: IAO_0000115

Axiom
database_cross_reference: GOC:bf
annotated target: negative regulation of signaling process
annotated source: negative regulation of signaling
annotated property: has_related_synonym

lamellipodium
type: Class
subclass of: cell projection
subclass of: Restriction
  on property: part_of
  some values from: cell leading edge
IAO_0000115: A thin sheetlike process extended by the leading edge of a crawling fibroblast; contains a dense meshwork of actin filaments.
id: GO:0030027
database_cross_reference: Wikipedia:Lamellipodia
has_obo_namespace: cellular_component
IAO_0000412: go.owl

Axiom
annotated target: A thin sheetlike process extended by the leading edge of a crawling fibroblast; contains a dense meshwork of actin filaments.
database_cross_reference: ISBN:0815316194
annotated source: lamellipodium
annotated property: IAO_0000115

actin filament-based process
type: Class
subclass of: single-organism cellular process
IAO_0000115: Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins.
id: GO:0030029
has_obo_namespace: biological_process
has_related_synonym: microfilament-based process
IAO_0000412: go.owl

Axiom
annotated target: Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins.
database_cross_reference: GOC:mah
annotated source: actin filament-based process
annotated property: IAO_0000115

cell projection organization
type: Class
subclass of: cellular component organization
subclass of: single-organism cellular process
IAO_0000115: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon.
id: GO:0030030
has_obo_namespace: biological_process
has_exact_synonym: cell projection organisation
has_related_synonym: cell projection organization and biogenesis
has_related_synonym: cell surface structure organization and biogenesis
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:mah
annotated target: cell projection organization and biogenesis
annotated source: cell projection organization
annotated property: has_related_synonym

Axiom
database_cross_reference: GOC:curators
annotated target: cell projection organisation
annotated source: cell projection organization
annotated property: has_exact_synonym

Axiom
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon.
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah
database_cross_reference: http://www.cogsci.princeton.edu/~wn/
annotated source: cell projection organization
annotated property: IAO_0000115

Axiom
database_cross_reference: GOC:mah
annotated target: cell surface structure organization and biogenesis
annotated source: cell projection organization
annotated property: has_related_synonym

cell projection assembly
type: Class
subclass of: cellular component assembly
subclass of: cell projection organization
IAO_0000115: Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon.
id: GO:0030031
has_obo_namespace: biological_process
has_related_synonym: cell projection biogenesis
has_exact_synonym: formation of a cell surface projection
IAO_0000412: go.owl
in_subset: goslim metagenomics
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:mah
annotated target: cell projection biogenesis
annotated source: cell projection assembly
annotated property: has_related_synonym

Axiom
annotated target: Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon.
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah
database_cross_reference: http://www.cogsci.princeton.edu/~wn/
annotated source: cell projection assembly
annotated property: IAO_0000115

actin filament-based movement
type: Class
subclass of: cellular component movement
subclass of: actin filament-based process
id: GO:0030048
IAO_0000115: Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins.
has_obo_namespace: biological_process
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:BHF
database_cross_reference: GOC:mah
annotated target: Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins.
annotated source: actin filament-based movement
annotated property: IAO_0000115

cell junction
type: Class
subclass of: cellular_component
IAO_0000115: A cellular component that forms a specialized region of connection between two cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.
id: GO:0030054
database_cross_reference: Wikipedia:Cell_junction
has_obo_namespace: cellular_component
IAO_0000412: go.owl

Axiom
annotated target: A cellular component that forms a specialized region of connection between two cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.
database_cross_reference: GOC:mah
database_cross_reference: ISBN:0198506732
database_cross_reference: http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html
annotated source: cell junction
annotated property: IAO_0000115

cell-substrate junction
type: Class
subclass of: cell junction
IAO_0000115: A cell junction that forms a connection between a cell and the extracellular matrix.
id: GO:0030055
has_exact_synonym: cell-matrix junction
has_obo_namespace: cellular_component
IAO_0000412: go.owl

Axiom
annotated target: A cell junction that forms a connection between a cell and the extracellular matrix.
database_cross_reference: GOC:hb
database_cross_reference: GOC:mah
annotated source: cell-substrate junction
annotated property: IAO_0000115

endocytic vesicle
type: Class
subclass of: cytoplasmic membrane-bounded vesicle
IAO_0000115: A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting.
id: GO:0030139
database_cross_reference: NIF_Subcellular:sao1362520468
has_obo_namespace: cellular_component
has_exact_synonym: endocytotic transport vesicle
has_exact_synonym: endocytotic vesicle
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
annotated target: A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting.
database_cross_reference: GOC:go_curators
database_cross_reference: PMID:19696797
annotated source: endocytic vesicle
annotated property: IAO_0000115

cell differentiation
type: Class
subclass of: cellular developmental process
id: GO:0030154
IAO_0000115: The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
database_cross_reference: Wikipedia:Cellular_differentiation
has_obo_namespace: biological_process
IAO_0000412: go.owl
in_subset: goslim generic
in_subset: goslim plant
in_subset: gosubset prok

Axiom
database_cross_reference: ISBN:0198506732
annotated target: The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
annotated source: cell differentiation
annotated property: IAO_0000115

filopodium
type: Class
subclass of: cell projection
has_alternative_id: GO:0030028
id: GO:0030175
database_cross_reference: NIF_Subcellular:sao-1046371754
IAO_0000115: Thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone; usually approximately 0.1 um wide, 5-10 um long, can be up to 50 um long in axon growth cones; contains a loose bundle of about 20 actin filaments oriented with their plus ends pointing outward.
database_cross_reference: Wikipedia:Filopodia
has_obo_namespace: cellular_component
IAO_0000412: go.owl
in_subset: goslim pir

Axiom
database_cross_reference: GOC:mah
database_cross_reference: ISBN:0815316194
annotated target: Thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone; usually approximately 0.1 um wide, 5-10 um long, can be up to 50 um long in axon growth cones; contains a loose bundle of about 20 actin filaments oriented with their plus ends pointing outward.
annotated source: filopodium
annotated property: IAO_0000115

chromosome condensation
type: Class
subclass of: DNA packaging
subclass of: chromosome organization
has_broad_synonym: DNA condensation
has_alternative_id: GO:0000068
id: GO:0030261
IAO_0000115: The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells.
has_obo_namespace: biological_process
has_exact_synonym: eukaryotic chromosome condensation
has_exact_synonym: nuclear chromosome condensation
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:bf
annotated target: nuclear chromosome condensation
annotated source: chromosome condensation
annotated property: has_exact_synonym

Axiom
database_cross_reference: GOC:bf
annotated target: eukaryotic chromosome condensation
annotated source: chromosome condensation
annotated property: has_exact_synonym

Axiom
annotated target: DNA condensation
database_cross_reference: Wikipedia:DNA_condensation
annotated source: chromosome condensation
annotated property: has_broad_synonym

Axiom
database_cross_reference: GOC:mah
database_cross_reference: ISBN:0815316194
annotated target: The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells.
annotated source: chromosome condensation
annotated property: IAO_0000115

apoptotic nuclear changes
type: Class
subclass of: cellular component disassembly involved in execution phase of apoptosis
IAO_0000115: Alterations undergone by nuclei at the molecular and morphological level and that contribute to the execution phase of apoptosis.
id: GO:0030262
has_narrow_synonym: apoptotic nuclear change
has_obo_namespace: biological_process
IAO_0000412: go.owl

Axiom
annotated target: Alterations undergone by nuclei at the molecular and morphological level and that contribute to the execution phase of apoptosis.
database_cross_reference: GOC:mah
database_cross_reference: GOC:mtg_apoptosis
annotated source: apoptotic nuclear changes
annotated property: IAO_0000115

axon
type: Class
subclass of: neuron projection
id: GO:0030424
database_cross_reference: NIF_Subcellular:sao1770195789
IAO_0000115: The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
database_cross_reference: Wikipedia:Axon
has_obo_namespace: cellular_component
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:nln
database_cross_reference: ISBN:0198506732
annotated target: The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
annotated source: axon
annotated property: IAO_0000115

dendrite
type: Class
subclass of: neuron projection
IAO_0000115: A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
id: GO:0030425
database_cross_reference: NIF_Subcellular:sao1211023249
database_cross_reference: Wikipedia:Dendrite
has_obo_namespace: cellular_component
IAO_0000412: go.owl

Axiom
annotated target: A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
database_cross_reference: GOC:dos
database_cross_reference: GOC:mah
database_cross_reference: GOC:nln
database_cross_reference: ISBN:0198506732
annotated source: dendrite
annotated property: IAO_0000115

cortical cytoskeleton
type: Class
subclass of: cytoskeleton
subclass of: cell cortex part
id: GO:0030863
IAO_0000115: The portion of the cytoskeleton that lies just beneath the plasma membrane.
has_obo_namespace: cellular_component
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:mah
annotated target: The portion of the cytoskeleton that lies just beneath the plasma membrane.
annotated source: cortical cytoskeleton
annotated property: IAO_0000115

cortical actin cytoskeleton
type: Class
equivalent class: Class
  intersection of: cortical cytoskeleton
  intersection of: Restriction
    on property: part_of
    some values from: actin cytoskeleton
subclass of: cortical cytoskeleton
subclass of: Restriction
  on property: part_of
  some values from: actin cytoskeleton
id: GO:0030864
IAO_0000115: The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane.
has_obo_namespace: cellular_component
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:mah
annotated target: The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane.
annotated source: cortical actin cytoskeleton
annotated property: IAO_0000115

microtubule organizing center organization
type: Class
subclass of: organelle organization
subclass of: Restriction
  on property: part_of
  some values from: microtubule cytoskeleton organization
IAO_0000115: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow.
id: GO:0031023
has_obo_namespace: biological_process
has_exact_synonym: microtubule organising center organisation
has_related_synonym: microtubule organizing center organization and biogenesis
IAO_0000412: go.owl
in_subset: goslim pir

Axiom
database_cross_reference: GOC:mah
annotated target: microtubule organizing center organization and biogenesis
annotated source: microtubule organizing center organization
annotated property: has_related_synonym

Axiom
database_cross_reference: GOC:curators
annotated target: microtubule organising center organisation
annotated source: microtubule organizing center organization
annotated property: has_exact_synonym

Axiom
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow.
database_cross_reference: GOC:dph
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah
annotated source: microtubule organizing center organization
annotated property: IAO_0000115

micronucleus
type: Class
subclass of: nucleus
IAO_0000115: A membrane-bounded organelle of ciliated protozoan cells that contains a diploid copy of the cell's complete genome. Sections of contiguous sequence in the macronucleus are often interrupted by internal eliminated sequences (IES), and may be permuted, in micronuclei. Genic transcription is not found in micronuclei. Some ciliate species may contain multiple micronuclei per cell.
id: GO:0031040
database_cross_reference: Wikipedia:Micronucleus
has_obo_namespace: cellular_component
IAO_0000412: go.owl

Axiom
annotated target: A membrane-bounded organelle of ciliated protozoan cells that contains a diploid copy of the cell's complete genome. Sections of contiguous sequence in the macronucleus are often interrupted by internal eliminated sequences (IES), and may be permuted, in micronuclei. Genic transcription is not found in micronuclei. Some ciliate species may contain multiple micronuclei per cell.
database_cross_reference: GOC:ns
annotated source: micronucleus
annotated property: IAO_0000115

cell leading edge
type: Class
subclass of: cell part
id: GO:0031252
IAO_0000115: The area of a motile cell closest to the direction of movement.
has_obo_namespace: cellular_component
has_exact_synonym: front of cell
has_exact_synonym: leading edge of cell
IAO_0000412: go.owl
in_subset: goslim pir

Axiom
database_cross_reference: GOC:pg
annotated target: The area of a motile cell closest to the direction of movement.
annotated source: cell leading edge
annotated property: IAO_0000115

regulation of cellular metabolic process
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: regulates
    some values from: cellular metabolic process
subclass of: regulation of metabolic process
subclass of: regulation of cellular process
subclass of: Restriction
  on property: regulates
  some values from: cellular metabolic process
IAO_0000115: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.
id: GO:0031323
has_obo_namespace: biological_process
has_exact_synonym: regulation of cellular metabolism
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
annotated target: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.
database_cross_reference: GOC:mah
annotated source: regulation of cellular metabolic process
annotated property: IAO_0000115

regulation of cellular biosynthetic process
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: regulates
    some values from: cellular biosynthetic process
subclass of: regulation of biosynthetic process
subclass of: regulation of cellular metabolic process
subclass of: Restriction
  on property: regulates
  some values from: cellular biosynthetic process
IAO_0000115: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.
id: GO:0031326
has_obo_namespace: biological_process
has_exact_synonym: regulation of cellular anabolism
has_exact_synonym: regulation of cellular biosynthesis
has_exact_synonym: regulation of cellular formation
has_exact_synonym: regulation of cellular synthesis
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
annotated target: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.
database_cross_reference: GOC:mah
annotated source: regulation of cellular biosynthetic process
annotated property: IAO_0000115

cytoplasmic vesicle
type: Class
equivalent class: Class
  intersection of: vesicle
  intersection of: Restriction
    on property: part_of
    some values from: cytoplasm
subclass of: vesicle
subclass of: intracellular organelle
subclass of: cytoplasmic part
subclass of: Restriction
  on property: part_of
  some values from: cytoplasm
IAO_0000115: A vesicle formed of membrane or protein, found in the cytoplasm of a cell.
id: GO:0031410
database_cross_reference: NIF_Subcellular:sao180601769
has_obo_namespace: cellular_component
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
annotated target: A vesicle formed of membrane or protein, found in the cytoplasm of a cell.
database_cross_reference: GOC:mah
annotated source: cytoplasmic vesicle
annotated property: IAO_0000115

motile cilium
type: Class
subclass of: cilium
IAO_0000115: A cilium which has a variable arrangement of axonemal microtubules, contains molecular motors, and beats with a characteristic whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface. Motile cilia are typically found in multiple copies on epithelial cells that line the lumenal ducts of various tissues. Motile cilia may also function as sensory organelles.
has_alternative_id: GO:0009434
id: GO:0031514
comment: MERGED COMMENT: TARGET COMMENT: MERGED COMMENT: TARGET COMMENT: Note that this term should not be confused with 'motile primary cilium ; GO:0031512': Motile cilia are distinct from motile primary cilia (GO:0031512) that are typically present during embryogenesis in a single copy per cell, affect asymmetric body plan organization, and move in a rotational manner, as opposed to a whip-like, manner. -------------------- SOURCE COMMENT: See also the cellular component term 'cilium ; GO:0005929'. -------------------- SOURCE COMMENT: See also the cellular component term 'cilium ; GO:0005929'.
has_obo_namespace: cellular_component
has_related_synonym: microtubule-based flagellum
has_exact_synonym: motile cilia
has_related_synonym: motile secondary cilium
IAO_0000412: go.owl

Axiom
annotated target: A cilium which has a variable arrangement of axonemal microtubules, contains molecular motors, and beats with a characteristic whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface. Motile cilia are typically found in multiple copies on epithelial cells that line the lumenal ducts of various tissues. Motile cilia may also function as sensory organelles.
database_cross_reference: GOC:dgh
database_cross_reference: GOC:kmv
database_cross_reference: PMID:17009929
database_cross_reference: PMID:20144998
annotated source: motile cilium
annotated property: IAO_0000115

Axiom
database_cross_reference: GOC:curators
annotated target: motile cilia
annotated source: motile cilium
annotated property: has_exact_synonym

Axiom
database_cross_reference: GOC:curators
annotated target: motile secondary cilium
annotated source: motile cilium
annotated property: has_related_synonym

cell-substrate adhesion
type: Class
subclass of: cell adhesion
id: GO:0031589
IAO_0000115: The attachment of a cell to the underlying substrate via adhesion molecules.
has_obo_namespace: biological_process
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:mah
database_cross_reference: GOC:pf
annotated target: The attachment of a cell to the underlying substrate via adhesion molecules.
annotated source: cell-substrate adhesion
annotated property: IAO_0000115

membrane-enclosed lumen
type: Class
subclass of: cellular_component
id: GO:0031974
IAO_0000115: The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen.
has_obo_namespace: cellular_component
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:add
database_cross_reference: GOC:mah
annotated target: The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen.
annotated source: membrane-enclosed lumen
annotated property: IAO_0000115

nuclear lumen
type: Class
subclass of: nuclear part
subclass of: intracellular organelle lumen
id: GO:0031981
IAO_0000115: The volume enclosed by the nuclear inner membrane.
has_obo_namespace: cellular_component
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:mah
database_cross_reference: GOC:pz
annotated target: The volume enclosed by the nuclear inner membrane.
annotated source: nuclear lumen
annotated property: IAO_0000115

vesicle
type: Class
subclass of: organelle
IAO_0000115: Any small, fluid-filled, spherical organelle enclosed by membrane or protein.
id: GO:0031982
database_cross_reference: NIF_Subcellular:sao221389602
database_cross_reference: Wikipedia:Vesicle_(biology)
has_obo_namespace: cellular_component
IAO_0000412: go.owl
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: gosubset prok

Axiom
annotated target: Any small, fluid-filled, spherical organelle enclosed by membrane or protein.
database_cross_reference: GOC:mah
database_cross_reference: GOC:pz
annotated source: vesicle
annotated property: IAO_0000115

membrane-bounded vesicle
type: Class
subclass of: vesicle
IAO_0000115: Any small, fluid-filled, spherical organelle enclosed by a lipid bilayer.
id: GO:0031988
has_obo_namespace: cellular_component
has_exact_synonym: membrane-enclosed vesicle
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
annotated target: Any small, fluid-filled, spherical organelle enclosed by a lipid bilayer.
database_cross_reference: GOC:mah
annotated source: membrane-bounded vesicle
annotated property: IAO_0000115

negative regulation of NF-kappaB transcription factor activity
type: Class
subclass of: negative regulation of sequence-specific DNA binding transcription factor activity
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.
id: GO:0032088
has_related_synonym: NF-kappaB inhibitor
has_obo_namespace: biological_process
has_exact_synonym: inhibition of NF-kappaB transcription factor
IAO_0000412: go.owl

Axiom
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.
database_cross_reference: GOC:dph
database_cross_reference: GOC:rl
database_cross_reference: GOC:tb
annotated source: negative regulation of NF-kappaB transcription factor activity
annotated property: IAO_0000115

Axiom
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb
annotated target: inhibition of NF-kappaB transcription factor
annotated source: negative regulation of NF-kappaB transcription factor activity
annotated property: has_exact_synonym

regulation of intracellular transport
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: regulates
    some values from: intracellular transport
subclass of: regulation of transport
subclass of: regulation of cellular localization
subclass of: Restriction
  on property: regulates
  some values from: intracellular transport
IAO_0000115: Any process that modulates the frequency, rate or extent of the directed movement of substances within cells.
id: GO:0032386
has_obo_namespace: biological_process
IAO_0000412: go.owl

Axiom
annotated target: Any process that modulates the frequency, rate or extent of the directed movement of substances within cells.
database_cross_reference: GOC:mah
annotated source: regulation of intracellular transport
annotated property: IAO_0000115

negative regulation of intracellular transport
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: negatively_regulates
    some values from: intracellular transport
subclass of: regulation of intracellular transport
subclass of: negative regulation of transport
subclass of: Restriction
  on property: negatively_regulates
  some values from: intracellular transport
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances within cells.
id: GO:0032387
has_obo_namespace: biological_process
has_exact_synonym: down regulation of intracellular transport
has_exact_synonym: down-regulation of intracellular transport
has_exact_synonym: downregulation of intracellular transport
has_narrow_synonym: inhibition of intracellular transport
IAO_0000412: go.owl

Axiom
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances within cells.
database_cross_reference: GOC:mah
annotated source: negative regulation of intracellular transport
annotated property: IAO_0000115

positive regulation of intracellular transport
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: positively_regulates
    some values from: intracellular transport
subclass of: regulation of intracellular transport
subclass of: positive regulation of transport
subclass of: Restriction
  on property: positively_regulates
  some values from: intracellular transport
IAO_0000115: Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells.
id: GO:0032388
has_narrow_synonym: activation of intracellular transport
has_obo_namespace: biological_process
has_narrow_synonym: stimulation of intracellular transport
has_exact_synonym: up regulation of intracellular transport
has_exact_synonym: up-regulation of intracellular transport
has_exact_synonym: upregulation of intracellular transport
IAO_0000412: go.owl

Axiom
annotated target: Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells.
database_cross_reference: GOC:mah
annotated source: positive regulation of intracellular transport
annotated property: IAO_0000115

actin filament bundle
type: Class
subclass of: cytoskeletal part
subclass of: Restriction
  on property: part_of
  some values from: actin cytoskeleton
IAO_0000115: An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness.
has_alternative_id: GO:0000141
has_alternative_id: GO:0030482
id: GO:0032432
has_related_synonym: actin cable
has_obo_namespace: cellular_component
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:mah
annotated target: actin cable
annotated source: actin filament bundle
annotated property: has_related_synonym

Axiom
annotated target: An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness.
database_cross_reference: GOC:mah
annotated source: actin filament bundle
annotated property: IAO_0000115

developmental process
type: Class
subclass of: biological_process
IAO_0000115: A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.
id: GO:0032502
has_obo_namespace: biological_process
has_narrow_synonym: development
IAO_0000412: go.owl
in_subset: goslim aspergillus
in_subset: goslim pir
in_subset: gosubset prok

Axiom
annotated target: A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.
database_cross_reference: GOC:isa_complete
annotated source: developmental process
annotated property: IAO_0000115

maintenance of protein location in cell
type: Class
equivalent class: Class
  intersection of: maintenance of protein location
  intersection of: Restriction
    on property: occurs in
    some values from: cell
subclass of: maintenance of protein location
subclass of: maintenance of location in cell
subclass of: Restriction
  on property: part_of
  some values from: cellular protein localization
subclass of: Restriction
  on property: occurs in
  some values from: cell
IAO_0000115: Any process in which a protein is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere.
id: GO:0032507
has_obo_namespace: biological_process
has_related_synonym: maintenance of protein localization in cell
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb
annotated target: maintenance of protein localization in cell
annotated source: maintenance of protein location in cell
annotated property: has_related_synonym

Axiom
annotated target: Any process in which a protein is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere.
database_cross_reference: GOC:isa_complete
database_cross_reference: GOC:mah
annotated source: maintenance of protein location in cell
annotated property: IAO_0000115

RNA biosynthetic process
type: Class
subclass of: macromolecule biosynthetic process
subclass of: RNA metabolic process
subclass of: nucleobase-containing compound biosynthetic process
id: GO:0032774
has_exact_synonym: RNA anabolism
has_exact_synonym: RNA biosynthesis
has_exact_synonym: RNA formation
has_exact_synonym: RNA synthesis
IAO_0000115: The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers.
has_obo_namespace: biological_process
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:mah
annotated target: The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers.
annotated source: RNA biosynthetic process
annotated property: IAO_0000115

regulation of localization
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: regulates
    some values from: localization
subclass of: regulation of biological process
subclass of: Restriction
  on property: regulates
  some values from: localization
IAO_0000115: Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location.
id: GO:0032879
has_obo_namespace: biological_process
has_exact_synonym: regulation of localisation
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
annotated target: Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location.
database_cross_reference: GOC:mah
annotated source: regulation of localization
annotated property: IAO_0000115

Axiom
database_cross_reference: GOC:mah
annotated target: regulation of localisation
annotated source: regulation of localization
annotated property: has_exact_synonym

regulation of protein localization
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: regulates
    some values from: protein localization
subclass of: regulation of localization
subclass of: Restriction
  on property: regulates
  some values from: protein localization
IAO_0000115: Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.
id: GO:0032880
has_obo_namespace: biological_process
has_exact_synonym: regulation of protein localisation
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
annotated target: Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.
database_cross_reference: GOC:dph
database_cross_reference: GOC:mah
database_cross_reference: GOC:tb
annotated source: regulation of protein localization
annotated property: IAO_0000115

Axiom
database_cross_reference: GOC:mah
annotated target: regulation of protein localisation
annotated source: regulation of protein localization
annotated property: has_exact_synonym

secretion by cell
type: Class
subclass of: single-organism cellular process
subclass of: secretion
subclass of: establishment of localization in cell
id: GO:0032940
IAO_0000115: The controlled release of a substance by a cell.
database_cross_reference: Wikipedia:Secretion
has_obo_namespace: biological_process
has_exact_synonym: cellular secretion
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:mah
annotated target: The controlled release of a substance by a cell.
annotated source: secretion by cell
annotated property: IAO_0000115

cellular component morphogenesis
type: Class
subclass of: anatomical structure morphogenesis
subclass of: cellular component organization
subclass of: single-organism developmental process
subclass of: cellular developmental process
id: GO:0032989
IAO_0000115: The process in which cellular structures, including whole cells or cell parts, are generated and organized.
has_obo_namespace: biological_process
has_exact_synonym: cellular structure morphogenesis
IAO_0000412: go.owl
in_subset: goslim pir
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb
annotated target: cellular structure morphogenesis
annotated source: cellular component morphogenesis
annotated property: has_exact_synonym

Axiom
database_cross_reference: GOC:dph
database_cross_reference: GOC:mah
database_cross_reference: GOC:tb
annotated target: The process in which cellular structures, including whole cells or cell parts, are generated and organized.
annotated source: cellular component morphogenesis
annotated property: IAO_0000115

macromolecular complex
type: Class
subclass of: cellular_component
IAO_0000115: A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.
id: GO:0032991
has_obo_namespace: cellular_component
has_exact_synonym: macromolecule complex
IAO_0000412: go.owl
in_subset: goslim pir
in_subset: gosubset prok

Axiom
annotated target: A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.
database_cross_reference: GOC:mah
annotated source: macromolecular complex
annotated property: IAO_0000115

macromolecule localization
type: Class
subclass of: localization
IAO_0000115: Any process in which a macromolecule is transported to, or maintained in, a specific location.
id: GO:0033036
has_obo_namespace: biological_process
has_exact_synonym: macromolecule localisation
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:mah
annotated target: macromolecule localisation
annotated source: macromolecule localization
annotated property: has_exact_synonym

Axiom
annotated target: Any process in which a macromolecule is transported to, or maintained in, a specific location.
database_cross_reference: GOC:mah
annotated source: macromolecule localization
annotated property: IAO_0000115

regulation of intracellular protein transport
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: regulates
    some values from: intracellular protein transport
subclass of: regulation of intracellular transport
subclass of: regulation of protein transport
subclass of: Restriction
  on property: regulates
  some values from: intracellular protein transport
IAO_0000115: Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells.
id: GO:0033157
has_obo_namespace: biological_process
IAO_0000412: go.owl

Axiom
annotated target: Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells.
database_cross_reference: GOC:mah
annotated source: regulation of intracellular protein transport
annotated property: IAO_0000115

protein localization to organelle
type: Class
subclass of: cellular protein localization
IAO_0000115: A process in which a protein is transported to, or maintained in, a location within an organelle.
id: GO:0033365
has_obo_namespace: biological_process
has_exact_synonym: protein localisation to organelle
has_exact_synonym: protein localization in organelle
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:mah
annotated target: protein localisation to organelle
annotated source: protein localization to organelle
annotated property: has_exact_synonym

Axiom
annotated target: A process in which a protein is transported to, or maintained in, a location within an organelle.
database_cross_reference: GOC:mah
annotated source: protein localization to organelle
annotated property: IAO_0000115

Axiom
database_cross_reference: GOC:mah
annotated target: protein localization in organelle
annotated source: protein localization to organelle
annotated property: has_exact_synonym

DNA polymerase activity
type: Class
subclass of: nucleotidyltransferase activity
IAO_0000115: Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a nucleic acid template and primer.
has_exact_synonym: DNA nucleotidyltransferase activity
id: GO:0034061
database_cross_reference: Reactome:REACT_115680
database_cross_reference: Reactome:REACT_115778
database_cross_reference: Reactome:REACT_115899
database_cross_reference: Reactome:REACT_115932
database_cross_reference: Reactome:REACT_116106
database_cross_reference: Reactome:REACT_116167
has_exact_synonym: deoxynucleate polymerase activity
has_exact_synonym: deoxyribonucleate nucleotidyltransferase activity
has_exact_synonym: deoxyribonucleic acid polymerase activity
has_exact_synonym: deoxyribonucleic polymerase activity
has_obo_namespace: molecular_function
IAO_0000412: go.owl
in_subset: goslim metagenomics
in_subset: gosubset prok

Elongation by Pol zeta complex, Gallus gallus
type: Axiom
annotated target: Reactome:REACT_115778
annotated source: DNA polymerase activity
annotated property: database_cross_reference

Axiom
database_cross_reference: EC:2.7.7.7
annotated target: deoxynucleate polymerase activity
annotated source: DNA polymerase activity
annotated property: has_exact_synonym

Axiom
database_cross_reference: EC:2.7.7.7
annotated target: deoxyribonucleic acid polymerase activity
annotated source: DNA polymerase activity
annotated property: has_exact_synonym

Elongation by Pol eta, Gallus gallus
type: Axiom
annotated target: Reactome:REACT_116167
annotated source: DNA polymerase activity
annotated property: database_cross_reference

Elongation by Pol kappa, Gallus gallus
type: Axiom
annotated target: Reactome:REACT_115899
annotated source: DNA polymerase activity
annotated property: database_cross_reference

Axiom
annotated target: DNA nucleotidyltransferase activity
database_cross_reference: EC:2.7.7.7
annotated source: DNA polymerase activity
annotated property: has_exact_synonym

Axiom
database_cross_reference: EC:2.7.7.7
annotated target: deoxyribonucleate nucleotidyltransferase activity
annotated source: DNA polymerase activity
annotated property: has_exact_synonym

Axiom
annotated target: Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a nucleic acid template and primer.
database_cross_reference: EC:2.7.7.7
database_cross_reference: GOC:mah
annotated source: DNA polymerase activity
annotated property: IAO_0000115

Insertion of correct bases opposite to the lesion by Pol kappa, Gallus gallus
type: Axiom
annotated target: Reactome:REACT_115680
annotated source: DNA polymerase activity
annotated property: database_cross_reference

Repair of ~27-30 bp long patch by DNA Pol Epsilon, Gallus gallus
type: Axiom
annotated target: Reactome:REACT_116106
annotated source: DNA polymerase activity
annotated property: database_cross_reference

Axiom
database_cross_reference: EC:2.7.7.7
annotated target: deoxyribonucleic polymerase activity
annotated source: DNA polymerase activity
annotated property: has_exact_synonym

Insertion of correct bases opposite to the lesion by Pol eta, Gallus gallus
type: Axiom
annotated target: Reactome:REACT_115932
annotated source: DNA polymerase activity
annotated property: database_cross_reference

substrate adhesion-dependent cell spreading
type: Class
subclass of: cell morphogenesis involved in differentiation
subclass of: cell-substrate adhesion
id: GO:0034446
IAO_0000115: The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate.
has_obo_namespace: biological_process
has_exact_synonym: cell spreading during cell substrate adhesion
has_exact_synonym: substrate adhesion dependent cell spreading
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:mah
database_cross_reference: GOC:pf
database_cross_reference: PMID:17050732
annotated target: The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate.
annotated source: substrate adhesion-dependent cell spreading
annotated property: IAO_0000115

protein localization to nucleus
type: Class
subclass of: protein localization to organelle
IAO_0000115: A process in which a protein is transported to, or maintained in, a location within the nucleus.
id: GO:0034504
has_obo_namespace: biological_process
has_exact_synonym: protein localisation to nucleus
has_exact_synonym: protein localization in cell nucleus
has_exact_synonym: protein localization in nucleus
IAO_0000412: go.owl

Axiom
annotated target: A process in which a protein is transported to, or maintained in, a location within the nucleus.
database_cross_reference: GOC:ecd
annotated source: protein localization to nucleus
annotated property: IAO_0000115

Axiom
database_cross_reference: GOC:mah
annotated target: protein localization in nucleus
annotated source: protein localization to nucleus
annotated property: has_exact_synonym

Axiom
database_cross_reference: GOC:mah
annotated target: protein localisation to nucleus
annotated source: protein localization to nucleus
annotated property: has_exact_synonym

cellular protein localization
type: Class
subclass of: protein localization
subclass of: cellular macromolecule localization
IAO_0000115: Any process in which a protein is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell.
has_alternative_id: GO:0016249
id: GO:0034613
has_obo_namespace: biological_process
has_exact_synonym: cellular protein localisation
has_narrow_synonym: channel localizer activity
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:mah
annotated target: cellular protein localisation
annotated source: cellular protein localization
annotated property: has_exact_synonym

Axiom
database_cross_reference: GOC:mah
annotated target: channel localizer activity
annotated source: cellular protein localization
annotated property: has_narrow_synonym

Axiom
annotated target: Any process in which a protein is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell.
database_cross_reference: GOC:mah
annotated source: cellular protein localization
annotated property: IAO_0000115

cellular nitrogen compound metabolic process
type: Class
subclass of: nitrogen compound metabolic process
subclass of: cellular metabolic process
id: GO:0034641
database_cross_reference: Reactome:REACT_102000
database_cross_reference: Reactome:REACT_103710
database_cross_reference: Reactome:REACT_107293
database_cross_reference: Reactome:REACT_108179
database_cross_reference: Reactome:REACT_109042
database_cross_reference: Reactome:REACT_13
database_cross_reference: Reactome:REACT_28699
database_cross_reference: Reactome:REACT_29108
database_cross_reference: Reactome:REACT_32429
database_cross_reference: Reactome:REACT_33347
database_cross_reference: Reactome:REACT_34326
database_cross_reference: Reactome:REACT_55564
database_cross_reference: Reactome:REACT_77741
database_cross_reference: Reactome:REACT_82379
database_cross_reference: Reactome:REACT_86268
database_cross_reference: Reactome:REACT_90299
database_cross_reference: Reactome:REACT_91959
database_cross_reference: Reactome:REACT_93580
database_cross_reference: Reactome:REACT_95666
database_cross_reference: Reactome:REACT_98086
database_cross_reference: Reactome:REACT_99241
IAO_0000115: The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells.
has_obo_namespace: biological_process
has_exact_synonym: cellular nitrogen compound metabolism
IAO_0000412: go.owl
in_subset: goslim generic
in_subset: gosubset prok

Metabolism of amino acids and derivatives, Schizosaccharomyces pombe
type: Axiom
annotated target: Reactome:REACT_99241
annotated source: cellular nitrogen compound metabolic process
annotated property: database_cross_reference

Metabolism of amino acids and derivatives, Arabidopsis thaliana
type: Axiom
annotated target: Reactome:REACT_107293
annotated source: cellular nitrogen compound metabolic process
annotated property: database_cross_reference

Metabolism of amino acids and derivatives, Oryza sativa
type: Axiom
annotated target: Reactome:REACT_90299
annotated source: cellular nitrogen compound metabolic process
annotated property: database_cross_reference

Metabolism of amino acids and derivatives, Caenorhabditis elegans
type: Axiom
annotated target: Reactome:REACT_29108
annotated source: cellular nitrogen compound metabolic process
annotated property: database_cross_reference

Metabolism of amino acids and derivatives, Gallus gallus
type: Axiom
annotated target: Reactome:REACT_55564
annotated source: cellular nitrogen compound metabolic process
annotated property: database_cross_reference

Metabolism of amino acids and derivatives, Escherichia coli
type: Axiom
annotated target: Reactome:REACT_103710
annotated source: cellular nitrogen compound metabolic process
annotated property: database_cross_reference

Metabolism of amino acids and derivatives, Sus scrofa
type: Axiom
annotated target: Reactome:REACT_109042
annotated source: cellular nitrogen compound metabolic process
annotated property: database_cross_reference

Axiom
database_cross_reference: GOC:mah
annotated target: The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells.
annotated source: cellular nitrogen compound metabolic process
annotated property: IAO_0000115

Metabolism of amino acids and derivatives, Saccharomyces cerevisiae
type: Axiom
annotated target: Reactome:REACT_28699
annotated source: cellular nitrogen compound metabolic process
annotated property: database_cross_reference

Metabolism of amino acids and derivatives, Staphylococcus aureus N315
type: Axiom
annotated target: Reactome:REACT_34326
annotated source: cellular nitrogen compound metabolic process
annotated property: database_cross_reference

Metabolism of amino acids and derivatives, Rattus norvegicus
type: Axiom
annotated target: Reactome:REACT_32429
annotated source: cellular nitrogen compound metabolic process
annotated property: database_cross_reference

Metabolism of amino acids and derivatives, Xenopus tropicalis
type: Axiom
annotated target: Reactome:REACT_108179
annotated source: cellular nitrogen compound metabolic process
annotated property: database_cross_reference

Metabolism of amino acids and derivatives, Plasmodium falciparum
type: Axiom
annotated target: Reactome:REACT_91959
annotated source: cellular nitrogen compound metabolic process
annotated property: database_cross_reference

Metabolism of amino acids and derivatives, Drosophila melanogaster
type: Axiom
annotated target: Reactome:REACT_86268
annotated source: cellular nitrogen compound metabolic process
annotated property: database_cross_reference

Metabolism of amino acids and derivatives, Mycobacterium tuberculosis
type: Axiom
annotated target: Reactome:REACT_102000
annotated source: cellular nitrogen compound metabolic process
annotated property: database_cross_reference

Metabolism of amino acids and derivatives, Mus musculus
type: Axiom
annotated target: Reactome:REACT_33347
annotated source: cellular nitrogen compound metabolic process
annotated property: database_cross_reference

Metabolism of amino acids and derivatives, Homo sapiens
type: Axiom
annotated target: Reactome:REACT_13
annotated source: cellular nitrogen compound metabolic process
annotated property: database_cross_reference

Metabolism of amino acids and derivatives, Danio rerio
type: Axiom
annotated target: Reactome:REACT_93580
annotated source: cellular nitrogen compound metabolic process
annotated property: database_cross_reference

Metabolism of amino acids and derivatives, Bos taurus
type: Axiom
annotated target: Reactome:REACT_82379
annotated source: cellular nitrogen compound metabolic process
annotated property: database_cross_reference

Metabolism of amino acids and derivatives, Taeniopygia guttata
type: Axiom
annotated target: Reactome:REACT_77741
annotated source: cellular nitrogen compound metabolic process
annotated property: database_cross_reference

Metabolism of amino acids and derivatives, Canis familiaris
type: Axiom
annotated target: Reactome:REACT_95666
annotated source: cellular nitrogen compound metabolic process
annotated property: database_cross_reference

Metabolism of amino acids and derivatives, Dictyostelium discoideum
type: Axiom
annotated target: Reactome:REACT_98086
annotated source: cellular nitrogen compound metabolic process
annotated property: database_cross_reference

cellular macromolecule biosynthetic process
type: Class
subclass of: macromolecule biosynthetic process
subclass of: cellular biosynthetic process
subclass of: cellular macromolecule metabolic process
id: GO:0034645
has_alternative_id: GO:0034961
IAO_0000115: The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells.
has_obo_namespace: biological_process
has_exact_synonym: cellular biopolymer biosynthetic process
has_exact_synonym: cellular macromolecule anabolism
has_exact_synonym: cellular macromolecule biosynthesis
has_exact_synonym: cellular macromolecule formation
has_exact_synonym: cellular macromolecule synthesis
IAO_0000412: go.owl

Axiom
database_cross_reference: CHEBI:33694
database_cross_reference: GOC:mah
annotated target: The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells.
annotated source: cellular macromolecule biosynthetic process
annotated property: IAO_0000115

Axiom
database_cross_reference: GOC:mah
annotated target: cellular macromolecule synthesis
annotated source: cellular macromolecule biosynthetic process
annotated property: has_exact_synonym

Axiom
database_cross_reference: GOC:mtg_chebi_dec09
annotated target: cellular biopolymer biosynthetic process
annotated source: cellular macromolecule biosynthetic process
annotated property: has_exact_synonym

Axiom
database_cross_reference: GOC:mah
annotated target: cellular macromolecule biosynthesis
annotated source: cellular macromolecule biosynthetic process
annotated property: has_exact_synonym

Axiom
database_cross_reference: GOC:mah
annotated target: cellular macromolecule anabolism
annotated source: cellular macromolecule biosynthetic process
annotated property: has_exact_synonym

Axiom
database_cross_reference: GOC:mah
annotated target: cellular macromolecule formation
annotated source: cellular macromolecule biosynthetic process
annotated property: has_exact_synonym

nucleobase-containing compound biosynthetic process
type: Class
subclass of: nucleobase-containing compound metabolic process
subclass of: heterocycle biosynthetic process
subclass of: aromatic compound biosynthetic process
subclass of: cellular nitrogen compound biosynthetic process
subclass of: organic cyclic compound biosynthetic process
id: GO:0034654
IAO_0000115: The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids.
has_obo_namespace: biological_process
has_exact_synonym: nucleobase, nucleoside, nucleotide and nucleic acid anabolism
has_exact_synonym: nucleobase, nucleoside, nucleotide and nucleic acid biosynthesis
has_exact_synonym: nucleobase, nucleoside, nucleotide and nucleic acid formation
has_narrow_synonym: nucleobase, nucleoside, nucleotide and nucleic acid synthesis
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:mah
annotated target: The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids.
annotated source: nucleobase-containing compound biosynthetic process
annotated property: IAO_0000115

nucleobase-containing compound catabolic process
type: Class
subclass of: nucleobase-containing compound metabolic process
subclass of: aromatic compound catabolic process
subclass of: cellular nitrogen compound catabolic process
subclass of: heterocycle catabolic process
subclass of: organic cyclic compound catabolic process
id: GO:0034655
IAO_0000115: The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids.
has_obo_namespace: biological_process
has_exact_synonym: nucleobase, nucleoside, nucleotide and nucleic acid breakdown
has_related_synonym: nucleobase, nucleoside, nucleotide and nucleic acid catabolic process
has_exact_synonym: nucleobase, nucleoside, nucleotide and nucleic acid catabolism
has_exact_synonym: nucleobase, nucleoside, nucleotide and nucleic acid degradation
IAO_0000412: go.owl
in_subset: goslim generic
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:mah
annotated target: The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids.
annotated source: nucleobase-containing compound catabolic process
annotated property: IAO_0000115

Axiom
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb
annotated target: nucleobase, nucleoside, nucleotide and nucleic acid catabolic process
annotated source: nucleobase-containing compound catabolic process
annotated property: has_related_synonym

intracellular signal transduction
type: Class
equivalent class: Class
  intersection of: signal transduction
  intersection of: Restriction
    on property: occurs in
    some values from: intracellular
subclass of: signal transduction
subclass of: Restriction
  on property: occurs in
  some values from: intracellular
creation date: 2010-05-14T01:14:37Z
has_alternative_id: GO:0007242
has_alternative_id: GO:0023013
has_alternative_id: GO:0023034
id: GO:0035556
IAO_0000115: The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
has_obo_namespace: biological_process
has_narrow_synonym: intracellular signal transduction pathway
has_exact_synonym: intracellular signaling cascade
has_exact_synonym: intracellular signaling chain
has_related_synonym: intracellular signaling pathway
created by: rfoulger
has_related_synonym: signal transduction via intracellular signaling cascade
has_narrow_synonym: signal transmission via intracellular cascade
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:signaling
database_cross_reference: ISBN:3527303782
annotated target: The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
annotated source: intracellular signal transduction
annotated property: IAO_0000115

Axiom
database_cross_reference: ISBN:3527303782
annotated target: intracellular signaling chain
annotated source: intracellular signal transduction
annotated property: has_exact_synonym

site of double-strand break
type: Class
subclass of: chromosomal part
creation date: 2011-05-17T03:04:42Z
IAO_0000115: A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.
has_related_synonym: DNA damage foci
has_related_synonym: DNA damage focus
id: GO:0035861
has_related_synonym: IRIF
has_obo_namespace: cellular_component
has_related_synonym: ionizing radiation-induced foci
created by: rfoulger
has_exact_synonym: site of DSB
IAO_0000412: go.owl

Axiom
database_cross_reference: PMID:20096808
database_cross_reference: PMID:21035408
annotated target: ionizing radiation-induced foci
annotated source: site of double-strand break
annotated property: has_related_synonym

Axiom
database_cross_reference: PMID:21035408
annotated target: site of DSB
annotated source: site of double-strand break
annotated property: has_exact_synonym

Axiom
annotated target: A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.
database_cross_reference: GOC:bf
database_cross_reference: GOC:mah
database_cross_reference: GOC:vw
database_cross_reference: PMID:20096808
database_cross_reference: PMID:21035408
annotated source: site of double-strand break
annotated property: IAO_0000115

Axiom
annotated target: IRIF
database_cross_reference: PMID:20096808
database_cross_reference: PMID:21035408
annotated source: site of double-strand break
annotated property: has_related_synonym

Axiom
annotated target: DNA damage focus
database_cross_reference: GOC:mah
database_cross_reference: PMID:20096808
database_cross_reference: PMID:21035408
annotated source: site of double-strand break
annotated property: has_related_synonym

Axiom
annotated target: DNA damage foci
database_cross_reference: GOC:vw
annotated source: site of double-strand break
annotated property: has_related_synonym

growth
type: Class
subclass of: biological_process
id: GO:0040007
has_alternative_id: GO:0048590
comment: See also the biological process term 'cell growth ; GO:0016049'.
IAO_0000115: The increase in size or mass of an entire organism, a part of an organism or a cell.
has_obo_namespace: biological_process
has_related_synonym: growth pattern
has_related_synonym: non-developmental growth
IAO_0000412: go.owl
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim plant
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:bf
database_cross_reference: GOC:ma
annotated target: The increase in size or mass of an entire organism, a part of an organism or a cell.
annotated source: growth
annotated property: IAO_0000115

Axiom
database_cross_reference: GOC:mah
annotated target: non-developmental growth
annotated source: growth
annotated property: has_related_synonym

locomotion
type: Class
subclass of: biological_process
id: GO:0040011
IAO_0000115: Self-propelled movement of a cell or organism from one location to another.
has_obo_namespace: biological_process
IAO_0000412: go.owl
in_subset: goslim generic
in_subset: goslim pir
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:dgh
annotated target: Self-propelled movement of a cell or organism from one location to another.
annotated source: locomotion
annotated property: IAO_0000115

regulation of protein import into nucleus
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: regulates
    some values from: protein import into nucleus
subclass of: regulation of intracellular protein transport
subclass of: regulation of nucleocytoplasmic transport
subclass of: regulation of protein localization to nucleus
subclass of: Restriction
  on property: regulates
  some values from: protein import into nucleus
IAO_0000115: Any process that modulates the frequency, rate or extent of movement of proteins from the cytoplasm to the nucleus.
id: GO:0042306
has_obo_namespace: biological_process
has_exact_synonym: regulation of protein import into cell nucleus
has_exact_synonym: regulation of protein transport from cytoplasm to nucleus
has_exact_synonym: regulation of protein-nucleus import
IAO_0000412: go.owl

Axiom
annotated target: Any process that modulates the frequency, rate or extent of movement of proteins from the cytoplasm to the nucleus.
database_cross_reference: GOC:jl
annotated source: regulation of protein import into nucleus
annotated property: IAO_0000115

positive regulation of protein import into nucleus
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: positively_regulates
    some values from: protein import into nucleus
subclass of: regulation of protein import into nucleus
subclass of: positive regulation of nucleocytoplasmic transport
subclass of: positive regulation of intracellular protein transport
subclass of: Restriction
  on property: positively_regulates
  some values from: protein import into nucleus
IAO_0000115: Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus.
id: GO:0042307
has_narrow_synonym: activation of protein import into nucleus
has_obo_namespace: biological_process
has_exact_synonym: positive regulation of protein import into cell nucleus
has_exact_synonym: positive regulation of protein transport from cytoplasm to nucleus
has_exact_synonym: positive regulation of protein-nucleus import
has_narrow_synonym: stimulation of protein import into nucleus
has_exact_synonym: up regulation of protein import into nucleus
has_exact_synonym: up-regulation of protein import into nucleus
has_exact_synonym: upregulation of protein import into nucleus
IAO_0000412: go.owl

Axiom
annotated target: Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus.
database_cross_reference: GOC:jl
annotated source: positive regulation of protein import into nucleus
annotated property: IAO_0000115

negative regulation of protein import into nucleus
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: negatively_regulates
    some values from: protein import into nucleus
subclass of: regulation of protein import into nucleus
subclass of: negative regulation of nucleocytoplasmic transport
subclass of: negative regulation of intracellular protein transport
subclass of: Restriction
  on property: negatively_regulates
  some values from: protein import into nucleus
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus.
id: GO:0042308
has_obo_namespace: biological_process
has_exact_synonym: down regulation of protein import into nucleus
has_exact_synonym: down-regulation of protein import into nucleus
has_exact_synonym: downregulation of protein import into nucleus
has_narrow_synonym: inhibition of protein import into nucleus
has_exact_synonym: negative regulation of protein import into cell nucleus
has_exact_synonym: negative regulation of protein transport from cytoplasm to nucleus
has_exact_synonym: negative regulation of protein-nucleus import
IAO_0000412: go.owl

Axiom
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus.
database_cross_reference: GOC:jl
annotated source: negative regulation of protein import into nucleus
annotated property: IAO_0000115

regulation of NF-kappaB import into nucleus
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: regulates
    some values from: NF-kappaB import into nucleus
subclass of: regulation of transcription factor import into nucleus
subclass of: regulation of I-kappaB kinase/NF-kappaB cascade
subclass of: Restriction
  on property: regulates
  some values from: NF-kappaB import into nucleus
IAO_0000115: Any process that modulates the frequency, rate or extent of the transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane.
id: GO:0042345
has_obo_namespace: biological_process
has_exact_synonym: regulation of NF-kappaB import into cell nucleus
has_exact_synonym: regulation of NF-kappaB transport from cytoplasm to nucleus
has_exact_synonym: regulation of NF-kappaB-nucleus import
IAO_0000412: go.owl

Axiom
annotated target: Any process that modulates the frequency, rate or extent of the transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane.
database_cross_reference: GOC:jl
database_cross_reference: ISBN:0198506732
annotated source: regulation of NF-kappaB import into nucleus
annotated property: IAO_0000115

positive regulation of NF-kappaB import into nucleus
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: positively_regulates
    some values from: NF-kappaB import into nucleus
subclass of: regulation of NF-kappaB import into nucleus
subclass of: positive regulation of transcription factor import into nucleus
subclass of: Restriction
  on property: positively_regulates
  some values from: NF-kappaB import into nucleus
IAO_0000115: Any process that activates or increases the frequency, rate or extent of transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane.
id: GO:0042346
has_narrow_synonym: activation of NF-kappaB import into nucleus
has_obo_namespace: biological_process
has_exact_synonym: positive regulation of NF-kappaB import into cell nucleus
has_exact_synonym: positive regulation of NF-kappaB transport from cytoplasm to nucleus
has_exact_synonym: positive regulation of NF-kappaB-nucleus import
has_narrow_synonym: stimulation of NF-kappaB import into nucleus
has_exact_synonym: up regulation of NF-kappaB import into nucleus
has_exact_synonym: up-regulation of NF-kappaB import into nucleus
has_exact_synonym: upregulation of NF-kappaB import into nucleus
IAO_0000412: go.owl

Axiom
annotated target: Any process that activates or increases the frequency, rate or extent of transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane.
database_cross_reference: GOC:jl
database_cross_reference: ISBN:0198506732
annotated source: positive regulation of NF-kappaB import into nucleus
annotated property: IAO_0000115

negative regulation of NF-kappaB import into nucleus
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: negatively_regulates
    some values from: NF-kappaB import into nucleus
subclass of: regulation of NF-kappaB import into nucleus
subclass of: negative regulation of transcription factor import into nucleus
subclass of: Restriction
  on property: negatively_regulates
  some values from: NF-kappaB import into nucleus
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate or extent of the transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane.
id: GO:0042347
has_obo_namespace: biological_process
has_exact_synonym: down regulation of NF-kappaB import into nucleus
has_exact_synonym: down-regulation of NF-kappaB import into nucleus
has_exact_synonym: downregulation of NF-kappaB import into nucleus
has_narrow_synonym: inhibition of NF-kappaB import into nucleus
has_exact_synonym: negative regulation of NF-kappaB import into cell nucleus
has_exact_synonym: negative regulation of NF-kappaB transport from cytoplasm to nucleus
has_exact_synonym: negative regulation of NF-kappaB-nucleus import
IAO_0000412: go.owl

Axiom
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of the transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane.
database_cross_reference: GOC:jl
database_cross_reference: ISBN:0198506732
annotated source: negative regulation of NF-kappaB import into nucleus
annotated property: IAO_0000115

NF-kappaB import into nucleus
type: Class
subclass of: transcription factor import into nucleus
subclass of: Restriction
  on property: part_of
  some values from: I-kappaB kinase/NF-kappaB cascade
id: GO:0042348
has_exact_synonym: NF-KB import into nucleus
has_exact_synonym: NF-kappaB import into cell nucleus
has_exact_synonym: NF-kappaB protein-nucleus import
has_exact_synonym: NF-kappaB transport from cytoplasm to nucleus
has_exact_synonym: NF-kappaB-nucleus import
IAO_0000115: The directed movement of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane.
has_obo_namespace: biological_process
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:bf
annotated target: NF-KB import into nucleus
annotated source: NF-kappaB import into nucleus
annotated property: has_exact_synonym

Axiom
database_cross_reference: GOC:jl
database_cross_reference: ISBN:0198506732
annotated target: The directed movement of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane.
annotated source: NF-kappaB import into nucleus
annotated property: IAO_0000115

actomyosin
type: Class
subclass of: cytoskeletal part
subclass of: Restriction
  on property: part_of
  some values from: actin cytoskeleton
IAO_0000115: Any complex of actin, myosin, and accessory proteins.
id: GO:0042641
has_exact_synonym: actomyosin complex
has_exact_synonym: actomyosin structure
has_obo_namespace: cellular_component
IAO_0000412: go.owl

Axiom
annotated target: Any complex of actin, myosin, and accessory proteins.
database_cross_reference: GOC:go_curators
annotated source: actomyosin
annotated property: IAO_0000115

monopolar cell growth
type: Class
subclass of: unidimensional cell growth
id: GO:0042814
IAO_0000115: Polarized growth from one end of a cell.
has_obo_namespace: biological_process
has_narrow_synonym: monopolar cell elongation
has_broad_synonym: monopolar growth
has_narrow_synonym: polar cell elongation
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:vw
annotated target: Polarized growth from one end of a cell.
annotated source: monopolar cell growth
annotated property: IAO_0000115

regulation of transcription factor import into nucleus
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: regulates
    some values from: transcription factor import into nucleus
subclass of: regulation of protein import into nucleus
subclass of: Restriction
  on property: regulates
  some values from: transcription factor import into nucleus
IAO_0000115: Any process that modulates the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus.
id: GO:0042990
has_obo_namespace: biological_process
has_exact_synonym: regulation of transcription factor import into cell nucleus
has_exact_synonym: regulation of transcription factor transport from cytoplasm to nucleus
has_exact_synonym: regulation of transcription factor-nucleus import
IAO_0000412: go.owl

Axiom
annotated target: Any process that modulates the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus.
database_cross_reference: GOC:jl
annotated source: regulation of transcription factor import into nucleus
annotated property: IAO_0000115

transcription factor import into nucleus
type: Class
subclass of: protein import into nucleus
id: GO:0042991
IAO_0000115: The directed movement of a transcription factor from the cytoplasm to the nucleus.
has_obo_namespace: biological_process
has_exact_synonym: transcription factor import into cell nucleus
has_exact_synonym: transcription factor transport from cytoplasm to nucleus
has_exact_synonym: transcription factor-nucleus import
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:jl
annotated target: The directed movement of a transcription factor from the cytoplasm to the nucleus.
annotated source: transcription factor import into nucleus
annotated property: IAO_0000115

negative regulation of transcription factor import into nucleus
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: negatively_regulates
    some values from: transcription factor import into nucleus
subclass of: negative regulation of protein import into nucleus
subclass of: regulation of transcription factor import into nucleus
subclass of: Restriction
  on property: negatively_regulates
  some values from: transcription factor import into nucleus
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus.
id: GO:0042992
has_obo_namespace: biological_process
has_exact_synonym: down regulation of transcription factor import into nucleus
has_exact_synonym: down-regulation of transcription factor import into nucleus
has_exact_synonym: downregulation of transcription factor import into nucleus
has_narrow_synonym: inhibition of transcription factor import into nucleus
has_exact_synonym: negative regulation of transcription factor import into cell nucleus
has_exact_synonym: negative regulation of transcription factor transport from cytoplasm to nucleus
has_exact_synonym: negative regulation of transcription factor-nucleus import
IAO_0000412: go.owl

Axiom
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus.
database_cross_reference: GOC:jl
annotated source: negative regulation of transcription factor import into nucleus
annotated property: IAO_0000115

positive regulation of transcription factor import into nucleus
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: positively_regulates
    some values from: transcription factor import into nucleus
subclass of: positive regulation of protein import into nucleus
subclass of: regulation of transcription factor import into nucleus
subclass of: Restriction
  on property: positively_regulates
  some values from: transcription factor import into nucleus
IAO_0000115: Any process that activates or increases the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus.
id: GO:0042993
has_narrow_synonym: activation of transcription factor import into nucleus
has_obo_namespace: biological_process
has_exact_synonym: positive regulation of transcription factor import into cell nucleus
has_exact_synonym: positive regulation of transcription factor transport from cytoplasm to nucleus
has_exact_synonym: positive regulation of transcription factor-nucleus import
has_narrow_synonym: stimulation of transcription factor import into nucleus
has_exact_synonym: up regulation of transcription factor import into nucleus
has_exact_synonym: up-regulation of transcription factor import into nucleus
has_exact_synonym: upregulation of transcription factor import into nucleus
IAO_0000412: go.owl

Axiom
annotated target: Any process that activates or increases the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus.
database_cross_reference: GOC:jl
annotated source: positive regulation of transcription factor import into nucleus
annotated property: IAO_0000115

cytoplasmic sequestering of transcription factor
type: Class
subclass of: negative regulation of transcription factor import into nucleus
subclass of: cytoplasmic sequestering of protein
id: GO:0042994
IAO_0000115: The selective interaction of a transcription factor with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus.
has_obo_namespace: biological_process
has_exact_synonym: cytoplasmic retention of transcription factor
has_exact_synonym: cytoplasmic sequestration of transcription factor
has_exact_synonym: cytoplasmic storage of transcription factor
has_exact_synonym: maintenance of transcription factor protein location in cytoplasm
has_exact_synonym: retention of transcription factor in cytoplasm
has_exact_synonym: sequestering of transcription factor in cytoplasm
has_exact_synonym: sequestration of transcription factor in cytoplasm
has_exact_synonym: storage of transcription factor in cytoplasm
has_exact_synonym: transcription factor binding, cytoplasmic sequestering
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb
annotated target: maintenance of transcription factor protein location in cytoplasm
annotated source: cytoplasmic sequestering of transcription factor
annotated property: has_exact_synonym

Axiom
database_cross_reference: GOC:jl
annotated target: The selective interaction of a transcription factor with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus.
annotated source: cytoplasmic sequestering of transcription factor
annotated property: IAO_0000115

cell projection
type: Class
subclass of: cell projection part
IAO_0000115: A prolongation or process extending from a cell, e.g. a flagellum or axon.
id: GO:0042995
has_broad_synonym: cell process
has_broad_synonym: cellular process
has_exact_synonym: cellular projection
has_obo_namespace: cellular_component
IAO_0000412: go.owl
in_subset: goslim pir
in_subset: gosubset prok

Axiom
annotated target: A prolongation or process extending from a cell, e.g. a flagellum or axon.
database_cross_reference: GOC:jl
database_cross_reference: http://www.cogsci.princeton.edu/~wn/
annotated source: cell projection
annotated property: IAO_0000115

neuron projection
type: Class
subclass of: cell projection
subclass of: neuron part
IAO_0000115: A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
id: GO:0043005
database_cross_reference: NIF_Subcellular:sao-867568886
has_obo_namespace: cellular_component
has_narrow_synonym: neurite
has_exact_synonym: neuron process
has_exact_synonym: neuron protrusion
has_exact_synonym: neuronal cell projection
IAO_0000412: go.owl
in_subset: goslim pir

Axiom
annotated target: A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
database_cross_reference: GOC:jl
database_cross_reference: http://www.cogsci.princeton.edu/~wn/
annotated source: neuron projection
annotated property: IAO_0000115

regulation of I-kappaB kinase/NF-kappaB cascade
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: regulates
    some values from: I-kappaB kinase/NF-kappaB cascade
subclass of: regulation of intracellular protein kinase cascade
subclass of: Restriction
  on property: regulates
  some values from: I-kappaB kinase/NF-kappaB cascade
IAO_0000115: Any process that modulates an I-kappaB kinase/NF-kappaB induced cascade.
id: GO:0043122
has_obo_namespace: biological_process
IAO_0000412: go.owl

Axiom
annotated target: Any process that modulates an I-kappaB kinase/NF-kappaB induced cascade.
database_cross_reference: GOC:jl
database_cross_reference: PMID:12773372
annotated source: regulation of I-kappaB kinase/NF-kappaB cascade
annotated property: IAO_0000115

negative regulation of I-kappaB kinase/NF-kappaB cascade
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: negatively_regulates
    some values from: I-kappaB kinase/NF-kappaB cascade
subclass of: negative regulation of intracellular protein kinase cascade
subclass of: regulation of I-kappaB kinase/NF-kappaB cascade
subclass of: Restriction
  on property: negatively_regulates
  some values from: I-kappaB kinase/NF-kappaB cascade
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate or extent of an I-kappaB kinase/NF-kappaB induced cascade.
id: GO:0043124
has_obo_namespace: biological_process
has_exact_synonym: down regulation of I-kappaB kinase/NF-kappaB cascade
has_exact_synonym: down-regulation of I-kappaB kinase/NF-kappaB cascade
has_exact_synonym: downregulation of I-kappaB kinase/NF-kappaB cascade
has_narrow_synonym: inhibition of I-kappaB kinase/NF-kappaB cascade
IAO_0000412: go.owl

Axiom
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of an I-kappaB kinase/NF-kappaB induced cascade.
database_cross_reference: GOC:jl
annotated source: negative regulation of I-kappaB kinase/NF-kappaB cascade
annotated property: IAO_0000115

macromolecule metabolic process
type: Class
subclass of: organic substance metabolic process
id: GO:0043170
has_alternative_id: GO:0043283
IAO_0000115: The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
has_obo_namespace: biological_process
has_exact_synonym: biopolymer metabolic process
has_exact_synonym: macromolecule metabolism
IAO_0000412: go.owl
in_subset: goslim pir
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:mtg_chebi_dec09
annotated target: biopolymer metabolic process
annotated source: macromolecule metabolic process
annotated property: has_exact_synonym

Axiom
database_cross_reference: CHEBI:33694
database_cross_reference: GOC:mah
annotated target: The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
annotated source: macromolecule metabolic process
annotated property: IAO_0000115

organelle
type: Class
subclass of: organelle part
id: GO:0043226
database_cross_reference: NIF_Subcellular:sao1539965131
IAO_0000115: Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.
database_cross_reference: Wikipedia:Organelle
has_obo_namespace: cellular_component
IAO_0000412: go.owl
in_subset: goslim generic
in_subset: goslim pir
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:go_curators
annotated target: Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.
annotated source: organelle
annotated property: IAO_0000115

membrane-bounded organelle
type: Class
subclass of: organelle
id: GO:0043227
database_cross_reference: NIF_Subcellular:sao414196390
IAO_0000115: Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
has_obo_namespace: cellular_component
has_exact_synonym: membrane-enclosed organelle
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:go_curators
annotated target: Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
annotated source: membrane-bounded organelle
annotated property: IAO_0000115

non-membrane-bounded organelle
type: Class
subclass of: organelle
id: GO:0043228
database_cross_reference: NIF_Subcellular:sao1456184038
IAO_0000115: Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes.
has_obo_namespace: cellular_component
has_exact_synonym: non-membrane-enclosed organelle
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:go_curators
annotated target: Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes.
annotated source: non-membrane-bounded organelle
annotated property: IAO_0000115

intracellular organelle
type: Class
subclass of: organelle
subclass of: intracellular part
id: GO:0043229
IAO_0000115: Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
has_obo_namespace: cellular_component
IAO_0000412: go.owl
in_subset: goslim pir
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:go_curators
annotated target: Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
annotated source: intracellular organelle
annotated property: IAO_0000115

intracellular membrane-bounded organelle
type: Class
subclass of: membrane-bounded organelle
subclass of: intracellular organelle
id: GO:0043231
IAO_0000115: Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
has_obo_namespace: cellular_component
has_exact_synonym: intracellular membrane-enclosed organelle
IAO_0000412: go.owl
in_subset: goslim pir
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:go_curators
annotated target: Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
annotated source: intracellular membrane-bounded organelle
annotated property: IAO_0000115

intracellular non-membrane-bounded organelle
type: Class
subclass of: non-membrane-bounded organelle
subclass of: intracellular organelle
id: GO:0043232
IAO_0000115: Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.
has_obo_namespace: cellular_component
has_exact_synonym: intracellular non-membrane-enclosed organelle
IAO_0000412: go.owl
in_subset: goslim pir
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:go_curators
annotated target: Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.
annotated source: intracellular non-membrane-bounded organelle
annotated property: IAO_0000115

organelle lumen
type: Class
subclass of: membrane-enclosed lumen
subclass of: organelle part
id: GO:0043233
IAO_0000115: The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen.
has_obo_namespace: cellular_component
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah
annotated target: The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen.
annotated source: organelle lumen
annotated property: IAO_0000115

protein complex
type: Class
subclass of: macromolecular complex
IAO_0000115: Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules.
id: GO:0043234
database_cross_reference: Wikipedia:Protein_complex
has_obo_namespace: cellular_component
has_exact_synonym: protein-protein complex
IAO_0000412: go.owl
in_subset: goslim generic
in_subset: goslim pir
in_subset: gosubset prok

Axiom
annotated target: Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules.
database_cross_reference: GOC:go_curators
annotated source: protein complex
annotated property: IAO_0000115

negative regulation of sequence-specific DNA binding transcription factor activity
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: negatively_regulates
    some values from: sequence-specific DNA binding transcription factor activity
subclass of: negative regulation of molecular function
subclass of: regulation of sequence-specific DNA binding transcription factor activity
subclass of: Restriction
  on property: negatively_regulates
  some values from: sequence-specific DNA binding transcription factor activity
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
id: GO:0043433
has_obo_namespace: biological_process
has_exact_synonym: down regulation of transcription factor activity
has_exact_synonym: down-regulation of transcription factor activity
has_exact_synonym: downregulation of transcription factor activity
has_narrow_synonym: inhibition of transcription factor activity
has_broad_synonym: negative regulation of transcription factor activity
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb
annotated target: negative regulation of transcription factor activity
annotated source: negative regulation of sequence-specific DNA binding transcription factor activity
annotated property: has_broad_synonym

Axiom
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
database_cross_reference: GOC:jl
annotated source: negative regulation of sequence-specific DNA binding transcription factor activity
annotated property: IAO_0000115

sequence-specific DNA binding
type: Class
subclass of: DNA binding
id: GO:0043565
IAO_0000115: Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
has_obo_namespace: molecular_function
has_exact_synonym: sequence specific DNA binding
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:jl
annotated target: Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
annotated source: sequence-specific DNA binding
annotated property: IAO_0000115

cellular component biogenesis
type: Class
subclass of: cellular component organization or biogenesis
IAO_0000115: A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component.
id: GO:0044085
has_alternative_id: GO:0071843
has_obo_namespace: biological_process
has_exact_synonym: cellular component biogenesis at cellular level
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
annotated target: A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component.
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah
annotated source: cellular component biogenesis
annotated property: IAO_0000115

negative regulation of molecular function
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: negatively_regulates
    some values from: molecular_function
subclass of: regulation of molecular function
subclass of: Restriction
  on property: negatively_regulates
  some values from: molecular_function
creation date: 2009-04-21T04:07:27Z
IAO_0000115: Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.
id: GO:0044092
has_obo_namespace: biological_process
created by: jane
IAO_0000412: go.owl

Axiom
annotated target: Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.
database_cross_reference: GO:jl
annotated source: negative regulation of molecular function
annotated property: IAO_0000115

positive regulation of molecular function
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: positively_regulates
    some values from: molecular_function
subclass of: regulation of molecular function
subclass of: Restriction
  on property: positively_regulates
  some values from: molecular_function
creation date: 2009-04-21T04:11:06Z
IAO_0000115: Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.
id: GO:0044093
has_obo_namespace: biological_process
created by: jane
IAO_0000412: go.owl

Axiom
annotated target: Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.
database_cross_reference: GO:jl
annotated source: positive regulation of molecular function
annotated property: IAO_0000115

transcription regulatory region DNA binding
type: Class
subclass of: regulatory region DNA binding
creation date: 2009-11-04T12:58:25Z
id: GO:0044212
IAO_0000115: Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
comment: The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding".
created by: jane
has_obo_namespace: molecular_function
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:jl
database_cross_reference: GOC:txnOH
annotated target: Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
database_cross_reference: SO:0005836
annotated source: transcription regulatory region DNA binding
annotated property: IAO_0000115

cellular metabolic process
type: Class
subclass of: metabolic process
subclass of: cellular process
id: GO:0044237
IAO_0000115: The chemical reactions and pathways by which individual cells transform chemical substances.
has_obo_namespace: biological_process
has_exact_synonym: cellular metabolism
has_related_synonym: intermediary metabolism
IAO_0000412: go.owl
in_subset: goslim pir
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:go_curators
annotated target: The chemical reactions and pathways by which individual cells transform chemical substances.
annotated source: cellular metabolic process
annotated property: IAO_0000115

Axiom
database_cross_reference: GOC:mah
annotated target: intermediary metabolism
annotated source: cellular metabolic process
annotated property: has_related_synonym

primary metabolic process
type: Class
subclass of: metabolic process
id: GO:0044238
IAO_0000115: The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
has_obo_namespace: biological_process
has_exact_synonym: primary metabolism
IAO_0000412: go.owl
in_subset: goslim pir
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:go_curators
annotated target: The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
database_cross_reference: http://www.metacyc.org
annotated source: primary metabolic process
annotated property: IAO_0000115

cellular catabolic process
type: Class
subclass of: catabolic process
subclass of: cellular metabolic process
id: GO:0044248
IAO_0000115: The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.
has_obo_namespace: biological_process
has_exact_synonym: cellular breakdown
has_exact_synonym: cellular catabolism
has_exact_synonym: cellular degradation
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:jl
annotated target: The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.
annotated source: cellular catabolic process
annotated property: IAO_0000115

cellular biosynthetic process
type: Class
subclass of: biosynthetic process
subclass of: cellular metabolic process
id: GO:0044249
IAO_0000115: The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.
has_obo_namespace: biological_process
has_exact_synonym: cellular anabolism
has_exact_synonym: cellular biosynthesis
has_exact_synonym: cellular formation
has_exact_synonym: cellular synthesis
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:jl
annotated target: The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.
annotated source: cellular biosynthetic process
annotated property: IAO_0000115

cellular macromolecule metabolic process
type: Class
subclass of: macromolecule metabolic process
subclass of: cellular metabolic process
has_alternative_id: GO:0034960
id: GO:0044260
IAO_0000115: The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells.
has_obo_namespace: biological_process
has_exact_synonym: cellular biopolymer metabolic process
has_exact_synonym: cellular macromolecule metabolism
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
database_cross_reference: CHEBI:33694
database_cross_reference: GOC:mah
annotated target: The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells.
annotated source: cellular macromolecule metabolic process
annotated property: IAO_0000115

Axiom
database_cross_reference: GOC:mtg_chebi_dec09
annotated target: cellular biopolymer metabolic process
annotated source: cellular macromolecule metabolic process
annotated property: has_exact_synonym

cellular macromolecule catabolic process
type: Class
subclass of: macromolecule catabolic process
subclass of: cellular catabolic process
subclass of: cellular macromolecule metabolic process
has_alternative_id: GO:0034962
id: GO:0044265
IAO_0000115: The chemical reactions and pathways resulting in the breakdown of a macromolecule, any large molecule including proteins, nucleic acids and carbohydrates, as carried out by individual cells.
has_obo_namespace: biological_process
has_exact_synonym: cellular biopolymer catabolic process
has_exact_synonym: cellular macromolecule breakdown
has_exact_synonym: cellular macromolecule catabolism
has_exact_synonym: cellular macromolecule degradation
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:mtg_chebi_dec09
annotated target: cellular biopolymer catabolic process
annotated source: cellular macromolecule catabolic process
annotated property: has_exact_synonym

Axiom
database_cross_reference: CHEBI:33694
database_cross_reference: GOC:jl
annotated target: The chemical reactions and pathways resulting in the breakdown of a macromolecule, any large molecule including proteins, nucleic acids and carbohydrates, as carried out by individual cells.
annotated source: cellular macromolecule catabolic process
annotated property: IAO_0000115

cellular nitrogen compound catabolic process
type: Class
subclass of: cellular nitrogen compound metabolic process
subclass of: cellular catabolic process
id: GO:0044270
IAO_0000115: The chemical reactions and pathways resulting in the breakdown of organic and inorganic nitrogenous compounds.
has_obo_namespace: biological_process
has_broad_synonym: nitrogen compound breakdown
has_broad_synonym: nitrogen compound catabolism
has_broad_synonym: nitrogen compound degradation
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:jl
database_cross_reference: ISBN:0198506732
annotated target: The chemical reactions and pathways resulting in the breakdown of organic and inorganic nitrogenous compounds.
annotated source: cellular nitrogen compound catabolic process
annotated property: IAO_0000115

cellular nitrogen compound biosynthetic process
type: Class
subclass of: cellular nitrogen compound metabolic process
subclass of: cellular biosynthetic process
id: GO:0044271
IAO_0000115: The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds.
has_obo_namespace: biological_process
has_broad_synonym: nitrogen compound anabolism
has_broad_synonym: nitrogen compound biosynthesis
has_broad_synonym: nitrogen compound formation
has_broad_synonym: nitrogen compound synthesis
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:jl
database_cross_reference: ISBN:0198506732
annotated target: The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds.
annotated source: cellular nitrogen compound biosynthetic process
annotated property: IAO_0000115

dendritic branch
type: Class
subclass of: cell projection part
subclass of: neuron part
subclass of: Restriction
  on property: part_of
  some values from: dendrite
creation date: 2010-02-05T04:18:53Z
IAO_0000115: A dendrite arising from another dendrite.
id: GO:0044307
database_cross_reference: NIF_Subcellular:sao884265541
has_obo_namespace: cellular_component
has_exact_synonym: dendrite branch
created by: jane
IAO_0000412: go.owl

Axiom
annotated target: A dendrite arising from another dendrite.
database_cross_reference: NIF_Subcellular:sao884265541
annotated source: dendritic branch
annotated property: IAO_0000115

organelle part
type: Class
equivalent class: Class
  intersection of: cellular_component
  intersection of: Restriction
    on property: part_of
    some values from: organelle
subclass of: cellular_component
subclass of: Restriction
  on property: part_of
  some values from: organelle
IAO_0000115: Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.
id: GO:0044422
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
has_obo_namespace: cellular_component
IAO_0000412: go.owl
in_subset: gocheck do not annotate
in_subset: gosubset prok

Axiom
annotated target: Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.
database_cross_reference: GOC:jl
annotated source: organelle part
annotated property: IAO_0000115

intracellular part
type: Class
equivalent class: Class
  intersection of: cellular_component
  intersection of: Restriction
    on property: part_of
    some values from: intracellular
subclass of: cell part
subclass of: Restriction
  on property: part_of
  some values from: intracellular
IAO_0000115: Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
id: GO:0044424
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
has_obo_namespace: cellular_component
IAO_0000412: go.owl
in_subset: gocheck do not annotate
in_subset: gosubset prok

Axiom
annotated target: Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
database_cross_reference: GOC:jl
annotated source: intracellular part
annotated property: IAO_0000115

chromosomal part
type: Class
equivalent class: Class
  intersection of: cellular_component
  intersection of: Restriction
    on property: part_of
    some values from: chromosome
subclass of: intracellular organelle part
subclass of: Restriction
  on property: part_of
  some values from: chromosome
IAO_0000115: Any constituent part of a chromosome, a structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
id: GO:0044427
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
has_obo_namespace: cellular_component
has_exact_synonym: chromosomal component
has_exact_synonym: chromosome component
has_exact_synonym: chromosome part
IAO_0000412: go.owl
in_subset: gocheck do not annotate
in_subset: gosubset prok

Axiom
annotated target: Any constituent part of a chromosome, a structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
database_cross_reference: GOC:jl
annotated source: chromosomal part
annotated property: IAO_0000115

nuclear part
type: Class
equivalent class: Class
  intersection of: cellular_component
  intersection of: Restriction
    on property: part_of
    some values from: nucleus
subclass of: intracellular organelle part
subclass of: Restriction
  on property: part_of
  some values from: nucleus
IAO_0000115: Any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated.
id: GO:0044428
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
has_obo_namespace: cellular_component
has_exact_synonym: nucleus component
IAO_0000412: go.owl
in_subset: gocheck do not annotate

Axiom
annotated target: Any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated.
database_cross_reference: GOC:jl
annotated source: nuclear part
annotated property: IAO_0000115

mitochondrial part
type: Class
equivalent class: Class
  intersection of: cellular_component
  intersection of: Restriction
    on property: part_of
    some values from: mitochondrion
subclass of: cytoplasmic part
subclass of: intracellular organelle part
subclass of: Restriction
  on property: part_of
  some values from: mitochondrion
IAO_0000115: Any constituent part of a mitochondrion, a semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
id: GO:0044429
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
has_obo_namespace: cellular_component
has_exact_synonym: mitochondrion component
IAO_0000412: go.owl
in_subset: gocheck do not annotate

Axiom
annotated target: Any constituent part of a mitochondrion, a semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
database_cross_reference: GOC:jl
annotated source: mitochondrial part
annotated property: IAO_0000115

cytoskeletal part
type: Class
equivalent class: Class
  intersection of: cellular_component
  intersection of: Restriction
    on property: part_of
    some values from: cytoskeleton
subclass of: intracellular organelle part
subclass of: Restriction
  on property: part_of
  some values from: cytoskeleton
IAO_0000115: Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice.
id: GO:0044430
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
has_obo_namespace: cellular_component
has_exact_synonym: cytoskeleton component
IAO_0000412: go.owl
in_subset: gocheck do not annotate

Axiom
annotated target: Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice.
database_cross_reference: GOC:jl
annotated source: cytoskeletal part
annotated property: IAO_0000115

Golgi apparatus part
type: Class
equivalent class: Class
  intersection of: cellular_component
  intersection of: Restriction
    on property: part_of
    some values from: Golgi apparatus
subclass of: cytoplasmic part
subclass of: intracellular organelle part
subclass of: Restriction
  on property: part_of
  some values from: Golgi apparatus
IAO_0000115: Any constituent part of the Golgi apparatus, a compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack.
id: GO:0044431
has_exact_synonym: Golgi component
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
has_obo_namespace: cellular_component
IAO_0000412: go.owl
in_subset: gocheck do not annotate

Axiom
annotated target: Any constituent part of the Golgi apparatus, a compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack.
database_cross_reference: GOC:jl
annotated source: Golgi apparatus part
annotated property: IAO_0000115

endoplasmic reticulum part
type: Class
equivalent class: Class
  intersection of: cellular_component
  intersection of: Restriction
    on property: part_of
    some values from: endoplasmic reticulum
subclass of: cytoplasmic part
subclass of: intracellular organelle part
subclass of: Restriction
  on property: part_of
  some values from: endoplasmic reticulum
IAO_0000115: Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae.
has_exact_synonym: ER component
id: GO:0044432
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
has_obo_namespace: cellular_component
IAO_0000412: go.owl
in_subset: gocheck do not annotate

Axiom
annotated target: Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae.
database_cross_reference: GOC:jl
annotated source: endoplasmic reticulum part
annotated property: IAO_0000115

cilium part
type: Class
equivalent class: Class
  intersection of: cellular_component
  intersection of: Restriction
    on property: part_of
    some values from: cilium
subclass of: intracellular organelle part
subclass of: cell projection part
subclass of: Restriction
  on property: part_of
  some values from: motile cilium
subclass of: Restriction
  on property: part_of
  some values from: cilium
IAO_0000115: Any constituent part of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
id: GO:0044441
has_alternative_id: GO:0044442
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. Also note that cilia and eukaryotic flagella are deemed to be equivalent.
has_obo_namespace: cellular_component
has_narrow_synonym: flagellar part
has_narrow_synonym: flagellum component
has_narrow_synonym: flagellum part
has_exact_synonym: microtubule-based flagellum part
IAO_0000412: go.owl
in_subset: gocheck do not annotate

Axiom
annotated target: Any constituent part of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
database_cross_reference: GOC:jl
annotated source: cilium part
annotated property: IAO_0000115

cytoplasmic part
type: Class
equivalent class: Class
  intersection of: cellular_component
  intersection of: Restriction
    on property: part_of
    some values from: cytoplasm
subclass of: intracellular part
subclass of: Restriction
  on property: part_of
  some values from: cytoplasm
IAO_0000115: Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
id: GO:0044444
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
has_obo_namespace: cellular_component
has_exact_synonym: cytoplasm component
IAO_0000412: go.owl
in_subset: gocheck do not annotate
in_subset: gosubset prok

Axiom
annotated target: Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
database_cross_reference: GOC:jl
annotated source: cytoplasmic part
annotated property: IAO_0000115

intracellular organelle part
type: Class
subclass of: organelle part
subclass of: intracellular part
subclass of: Restriction
  on property: part_of
  some values from: intracellular organelle
IAO_0000115: A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.
id: GO:0044446
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
has_obo_namespace: cellular_component
IAO_0000412: go.owl
in_subset: gocheck do not annotate
in_subset: gosubset prok

Axiom
annotated target: A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.
database_cross_reference: GOC:jl
annotated source: intracellular organelle part
annotated property: IAO_0000115

cell cortex part
type: Class
equivalent class: Class
  intersection of: cellular_component
  intersection of: Restriction
    on property: part_of
    some values from: cell cortex
subclass of: cytoplasmic part
subclass of: Restriction
  on property: part_of
  some values from: cell cortex
IAO_0000115: Any constituent part of the cell cortex, the region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
id: GO:0044448
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
has_obo_namespace: cellular_component
IAO_0000412: go.owl
in_subset: gocheck do not annotate

Axiom
annotated target: Any constituent part of the cell cortex, the region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
database_cross_reference: GOC:jl
annotated source: cell cortex part
annotated property: IAO_0000115

nucleoplasm part
type: Class
equivalent class: Class
  intersection of: cellular_component
  intersection of: Restriction
    on property: part_of
    some values from: nucleoplasm
subclass of: nuclear part
subclass of: Restriction
  on property: part_of
  some values from: nucleoplasm
IAO_0000115: Any constituent part of the nucleoplasm, that part of the nuclear content other than the chromosomes or the nucleolus.
id: GO:0044451
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
has_obo_namespace: cellular_component
IAO_0000412: go.owl
in_subset: gocheck do not annotate

Axiom
annotated target: Any constituent part of the nucleoplasm, that part of the nuclear content other than the chromosomes or the nucleolus.
database_cross_reference: GOC:jl
annotated source: nucleoplasm part
annotated property: IAO_0000115

cell projection part
type: Class
equivalent class: Class
  intersection of: cellular_component
  intersection of: Restriction
    on property: part_of
    some values from: cell projection
subclass of: cell part
subclass of: Restriction
  on property: part_of
  some values from: cell projection
IAO_0000115: Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon.
id: GO:0044463
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
has_obo_namespace: cellular_component
IAO_0000412: go.owl
in_subset: gocheck do not annotate
in_subset: gosubset prok

Axiom
annotated target: Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon.
database_cross_reference: GOC:jl
annotated source: cell projection part
annotated property: IAO_0000115

cell part
type: Class
equivalent class: Class
  intersection of: cellular_component
  intersection of: Restriction
    on property: part_of
    some values from: cell
subclass of: cellular_component
subclass of: Restriction
  on property: part_of
  some values from: cell
IAO_0000115: Any constituent part of a cell, the basic structural and functional unit of all organisms.
id: GO:0044464
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
has_obo_namespace: cellular_component
has_related_synonym: protoplast
IAO_0000412: go.owl
in_subset: gocheck do not annotate
in_subset: goslim pir
in_subset: gosubset prok

Axiom
annotated target: Any constituent part of a cell, the basic structural and functional unit of all organisms.
database_cross_reference: GOC:jl
annotated source: cell part
annotated property: IAO_0000115

Axiom
database_cross_reference: GOC:mah
annotated target: protoplast
annotated source: cell part
annotated property: has_related_synonym

single-organism process
type: Class
subclass of: biological_process
creation date: 2012-09-19T15:05:24Z
IAO_0000115: A biological process that involves only one organism.
id: GO:0044699
has_obo_namespace: biological_process
created by: janelomax
has_exact_synonym: single organism process
IAO_0000412: go.owl

Axiom
annotated target: A biological process that involves only one organism.
database_cross_reference: GOC:jl
annotated source: single-organism process
annotated property: IAO_0000115

single organism signaling
type: Class
subclass of: signaling
subclass of: single-organism process
creation date: 2012-09-19T15:12:49Z
IAO_0000115: A signaling process occurring within a single organism.
id: GO:0044700
has_obo_namespace: biological_process
created by: janelomax
IAO_0000412: go.owl

Axiom
annotated target: A signaling process occurring within a single organism.
database_cross_reference: GOC:jl
annotated source: single organism signaling
annotated property: IAO_0000115

protein targeting to nucleus
type: Class
subclass of: protein targeting
creation date: 2012-11-07T15:45:54Z
id: GO:0044744
IAO_0000115: The process of directing proteins towards the nucleus, usually using signals contained within the protein.
has_obo_namespace: biological_process
created by: janelomax
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:jl
annotated target: The process of directing proteins towards the nucleus, usually using signals contained within the protein.
annotated source: protein targeting to nucleus
annotated property: IAO_0000115

single-organism cellular process
type: Class
subclass of: cellular process
subclass of: single-organism process
creation date: 2012-12-11T16:56:55Z
IAO_0000115: Any process that is carried out at the cellular level, occurring within a single organism.
id: GO:0044763
has_obo_namespace: biological_process
created by: janelomax
IAO_0000412: go.owl

Axiom
annotated target: Any process that is carried out at the cellular level, occurring within a single organism.
database_cross_reference: GOC:jl
annotated source: single-organism cellular process
annotated property: IAO_0000115

single-organism transport
type: Class
subclass of: transport
subclass of: single-organism process
creation date: 2012-12-13T16:25:32Z
id: GO:0044765
IAO_0000115: The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore, involving a single organism.
has_obo_namespace: biological_process
created by: janelomax
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:jl
annotated target: The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore, involving a single organism.
annotated source: single-organism transport
annotated property: IAO_0000115

single-organism developmental process
type: Class
subclass of: developmental process
subclass of: single-organism process
creation date: 2012-12-19T12:21:31Z
IAO_0000115: A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition, involving only one organism.
id: GO:0044767
has_obo_namespace: biological_process
created by: janelomax
IAO_0000412: go.owl

Axiom
annotated target: A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition, involving only one organism.
database_cross_reference: GOC:jl
annotated source: single-organism developmental process
annotated property: IAO_0000115

cell cycle phase transition
type: Class
subclass of: cell cycle process
creation date: 2013-02-28T12:54:59Z
id: GO:0044770
IAO_0000115: The cell cycle process by which a cell commits to entering the next cell cycle phase.
has_obo_namespace: biological_process
has_exact_synonym: cell cycle transition
created by: janelomax
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:mtg_cell_cycle
annotated target: The cell cycle process by which a cell commits to entering the next cell cycle phase.
annotated source: cell cycle phase transition
annotated property: IAO_0000115

mitotic cell cycle phase transition
type: Class
equivalent class: Class
  intersection of: cell cycle phase transition
  intersection of: Restriction
    on property: part_of
    some values from: mitotic cell cycle
subclass of: cell cycle phase transition
subclass of: Restriction
  on property: part_of
  some values from: mitotic cell cycle
creation date: 2013-02-28T13:09:33Z
id: GO:0044772
IAO_0000115: The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase.
has_obo_namespace: biological_process
created by: janelomax
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:mtg_cell_cycle
annotated target: The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase.
annotated source: mitotic cell cycle phase transition
annotated property: IAO_0000115

G0 to G1 transition
type: Class
subclass of: single-organism cellular process
id: GO:0045023
IAO_0000115: The mitotic cell cycle phase transition whose occurrence commits the cell from the G0 quiescent state to the G1 phase. Under certain conditions, cells exit the cell cycle during G1 and remain in the G0 state as nongrowing, non-dividing (quiescent) cells. Appropriate stimulation of such cells induces them to return to G1 and resume growth and division. The G0 to G1 transition is accompanied by many changes in the program of gene expression.
has_obo_namespace: biological_process
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:mtg_cell_cycle
database_cross_reference: ISBN:0716731363
annotated target: The mitotic cell cycle phase transition whose occurrence commits the cell from the G0 quiescent state to the G1 phase. Under certain conditions, cells exit the cell cycle during G1 and remain in the G0 state as nongrowing, non-dividing (quiescent) cells. Appropriate stimulation of such cells induces them to return to G1 and resume growth and division. The G0 to G1 transition is accompanied by many changes in the program of gene expression.
annotated source: G0 to G1 transition
annotated property: IAO_0000115

plasma membrane fusion
type: Class
subclass of: cellular membrane fusion
has_alternative_id: GO:0006947
id: GO:0045026
IAO_0000115: The joining of two or more lipid bilayer membranes that surround a cell.
has_obo_namespace: biological_process
has_broad_synonym: cell fusion
has_broad_synonym: cell-cell fusion
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:elh
database_cross_reference: GOC:mtg_muscle
annotated target: The joining of two or more lipid bilayer membranes that surround a cell.
annotated source: plasma membrane fusion
annotated property: IAO_0000115

establishment of protein localization
type: Class
subclass of: establishment of localization
subclass of: Restriction
  on property: part_of
  some values from: protein localization
id: GO:0045184
IAO_0000115: The directed movement of a protein to a specific location.
has_obo_namespace: biological_process
has_exact_synonym: establishment of protein localisation
has_exact_synonym: protein positioning
has_exact_synonym: protein recruitment
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:bf
annotated target: The directed movement of a protein to a specific location.
annotated source: establishment of protein localization
annotated property: IAO_0000115

Axiom
database_cross_reference: GOC:mah
annotated target: establishment of protein localisation
annotated source: establishment of protein localization
annotated property: has_exact_synonym

maintenance of protein location
type: Class
subclass of: maintenance of location
subclass of: Restriction
  on property: part_of
  some values from: protein localization
IAO_0000115: Any process in which a protein is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of proteins that do move away.
id: GO:0045185
has_narrow_synonym: active protein retrieval
has_obo_namespace: biological_process
has_related_synonym: maintenance of protein localization
has_narrow_synonym: protein retention
has_narrow_synonym: protein sequestering
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb
annotated target: maintenance of protein localization
annotated source: maintenance of protein location
annotated property: has_related_synonym

Axiom
annotated target: Any process in which a protein is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of proteins that do move away.
database_cross_reference: GOC:bf
annotated source: maintenance of protein location
annotated property: IAO_0000115

phagocytic vesicle
type: Class
subclass of: endocytic vesicle
IAO_0000115: A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
id: GO:0045335
database_cross_reference: Wikipedia:Phagosome
has_obo_namespace: cellular_component
has_exact_synonym: phagosome
IAO_0000412: go.owl

Axiom
annotated target: A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
database_cross_reference: GOC:go_curators
database_cross_reference: ISBN:0198506732
annotated source: phagocytic vesicle
annotated property: IAO_0000115

heterocycle metabolic process
type: Class
subclass of: cellular metabolic process
id: GO:0046483
IAO_0000115: The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings).
has_obo_namespace: biological_process
has_exact_synonym: heterocycle metabolism
IAO_0000412: go.owl
in_subset: goslim pir
in_subset: gosubset prok

Axiom
database_cross_reference: CHEBI:5686
database_cross_reference: ISBN:0198506732
annotated target: The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings).
annotated source: heterocycle metabolic process
annotated property: IAO_0000115

heterocycle catabolic process
type: Class
subclass of: cellular catabolic process
subclass of: heterocycle metabolic process
id: GO:0046700
IAO_0000115: The chemical reactions and pathways resulting in the breakdown of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings).
has_obo_namespace: biological_process
has_exact_synonym: heterocycle breakdown
has_exact_synonym: heterocycle catabolism
has_exact_synonym: heterocycle degradation
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:ai
annotated target: The chemical reactions and pathways resulting in the breakdown of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings).
annotated source: heterocycle catabolic process
annotated property: IAO_0000115

regulation of nucleocytoplasmic transport
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: regulates
    some values from: nucleocytoplasmic transport
subclass of: regulation of intracellular transport
subclass of: Restriction
  on property: regulates
  some values from: nucleocytoplasmic transport
IAO_0000115: Any process that modulates the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm.
id: GO:0046822
has_obo_namespace: biological_process
IAO_0000412: go.owl

Axiom
annotated target: Any process that modulates the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm.
database_cross_reference: GOC:bf
annotated source: regulation of nucleocytoplasmic transport
annotated property: IAO_0000115

negative regulation of nucleocytoplasmic transport
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: negatively_regulates
    some values from: nucleocytoplasmic transport
subclass of: negative regulation of intracellular transport
subclass of: regulation of nucleocytoplasmic transport
subclass of: Restriction
  on property: negatively_regulates
  some values from: nucleocytoplasmic transport
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances between the cytoplasm and the nucleus.
id: GO:0046823
has_obo_namespace: biological_process
has_exact_synonym: down regulation of nucleocytoplasmic transport
has_exact_synonym: down-regulation of nucleocytoplasmic transport
has_exact_synonym: downregulation of nucleocytoplasmic transport
has_narrow_synonym: inhibition of nucleocytoplasmic transport
IAO_0000412: go.owl

Axiom
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances between the cytoplasm and the nucleus.
database_cross_reference: GOC:bf
annotated source: negative regulation of nucleocytoplasmic transport
annotated property: IAO_0000115

positive regulation of nucleocytoplasmic transport
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: positively_regulates
    some values from: nucleocytoplasmic transport
subclass of: positive regulation of intracellular transport
subclass of: regulation of nucleocytoplasmic transport
subclass of: Restriction
  on property: positively_regulates
  some values from: nucleocytoplasmic transport
IAO_0000115: Any process that activates or increases the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm.
id: GO:0046824
has_narrow_synonym: activation of nucleocytoplasmic transport
has_obo_namespace: biological_process
has_narrow_synonym: stimulation of nucleocytoplasmic transport
has_exact_synonym: up regulation of nucleocytoplasmic transport
has_exact_synonym: up-regulation of nucleocytoplasmic transport
has_exact_synonym: upregulation of nucleocytoplasmic transport
IAO_0000412: go.owl

Axiom
annotated target: Any process that activates or increases the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm.
database_cross_reference: GOC:bf
annotated source: positive regulation of nucleocytoplasmic transport
annotated property: IAO_0000115

secretion
type: Class
subclass of: single-organism transport
id: GO:0046903
IAO_0000115: The controlled release of a substance by a cell or a tissue.
has_obo_namespace: biological_process
IAO_0000412: go.owl
in_subset: goslim pir
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:ai
annotated target: The controlled release of a substance by a cell or a tissue.
annotated source: secretion
annotated property: IAO_0000115

intracellular transport
type: Class
equivalent class: Class
  intersection of: transport
  intersection of: Restriction
    on property: occurs in
    some values from: intracellular
subclass of: transport
subclass of: establishment of localization in cell
subclass of: Restriction
  on property: occurs in
  some values from: intracellular
id: GO:0046907
IAO_0000115: The directed movement of substances within a cell.
has_obo_namespace: biological_process
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:ai
annotated target: The directed movement of substances within a cell.
annotated source: intracellular transport
annotated property: IAO_0000115

organelle fission
type: Class
subclass of: organelle organization
id: GO:0048285
IAO_0000115: The creation of two or more organelles by division of one organelle.
has_obo_namespace: biological_process
IAO_0000412: go.owl
in_subset: goslim pir
in_subset: goslim yeast

Axiom
database_cross_reference: GOC:jid
annotated target: The creation of two or more organelles by division of one organelle.
annotated source: organelle fission
annotated property: IAO_0000115

cell development
type: Class
subclass of: single-organism developmental process
subclass of: anatomical structure development
subclass of: cellular developmental process
subclass of: Restriction
  on property: part_of
  some values from: cell differentiation
id: GO:0048468
IAO_0000115: The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.
has_obo_namespace: biological_process
has_related_synonym: terminal differentiation
IAO_0000412: go.owl
in_subset: goslim candida
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb
annotated target: terminal differentiation
annotated source: cell development
annotated property: has_related_synonym

Axiom
database_cross_reference: GOC:go_curators
annotated target: The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.
annotated source: cell development
annotated property: IAO_0000115

positive regulation of biological process
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: positively_regulates
    some values from: biological_process
subclass of: regulation of biological process
subclass of: Restriction
  on property: positively_regulates
  some values from: biological_process
IAO_0000115: Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
has_alternative_id: GO:0043119
id: GO:0048518
has_narrow_synonym: activation of biological process
has_obo_namespace: biological_process
has_exact_synonym: positive regulation of physiological process
has_narrow_synonym: stimulation of biological process
has_exact_synonym: up regulation of biological process
has_exact_synonym: up-regulation of biological process
has_exact_synonym: upregulation of biological process
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
annotated target: Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
database_cross_reference: GOC:jid
annotated source: positive regulation of biological process
annotated property: IAO_0000115

negative regulation of biological process
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: negatively_regulates
    some values from: biological_process
subclass of: regulation of biological process
subclass of: Restriction
  on property: negatively_regulates
  some values from: biological_process
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
has_alternative_id: GO:0043118
id: GO:0048519
has_obo_namespace: biological_process
has_exact_synonym: down regulation of biological process
has_exact_synonym: down-regulation of biological process
has_exact_synonym: downregulation of biological process
has_narrow_synonym: inhibition of biological process
has_exact_synonym: negative regulation of physiological process
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
database_cross_reference: GOC:jid
annotated source: negative regulation of biological process
annotated property: IAO_0000115

negative regulation of cellular process
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: negatively_regulates
    some values from: cellular process
subclass of: negative regulation of biological process
subclass of: regulation of cellular process
subclass of: Restriction
  on property: negatively_regulates
  some values from: cellular process
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
id: GO:0048523
has_alternative_id: GO:0051243
has_obo_namespace: biological_process
has_exact_synonym: down regulation of cellular process
has_exact_synonym: down-regulation of cellular process
has_exact_synonym: downregulation of cellular process
has_narrow_synonym: inhibition of cellular process
has_exact_synonym: negative regulation of cellular physiological process
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
database_cross_reference: GOC:jid
annotated source: negative regulation of cellular process
annotated property: IAO_0000115

regulation of response to stimulus
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: regulates
    some values from: response to stimulus
subclass of: regulation of biological process
subclass of: Restriction
  on property: regulates
  some values from: response to stimulus
IAO_0000115: Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
id: GO:0048583
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
has_obo_namespace: biological_process
IAO_0000412: go.owl
in_subset: gocheck do not manually annotate
in_subset: gosubset prok

Axiom
annotated target: Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
database_cross_reference: GOC:jid
annotated source: regulation of response to stimulus
annotated property: IAO_0000115

negative regulation of response to stimulus
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: negatively_regulates
    some values from: response to stimulus
subclass of: negative regulation of biological process
subclass of: regulation of response to stimulus
subclass of: Restriction
  on property: negatively_regulates
  some values from: response to stimulus
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
id: GO:0048585
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
has_obo_namespace: biological_process
has_exact_synonym: down regulation of response to stimulus
has_exact_synonym: down-regulation of response to stimulus
has_exact_synonym: downregulation of response to stimulus
has_narrow_synonym: inhibition of response to stimulus
IAO_0000412: go.owl
in_subset: gocheck do not manually annotate

Axiom
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
database_cross_reference: GOC:jid
annotated source: negative regulation of response to stimulus
annotated property: IAO_0000115

developmental growth
type: Class
subclass of: growth
subclass of: single-organism developmental process
id: GO:0048589
IAO_0000115: The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another.
has_obo_namespace: biological_process
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:go_curators
annotated target: The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another.
annotated source: developmental growth
annotated property: IAO_0000115

anatomical structure development
type: Class
subclass of: developmental process
id: GO:0048856
IAO_0000115: The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
comment: This term was added by GO_REF:0000021.
has_obo_namespace: biological_process
has_exact_synonym: development of an anatomical structure
IAO_0000412: go.owl
in_subset: goslim generic

Axiom
database_cross_reference: GOC:mtg_15jun06
database_cross_reference: GO_REF:0000021
annotated target: The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
annotated source: anatomical structure development
annotated property: IAO_0000115

cellular developmental process
type: Class
subclass of: developmental process
subclass of: single-organism cellular process
IAO_0000115: A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.
id: GO:0048869
has_obo_namespace: biological_process
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
annotated target: A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.
database_cross_reference: GOC:isa_complete
annotated source: cellular developmental process
annotated property: IAO_0000115

cell motility
type: Class
subclass of: cellular component movement
subclass of: locomotion
subclass of: Restriction
  on property: part_of
  some values from: localization of cell
IAO_0000115: Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another.
id: GO:0048870
has_obo_namespace: biological_process
has_exact_synonym: cell locomotion
has_related_synonym: cell movement
has_exact_synonym: movement of a cell
IAO_0000412: go.owl
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: gosubset prok

Axiom
annotated target: Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another.
database_cross_reference: GOC:dgh
database_cross_reference: GOC:dph
database_cross_reference: GOC:isa_complete
database_cross_reference: GOC:mlg
annotated source: cell motility
annotated property: IAO_0000115

chromosome localization
type: Class
subclass of: organelle localization
IAO_0000115: Any process in which a chromosome is transported to, or maintained in, a specific location.
id: GO:0050000
has_obo_namespace: biological_process
has_exact_synonym: chromosome localisation
has_exact_synonym: establishment and maintenance of chromosome localization
has_exact_synonym: establishment and maintenance of chromosome position
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:mah
annotated target: chromosome localisation
annotated source: chromosome localization
annotated property: has_exact_synonym

Axiom
annotated target: Any process in which a chromosome is transported to, or maintained in, a specific location.
database_cross_reference: GOC:ai
annotated source: chromosome localization
annotated property: IAO_0000115

regulation of biological process
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: regulates
    some values from: biological_process
subclass of: biological regulation
subclass of: Restriction
  on property: regulates
  some values from: biological_process
IAO_0000115: Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
id: GO:0050789
has_alternative_id: GO:0050791
has_obo_namespace: biological_process
has_exact_synonym: regulation of physiological process
IAO_0000412: go.owl
in_subset: goslim aspergillus
in_subset: goslim candida
in_subset: gosubset prok

Axiom
annotated target: Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
database_cross_reference: GOC:ai
database_cross_reference: GOC:go_curators
annotated source: regulation of biological process
annotated property: IAO_0000115

regulation of cellular process
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: regulates
    some values from: cellular process
subclass of: regulation of biological process
subclass of: Restriction
  on property: regulates
  some values from: cellular process
IAO_0000115: Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
id: GO:0050794
has_alternative_id: GO:0051244
has_obo_namespace: biological_process
has_exact_synonym: regulation of cellular physiological process
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
annotated target: Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
database_cross_reference: GOC:go_curators
annotated source: regulation of cellular process
annotated property: IAO_0000115

response to stimulus
type: Class
subclass of: biological_process
IAO_0000115: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism.
id: GO:0050896
has_alternative_id: GO:0051869
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
has_obo_namespace: biological_process
has_exact_synonym: physiological response to stimulus
IAO_0000412: go.owl
in_subset: gocheck do not manually annotate
in_subset: goslim pir
in_subset: gosubset prok

Axiom
annotated target: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism.
database_cross_reference: GOC:ai
database_cross_reference: GOC:bf
annotated source: response to stimulus
annotated property: IAO_0000115

regulation of transport
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: regulates
    some values from: transport
subclass of: regulation of localization
subclass of: Restriction
  on property: regulates
  some values from: transport
IAO_0000115: Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
id: GO:0051049
has_obo_namespace: biological_process
IAO_0000412: go.owl
in_subset: goslim yeast
in_subset: gosubset prok

Axiom
annotated target: Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
database_cross_reference: GOC:ai
annotated source: regulation of transport
annotated property: IAO_0000115

positive regulation of transport
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: positively_regulates
    some values from: transport
subclass of: positive regulation of biological process
subclass of: regulation of transport
subclass of: Restriction
  on property: positively_regulates
  some values from: transport
IAO_0000115: Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
id: GO:0051050
has_narrow_synonym: activation of transport
has_obo_namespace: biological_process
has_narrow_synonym: stimulation of transport
has_exact_synonym: up regulation of transport
has_exact_synonym: up-regulation of transport
has_exact_synonym: upregulation of transport
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
annotated target: Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
database_cross_reference: GOC:ai
annotated source: positive regulation of transport
annotated property: IAO_0000115

negative regulation of transport
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: negatively_regulates
    some values from: transport
subclass of: negative regulation of biological process
subclass of: regulation of transport
subclass of: Restriction
  on property: negatively_regulates
  some values from: transport
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
id: GO:0051051
has_obo_namespace: biological_process
has_exact_synonym: down regulation of transport
has_exact_synonym: down-regulation of transport
has_exact_synonym: downregulation of transport
has_narrow_synonym: inhibition of transport
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
database_cross_reference: GOC:ai
annotated source: negative regulation of transport
annotated property: IAO_0000115

regulation of sequence-specific DNA binding transcription factor activity
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: regulates
    some values from: sequence-specific DNA binding transcription factor activity
subclass of: regulation of transcription, DNA-dependent
subclass of: regulation of molecular function
subclass of: Restriction
  on property: regulates
  some values from: sequence-specific DNA binding transcription factor activity
IAO_0000115: Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
id: GO:0051090
database_cross_reference: Reactome:REACT_104536
database_cross_reference: Reactome:REACT_107559
database_cross_reference: Reactome:REACT_109535
database_cross_reference: Reactome:REACT_110257
database_cross_reference: Reactome:REACT_110693
database_cross_reference: Reactome:REACT_21326
database_cross_reference: Reactome:REACT_82719
database_cross_reference: Reactome:REACT_83365
database_cross_reference: Reactome:REACT_90659
database_cross_reference: Reactome:REACT_92725
database_cross_reference: Reactome:REACT_96476
database_cross_reference: Reactome:REACT_99415
has_obo_namespace: biological_process
has_broad_synonym: regulation of transcription factor activity
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb
annotated target: regulation of transcription factor activity
annotated source: regulation of sequence-specific DNA binding transcription factor activity
annotated property: has_broad_synonym

Activation of the AP-1 family of transcription factors, Danio rerio
type: Axiom
annotated target: Reactome:REACT_107559
annotated source: regulation of sequence-specific DNA binding transcription factor activity
annotated property: database_cross_reference

Activation of the AP-1 family of transcription factors, Homo sapiens
type: Axiom
annotated target: Reactome:REACT_21326
annotated source: regulation of sequence-specific DNA binding transcription factor activity
annotated property: database_cross_reference

Activation of the AP-1 family of transcription factors, Schizosaccharomyces pombe
type: Axiom
annotated target: Reactome:REACT_109535
annotated source: regulation of sequence-specific DNA binding transcription factor activity
annotated property: database_cross_reference

Activation of the AP-1 family of transcription factors, Rattus norvegicus
type: Axiom
annotated target: Reactome:REACT_96476
annotated source: regulation of sequence-specific DNA binding transcription factor activity
annotated property: database_cross_reference

Activation of the AP-1 family of transcription factors, Taeniopygia guttata
type: Axiom
annotated target: Reactome:REACT_90659
annotated source: regulation of sequence-specific DNA binding transcription factor activity
annotated property: database_cross_reference

Axiom
annotated target: Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
database_cross_reference: GOC:ai
annotated source: regulation of sequence-specific DNA binding transcription factor activity
annotated property: IAO_0000115

Activation of the AP-1 family of transcription factors, Xenopus tropicalis
type: Axiom
annotated target: Reactome:REACT_82719
annotated source: regulation of sequence-specific DNA binding transcription factor activity
annotated property: database_cross_reference

Activation of the AP-1 family of transcription factors, Bos taurus
type: Axiom
annotated target: Reactome:REACT_104536
annotated source: regulation of sequence-specific DNA binding transcription factor activity
annotated property: database_cross_reference

Activation of the AP-1 family of transcription factors, Canis familiaris
type: Axiom
annotated target: Reactome:REACT_92725
annotated source: regulation of sequence-specific DNA binding transcription factor activity
annotated property: database_cross_reference

Activation of the AP-1 family of transcription factors, Drosophila melanogaster
type: Axiom
annotated target: Reactome:REACT_110257
annotated source: regulation of sequence-specific DNA binding transcription factor activity
annotated property: database_cross_reference

Activation of the AP-1 family of transcription factors, Gallus gallus
type: Axiom
annotated target: Reactome:REACT_110693
annotated source: regulation of sequence-specific DNA binding transcription factor activity
annotated property: database_cross_reference

Activation of the AP-1 family of transcription factors, Mus musculus
type: Axiom
annotated target: Reactome:REACT_99415
annotated source: regulation of sequence-specific DNA binding transcription factor activity
annotated property: database_cross_reference

Activation of the AP-1 family of transcription factors, Sus scrofa
type: Axiom
annotated target: Reactome:REACT_83365
annotated source: regulation of sequence-specific DNA binding transcription factor activity
annotated property: database_cross_reference

positive regulation of sequence-specific DNA binding transcription factor activity
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: positively_regulates
    some values from: sequence-specific DNA binding transcription factor activity
subclass of: positive regulation of molecular function
subclass of: regulation of sequence-specific DNA binding transcription factor activity
subclass of: Restriction
  on property: positively_regulates
  some values from: sequence-specific DNA binding transcription factor activity
IAO_0000115: Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
id: GO:0051091
has_narrow_synonym: activation of transcription factor activity
has_obo_namespace: biological_process
has_broad_synonym: positive regulation of transcription factor activity
has_narrow_synonym: stimulation of transcription factor activity
has_exact_synonym: up regulation of transcription factor activity
has_exact_synonym: up-regulation of transcription factor activity
has_exact_synonym: upregulation of transcription factor activity
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb
annotated target: positive regulation of transcription factor activity
annotated source: positive regulation of sequence-specific DNA binding transcription factor activity
annotated property: has_broad_synonym

Axiom
annotated target: Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
database_cross_reference: GOC:ai
annotated source: positive regulation of sequence-specific DNA binding transcription factor activity
annotated property: IAO_0000115

positive regulation of NF-kappaB transcription factor activity
type: Class
subclass of: positive regulation of sequence-specific DNA binding transcription factor activity
IAO_0000115: Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
id: GO:0051092
has_exact_synonym: NF-kappaB activation
database_cross_reference: Reactome:REACT_107873
database_cross_reference: Reactome:REACT_113398
database_cross_reference: Reactome:REACT_113766
database_cross_reference: Reactome:REACT_21281
database_cross_reference: Reactome:REACT_31084
database_cross_reference: Reactome:REACT_33907
database_cross_reference: Reactome:REACT_34168
database_cross_reference: Reactome:REACT_34256
database_cross_reference: Reactome:REACT_87914
database_cross_reference: Reactome:REACT_95400
has_exact_synonym: activation of NF-kappaB
has_exact_synonym: activation of NF-kappaB transcription factor
has_obo_namespace: biological_process
IAO_0000412: go.owl

TAK1 activates NFkB by phosphorylation and activation of IKKs complex, Mus musculus
type: Axiom
annotated target: Reactome:REACT_95400
annotated source: positive regulation of NF-kappaB transcription factor activity
annotated property: database_cross_reference

Axiom
annotated target: Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb
database_cross_reference: PMID:15087454
database_cross_reference: PMID:15170030
annotated source: positive regulation of NF-kappaB transcription factor activity
annotated property: IAO_0000115

TAK1 activates NFkB by phosphorylation and activation of IKKs complex, Rattus norvegicus
type: Axiom
annotated target: Reactome:REACT_107873
annotated source: positive regulation of NF-kappaB transcription factor activity
annotated property: database_cross_reference

TAK1 activates NFkB by phosphorylation and activation of IKKs complex, Sus scrofa
type: Axiom
annotated target: Reactome:REACT_34168
annotated source: positive regulation of NF-kappaB transcription factor activity
annotated property: database_cross_reference

TAK1 activates NFkB by phosphorylation and activation of IKKs complex, Bos taurus
type: Axiom
annotated target: Reactome:REACT_34256
annotated source: positive regulation of NF-kappaB transcription factor activity
annotated property: database_cross_reference

TAK1 activates NFkB by phosphorylation and activation of IKKs complex, Xenopus tropicalis
type: Axiom
annotated target: Reactome:REACT_87914
annotated source: positive regulation of NF-kappaB transcription factor activity
annotated property: database_cross_reference

TAK1 activates NFkB by phosphorylation and activation of IKKs complex, Danio rerio
type: Axiom
annotated target: Reactome:REACT_33907
annotated source: positive regulation of NF-kappaB transcription factor activity
annotated property: database_cross_reference

TAK1 activates NFkB by phosphorylation and activation of IKKs complex, Homo sapiens
type: Axiom
annotated target: Reactome:REACT_21281
annotated source: positive regulation of NF-kappaB transcription factor activity
annotated property: database_cross_reference

Axiom
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb
annotated target: activation of NF-kappaB transcription factor
annotated source: positive regulation of NF-kappaB transcription factor activity
annotated property: has_exact_synonym

TAK1 activates NFkB by phosphorylation and activation of IKKs complex, Canis familiaris
type: Axiom
annotated target: Reactome:REACT_31084
annotated source: positive regulation of NF-kappaB transcription factor activity
annotated property: database_cross_reference

TAK1 activates NFkB by phosphorylation and activation of IKKs complex, Taeniopygia guttata
type: Axiom
annotated target: Reactome:REACT_113398
annotated source: positive regulation of NF-kappaB transcription factor activity
annotated property: database_cross_reference

TAK1 activates NFkB by phosphorylation and activation of IKKs complex, Drosophila melanogaster
type: Axiom
annotated target: Reactome:REACT_113766
annotated source: positive regulation of NF-kappaB transcription factor activity
annotated property: database_cross_reference

nuclear transport
type: Class
subclass of: intracellular transport
id: GO:0051169
database_cross_reference: Reactome:REACT_9004
IAO_0000115: The directed movement of substances into, out of, or within the nucleus.
database_cross_reference: Wikipedia:Nuclear_transport
has_obo_namespace: biological_process
has_exact_synonym: nucleus transport
IAO_0000412: go.owl
in_subset: goslim yeast

Axiom
database_cross_reference: GOC:ai
annotated target: The directed movement of substances into, out of, or within the nucleus.
annotated source: nuclear transport
annotated property: IAO_0000115

Import of PIC to the Host Nucleus, Homo sapiens
type: Axiom
annotated target: Reactome:REACT_9004
annotated source: nuclear transport
annotated property: database_cross_reference

nuclear import
type: Class
subclass of: nucleocytoplasmic transport
subclass of: cytoplasmic transport
subclass of: single-organism transport
id: GO:0051170
database_cross_reference: Reactome:REACT_10010
database_cross_reference: Reactome:REACT_32050
database_cross_reference: Reactome:REACT_91459
database_cross_reference: Reactome:REACT_97007
IAO_0000115: The directed movement of substances into the nucleus.
has_obo_namespace: biological_process
has_exact_synonym: import into nucleus
has_exact_synonym: nucleus import
has_exact_synonym: substance nuclear import
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:ai
annotated target: The directed movement of substances into the nucleus.
annotated source: nuclear import
annotated property: IAO_0000115

snRNP nuclear import and release, Xenopus tropicalis
type: Axiom
annotated target: Reactome:REACT_32050
annotated source: nuclear import
annotated property: database_cross_reference

snRNP nuclear import and release, Mus musculus
type: Axiom
annotated target: Reactome:REACT_91459
annotated source: nuclear import
annotated property: database_cross_reference

snRNP nuclear import and release, Homo sapiens
type: Axiom
annotated target: Reactome:REACT_10010
annotated source: nuclear import
annotated property: database_cross_reference

snRNP nuclear import and release, Danio rerio
type: Axiom
annotated target: Reactome:REACT_97007
annotated source: nuclear import
annotated property: database_cross_reference

regulation of nitrogen compound metabolic process
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: regulates
    some values from: nitrogen compound metabolic process
subclass of: regulation of metabolic process
subclass of: Restriction
  on property: regulates
  some values from: nitrogen compound metabolic process
IAO_0000115: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds.
id: GO:0051171
has_obo_namespace: biological_process
has_exact_synonym: regulation of nitrogen metabolic process
has_exact_synonym: regulation of nitrogen metabolism
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:tb
annotated target: regulation of nitrogen metabolic process
annotated source: regulation of nitrogen compound metabolic process
annotated property: has_exact_synonym

Axiom
annotated target: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds.
database_cross_reference: GOC:ai
database_cross_reference: GOC:tb
annotated source: regulation of nitrogen compound metabolic process
annotated property: IAO_0000115

localization
type: Class
subclass of: biological_process
IAO_0000115: Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location.
id: GO:0051179
has_obo_namespace: biological_process
has_narrow_synonym: establishment and maintenance of cellular component location
has_exact_synonym: establishment and maintenance of localization
has_exact_synonym: establishment and maintenance of position
has_narrow_synonym: establishment and maintenance of substance location
has_narrow_synonym: establishment and maintenance of substrate location
has_exact_synonym: localisation
IAO_0000412: go.owl
in_subset: goslim pir
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:mah
annotated target: localisation
annotated source: localization
annotated property: has_exact_synonym

Axiom
annotated target: Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location.
database_cross_reference: GOC:ai
annotated source: localization
annotated property: IAO_0000115

cytoplasmic sequestering of protein
type: Class
equivalent class: Class
  intersection of: maintenance of protein location
  intersection of: Restriction
    on property: occurs in
    some values from: cytoplasm
subclass of: maintenance of protein location in cell
subclass of: negative regulation of protein transport
subclass of: Restriction
  on property: occurs in
  some values from: cytoplasm
id: GO:0051220
IAO_0000115: The selective interaction of a protein with specific molecules in the cytoplasm, thereby inhibiting its transport into other areas of the cell.
has_obo_namespace: biological_process
has_exact_synonym: cytoplasmic retention of protein
has_exact_synonym: cytoplasmic sequestration of protein
has_exact_synonym: cytoplasmic storage of protein
has_exact_synonym: maintenance of protein location in cytoplasm
has_exact_synonym: retention of protein in cytoplasm
has_exact_synonym: sequestering of protein in cytoplasm
has_exact_synonym: sequestration of protein in cytoplasm
has_exact_synonym: storage of protein in cytoplasm
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb
annotated target: maintenance of protein location in cytoplasm
annotated source: cytoplasmic sequestering of protein
annotated property: has_exact_synonym

Axiom
database_cross_reference: GOC:ai
annotated target: The selective interaction of a protein with specific molecules in the cytoplasm, thereby inhibiting its transport into other areas of the cell.
annotated source: cytoplasmic sequestering of protein
annotated property: IAO_0000115

positive regulation of protein transport
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: positively_regulates
    some values from: protein transport
subclass of: positive regulation of transport
subclass of: regulation of protein transport
subclass of: Restriction
  on property: positively_regulates
  some values from: protein transport
IAO_0000115: Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
id: GO:0051222
has_narrow_synonym: activation of protein transport
has_obo_namespace: biological_process
has_narrow_synonym: stimulation of protein transport
has_exact_synonym: up regulation of protein transport
has_exact_synonym: up-regulation of protein transport
has_exact_synonym: upregulation of protein transport
IAO_0000412: go.owl

Axiom
annotated target: Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
database_cross_reference: GOC:ai
annotated source: positive regulation of protein transport
annotated property: IAO_0000115

regulation of protein transport
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: regulates
    some values from: protein transport
subclass of: regulation of transport
subclass of: regulation of establishment of protein localization
subclass of: Restriction
  on property: regulates
  some values from: protein transport
IAO_0000115: Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
id: GO:0051223
has_obo_namespace: biological_process
IAO_0000412: go.owl

Axiom
annotated target: Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
database_cross_reference: GOC:ai
annotated source: regulation of protein transport
annotated property: IAO_0000115

negative regulation of protein transport
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: negatively_regulates
    some values from: protein transport
subclass of: negative regulation of transport
subclass of: regulation of protein transport
subclass of: Restriction
  on property: negatively_regulates
  some values from: protein transport
IAO_0000115: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
id: GO:0051224
has_obo_namespace: biological_process
has_exact_synonym: down regulation of protein transport
has_exact_synonym: down-regulation of protein transport
has_exact_synonym: downregulation of protein transport
has_narrow_synonym: inhibition of protein transport
IAO_0000412: go.owl

Axiom
annotated target: Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
database_cross_reference: GOC:ai
annotated source: negative regulation of protein transport
annotated property: IAO_0000115

establishment of localization
type: Class
subclass of: biological_process
subclass of: Restriction
  on property: part_of
  some values from: localization
id: GO:0051234
IAO_0000115: The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.
has_obo_namespace: biological_process
has_exact_synonym: establishment of localisation
IAO_0000412: go.owl
in_subset: goslim pir
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:ai
annotated target: The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.
annotated source: establishment of localization
annotated property: IAO_0000115

Axiom
database_cross_reference: GOC:mah
annotated target: establishment of localisation
annotated source: establishment of localization
annotated property: has_exact_synonym

maintenance of location
type: Class
subclass of: regulation of biological quality
subclass of: Restriction
  on property: part_of
  some values from: localization
IAO_0000115: Any process in which a cell, substance or cellular entity, such as a protein complex or organelle, is maintained in a location and prevented from moving elsewhere.
id: GO:0051235
has_obo_namespace: biological_process
has_narrow_synonym: retention
has_narrow_synonym: sequestering
has_narrow_synonym: storage
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
annotated target: Any process in which a cell, substance or cellular entity, such as a protein complex or organelle, is maintained in a location and prevented from moving elsewhere.
database_cross_reference: GOC:ai
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb
annotated source: maintenance of location
annotated property: IAO_0000115

regulation of RNA metabolic process
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: regulates
    some values from: RNA metabolic process
subclass of: regulation of nucleobase-containing compound metabolic process
subclass of: regulation of macromolecule metabolic process
subclass of: Restriction
  on property: regulates
  some values from: RNA metabolic process
IAO_0000115: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA.
id: GO:0051252
has_obo_namespace: biological_process
has_exact_synonym: regulation of RNA metabolism
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
annotated target: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA.
database_cross_reference: GOC:ai
annotated source: regulation of RNA metabolic process
annotated property: IAO_0000115

chromosome organization
type: Class
subclass of: organelle organization
IAO_0000115: A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information.
has_alternative_id: GO:0007001
id: GO:0051276
has_alternative_id: GO:0051277
has_obo_namespace: biological_process
has_exact_synonym: chromosome organisation
has_related_synonym: chromosome organization and biogenesis
has_related_synonym: maintenance of genome integrity
has_related_synonym: nuclear genome maintenance
IAO_0000412: go.owl
in_subset: goslim generic
in_subset: goslim pir
in_subset: goslim pombe
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:mah
annotated target: chromosome organization and biogenesis
annotated source: chromosome organization
annotated property: has_related_synonym

Axiom
annotated target: A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information.
database_cross_reference: GOC:ai
database_cross_reference: GOC:dph
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah
annotated source: chromosome organization
annotated property: IAO_0000115

centrosome organization
type: Class
subclass of: microtubule organizing center organization
IAO_0000115: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized.
id: GO:0051297
has_obo_namespace: biological_process
has_exact_synonym: centrosome organisation
has_related_synonym: centrosome organization and biogenesis
IAO_0000412: go.owl

Axiom
annotated target: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized.
database_cross_reference: GOC:ai
database_cross_reference: GOC:dph
database_cross_reference: GOC:jl
database_cross_reference: GOC:mah
annotated source: centrosome organization
annotated property: IAO_0000115

Axiom
database_cross_reference: GOC:curators
annotated target: centrosome organisation
annotated source: centrosome organization
annotated property: has_exact_synonym

Axiom
database_cross_reference: GOC:mah
annotated target: centrosome organization and biogenesis
annotated source: centrosome organization
annotated property: has_related_synonym

centrosome duplication
type: Class
subclass of: cell cycle process
subclass of: centrosome organization
subclass of: Restriction
  on property: part_of
  some values from: centrosome cycle
id: GO:0051298
IAO_0000115: The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized.
has_obo_namespace: biological_process
has_exact_synonym: centrosome replication
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:ai
annotated target: The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized.
annotated source: centrosome duplication
annotated property: IAO_0000115

cell division
type: Class
subclass of: single-organism cellular process
id: GO:0051301
comment: Note that this term differs from 'cytokinesis ; GO:0000910' in that cytokinesis excludes nuclear division; in prokaryotes, there is little difference between cytokinesis and cell division. Note that there is no relationship between this term and 'nuclear division ; GO:0000280' because cell division can take place without nuclear division (as in prokaryotes) and vice versa (as in syncytium formation by mitosis without cytokinesis.
IAO_0000115: The process resulting in the physical partitioning and separation of a cell into daughter cells.
database_cross_reference: Wikipedia:Cell_division
has_obo_namespace: biological_process
IAO_0000412: go.owl
in_subset: goslim generic
in_subset: goslim metagenomics
in_subset: goslim pir
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:go_curators
annotated target: The process resulting in the physical partitioning and separation of a cell into daughter cells.
annotated source: cell division
annotated property: IAO_0000115

establishment of chromosome localization
type: Class
subclass of: establishment of localization in cell
subclass of: establishment of organelle localization
subclass of: Restriction
  on property: part_of
  some values from: chromosome localization
id: GO:0051303
IAO_0000115: The directed movement of a chromosome to a specific location.
has_obo_namespace: biological_process
has_exact_synonym: chromosome positioning
has_exact_synonym: establishment of chromosome localisation
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:ai
annotated target: The directed movement of a chromosome to a specific location.
annotated source: establishment of chromosome localization
annotated property: IAO_0000115

Axiom
database_cross_reference: GOC:mah
annotated target: establishment of chromosome localisation
annotated source: establishment of chromosome localization
annotated property: has_exact_synonym

metaphase plate congression
type: Class
subclass of: establishment of chromosome localization
subclass of: Restriction
  on property: part_of
  some values from: chromosome segregation
id: GO:0051310
IAO_0000115: The alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the spindle.
has_obo_namespace: biological_process
has_exact_synonym: chromosome congression
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:ascb_2009
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb
annotated target: chromosome congression
annotated source: metaphase plate congression
annotated property: has_exact_synonym

Axiom
database_cross_reference: GOC:ai
annotated target: The alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the spindle.
annotated source: metaphase plate congression
annotated property: IAO_0000115

chromosome decondensation
type: Class
subclass of: chromosome organization
id: GO:0051312
IAO_0000115: The alteration of chromosome structure from the condensed form to a relaxed disperse form.
has_obo_namespace: biological_process
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:ai
annotated target: The alteration of chromosome structure from the condensed form to a relaxed disperse form.
annotated source: chromosome decondensation
annotated property: IAO_0000115

G1 phase
type: Class
subclass of: cell cycle phase
subclass of: Restriction
  on property: part_of
  some values from: interphase
id: GO:0051318
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct process is 'regulation of x/y phase transition'.
IAO_0000115: The cell cycle 'gap' phase which is the interval between the completion of DNA segregation (usually by mitosis or meiosis) and the beginning of DNA synthesis.
database_cross_reference: Wikipedia:G1_phase
has_obo_namespace: biological_process
IAO_0000412: go.owl
in_subset: gocheck do not annotate

Axiom
database_cross_reference: GOC:mtg_cell_cycle
annotated target: The cell cycle 'gap' phase which is the interval between the completion of DNA segregation (usually by mitosis or meiosis) and the beginning of DNA synthesis.
annotated source: G1 phase
annotated property: IAO_0000115

G2 phase
type: Class
subclass of: cell cycle phase
subclass of: Restriction
  on property: part_of
  some values from: interphase
id: GO:0051319
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct process is 'regulation of x/y phase transition'.
IAO_0000115: The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation (usually by mitosis or meiosis).
database_cross_reference: Wikipedia:G2_phase
has_obo_namespace: biological_process
IAO_0000412: go.owl
in_subset: gocheck do not annotate

Axiom
database_cross_reference: GOC:mtg_cell_cycle
annotated target: The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation (usually by mitosis or meiosis).
annotated source: G2 phase
annotated property: IAO_0000115

S phase
type: Class
subclass of: cell cycle phase
subclass of: Restriction
  on property: part_of
  some values from: interphase
id: GO:0051320
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct process is 'regulation of x/y phase transition'.
has_exact_synonym: S-phase
IAO_0000115: The cell cycle phase, following G1, during which DNA synthesis takes place.
database_cross_reference: Wikipedia:S_phase
has_obo_namespace: biological_process
IAO_0000412: go.owl
in_subset: gocheck do not annotate

Axiom
database_cross_reference: GOC:mtg_cell_cycle
annotated target: The cell cycle phase, following G1, during which DNA synthesis takes place.
annotated source: S phase
annotated property: IAO_0000115

metaphase
type: Class
subclass of: cell cycle phase
subclass of: Restriction
  on property: part_of
  some values from: M phase
id: GO:0051323
database_cross_reference: NIF_Subcellular:sao888950834
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct process is 'regulation of x/y phase transition'.
IAO_0000115: The cell cycle phase, following prophase or prometaphase in higher eukaryotes, during which chromosomes become aligned on the equatorial plate of the cell.
database_cross_reference: Wikipedia:Metaphase
has_obo_namespace: biological_process
IAO_0000412: go.owl
in_subset: gocheck do not annotate

Axiom
database_cross_reference: GOC:mtg_cell_cycle
annotated target: The cell cycle phase, following prophase or prometaphase in higher eukaryotes, during which chromosomes become aligned on the equatorial plate of the cell.
annotated source: metaphase
annotated property: IAO_0000115

prophase
type: Class
subclass of: cell cycle phase
subclass of: Restriction
  on property: part_of
  some values from: M phase
id: GO:0051324
database_cross_reference: NIF_Subcellular:sao1856556831
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct process is 'regulation of x/y phase transition'.
IAO_0000115: The cell cycle phase which is the first stage of M phase of meiosis and mitosis and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell.
database_cross_reference: Wikipedia:Prophase
has_obo_namespace: biological_process
IAO_0000412: go.owl
in_subset: gocheck do not annotate

Axiom
database_cross_reference: GOC:mtg_cell_cycle
annotated target: The cell cycle phase which is the first stage of M phase of meiosis and mitosis and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell.
annotated source: prophase
annotated property: IAO_0000115

interphase
type: Class
subclass of: cell cycle phase
id: GO:0051325
database_cross_reference: NIF_Subcellular:sao727427771
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct process is 'regulation of x/y phase transition'.
IAO_0000115: The cell cycle phase following cytokinesis which begins with G1 phase, proceeds through S phase and G2 phase and ends when prophase of meiosis or mitosis begins. During interphase the cell readies itself for meiosis or mitosis and the replication of its DNA occurs.
database_cross_reference: Wikipedia:Interphase
has_obo_namespace: biological_process
has_exact_synonym: karyostasis
has_broad_synonym: resting phase
IAO_0000412: go.owl
in_subset: gocheck do not annotate

Axiom
database_cross_reference: GOC:mtg_cell_cycle
annotated target: The cell cycle phase following cytokinesis which begins with G1 phase, proceeds through S phase and G2 phase and ends when prophase of meiosis or mitosis begins. During interphase the cell readies itself for meiosis or mitosis and the replication of its DNA occurs.
annotated source: interphase
annotated property: IAO_0000115

interphase of mitotic cell cycle
type: Class
equivalent class: Class
  intersection of: interphase
  intersection of: Restriction
    on property: part_of
    some values from: mitotic cell cycle
subclass of: interphase
subclass of: Restriction
  on property: part_of
  some values from: mitotic cell cycle
id: GO:0051329
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct process is 'regulation of x/y phase transition'.
IAO_0000115: The cell cycle phase following cytokinesis which begins with G1 phase, proceeds through S phase and G2 phase and ends when mitotic prophase begins. During interphase the cell readies itself for mitosis and the replication of its DNA occurs.
has_obo_namespace: biological_process
IAO_0000412: go.owl
in_subset: gocheck do not annotate

Axiom
database_cross_reference: GOC:mtg_cell_cycle
annotated target: The cell cycle phase following cytokinesis which begins with G1 phase, proceeds through S phase and G2 phase and ends when mitotic prophase begins. During interphase the cell readies itself for mitosis and the replication of its DNA occurs.
annotated source: interphase of mitotic cell cycle
annotated property: IAO_0000115

organelle localization
type: Class
subclass of: cellular localization
IAO_0000115: Any process in which an organelle is transported to, and/or maintained in, a specific location.
id: GO:0051640
has_obo_namespace: biological_process
has_exact_synonym: establishment and maintenance of organelle localization
has_exact_synonym: organelle localisation
IAO_0000412: go.owl
in_subset: goslim pir

Axiom
database_cross_reference: GOC:mah
annotated target: organelle localisation
annotated source: organelle localization
annotated property: has_exact_synonym

Axiom
annotated target: Any process in which an organelle is transported to, and/or maintained in, a specific location.
database_cross_reference: GOC:ai
annotated source: organelle localization
annotated property: IAO_0000115

cellular localization
type: Class
subclass of: single-organism cellular process
subclass of: localization
IAO_0000115: A localization process that takes place at the cellular level; as a result of a cellular localization process, a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within or in the membrane of a cell.
id: GO:0051641
has_obo_namespace: biological_process
has_exact_synonym: cellular localisation
has_exact_synonym: establishment and maintenance of cellular localization
has_exact_synonym: establishment and maintenance of localization in cell or cell membrane
has_narrow_synonym: intracellular localization
has_narrow_synonym: localization within cell
IAO_0000412: go.owl
in_subset: goslim pir
in_subset: gosubset prok

Axiom
annotated target: A localization process that takes place at the cellular level; as a result of a cellular localization process, a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within or in the membrane of a cell.
database_cross_reference: GOC:ai
database_cross_reference: GOC:mah
annotated source: cellular localization
annotated property: IAO_0000115

Axiom
database_cross_reference: GOC:mah
annotated target: cellular localisation
annotated source: cellular localization
annotated property: has_exact_synonym

establishment of localization in cell
type: Class
equivalent class: Class
  intersection of: establishment of localization
  intersection of: Restriction
    on property: occurs in
    some values from: cell
subclass of: establishment of localization
subclass of: Restriction
  on property: occurs in
  some values from: cell
subclass of: Restriction
  on property: part_of
  some values from: cellular localization
id: GO:0051649
IAO_0000115: The directed movement of a substance or cellular entity, such as a protein complex or organelle, to a specific location within, or in the membrane of, a cell.
has_obo_namespace: biological_process
has_related_synonym: establishment of cellular localization
has_narrow_synonym: establishment of intracellular localization
has_exact_synonym: establishment of localisation in cell
has_narrow_synonym: establishment of localization within cell
has_narrow_synonym: positioning within cell
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb
annotated target: establishment of cellular localization
annotated source: establishment of localization in cell
annotated property: has_related_synonym

Axiom
database_cross_reference: GOC:mah
annotated target: establishment of localisation in cell
annotated source: establishment of localization in cell
annotated property: has_exact_synonym

Axiom
database_cross_reference: GOC:ai
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb
annotated target: The directed movement of a substance or cellular entity, such as a protein complex or organelle, to a specific location within, or in the membrane of, a cell.
annotated source: establishment of localization in cell
annotated property: IAO_0000115

maintenance of location in cell
type: Class
subclass of: single-organism cellular process
subclass of: maintenance of location
subclass of: Restriction
  on property: part_of
  some values from: cellular localization
IAO_0000115: Any process in which a substance or cellular entity, such as a protein complex or organelle, is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere.
id: GO:0051651
has_obo_namespace: biological_process
has_narrow_synonym: cellular retention
has_narrow_synonym: cellular sequestering
has_narrow_synonym: cellular storage
has_narrow_synonym: intracellular retention
has_narrow_synonym: intracellular sequestering
has_narrow_synonym: intracellular storage
has_related_synonym: maintenance of cellular localization
has_narrow_synonym: maintenance of intracellular localization
has_related_synonym: maintenance of localization in cell
has_narrow_synonym: maintenance of localization within cell
has_narrow_synonym: retention within cell
has_narrow_synonym: sequestering within cell
has_narrow_synonym: storage within cell
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb
annotated target: maintenance of cellular localization
annotated source: maintenance of location in cell
annotated property: has_related_synonym

Axiom
annotated target: Any process in which a substance or cellular entity, such as a protein complex or organelle, is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere.
database_cross_reference: GOC:ai
annotated source: maintenance of location in cell
annotated property: IAO_0000115

Axiom
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb
annotated target: maintenance of localization in cell
annotated source: maintenance of location in cell
annotated property: has_related_synonym

establishment of organelle localization
type: Class
subclass of: establishment of localization
subclass of: Restriction
  on property: part_of
  some values from: organelle localization
id: GO:0051656
IAO_0000115: The directed movement of an organelle to a specific location.
has_obo_namespace: biological_process
has_exact_synonym: establishment of organelle localisation
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:ai
annotated target: The directed movement of an organelle to a specific location.
annotated source: establishment of organelle localization
annotated property: IAO_0000115

Axiom
database_cross_reference: GOC:mah
annotated target: establishment of organelle localisation
annotated source: establishment of organelle localization
annotated property: has_exact_synonym

localization of cell
type: Class
subclass of: localization
IAO_0000115: Any process in which a cell is transported to, and/or maintained in, a specific location.
id: GO:0051674
has_obo_namespace: biological_process
has_exact_synonym: cell localization
has_exact_synonym: establishment and maintenance of cell localization
has_exact_synonym: establishment and maintenance of localization of cell
has_exact_synonym: localisation of cell
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
database_cross_reference: GOC:mah
annotated target: localisation of cell
annotated source: localization of cell
annotated property: has_exact_synonym

Axiom
annotated target: Any process in which a cell is transported to, and/or maintained in, a specific location.
database_cross_reference: GOC:ai
annotated source: localization of cell
annotated property: IAO_0000115

cellular response to stimulus
type: Class
subclass of: single-organism cellular process
subclass of: response to stimulus
IAO_0000115: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell.
id: GO:0051716
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
has_obo_namespace: biological_process
IAO_0000412: go.owl
in_subset: gocheck do not manually annotate
in_subset: gosubset prok

Axiom
annotated target: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell.
database_cross_reference: GOC:bf
database_cross_reference: GOC:jl
annotated source: cellular response to stimulus
annotated property: IAO_0000115

regulation of macromolecule metabolic process
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: regulates
    some values from: macromolecule metabolic process
subclass of: regulation of metabolic process
subclass of: Restriction
  on property: regulates
  some values from: macromolecule metabolic process
IAO_0000115: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
id: GO:0060255
has_obo_namespace: biological_process
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
annotated target: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb
annotated source: regulation of macromolecule metabolic process
annotated property: IAO_0000115

regulation of cellular localization
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: regulates
    some values from: cellular localization
subclass of: regulation of localization
subclass of: regulation of cellular process
subclass of: Restriction
  on property: regulates
  some values from: cellular localization
IAO_0000115: Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell.
id: GO:0060341
has_obo_namespace: biological_process
has_exact_synonym: regulation of cellular localisation
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:mah
annotated target: regulation of cellular localisation
annotated source: regulation of cellular localization
annotated property: has_exact_synonym

Axiom
annotated target: Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb
annotated source: regulation of cellular localization
annotated property: IAO_0000115

developmental growth involved in morphogenesis
type: Class
equivalent class: Class
  intersection of: developmental growth
  intersection of: Restriction
    on property: part_of
    some values from: anatomical structure morphogenesis
subclass of: developmental growth
subclass of: Restriction
  on property: part_of
  some values from: anatomical structure morphogenesis
creation date: 2009-04-28T08:42:53Z
id: GO:0060560
IAO_0000115: The increase in size or mass of an anatomical structure that contributes to the structure attaining its shape.
has_obo_namespace: biological_process
has_exact_synonym: differential growth
created by: dph
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:dph
annotated target: The increase in size or mass of an anatomical structure that contributes to the structure attaining its shape.
annotated source: developmental growth involved in morphogenesis
annotated property: IAO_0000115

Axiom
database_cross_reference: GOC:dph
annotated target: differential growth
annotated source: developmental growth involved in morphogenesis
annotated property: has_exact_synonym

membrane organization
type: Class
subclass of: cellular component organization
creation date: 2010-02-08T02:43:11Z
IAO_0000115: A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
id: GO:0061024
has_obo_namespace: biological_process
created by: dph
has_exact_synonym: membrane organisation
IAO_0000412: go.owl
in_subset: goslim generic

Axiom
database_cross_reference: GOC:mah
annotated target: membrane organisation
annotated source: membrane organization
annotated property: has_exact_synonym

Axiom
annotated target: A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb
annotated source: membrane organization
annotated property: IAO_0000115

membrane fusion
type: Class
subclass of: membrane organization
creation date: 2010-02-08T02:48:06Z
id: GO:0061025
IAO_0000115: The membrane organization process that joins two lipid bilayers to form a single membrane.
has_obo_namespace: biological_process
created by: dph
IAO_0000412: go.owl
in_subset: goslim yeast

Axiom
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb
annotated target: The membrane organization process that joins two lipid bilayers to form a single membrane.
annotated source: membrane fusion
annotated property: IAO_0000115

endoplasmic reticulum polarization
type: Class
subclass of: endoplasmic reticulum organization
subclass of: establishment or maintenance of cell polarity
creation date: 2010-06-25T09:51:48Z
id: GO:0061163
IAO_0000115: The endoplasmic reticulum organization process that results in the structure of the endoplasmic reticulum being oriented in the cell.
has_obo_namespace: biological_process
created by: dph
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:dph
database_cross_reference: GOC:vw
annotated target: The endoplasmic reticulum organization process that results in the structure of the endoplasmic reticulum being oriented in the cell.
annotated source: endoplasmic reticulum polarization
annotated property: IAO_0000115

biological regulation
type: Class
subclass of: biological_process
IAO_0000115: Any process that modulates a measurable attribute of any biological process, quality or function.
id: GO:0065007
has_obo_namespace: biological_process
has_broad_synonym: regulation
IAO_0000412: go.owl
in_subset: goslim pir
in_subset: gosubset prok

Axiom
annotated target: Any process that modulates a measurable attribute of any biological process, quality or function.
database_cross_reference: GOC:dph
database_cross_reference: GOC:isa_complete
database_cross_reference: GOC:mah
database_cross_reference: GOC:pr
database_cross_reference: GOC:vw
annotated source: biological regulation
annotated property: IAO_0000115

regulation of biological quality
type: Class
subclass of: biological regulation
IAO_0000115: Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc.
id: GO:0065008
has_obo_namespace: biological_process
has_exact_synonym: regulation of biological attribute
has_exact_synonym: regulation of biological characteristic
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
annotated target: Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc.
database_cross_reference: GOC:dph
database_cross_reference: GOC:isa_complete
database_cross_reference: GOC:mah
database_cross_reference: GOC:pr
database_cross_reference: GOC:vw
annotated source: regulation of biological quality
annotated property: IAO_0000115

regulation of molecular function
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: regulates
    some values from: molecular_function
subclass of: biological regulation
subclass of: Restriction
  on property: regulates
  some values from: molecular_function
IAO_0000115: Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.
id: GO:0065009
has_obo_namespace: biological_process
has_exact_synonym: regulation of a molecular function
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
annotated target: Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.
database_cross_reference: GOC:isa_complete
annotated source: regulation of molecular function
annotated property: IAO_0000115

intracellular organelle lumen
type: Class
subclass of: organelle lumen
subclass of: intracellular organelle part
IAO_0000115: An organelle lumen that is part of an intracellular organelle.
id: GO:0070013
has_obo_namespace: cellular_component
IAO_0000412: go.owl

Axiom
annotated target: An organelle lumen that is part of an intracellular organelle.
database_cross_reference: GOC:mah
annotated source: intracellular organelle lumen
annotated property: IAO_0000115

anchoring junction
type: Class
subclass of: cell junction
IAO_0000115: A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.
id: GO:0070161
has_exact_synonym: anchoring cell junction
has_obo_namespace: cellular_component
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:mah
annotated target: anchoring cell junction
annotated source: anchoring junction
annotated property: has_exact_synonym

Axiom
annotated target: A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.
database_cross_reference: ISBN:0815332181
annotated source: anchoring junction
annotated property: IAO_0000115

regulation of establishment of protein localization
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: regulates
    some values from: establishment of protein localization
subclass of: regulation of protein localization
subclass of: Restriction
  on property: regulates
  some values from: establishment of protein localization
IAO_0000115: Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location.
id: GO:0070201
has_obo_namespace: biological_process
has_exact_synonym: regulation of establishment of protein localisation
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:mah
annotated target: regulation of establishment of protein localisation
annotated source: regulation of establishment of protein localization
annotated property: has_exact_synonym

Axiom
annotated target: Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location.
database_cross_reference: GOC:BHF
database_cross_reference: GOC:mah
annotated source: regulation of establishment of protein localization
annotated property: IAO_0000115

actin-mediated cell contraction
type: Class
subclass of: actin filament-based movement
id: GO:0070252
IAO_0000115: The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of all or part of the cell body.
has_obo_namespace: biological_process
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:mah
annotated target: The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of all or part of the cell body.
annotated source: actin-mediated cell contraction
annotated property: IAO_0000115

cellular macromolecule localization
type: Class
subclass of: macromolecule localization
subclass of: cellular localization
creation date: 2009-06-16T04:08:29Z
IAO_0000115: Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell.
id: GO:0070727
has_obo_namespace: biological_process
has_exact_synonym: cellular macromolecule localisation
created by: midori
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:mah
annotated target: cellular macromolecule localisation
annotated source: cellular macromolecule localization
annotated property: has_exact_synonym

Axiom
annotated target: Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell.
database_cross_reference: GOC:mah
annotated source: cellular macromolecule localization
annotated property: IAO_0000115

DNA conformation change
type: Class
subclass of: DNA metabolic process
creation date: 2009-11-09T11:36:34Z
IAO_0000115: A cellular process that results in a change in the spatial configuration of a DNA molecule. A conformation change can bend DNA, or alter the, twist, writhe, or linking number of a DNA molecule.
has_exact_synonym: DNA conformation modification
id: GO:0071103
has_obo_namespace: biological_process
created by: midori
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
annotated target: DNA conformation modification
database_cross_reference: GOC:mah
annotated source: DNA conformation change
annotated property: has_exact_synonym

Axiom
annotated target: A cellular process that results in a change in the spatial configuration of a DNA molecule. A conformation change can bend DNA, or alter the, twist, writhe, or linking number of a DNA molecule.
database_cross_reference: GOC:mah
annotated source: DNA conformation change
annotated property: IAO_0000115

organic substance transport
type: Class
subclass of: transport
creation date: 2010-03-08T02:15:14Z
id: GO:0071702
IAO_0000115: The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon.
has_obo_namespace: biological_process
created by: midori
IAO_0000412: go.owl

Axiom
database_cross_reference: CHEBI:50860
database_cross_reference: GOC:mah
annotated target: The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon.
annotated source: organic substance transport
annotated property: IAO_0000115

organic substance metabolic process
type: Class
subclass of: metabolic process
creation date: 2010-03-08T03:32:18Z
id: GO:0071704
IAO_0000115: The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon.
has_obo_namespace: biological_process
created by: midori
has_exact_synonym: organic molecular entity metabolic process
has_exact_synonym: organic molecular entity metabolism
has_exact_synonym: organic substance metabolism
IAO_0000412: go.owl

Axiom
database_cross_reference: CHEBI:50860
database_cross_reference: GOC:mah
annotated target: The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon.
annotated source: organic substance metabolic process
annotated property: IAO_0000115

cellular component organization or biogenesis
type: Class
subclass of: biological_process
creation date: 2010-09-10T01:39:16Z
IAO_0000115: A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component.
id: GO:0071840
has_alternative_id: GO:0071841
has_obo_namespace: biological_process
has_exact_synonym: cellular component organisation or biogenesis
has_exact_synonym: cellular component organisation or biogenesis at cellular level
has_exact_synonym: cellular component organization or biogenesis at cellular level
created by: midori
IAO_0000412: go.owl

Axiom
annotated target: A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component.
database_cross_reference: GOC:mah
annotated source: cellular component organization or biogenesis
annotated property: IAO_0000115

Axiom
database_cross_reference: GOC:mah
annotated target: cellular component organisation or biogenesis at cellular level
annotated source: cellular component organization or biogenesis
annotated property: has_exact_synonym

Axiom
database_cross_reference: GOC:mah
annotated target: cellular component organisation or biogenesis
annotated source: cellular component organization or biogenesis
annotated property: has_exact_synonym

DNA biosynthetic process
type: Class
subclass of: DNA metabolic process
subclass of: cellular macromolecule biosynthetic process
subclass of: nucleobase-containing compound biosynthetic process
creation date: 2010-09-15T02:14:33Z
has_exact_synonym: DNA anabolism
has_exact_synonym: DNA biosynthesis
has_exact_synonym: DNA formation
has_exact_synonym: DNA synthesis
id: GO:0071897
IAO_0000115: The cellular DNA metabolic process resulting in the formation of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one.
has_obo_namespace: biological_process
created by: midori
IAO_0000412: go.owl
in_subset: gosubset prok

Axiom
annotated target: DNA formation
database_cross_reference: GOC:mah
annotated source: DNA biosynthetic process
annotated property: has_exact_synonym

Axiom
annotated target: DNA biosynthesis
database_cross_reference: GOC:mah
annotated source: DNA biosynthetic process
annotated property: has_exact_synonym

Axiom
annotated target: DNA synthesis
database_cross_reference: GOC:mah
annotated source: DNA biosynthetic process
annotated property: has_exact_synonym

Axiom
database_cross_reference: GOC:mah
annotated target: The cellular DNA metabolic process resulting in the formation of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one.
annotated source: DNA biosynthetic process
annotated property: IAO_0000115

Axiom
annotated target: DNA anabolism
database_cross_reference: GOC:mah
annotated source: DNA biosynthetic process
annotated property: has_exact_synonym

cell periphery
type: Class
subclass of: cell part
creation date: 2010-10-04T01:51:47Z
id: GO:0071944
IAO_0000115: The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.
has_obo_namespace: cellular_component
created by: midori
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:mah
annotated target: The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.
annotated source: cell periphery
annotated property: IAO_0000115

regulation of primary metabolic process
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: regulates
    some values from: primary metabolic process
subclass of: regulation of metabolic process
subclass of: Restriction
  on property: regulates
  some values from: primary metabolic process
creation date: 2009-04-22T04:30:52Z
IAO_0000115: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
id: GO:0080090
has_obo_namespace: biological_process
created by: donghui
IAO_0000412: go.owl

Axiom
annotated target: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
database_cross_reference: PMID:19211694
annotated source: regulation of primary metabolic process
annotated property: IAO_0000115

nucleic acid metabolic process
type: Class
subclass of: nucleobase-containing compound metabolic process
subclass of: macromolecule metabolic process
creation date: 2010-04-07T10:18:47Z
IAO_0000115: Any cellular metabolic process involving nucleic acids.
id: GO:0090304
has_obo_namespace: biological_process
created by: tanyaberardini
IAO_0000412: go.owl

Axiom
annotated target: Any cellular metabolic process involving nucleic acids.
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb
annotated source: nucleic acid metabolic process
annotated property: IAO_0000115

nucleic acid phosphodiester bond hydrolysis
type: Class
subclass of: nucleic acid metabolic process
creation date: 2010-04-07T10:26:30Z
id: GO:0090305
IAO_0000115: The nucleic acid metabolic process in which the phosphodiester bonds between nucleotides are cleaved by hydrolysis.
has_obo_namespace: biological_process
has_exact_synonym: nucleic acid cleavage
created by: tanyaberardini
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb
annotated target: The nucleic acid metabolic process in which the phosphodiester bonds between nucleotides are cleaved by hydrolysis.
annotated source: nucleic acid phosphodiester bond hydrolysis
annotated property: IAO_0000115

Axiom
database_cross_reference: GOC:dph
database_cross_reference: GOC:tb
annotated target: nucleic acid cleavage
annotated source: nucleic acid phosphodiester bond hydrolysis
annotated property: has_exact_synonym

positive regulation of intracellular protein transport
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: positively_regulates
    some values from: intracellular protein transport
subclass of: positive regulation of intracellular transport
subclass of: regulation of intracellular protein transport
subclass of: positive regulation of protein transport
subclass of: Restriction
  on property: positively_regulates
  some values from: intracellular protein transport
creation date: 2010-04-16T03:45:07Z
IAO_0000115: Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells.
id: GO:0090316
has_obo_namespace: biological_process
created by: tanyaberardini
IAO_0000412: go.owl

Axiom
annotated target: Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells.
database_cross_reference: GOC:tb
annotated source: positive regulation of intracellular protein transport
annotated property: IAO_0000115

negative regulation of intracellular protein transport
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: negatively_regulates
    some values from: intracellular protein transport
subclass of: negative regulation of intracellular transport
subclass of: regulation of intracellular protein transport
subclass of: negative regulation of protein transport
subclass of: Restriction
  on property: negatively_regulates
  some values from: intracellular protein transport
creation date: 2010-04-16T03:45:07Z
IAO_0000115: Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells.
id: GO:0090317
has_obo_namespace: biological_process
created by: tanyaberardini
IAO_0000412: go.owl

Axiom
annotated target: Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells.
database_cross_reference: GOC:tb
annotated source: negative regulation of intracellular protein transport
annotated property: IAO_0000115

organic cyclic compound binding
type: Class
subclass of: binding
creation date: 2011-09-23T02:31:01Z
id: GO:0097159
IAO_0000115: Interacting selectively and non-covalently with an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure.
has_obo_namespace: molecular_function
created by: paola
IAO_0000412: go.owl

Axiom
database_cross_reference: CHEBI:33832
database_cross_reference: GOC:sjw
annotated target: Interacting selectively and non-covalently with an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure.
database_cross_reference: PMID:7583672
annotated source: organic cyclic compound binding
annotated property: IAO_0000115

execution phase of apoptosis
type: Class
subclass of: single-organism cellular process
subclass of: Restriction
  on property: part_of
  some values from: apoptotic process
creation date: 2011-11-23T09:45:24Z
IAO_0000115: A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. The execution phase ends when the cell has died.
id: GO:0097194
has_narrow_synonym: apoptosis
has_obo_namespace: biological_process
has_exact_synonym: execution phase of apoptotic process
created by: paola
IAO_0000412: go.owl

Axiom
annotated target: A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. The execution phase ends when the cell has died.
database_cross_reference: GOC:mtg_apoptosis
annotated source: execution phase of apoptosis
annotated property: IAO_0000115

microtubule bundle
type: Class
subclass of: cytoskeletal part
subclass of: Restriction
  on property: has_part
  some values from: microtubule
creation date: 2012-11-07T15:01:27Z
IAO_0000115: An arrangement of closely apposed microtubules running parallel to each other.
id: GO:0097427
has_obo_namespace: cellular_component
has_exact_synonym: microtubule fascicle
created by: paola
IAO_0000412: go.owl

Axiom
annotated target: An arrangement of closely apposed microtubules running parallel to each other.
database_cross_reference: NIF_Subcellular:sao1872343973
annotated source: microtubule bundle
annotated property: IAO_0000115

neuron part
type: Class
subclass of: cell part
creation date: 2012-12-19T16:53:50Z
IAO_0000115: Any constituent part of a neuron, the basic cellular unit of nervous tissue. A typical neuron consists of a cell body (often called the soma), an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system.
id: GO:0097458
has_obo_namespace: cellular_component
created by: paola
IAO_0000412: go.owl
in_subset: gocheck do not annotate

Axiom
annotated target: Any constituent part of a neuron, the basic cellular unit of nervous tissue. A typical neuron consists of a cell body (often called the soma), an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system.
database_cross_reference: GOC:pr
database_cross_reference: http://en.wikipedia.org/wiki/Neuron
annotated source: neuron part
annotated property: IAO_0000115

regulation of protein localization to nucleus
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: regulates
    some values from: protein localization to nucleus
subclass of: regulation of protein localization
subclass of: regulation of cellular localization
subclass of: Restriction
  on property: regulates
  some values from: protein localization to nucleus
creation date: 2012-03-12T01:23:44Z
IAO_0000115: Any process that modulates the frequency, rate or extent of protein localization to nucleus.
id: GO:1900180
created by: bf
has_obo_namespace: biological_process
has_exact_synonym: regulation of protein localisation to nucleus
has_exact_synonym: regulation of protein localization in cell nucleus
has_exact_synonym: regulation of protein localization in nucleus
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:TermGenie
annotated target: regulation of protein localization in cell nucleus
annotated source: regulation of protein localization to nucleus
annotated property: has_exact_synonym

Axiom
annotated target: Any process that modulates the frequency, rate or extent of protein localization to nucleus.
database_cross_reference: GOC:TermGenie
annotated source: regulation of protein localization to nucleus
annotated property: IAO_0000115

Axiom
database_cross_reference: GOC:TermGenie
annotated target: regulation of protein localisation to nucleus
annotated source: regulation of protein localization to nucleus
annotated property: has_exact_synonym

Axiom
database_cross_reference: GOC:TermGenie
annotated target: regulation of protein localization in nucleus
annotated source: regulation of protein localization to nucleus
annotated property: has_exact_synonym

organic cyclic compound metabolic process
type: Class
subclass of: organic substance metabolic process
creation date: 2012-09-14T09:03:51Z
id: GO:1901360
IAO_0000115: The chemical reactions and pathways involving organic cyclic compound.
created by: bf
has_obo_namespace: biological_process
has_exact_synonym: organic cyclic compound metabolism
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:TermGenie
annotated target: The chemical reactions and pathways involving organic cyclic compound.
annotated source: organic cyclic compound metabolic process
annotated property: IAO_0000115

Axiom
database_cross_reference: GOC:TermGenie
annotated target: organic cyclic compound metabolism
annotated source: organic cyclic compound metabolic process
annotated property: has_exact_synonym

organic cyclic compound catabolic process
type: Class
subclass of: organic cyclic compound metabolic process
subclass of: organic substance catabolic process
creation date: 2012-09-14T09:05:04Z
id: GO:1901361
IAO_0000115: The chemical reactions and pathways resulting in the breakdown of organic cyclic compound.
created by: bf
has_obo_namespace: biological_process
has_exact_synonym: organic cyclic compound breakdown
has_exact_synonym: organic cyclic compound catabolism
has_exact_synonym: organic cyclic compound degradation
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:TermGenie
annotated target: organic cyclic compound breakdown
annotated source: organic cyclic compound catabolic process
annotated property: has_exact_synonym

Axiom
database_cross_reference: GOC:TermGenie
annotated target: The chemical reactions and pathways resulting in the breakdown of organic cyclic compound.
annotated source: organic cyclic compound catabolic process
annotated property: IAO_0000115

Axiom
database_cross_reference: GOC:TermGenie
annotated target: organic cyclic compound degradation
annotated source: organic cyclic compound catabolic process
annotated property: has_exact_synonym

Axiom
database_cross_reference: GOC:TermGenie
annotated target: organic cyclic compound catabolism
annotated source: organic cyclic compound catabolic process
annotated property: has_exact_synonym

organic cyclic compound biosynthetic process
type: Class
subclass of: organic cyclic compound metabolic process
subclass of: organic substance biosynthetic process
creation date: 2012-09-14T09:05:22Z
id: GO:1901362
IAO_0000115: The chemical reactions and pathways resulting in the formation of organic cyclic compound.
created by: bf
has_obo_namespace: biological_process
has_exact_synonym: organic cyclic compound anabolism
has_exact_synonym: organic cyclic compound biosynthesis
has_exact_synonym: organic cyclic compound formation
has_exact_synonym: organic cyclic compound synthesis
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:TermGenie
annotated target: organic cyclic compound anabolism
annotated source: organic cyclic compound biosynthetic process
annotated property: has_exact_synonym

Axiom
database_cross_reference: GOC:TermGenie
annotated target: The chemical reactions and pathways resulting in the formation of organic cyclic compound.
annotated source: organic cyclic compound biosynthetic process
annotated property: IAO_0000115

Axiom
database_cross_reference: GOC:TermGenie
annotated target: organic cyclic compound formation
annotated source: organic cyclic compound biosynthetic process
annotated property: has_exact_synonym

Axiom
database_cross_reference: GOC:TermGenie
annotated target: organic cyclic compound biosynthesis
annotated source: organic cyclic compound biosynthetic process
annotated property: has_exact_synonym

Axiom
database_cross_reference: GOC:TermGenie
annotated target: organic cyclic compound synthesis
annotated source: organic cyclic compound biosynthetic process
annotated property: has_exact_synonym

heterocyclic compound binding
type: Class
subclass of: binding
creation date: 2012-09-14T13:53:50Z
id: GO:1901363
IAO_0000115: Interacting selectively and non-covalently with heterocyclic compound.
created by: bf
has_obo_namespace: molecular_function
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:TermGenie
annotated target: Interacting selectively and non-covalently with heterocyclic compound.
annotated source: heterocyclic compound binding
annotated property: IAO_0000115

organic substance catabolic process
type: Class
subclass of: catabolic process
subclass of: organic substance metabolic process
creation date: 2012-11-05T11:04:36Z
id: GO:1901575
IAO_0000115: The chemical reactions and pathways resulting in the breakdown of an organic substance, any molecular entity containing carbon.
has_obo_namespace: biological_process
has_exact_synonym: organic molecular entity breakdown
has_exact_synonym: organic molecular entity catabolic process
has_exact_synonym: organic molecular entity catabolism
has_exact_synonym: organic molecular entity degradation
has_exact_synonym: organic substance breakdown
has_exact_synonym: organic substance catabolism
has_exact_synonym: organic substance degradation
created by: pr
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:TermGenie
annotated target: organic molecular entity degradation
annotated source: organic substance catabolic process
annotated property: has_exact_synonym

Axiom
database_cross_reference: GOC:TermGenie
annotated target: organic molecular entity breakdown
annotated source: organic substance catabolic process
annotated property: has_exact_synonym

Axiom
database_cross_reference: GOC:TermGenie
annotated target: organic molecular entity catabolism
annotated source: organic substance catabolic process
annotated property: has_exact_synonym

Axiom
database_cross_reference: GOC:TermGenie
database_cross_reference: GOC:pr
annotated target: The chemical reactions and pathways resulting in the breakdown of an organic substance, any molecular entity containing carbon.
annotated source: organic substance catabolic process
annotated property: IAO_0000115

organic substance biosynthetic process
type: Class
subclass of: biosynthetic process
subclass of: organic substance metabolic process
creation date: 2012-11-05T11:04:40Z
id: GO:1901576
IAO_0000115: The chemical reactions and pathways resulting in the formation of an organic substance, any molecular entity containing carbon.
has_obo_namespace: biological_process
has_exact_synonym: organic molecular entity anabolism
has_exact_synonym: organic molecular entity biosynthesis
has_exact_synonym: organic molecular entity biosynthetic process
has_exact_synonym: organic molecular entity formation
has_exact_synonym: organic molecular entity synthesis
has_exact_synonym: organic substance anabolism
has_exact_synonym: organic substance biosynthesis
has_exact_synonym: organic substance formation
has_exact_synonym: organic substance synthesis
created by: pr
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:TermGenie
annotated target: organic molecular entity formation
annotated source: organic substance biosynthetic process
annotated property: has_exact_synonym

Axiom
database_cross_reference: GOC:TermGenie
database_cross_reference: GOC:pr
annotated target: The chemical reactions and pathways resulting in the formation of an organic substance, any molecular entity containing carbon.
annotated source: organic substance biosynthetic process
annotated property: IAO_0000115

Axiom
database_cross_reference: GOC:TermGenie
annotated target: organic molecular entity anabolism
annotated source: organic substance biosynthetic process
annotated property: has_exact_synonym

Axiom
database_cross_reference: GOC:TermGenie
annotated target: organic molecular entity biosynthesis
annotated source: organic substance biosynthetic process
annotated property: has_exact_synonym

Axiom
database_cross_reference: GOC:TermGenie
annotated target: organic molecular entity synthesis
annotated source: organic substance biosynthetic process
annotated property: has_exact_synonym

regulation of cellular macromolecule biosynthetic process
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: regulates
    some values from: cellular macromolecule biosynthetic process
subclass of: regulation of macromolecule biosynthetic process
subclass of: regulation of cellular biosynthetic process
subclass of: Restriction
  on property: regulates
  some values from: cellular macromolecule biosynthetic process
creation date: 2010-09-15T08:55:45Z
IAO_0000115: Any process that modulates the frequency, rate or extent of cellular macromolecule biosynthetic process.
id: GO:2000112
has_obo_namespace: biological_process
has_exact_synonym: regulation of cellular biopolymer biosynthetic process
has_exact_synonym: regulation of cellular macromolecule anabolism
has_exact_synonym: regulation of cellular macromolecule biosynthesis
has_exact_synonym: regulation of cellular macromolecule formation
has_exact_synonym: regulation of cellular macromolecule synthesis
created by: tanyaberardini
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:obol
annotated target: regulation of cellular macromolecule formation
annotated source: regulation of cellular macromolecule biosynthetic process
annotated property: has_exact_synonym

Axiom
database_cross_reference: GOC:obol
annotated target: regulation of cellular biopolymer biosynthetic process
annotated source: regulation of cellular macromolecule biosynthetic process
annotated property: has_exact_synonym

Axiom
database_cross_reference: GOC:obol
annotated target: regulation of cellular macromolecule anabolism
annotated source: regulation of cellular macromolecule biosynthetic process
annotated property: has_exact_synonym

Axiom
database_cross_reference: GOC:obol
annotated target: regulation of cellular macromolecule synthesis
annotated source: regulation of cellular macromolecule biosynthetic process
annotated property: has_exact_synonym

Axiom
annotated target: Any process that modulates the frequency, rate or extent of cellular macromolecule biosynthetic process.
database_cross_reference: GOC:obol
annotated source: regulation of cellular macromolecule biosynthetic process
annotated property: IAO_0000115

Axiom
database_cross_reference: GOC:obol
annotated target: regulation of cellular macromolecule biosynthesis
annotated source: regulation of cellular macromolecule biosynthetic process
annotated property: has_exact_synonym

regulation of RNA biosynthetic process
type: Class
equivalent class: Class
  intersection of: biological regulation
  intersection of: Restriction
    on property: regulates
    some values from: RNA biosynthetic process
subclass of: regulation of macromolecule biosynthetic process
subclass of: regulation of cellular biosynthetic process
subclass of: regulation of RNA metabolic process
subclass of: Restriction
  on property: regulates
  some values from: RNA biosynthetic process
creation date: 2011-10-17T11:36:25Z
IAO_0000115: Any process that modulates the frequency, rate or extent of RNA biosynthetic process.
id: GO:2001141
has_obo_namespace: biological_process
created by: dph
has_exact_synonym: regulation of RNA anabolism
has_exact_synonym: regulation of RNA biosynthesis
has_exact_synonym: regulation of RNA formation
has_exact_synonym: regulation of RNA synthesis
IAO_0000412: go.owl

Axiom
database_cross_reference: GOC:obol
annotated target: regulation of RNA anabolism
annotated source: regulation of RNA biosynthetic process
annotated property: has_exact_synonym

Axiom
annotated target: Any process that modulates the frequency, rate or extent of RNA biosynthetic process.
database_cross_reference: GOC:dph
annotated source: regulation of RNA biosynthetic process
annotated property: IAO_0000115

Axiom
database_cross_reference: GOC:obol
annotated target: regulation of RNA synthesis
annotated source: regulation of RNA biosynthetic process
annotated property: has_exact_synonym

Axiom
database_cross_reference: GOC:obol
annotated target: regulation of RNA biosynthesis
annotated source: regulation of RNA biosynthetic process
annotated property: has_exact_synonym

Axiom
database_cross_reference: GOC:obol
annotated target: regulation of RNA formation
annotated source: regulation of RNA biosynthetic process
annotated property: has_exact_synonym

quality
type: Class
IAO_0000115: A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities.
id: PATO:0000001
has_alternative_id: PATO:0000072
has_obo_namespace: quality
has_exact_synonym: trait
IAO_0000412: pato.owl

Axiom
annotated target: A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: quality

speed
type: Class
subclass of: movement quality
IAO_0000115: A physical quality inhering in a bearer by virtue of the bearer's scalar absolute value of the rate of change of the bearer's position.
id: PATO:0000008
has_obo_namespace: quality
has_related_synonym: velocity
IAO_0000412: pato.owl
in_subset: attribute slim
in_subset: scalar slim

Axiom
annotated target: A physical quality inhering in a bearer by virtue of the bearer's scalar absolute value of the rate of change of the bearer's position.
database_cross_reference: Wikipedia:http://en.wikipedia.org/wiki/Velocity
annotated property: IAO_0000115
annotated source: speed

color brightness
type: Class
subclass of: optical quality
IAO_0000115: A scalar optical property that is the intensity, value or amount of perceived light.
comment: Color brightness refers to the intensity, lightness or value of the light present. Think of this as a dimmer switch.
id: PATO:0000016
has_exact_synonym: color intensity
has_exact_synonym: color lightness
has_exact_synonym: color value
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: attribute slim

Axiom
annotated target: A scalar optical property that is the intensity, value or amount of perceived light.
database_cross_reference: PATOC:MAH
annotated property: IAO_0000115
annotated source: color brightness

frequency
type: Class
subclass of: rate
IAO_0000115: A physical quality which inheres in a bearer by virtue of the number of the bearer's repetitive actions in a particular time.
id: PATO:0000044
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: attribute slim
in_subset: scalar slim

Axiom
annotated target: A physical quality which inheres in a bearer by virtue of the number of the bearer's repetitive actions in a particular time.
database_cross_reference: Wikipedia:http://en.wikipedia.org/wiki/frequency
annotated property: IAO_0000115
annotated source: frequency

intensity
type: Class
subclass of: qualitative
IAO_0000115: A quality inhering in a bearer by virtue of the bearer's possessing or displaying a distinctive feature in type or degree or effect or force.
id: PATO:0000049
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: attribute slim

Axiom
annotated target: A quality inhering in a bearer by virtue of the bearer's possessing or displaying a distinctive feature in type or degree or effect or force.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: intensity

morphology
type: Class
subclass of: physical object quality
IAO_0000115: A quality of a single physical entity inhering in the bearer by virtue of the bearer's size or shape or structure.
id: PATO:0000051
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: attribute slim

Axiom
annotated target: A quality of a single physical entity inhering in the bearer by virtue of the bearer's size or shape or structure.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: morphology

shape
type: Class
subclass of: morphology
IAO_0000115: A morphological quality inhering in a bearer by virtue of the bearer's ratios of distances between its features (points, edges, surfaces and also holes etc).
id: PATO:0000052
has_alternative_id: PATO:0001647
comment: Shapes are invariant on size transformations. Shapes can be subdivided into 2D and 3D shapes, We can also make a distinction between shapes of complete self-connected objects, and shapes of parts of objects.
has_obo_namespace: quality
has_exact_synonym: relational shape quality
IAO_0000412: pato.owl
in_subset: attribute slim

Axiom
annotated target: A morphological quality inhering in a bearer by virtue of the bearer's ratios of distances between its features (points, edges, surfaces and also holes etc).
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: shape

occurrence quality
type: Class
subclass of: temporal distribution quality
IAO_0000115: A quality of a single process inhering in a bearer by virtue of the bearer's occurrence.
id: PATO:0000057
has_alternative_id: PATO:0000156
has_alternative_id: PATO:0000158
has_exact_synonym: incidence
has_obo_namespace: quality
has_exact_synonym: temporal
IAO_0000412: pato.owl
in_subset: attribute slim

Axiom
annotated target: A quality of a single process inhering in a bearer by virtue of the bearer's occurrence.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: occurrence quality

spatial pattern
type: Class
subclass of: position
IAO_0000115: A spatial quality inhering in a bearer by virtue of the bearer's exhibiting repetition of placement of its parts.
id: PATO:0000060
has_alternative_id: PATO:0000132
has_alternative_id: PATO:0001565
has_exact_synonym: distribution
has_related_synonym: pattern
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: attribute slim

Axiom
annotated target: A spatial quality inhering in a bearer by virtue of the bearer's exhibiting repetition of placement of its parts.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: spatial pattern

qualitative
type: Class
subclass of: quality
id: PATO:0000068
comment: TODO: define this or obsolete it and move children somewhere else.
has_obo_namespace: quality
IAO_0000412: pato.owl

deviation(from_normal)
type: Class
subclass of: qualitative
IAO_0000115: A quality inhering in a bearer by virtue of the whether the bearer differs from normal or average.
id: PATO:0000069
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: attribute slim

Axiom
annotated target: A quality inhering in a bearer by virtue of the whether the bearer differs from normal or average.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: deviation(from_normal)

size
type: Class
subclass of: morphology
IAO_0000115: A morphology quality inhering in a bearer by virtue of the bearer's physical magnitude.
id: PATO:0000117
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: attribute slim
in_subset: scalar slim

Axiom
annotated target: A morphology quality inhering in a bearer by virtue of the bearer's physical magnitude.
database_cross_reference: WordNet:WordNet
annotated property: IAO_0000115
annotated source: size

length
type: Class
subclass of: 1-D extent
IAO_0000115: A 1-D extent quality which is equal to the distance between two points.
id: PATO:0000122
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: attribute slim
in_subset: mpath slim
in_subset: scalar slim

Axiom
annotated target: A 1-D extent quality which is equal to the distance between two points.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: length

mass
type: Class
subclass of: physical quality
IAO_0000115: A physical quality that inheres in a bearer by virtue of the proportion of the bearer's amount of matter.
id: PATO:0000125
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: attribute slim
in_subset: relational slim
in_subset: scalar slim

Axiom
annotated target: A physical quality that inheres in a bearer by virtue of the proportion of the bearer's amount of matter.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: mass

position
type: Class
subclass of: physical quality
IAO_0000115: A spatial quality inhering in a bearer by virtue of the bearer's spatial location relative to other objects in the vicinity.
id: PATO:0000140
has_alternative_id: PATO:0001032
has_alternative_id: PATO:0001631
has_exact_synonym: location
has_exact_synonym: placement
has_obo_namespace: quality
has_exact_synonym: relational spatial quality
IAO_0000412: pato.owl
in_subset: attribute slim

Axiom
annotated target: A spatial quality inhering in a bearer by virtue of the bearer's spatial location relative to other objects in the vicinity.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: position

structure
type: Class
subclass of: morphology
IAO_0000115: A morphology quality inhering in a bearer by virtue of the bearer's relative position, shape, arrangements and connectivity of an organism's various parts; the pattern underlying its form.
id: PATO:0000141
has_alternative_id: PATO:0001452
has_obo_namespace: quality
has_exact_synonym: relational structural quality
IAO_0000412: pato.owl
in_subset: attribute slim

Axiom
annotated target: A morphology quality inhering in a bearer by virtue of the bearer's relative position, shape, arrangements and connectivity of an organism's various parts; the pattern underlying its form.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: structure

rate
type: Class
subclass of: physical quality of a process
IAO_0000115: A quality of a single process inhering in a bearer by virtue of the bearer's occurrence per unit time.
id: PATO:0000161
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: attribute slim
in_subset: scalar slim

Axiom
annotated target: A quality of a single process inhering in a bearer by virtue of the bearer's occurrence per unit time.
database_cross_reference: PATOC:melissa
annotated property: IAO_0000115
annotated source: rate

viability
type: Class
subclass of: organismal quality
IAO_0000115: An organismal quality inhering in a bearer or a population by virtue of the bearer's disposition to survive and develop normally or the number of surviving individuals in a given population.
id: PATO:0000169
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: attribute slim
in_subset: disposition slim

Axiom
annotated target: An organismal quality inhering in a bearer or a population by virtue of the bearer's disposition to survive and develop normally or the number of surviving individuals in a given population.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: viability

arrested
type: Class
subclass of: decreased occurrence
subclass of: offset quality
subclass of: Restriction
  on property: decreased_in_magnitude_relative_to
  some values from: normal
IAO_0000115: A quality of a process which ends earlier than the natural end time or reference process.
id: PATO:0000297
has_alternative_id: PATO:0001508
comment: TODO: the definition is incorrect. See absent.
has_exact_synonym: abolished
has_related_synonym: incomplete
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: value slim

Axiom
annotated target: A quality of a process which ends earlier than the natural end time or reference process.
database_cross_reference: PATOC:LC
annotated property: IAO_0000115
annotated source: arrested

increased speed
type: Class
equivalent class: Class
  intersection of: speed
  intersection of: Restriction
    on property: increased_in_magnitude_relative_to
    some values from: normal
subclass of: speed
subclass of: increased object quality
subclass of: Restriction
  on property: increased_in_magnitude_relative_to
  some values from: normal
IAO_0000115: A speed which is relatively high.
id: PATO:0000303
has_related_synonym: fast speed
has_exact_synonym: high speed
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: value slim

Axiom
annotated target: A speed which is relatively high.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: increased speed

decreased speed
type: Class
equivalent class: Class
  intersection of: speed
  intersection of: Restriction
    on property: decreased_in_magnitude_relative_to
    some values from: normal
subclass of: speed
subclass of: decreased object quality
subclass of: Restriction
  on property: decreased_in_magnitude_relative_to
  some values from: normal
IAO_0000115: A speed which is relatively low.
id: PATO:0000304
has_obo_namespace: quality
has_exact_synonym: slow
has_exact_synonym: slow speed
IAO_0000412: pato.owl
in_subset: value slim

Axiom
annotated target: A speed which is relatively low.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: decreased speed

irregular spatial pattern
type: Class
subclass of: spatial pattern
IAO_0000115: A spatial pattern inhering in a bearer by virtue of the bearer's magnitude of or the relationships between its repeated parts lack consistency.
id: PATO:0000330
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: cell quality
in_subset: mpath slim
in_subset: value slim

Axiom
annotated target: A spatial pattern inhering in a bearer by virtue of the bearer's magnitude of or the relationships between its repeated parts lack consistency.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: irregular spatial pattern

increased frequency
type: Class
equivalent class: Class
  intersection of: frequency
  intersection of: Restriction
    on property: increased_in_magnitude_relative_to
    some values from: normal
subclass of: frequency
subclass of: increased rate
subclass of: Restriction
  on property: increased_in_magnitude_relative_to
  some values from: normal
IAO_0000115: A frequency which is relatively high.
id: PATO:0000380
has_related_synonym: frequent
has_exact_synonym: high frequency
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: mpath slim
in_subset: value slim

Axiom
annotated target: A frequency which is relatively high.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: increased frequency

decreased frequency
type: Class
equivalent class: Class
  intersection of: frequency
  intersection of: Restriction
    on property: decreased_in_magnitude_relative_to
    some values from: normal
subclass of: frequency
subclass of: decreased rate
subclass of: Restriction
  on property: decreased_in_magnitude_relative_to
  some values from: normal
IAO_0000115: A frequency which is relatively low.
id: PATO:0000381
has_related_synonym: infrequent
has_exact_synonym: low frequency
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: mpath slim
in_subset: value slim

Axiom
annotated target: A frequency which is relatively low.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: decreased frequency

mild
type: Class
subclass of: intensity
IAO_0000115: An intensity which is less than moderate in type or degree or effect or force.
id: PATO:0000394
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: mpath slim
in_subset: value slim

Axiom
annotated target: An intensity which is less than moderate in type or degree or effect or force.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: mild

severe
type: Class
subclass of: intensity
IAO_0000115: An intensity which is extremely bad or unpleasant in type or degree or effect or force.
id: PATO:0000396
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: mpath slim
in_subset: value slim

Axiom
annotated target: An intensity which is extremely bad or unpleasant in type or degree or effect or force.
database_cross_reference: WordNet:WordNet
annotated property: IAO_0000115
annotated source: severe

circular
type: Class
subclass of: elliptic
IAO_0000115: A shape quality inhering in a bearer by virtue of the bearer's being such that every part of the surface or the circumference is equidistant from the center.
id: PATO:0000411
has_obo_namespace: quality
has_related_synonym: round
has_related_synonym: rounded
IAO_0000412: pato.owl
in_subset: cell quality
in_subset: mpath slim
in_subset: value slim

Axiom
annotated target: A shape quality inhering in a bearer by virtue of the bearer's being such that every part of the surface or the circumference is equidistant from the center.
database_cross_reference: thefreedictionary.com:thefreedictionary.com
annotated property: IAO_0000115
annotated source: circular

regular spatial pattern
type: Class
subclass of: spatial pattern
IAO_0000115: A pattern quality inhering in a bearer by virtue of the bearer's having a repeatable or predictable placement.
id: PATO:0000440
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: mpath slim
in_subset: relational slim
in_subset: value slim

Axiom
annotated target: A pattern quality inhering in a bearer by virtue of the bearer's having a repeatable or predictable placement.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: regular spatial pattern

abnormal
type: Class
subclass of: deviation(from_normal)
IAO_0000115: A quality inhering in a bearer by virtue of the bearer's deviation from normal or average.
id: PATO:0000460
has_related_synonym: aberrant
has_related_synonym: atypia
has_related_synonym: atypical
has_related_synonym: defective
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: abnormal slim
in_subset: mpath slim
in_subset: value slim

Axiom
annotated target: A quality inhering in a bearer by virtue of the bearer's deviation from normal or average.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: abnormal

normal
type: Class
subclass of: deviation(from_normal)
IAO_0000115: A quality inhering in a bearer by virtue of the bearer's exhibiting no deviation from normal or average.
id: PATO:0000461
has_related_synonym: average
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: abnormal slim
in_subset: mpath slim
in_subset: value slim

Axiom
annotated target: A quality inhering in a bearer by virtue of the bearer's exhibiting no deviation from normal or average.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: normal

increased duration
type: Class
equivalent class: Class
  intersection of: duration quality of a process
  intersection of: Restriction
    on property: increased_in_magnitude_relative_to
    some values from: normal
subclass of: duration quality of a process
subclass of: increased process quality
subclass of: Restriction
  on property: increased_in_magnitude_relative_to
  some values from: normal
IAO_0000115: A duration quality of a process which is relatively high.
id: PATO:0000498
has_alternative_id: PATO:0000715
has_related_synonym: chronic
has_exact_synonym: high time
has_exact_synonym: increased period
has_exact_synonym: increased time
has_related_synonym: prolonged period
has_obo_namespace: quality
has_related_synonym: slow time
IAO_0000412: pato.owl
in_subset: value slim

Axiom
annotated target: A duration quality of a process which is relatively high.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: increased duration

decreased duration
type: Class
equivalent class: Class
  intersection of: duration quality of a process
  intersection of: Restriction
    on property: decreased_in_magnitude_relative_to
    some values from: normal
subclass of: duration quality of a process
subclass of: decreased process quality
subclass of: Restriction
  on property: decreased_in_magnitude_relative_to
  some values from: normal
IAO_0000115: A duration quality of a process which is relatively low.
id: PATO:0000499
has_alternative_id: PATO:0000716
has_exact_synonym: decreased period
has_exact_synonym: decreased time
has_related_synonym: fast time
has_exact_synonym: low period
has_obo_namespace: quality
has_exact_synonym: shortened period
IAO_0000412: pato.owl
in_subset: value slim

Axiom
annotated target: A duration quality of a process which is relatively low.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: decreased duration

delayed
type: Class
subclass of: onset quality
IAO_0000115: A quality of a process which starts later than the natural start time or the reference process.
id: PATO:0000502
has_related_synonym: late
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: value slim

Axiom
annotated target: A quality of a process which starts later than the natural start time or the reference process.
database_cross_reference: PATOC:LC
annotated property: IAO_0000115
annotated source: delayed

increased length
type: Class
equivalent class: Class
  intersection of: length
  intersection of: Restriction
    on property: increased_in_magnitude_relative_to
    some values from: normal
subclass of: length
subclass of: increased size
subclass of: Restriction
  on property: increased_in_magnitude_relative_to
  some values from: normal
IAO_0000115: A length quality which is relatively large.
id: PATO:0000573
has_exact_synonym: long
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: value slim

Axiom
annotated target: A length quality which is relatively large.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: increased length

decreased length
type: Class
equivalent class: Class
  intersection of: length
  intersection of: Restriction
    on property: decreased_in_magnitude_relative_to
    some values from: normal
subclass of: length
subclass of: decreased size
subclass of: Restriction
  on property: decreased_in_magnitude_relative_to
  some values from: normal
IAO_0000115: A length quality which is relatively small.
id: PATO:0000574
has_obo_namespace: quality
has_exact_synonym: short
has_related_synonym: shortened
has_related_synonym: stubby
IAO_0000412: pato.owl
in_subset: value slim

Axiom
annotated target: A length quality which is relatively small.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: decreased length

increased size
type: Class
equivalent class: Class
  intersection of: size
  intersection of: Restriction
    on property: increased_in_magnitude_relative_to
    some values from: normal
subclass of: size
subclass of: increased object quality
subclass of: Restriction
  on property: increased_in_magnitude_relative_to
  some values from: normal
IAO_0000115: A size quality which is relatively high.
id: PATO:0000586
has_alternative_id: PATO:0001202
has_related_synonym: big
has_related_synonym: enlarged
has_related_synonym: expanded
has_related_synonym: great
has_related_synonym: large
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: value slim

Axiom
annotated target: A size quality which is relatively high.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: increased size

decreased size
type: Class
equivalent class: Class
  intersection of: size
  intersection of: Restriction
    on property: decreased_in_magnitude_relative_to
    some values from: normal
subclass of: size
subclass of: decreased object quality
subclass of: Restriction
  on property: decreased_in_magnitude_relative_to
  some values from: normal
IAO_0000115: A size quality which is relatively low.
id: PATO:0000587
has_narrow_synonym: hypoplasia
has_obo_namespace: quality
has_related_synonym: small
has_related_synonym: tiny
has_narrow_synonym: underdeveloped
IAO_0000412: pato.owl
in_subset: value slim

Axiom
annotated target: A size quality which is relatively low.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: decreased size

increased thickness
type: Class
equivalent class: Class
  intersection of: thickness
  intersection of: Restriction
    on property: increased_in_magnitude_relative_to
    some values from: normal
subclass of: increased size
subclass of: thickness
subclass of: Restriction
  on property: increased_in_magnitude_relative_to
  some values from: normal
IAO_0000115: A thickness which is relatively high.
id: PATO:0000591
has_exact_synonym: high thickness
has_obo_namespace: quality
has_exact_synonym: stout
has_related_synonym: thick
has_exact_synonym: thickened
IAO_0000412: pato.owl
in_subset: mpath slim
in_subset: value slim

Axiom
annotated target: A thickness which is relatively high.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: increased thickness

decreased thickness
type: Class
equivalent class: Class
  intersection of: thickness
  intersection of: Restriction
    on property: decreased_in_magnitude_relative_to
    some values from: normal
subclass of: decreased size
subclass of: thickness
subclass of: Restriction
  on property: decreased_in_magnitude_relative_to
  some values from: normal
IAO_0000115: A thickness which is relatively low.
id: PATO:0000592
has_exact_synonym: low thickness
has_obo_namespace: quality
has_related_synonym: slender
has_related_synonym: thin
IAO_0000412: pato.owl
in_subset: mpath slim
in_subset: value slim

Axiom
annotated target: A thickness which is relatively low.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: decreased thickness

increased volume
type: Class
equivalent class: Class
  intersection of: volume
  intersection of: Restriction
    on property: increased_in_magnitude_relative_to
    some values from: normal
subclass of: increased size
subclass of: volume
subclass of: Restriction
  on property: increased_in_magnitude_relative_to
  some values from: normal
IAO_0000115: A volume which is relatively high.
id: PATO:0000595
has_exact_synonym: high volume
has_related_synonym: large volume
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: mpath slim
in_subset: value slim

Axiom
annotated target: A volume which is relatively high.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: increased volume

decreased volume
type: Class
equivalent class: Class
  intersection of: volume
  intersection of: Restriction
    on property: decreased_in_magnitude_relative_to
    some values from: normal
subclass of: decreased size
subclass of: volume
subclass of: Restriction
  on property: decreased_in_magnitude_relative_to
  some values from: normal
IAO_0000115: A volume which is relatively low.
id: PATO:0000596
has_exact_synonym: low volume
has_obo_namespace: quality
has_related_synonym: small volume
IAO_0000412: pato.owl
in_subset: mpath slim
in_subset: value slim

Axiom
annotated target: A volume which is relatively low.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: decreased volume

decreased width
type: Class
equivalent class: Class
  intersection of: width
  intersection of: Restriction
    on property: decreased_in_magnitude_relative_to
    some values from: normal
subclass of: decreased size
subclass of: width
subclass of: Restriction
  on property: decreased_in_magnitude_relative_to
  some values from: normal
IAO_0000115: A width which is relatively small.
id: PATO:0000599
has_related_synonym: narrow
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: value slim

Axiom
annotated target: A width which is relatively small.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: decreased width

increased width
type: Class
equivalent class: Class
  intersection of: width
  intersection of: Restriction
    on property: increased_in_magnitude_relative_to
    some values from: normal
subclass of: increased size
subclass of: width
subclass of: Restriction
  on property: increased_in_magnitude_relative_to
  some values from: normal
IAO_0000115: A width which is relatively large.
id: PATO:0000600
has_related_synonym: broad
has_obo_namespace: quality
has_related_synonym: wide
has_related_synonym: wide/broad
IAO_0000412: pato.owl
in_subset: value slim

Axiom
annotated target: A width which is relatively large.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: increased width

asymmetrical
type: Class
subclass of: symmetry
IAO_0000115: A symmetry quality inhering in a bearer by virtue of the bearer's lacking symmetry.
id: PATO:0000616
has_exact_synonym: asymmetric
has_exact_synonym: asymmetry
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: cell quality
in_subset: mpath slim
in_subset: value slim

Axiom
annotated target: A symmetry quality inhering in a bearer by virtue of the bearer's lacking symmetry.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: asymmetrical

bilateral
type: Class
subclass of: position
IAO_0000115: A positional quality inhering in a bearer by virtue of the bearer's having two sides; two-sided.
id: PATO:0000618
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: mpath slim
in_subset: value slim

Axiom
annotated target: A positional quality inhering in a bearer by virtue of the bearer's having two sides; two-sided.
database_cross_reference: thefreedictionary.com:thefreedictionary.com
annotated property: IAO_0000115
annotated source: bilateral

apoptotic
type: Class
subclass of: structure
IAO_0000115: A structural quality inhering in a bearer by virtue of the bearer's consisting of blebbing of the nucleus and DNA fragmentation due to the cell undergoing a specific form of programmed cell death termed apoptosis.
database_cross_reference: GO:0006915
id: PATO:0000638
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: value slim

Axiom
annotated target: A structural quality inhering in a bearer by virtue of the bearer's consisting of blebbing of the nucleus and DNA fragmentation due to the cell undergoing a specific form of programmed cell death termed apoptosis.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: apoptotic

high brightness
type: Class
subclass of: color brightness
IAO_0000115: A color brightness which is relatively high.
id: PATO:0000665
has_exact_synonym: light
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: value slim

Axiom
annotated target: A color brightness which is relatively high.
database_cross_reference: PATOC:MAH
annotated property: IAO_0000115
annotated source: high brightness

continuous
type: Class
subclass of: occurrence quality
IAO_0000115: A quality of a single process inhering in a bearer by virtue of the bearer's being uninterrupted in time, sequence, substance, or extent.
has_alternative_id: PATO:0000429
id: PATO:0000689
has_obo_namespace: quality
has_exact_synonym: uninterrupted
IAO_0000412: pato.owl
in_subset: value slim

Axiom
annotated target: A quality of a single process inhering in a bearer by virtue of the bearer's being uninterrupted in time, sequence, substance, or extent.
database_cross_reference: thefreedictionary.com:thefreedictionary.com
annotated property: IAO_0000115
annotated source: continuous

lethal (sensu genetics)
type: Class
subclass of: viability
IAO_0000115: A viability quality inhering in a population by virtue of the bearer's long term survival inability.
id: PATO:0000718
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: disposition slim
in_subset: value slim

Axiom
annotated target: A viability quality inhering in a population by virtue of the bearer's long term survival inability.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: lethal (sensu genetics)

viable
type: Class
subclass of: viability
IAO_0000115: A viability quality inhering in a bearer or a population by virtue of the bearer's ability to survive or the long term survival ability of a given population.
id: PATO:0000719
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: disposition slim
in_subset: value slim

Axiom
annotated target: A viability quality inhering in a bearer or a population by virtue of the bearer's ability to survive or the long term survival ability of a given population.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: viable

decreased rate
type: Class
equivalent class: Class
  intersection of: rate
  intersection of: Restriction
    on property: decreased_in_magnitude_relative_to
    some values from: normal
subclass of: rate
subclass of: decreased process quality
subclass of: Restriction
  on property: decreased_in_magnitude_relative_to
  some values from: normal
IAO_0000115: A rate which is relatively low.
id: PATO:0000911
has_obo_namespace: quality
has_exact_synonym: slow rate
IAO_0000412: pato.owl
in_subset: mpath slim
in_subset: value slim

Axiom
annotated target: A rate which is relatively low.
database_cross_reference: PATO:GVG
annotated property: IAO_0000115
annotated source: decreased rate

increased rate
type: Class
equivalent class: Class
  intersection of: rate
  intersection of: Restriction
    on property: increased_in_magnitude_relative_to
    some values from: normal
subclass of: rate
subclass of: increased process quality
subclass of: Restriction
  on property: increased_in_magnitude_relative_to
  some values from: normal
IAO_0000115: A rate which is relatively high.
id: PATO:0000912
has_exact_synonym: fast rate
has_exact_synonym: high rate
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: mpath slim
in_subset: value slim

Axiom
annotated target: A rate which is relatively high.
database_cross_reference: PATO:GVG
annotated property: IAO_0000115
annotated source: increased rate

thickness
type: Class
subclass of: 1-D extent
IAO_0000115: A 1-D extent quality which is equal to the dimension through an object as opposed to its length or width.
id: PATO:0000915
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: attribute slim
in_subset: scalar slim

Axiom
annotated target: A 1-D extent quality which is equal to the dimension through an object as opposed to its length or width.
database_cross_reference: WordNet:WordNet
annotated property: IAO_0000115
annotated source: thickness

volume
type: Class
subclass of: 3-D extent
IAO_0000115: A 3-D extent quality inhering in a bearer by virtue of the bearer's amount of 3-dimensional space it occupies.
id: PATO:0000918
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: attribute slim
in_subset: mpath slim
in_subset: scalar slim

Axiom
annotated target: A 3-D extent quality inhering in a bearer by virtue of the bearer's amount of 3-dimensional space it occupies.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: volume

width
type: Class
subclass of: 1-D extent
IAO_0000115: A 1-D extent quality which is equal to the distance from one side of an object to another side which is opposite.
id: PATO:0000921
comment: This term is for curator easiness - we might consider obsoleting this but we have to consider how curators are going to represent them if we do.
has_related_synonym: breadth
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: attribute slim
in_subset: scalar slim

Axiom
annotated target: A 1-D extent quality which is equal to the distance from one side of an object to another side which is opposite.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: width

disorganized
type: Class
subclass of: organization quality
IAO_0000115: A structural quality inhering in a bearer by virtue of the bearer's lacking organisation.
id: PATO:0000937
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: mpath slim
in_subset: value slim

Axiom
annotated target: A structural quality inhering in a bearer by virtue of the bearer's lacking organisation.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: disorganized

elliptic
type: Class
subclass of: superelliptic
IAO_0000115: A spheroid quality inhering in a bearer by virtue of the bearer's being oval with two axes of symmetry, as produced by a conical section.
id: PATO:0000947
has_exact_synonym: ellipse-shaped
has_exact_synonym: ellipsoid
has_exact_synonym: elliptical
has_related_synonym: oval
has_related_synonym: ovoid
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: cell quality
in_subset: mpath slim
in_subset: value slim

Axiom
annotated target: A spheroid quality inhering in a bearer by virtue of the bearer's being oval with two axes of symmetry, as produced by a conical section.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: elliptic

symmetry
type: Class
subclass of: regular spatial pattern
IAO_0000115: A pattern quality of inhering in a bearer by virtue of the correspondence in size, shape, and relative position of the bearer's parts on opposite sides of a dividing line or median plane or about a center or axis.
id: PATO:0000965
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: attribute slim

Axiom
annotated target: A pattern quality of inhering in a bearer by virtue of the correspondence in size, shape, and relative position of the bearer's parts on opposite sides of a dividing line or median plane or about a center or axis.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: symmetry

physical quality
type: Class
subclass of: physical object quality
IAO_0000115: A quality of a physical entity that exists through action of continuants at the physical level of organisation in relation to other entities.
id: PATO:0001018
has_alternative_id: PATO:0002079
database_cross_reference: Wikipedia:Physical_property
has_obo_namespace: quality
has_exact_synonym: relational physical quality
IAO_0000412: pato.owl
in_subset: attribute slim

Axiom
annotated target: A quality of a physical entity that exists through action of continuants at the physical level of organisation in relation to other entities.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: physical quality

elongated
type: Class
subclass of: shape
IAO_0000115: A quality inhering in a bearer by virtue of the bearer's length being notably higher than its width.
id: PATO:0001154
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: value slim

Axiom
annotated target: A quality inhering in a bearer by virtue of the bearer's length being notably higher than its width.
database_cross_reference: WordNet:WordNet
annotated property: IAO_0000115
annotated source: elongated

process quality
type: Class
subclass of: quality
IAO_0000115: A quality which inheres in an process.
id: PATO:0001236
has_alternative_id: PATO:0001239
has_alternative_id: PATO:0001240
comment: See comments of relational quality of a physical entity.
has_obo_namespace: quality
has_exact_synonym: quality of a process
has_exact_synonym: quality of occurrent
has_exact_synonym: quality of process
has_exact_synonym: relational quality of occurrent
IAO_0000412: pato.owl

Axiom
annotated target: A quality which inheres in an process.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: process quality

physical object quality
type: Class
subclass of: quality
IAO_0000115: A quality which inheres in a continuant.
has_alternative_id: PATO:0001237
has_alternative_id: PATO:0001238
id: PATO:0001241
comment: Relational qualities are qualities that hold between multiple entities. Normal (monadic) qualities such as the shape of a eyeball exist purely as a quality of that eyeball. A relational quality such as sensitivity to light is a quality of that eyeball (and connecting nervous system) as it relates to incoming light waves/particles.
has_exact_synonym: monadic quality of a continuant
has_narrow_synonym: monadic quality of an object
has_narrow_synonym: monadic quality of continuant
has_exact_synonym: multiply inhering quality of a physical entity
has_obo_namespace: quality
has_exact_synonym: quality of a continuant
has_exact_synonym: quality of a single physical entity
has_exact_synonym: quality of an object
has_exact_synonym: quality of continuant
database_cross_reference: snap:Quality
IAO_0000412: pato.owl

Axiom
annotated target: A quality which inheres in a continuant.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: physical object quality

electromagnetic (EM) radiation quality
type: Class
subclass of: radiation quality
IAO_0000115: A physical quality that inheres in an bearer by virtue of how that bearer interacts with electromagnetic radiation.
id: PATO:0001291
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: attribute slim

Axiom
annotated target: A physical quality that inheres in an bearer by virtue of how that bearer interacts with electromagnetic radiation.
database_cross_reference: Wikipedia:http://en.wikipedia.org/wiki/Electromagnetic_radiation
annotated property: IAO_0000115
annotated source: electromagnetic (EM) radiation quality

optical quality
type: Class
subclass of: electromagnetic (EM) radiation quality
IAO_0000115: An EM radiation quality in which the EM radiation is within the fiat range of the spectrum visible deemed to be light.
id: PATO:0001300
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: attribute slim

Axiom
annotated target: An EM radiation quality in which the EM radiation is within the fiat range of the spectrum visible deemed to be light.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: optical quality

variability
type: Class
subclass of: physical quality
IAO_0000115: A quality inhering in a bearer by virtue of the bearer's disposition to varying or changing.
id: PATO:0001303
has_obo_namespace: quality
has_related_synonym: variability of a physical quality
IAO_0000412: pato.owl
in_subset: attribute slim

Axiom
annotated target: A quality inhering in a bearer by virtue of the bearer's disposition to varying or changing.
database_cross_reference: Dictionary:http://dictionary.reference.com/
annotated property: IAO_0000115
annotated source: variability

duration quality of a process
type: Class
subclass of: physical quality of a process
IAO_0000115: A process quality inhering in a bearer by virtue of the bearer's magnitude of the temporal extent between the starting and ending point.
has_alternative_id: PATO:0000081
id: PATO:0001309
has_exact_synonym: period
has_obo_namespace: quality
has_related_synonym: time
IAO_0000412: pato.owl
in_subset: attribute slim

Axiom
annotated target: A process quality inhering in a bearer by virtue of the bearer's magnitude of the temporal extent between the starting and ending point.
database_cross_reference: PATOC:mellybelly
annotated property: IAO_0000115
annotated source: duration quality of a process

area
type: Class
subclass of: 2-D extent
IAO_0000115: A 2-D extent quality inhering in a bearer by virtue of the bearer's two dimensional extent.
id: PATO:0001323
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: attribute slim
in_subset: mpath slim
in_subset: scalar slim

Axiom
annotated target: A 2-D extent quality inhering in a bearer by virtue of the bearer's two dimensional extent.
database_cross_reference: Wikipedia:http://en.wikipedia.org/wiki/Area
annotated property: IAO_0000115
annotated source: area

radial symmetry
type: Class
subclass of: symmetry
IAO_0000115: A symmetry quality inhering in a bearer by virtue of the bearer's having equal proportion around a central point or axis.
id: PATO:0001325
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: attribute slim
in_subset: cell quality

Axiom
annotated target: A symmetry quality inhering in a bearer by virtue of the bearer's having equal proportion around a central point or axis.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: radial symmetry

spiny
type: Class
subclass of: surface feature shape
IAO_0000115: A surface feature shape quality inhering in a bearer by virtue of the bearer's having spines, thorns or similar thin projections on its surface.
id: PATO:0001365
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: cell quality
in_subset: value slim

Axiom
annotated target: A surface feature shape quality inhering in a bearer by virtue of the bearer's having spines, thorns or similar thin projections on its surface.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: spiny

ploidy
type: Class
subclass of: cellular quality
IAO_0000115: A cellular quality inhering in a bearer by virtue of the bearer's number of homologous sets of chromosomes in the nucleus or primary chromosome-containing compartment of the cell, each set essentially coding for all the biological traits of the organism.
id: PATO:0001374
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: attribute slim

Axiom
annotated target: A cellular quality inhering in a bearer by virtue of the bearer's number of homologous sets of chromosomes in the nucleus or primary chromosome-containing compartment of the cell, each set essentially coding for all the biological traits of the organism.
database_cross_reference: Wikipedia:http://en.wikipedia.org/wiki/Ploidy
annotated property: IAO_0000115
annotated source: ploidy

polyploid
type: Class
subclass of: euploid
IAO_0000115: A ploidy quality inhering in a bearer by virtue of the bearer's containing more than two homologous sets of chromosomes.
id: PATO:0001377
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: cell quality
in_subset: value slim

Axiom
annotated target: A ploidy quality inhering in a bearer by virtue of the bearer's containing more than two homologous sets of chromosomes.
database_cross_reference: Wikipedia:http://en.wikipedia.org/wiki/Polyploid
annotated property: IAO_0000115
annotated source: polyploid

euploid
type: Class
subclass of: ploidy
IAO_0000115: A ploidy quality inhering in a bearer by virtue of the bearer's containing an integral multiple of the monoploid number, possibly excluding the sex-determining chromosomes.
id: PATO:0001393
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: cell quality
in_subset: value slim

Axiom
annotated target: A ploidy quality inhering in a bearer by virtue of the bearer's containing an integral multiple of the monoploid number, possibly excluding the sex-determining chromosomes.
database_cross_reference: Wikipedia:http://en.wikipedia.org/wiki/Euploid
annotated property: IAO_0000115
annotated source: euploid

cellular quality
type: Class
subclass of: physical object quality
IAO_0000115: A monadic quality of continuant that exists at the cellular level of organisation.
id: PATO:0001396
has_obo_namespace: quality
IAO_0000412: pato.owl

Axiom
annotated target: A monadic quality of continuant that exists at the cellular level of organisation.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: cellular quality

nucleate quality
type: Class
subclass of: cellular quality
IAO_0000115: A cellular quality inhering in a bearer by virtue of bearer's number of nuclei.
id: PATO:0001404
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: attribute slim

Axiom
annotated target: A cellular quality inhering in a bearer by virtue of bearer's number of nuclei.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: nucleate quality

binucleate
type: Class
subclass of: multinucleate
IAO_0000115: A nucleate quality inhering in a bearer by virtue of the bearer's having two nuclei.
id: PATO:0001406
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: cell quality
in_subset: mpath slim
in_subset: value slim

Axiom
annotated target: A nucleate quality inhering in a bearer by virtue of the bearer's having two nuclei.
database_cross_reference: Biology-online:Biology-online
annotated property: IAO_0000115
annotated source: binucleate

mononucleate
type: Class
subclass of: nucleate quality
IAO_0000115: A nucleate quality inhering in a bearer by virtue of the bearer's having one nucleus.
id: PATO:0001407
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: cell quality
in_subset: mpath slim
in_subset: value slim

Axiom
annotated target: A nucleate quality inhering in a bearer by virtue of the bearer's having one nucleus.
database_cross_reference: Biology-online:Biology-online
annotated property: IAO_0000115
annotated source: mononucleate

wholeness
type: Class
subclass of: structure
IAO_0000115: A structural quality inhering in a bearer by virtue of whether the bearer includes all its components.
id: PATO:0001442
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: attribute slim

Axiom
annotated target: A structural quality inhering in a bearer by virtue of whether the bearer includes all its components.
database_cross_reference: thefreedictionary.com:thefreedictionary.com
annotated property: IAO_0000115
annotated source: wholeness

broken
type: Class
subclass of: wholeness
IAO_0000115: A broken quality inhering in a bearer by virtue of the bearer's being broken open.
has_alternative_id: PATO:0001443
id: PATO:0001444
has_alternative_id: PATO:0001820
has_exact_synonym: burst
has_related_synonym: cracked
has_exact_synonym: fractured
has_exact_synonym: fragmented
has_related_synonym: hemorrhaged
has_obo_namespace: quality
has_exact_synonym: ruptured
has_related_synonym: split
has_related_synonym: torn
IAO_0000412: pato.owl
in_subset: attribute slim
in_subset: value slim

Axiom
annotated target: A broken quality inhering in a bearer by virtue of the bearer's being broken open.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: broken

punctate
type: Class
subclass of: irregular spatial pattern
IAO_0000115: A pattern inhering in a surface by virtue of the bearer's being marked by the presence of dots, punctures, points or pits.
id: PATO:0001512
has_related_synonym: dotted
has_obo_namespace: quality
has_related_synonym: spotted
has_related_synonym: stippled
IAO_0000412: pato.owl
in_subset: mpath slim
in_subset: value slim

Axiom
annotated target: A pattern inhering in a surface by virtue of the bearer's being marked by the presence of dots, punctures, points or pits.
database_cross_reference: medical-dictionary:medical-dictionary
annotated property: IAO_0000115
annotated source: punctate

has number of
type: Class
subclass of: physical object quality
database_cross_reference: OBO_REL:has_part
id: PATO:0001555
IAO_0000115: The number of parts of a particular type that the bearer entity has. This is a relational quality, and thus holds between two entities: the bearer of the quality, and the type of parts.
has_related_synonym: cardinality
has_exact_synonym: extra or missing physical or functional parts
has_exact_synonym: has or lacks parts of type
has_exact_synonym: mereological quality
has_related_synonym: number
has_exact_synonym: number of
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: attribute slim
in_subset: relational slim

Axiom
database_cross_reference: PATOC:CJM
annotated target: The number of parts of a particular type that the bearer entity has. This is a relational quality, and thus holds between two entities: the bearer of the quality, and the type of parts.
annotated property: IAO_0000115
annotated source: has number of

lacking processual parts
type: Class
subclass of: extra or missing processual parts
IAO_0000115: A quality of a process inhering in a bearer by virtue of the bearer's lacking a processual part as specified by the additional entity.
id: PATO:0001558
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: relational slim
in_subset: value slim

Axiom
annotated target: A quality of a process inhering in a bearer by virtue of the bearer's lacking a processual part as specified by the additional entity.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: lacking processual parts

decreased mass
type: Class
equivalent class: Class
  intersection of: mass
  intersection of: Restriction
    on property: decreased_in_magnitude_relative_to
    some values from: normal
subclass of: mass
subclass of: decreased object quality
subclass of: Restriction
  on property: decreased_in_magnitude_relative_to
  some values from: normal
IAO_0000115: A mass which is lower than normal or average.
has_alternative_id: PATO:0000579
id: PATO:0001562
has_exact_synonym: low mass
has_obo_namespace: quality
has_exact_synonym: small mass
IAO_0000412: pato.owl
in_subset: value slim

Axiom
annotated target: A mass which is lower than normal or average.
database_cross_reference: PATO:GVG
annotated property: IAO_0000115
annotated source: decreased mass

increased mass
type: Class
equivalent class: Class
  intersection of: mass
  intersection of: Restriction
    on property: increased_in_magnitude_relative_to
    some values from: normal
subclass of: mass
subclass of: increased object quality
subclass of: Restriction
  on property: increased_in_magnitude_relative_to
  some values from: normal
IAO_0000115: A mass which is higher than normal or average.
has_alternative_id: PATO:0000578
id: PATO:0001563
has_exact_synonym: high mass
has_exact_synonym: large mass
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: value slim

Axiom
annotated target: A mass which is higher than normal or average.
database_cross_reference: PATO:GVG
annotated property: IAO_0000115
annotated source: increased mass

extra or missing processual parts
type: Class
subclass of: process quality
IAO_0000115: A quality of a process inhering in a bearer by virtue of the bearer's processual parts.
id: PATO:0001564
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: relational slim

Axiom
annotated target: A quality of a process inhering in a bearer by virtue of the bearer's processual parts.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: extra or missing processual parts

deformed
type: Class
subclass of: morphology
IAO_0000115: A morphological quality inhering in a bearer by virtue of the bearer's being distorted in form.
id: PATO:0001617
has_related_synonym: disfigured
has_related_synonym: distorted
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: value slim

Axiom
annotated target: A morphological quality inhering in a bearer by virtue of the bearer's being distorted in form.
database_cross_reference: thefreedictionary.com:thefreedictionary.com
annotated property: IAO_0000115
annotated source: deformed

aggregated
type: Class
subclass of: irregular spatial pattern
IAO_0000115: A spatial pattern inhering in a bearer by virtue of the bearer's being gathered or tending to gather into a mass or whole.
id: PATO:0001629
has_exact_synonym: clustered
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: mpath slim
in_subset: value slim

Axiom
annotated target: A spatial pattern inhering in a bearer by virtue of the bearer's being gathered or tending to gather into a mass or whole.
database_cross_reference: WordNet:WordNet
annotated property: IAO_0000115
annotated source: aggregated

dispersed
type: Class
subclass of: position
IAO_0000115: A positional quality inhering in a bearer by virtue of the bearer's being distributed or spread over a considerable extent.
id: PATO:0001630
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: mpath slim
in_subset: value slim

Axiom
annotated target: A positional quality inhering in a bearer by virtue of the bearer's being distributed or spread over a considerable extent.
database_cross_reference: WordNet:WordNet
annotated property: IAO_0000115
annotated source: dispersed

1-D extent
type: Class
subclass of: size
has_exact_synonym: 1-D size
IAO_0000115: A size quality inhering in an bearer by virtue of the bearer's extension in one dimension.
id: PATO:0001708
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: attribute slim

Axiom
annotated target: A size quality inhering in an bearer by virtue of the bearer's extension in one dimension.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: 1-D extent

2-D extent
type: Class
subclass of: size
has_exact_synonym: 2-D size
IAO_0000115: A size quality inhering in an bearer by virtue of the bearer's extension in two dimensions.
id: PATO:0001709
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: attribute slim

Axiom
annotated target: A size quality inhering in an bearer by virtue of the bearer's extension in two dimensions.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: 2-D extent

3-D extent
type: Class
subclass of: size
has_exact_synonym: 3D size
IAO_0000115: A size quality inhering in an bearer by virtue of the bearer's extension in three dimensions.
id: PATO:0001710
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: attribute slim

Axiom
annotated target: A size quality inhering in an bearer by virtue of the bearer's extension in three dimensions.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: 3-D extent

radiation quality
type: Class
subclass of: physical quality
IAO_0000115: A quality that inheres in an bearer by virtue of how that bearer interacts with radiation.
id: PATO:0001739
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: attribute slim

Axiom
annotated target: A quality that inheres in an bearer by virtue of how that bearer interacts with radiation.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: radiation quality

surrounding
type: Class
subclass of: position
IAO_0000115: A spatial quality inhering in a bearer by virtue of the bearer's being extended on all sides of another entity simultaneously.
id: PATO:0001772
has_exact_synonym: encircling
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: relational slim
in_subset: value slim

Axiom
annotated target: A spatial quality inhering in a bearer by virtue of the bearer's being extended on all sides of another entity simultaneously.
database_cross_reference: thefreedictionary.com:thefreedictionary.com
annotated property: IAO_0000115
annotated source: surrounding

triangular
type: Class
subclass of: 2-D shape
IAO_0000115: A shape quality inhering in a bearer by virtue of the bearer's having three angles.
id: PATO:0001875
has_exact_synonym: deltoid
has_obo_namespace: quality
has_related_synonym: triangle
has_related_synonym: triangle-shaped
IAO_0000412: pato.owl
in_subset: cell quality
in_subset: value slim

Axiom
annotated target: A shape quality inhering in a bearer by virtue of the bearer's having three angles.
database_cross_reference: wordreference:wordreference
annotated property: IAO_0000115
annotated source: triangular

arrow-shaped
type: Class
subclass of: shape
IAO_0000115: A shape quality inhering in a bearer by virtue of the bearer's forming two equal obtuse triangles with a short side in common.
comment: Gradually enlarged at the base, like the head of an arrow.
id: PATO:0001881
has_obo_namespace: quality
has_exact_synonym: sagittate
IAO_0000412: pato.owl
in_subset: cell quality
in_subset: value slim

Axiom
annotated target: A shape quality inhering in a bearer by virtue of the bearer's forming two equal obtuse triangles with a short side in common.
database_cross_reference: ISBN:0881923214
database_cross_reference: RKC:RKC
annotated property: IAO_0000115
annotated source: arrow-shaped

movement quality
type: Class
subclass of: physical quality
IAO_0000115: A physical quality inhering in a bearer by virtue of the bearer's participation in movement.
id: PATO:0001906
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: attribute slim

Axiom
annotated target: A physical quality inhering in a bearer by virtue of the bearer's participation in movement.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: movement quality

multinucleate
type: Class
subclass of: nucleate quality
IAO_0000115: A nucleate quality inhering in a bearer by virtue of the bearer's having more than one nucleus.
id: PATO:0001908
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: mpath slim
in_subset: value slim

Axiom
annotated target: A nucleate quality inhering in a bearer by virtue of the bearer's having more than one nucleus.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: multinucleate

surface feature shape
type: Class
subclass of: shape
IAO_0000115: A surface shape quality inhering in a bearer by virtue of the bearer's shape of features present on its surface or outer shell.
id: PATO:0001925
comment: This quality either inheres directly in the surface, or in the entity that has the surface. For example, to say that a particular fly wing is curved is shorthand for saying the wing has a surface which is curved.
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: attribute slim

Axiom
annotated target: A surface shape quality inhering in a bearer by virtue of the bearer's shape of features present on its surface or outer shell.
database_cross_reference: PATOC:CJM
annotated property: IAO_0000115
annotated source: surface feature shape

variability of shape
type: Class
subclass of: variability
subclass of: Restriction
  on property: towards
  some values from: shape
IAO_0000115: A variability quality inhering in a bearer by virtue of whether the bearer exhibits shape variation or change.
id: PATO:0001929
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: attribute slim

Axiom
annotated target: A variability quality inhering in a bearer by virtue of whether the bearer exhibits shape variation or change.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: variability of shape

variability of size
type: Class
subclass of: variability
subclass of: Restriction
  on property: towards
  some values from: size
IAO_0000115: A variability quality inhering in a bearer by virtue of whether the bearer exhibits size variation or change.
id: PATO:0001956
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: attribute slim

Axiom
annotated target: A variability quality inhering in a bearer by virtue of whether the bearer exhibits size variation or change.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: variability of size

increased variability of size
type: Class
equivalent class: Class
  intersection of: variability of size
  intersection of: Restriction
    on property: increased_in_magnitude_relative_to
    some values from: normal
subclass of: variability of size
subclass of: increased object quality
subclass of: Restriction
  on property: increased_in_magnitude_relative_to
  some values from: normal
IAO_0000115: A variability of size which is relatively high.
id: PATO:0001958
has_exact_synonym: high variability of size
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: value slim

Axiom
annotated target: A variability of size which is relatively high.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: increased variability of size

lobed
type: Class
subclass of: shape
IAO_0000115: A shape quality inhering in a bearer by virtue of the bearer's being partly divided into a determinate number of regions.
id: PATO:0001979
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: mpath slim
in_subset: value slim

Axiom
annotated target: A shape quality inhering in a bearer by virtue of the bearer's being partly divided into a determinate number of regions.
database_cross_reference: ISBN:0881923214
annotated property: IAO_0000115
annotated source: lobed

organismal quality
type: Class
subclass of: physical object quality
IAO_0000115: A quality that inheres in an entire organism or part of an organism.
id: PATO:0001995
has_obo_namespace: quality
IAO_0000412: pato.owl

Axiom
annotated target: A quality that inheres in an entire organism or part of an organism.
database_cross_reference: PATOC:CJM
annotated property: IAO_0000115
annotated source: organismal quality

lacks parts or has fewer parts of type
type: Class
subclass of: altered number of
id: PATO:0001999
IAO_0000115: The bearer of this quality has_part < n of the indicated entity type, where n is the normal amount for a comparable organism. Note that the bearer of the quality is the whole, not the part. Formally: If a bearer entity e has fewer parts of type X at time t, then the number of instances x of X at t such that x part_of e is < n, where n is either the normal number for comparable entities, or n is stated explicitly. This case includes the limit case, where the bearer lacks all parts of the specified type.
has_exact_synonym: loss of
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: relational slim

Axiom
database_cross_reference: PATOC:CJM
annotated target: The bearer of this quality has_part < n of the indicated entity type, where n is the normal amount for a comparable organism. Note that the bearer of the quality is the whole, not the part. Formally: If a bearer entity e has fewer parts of type X at time t, then the number of instances x of X at t such that x part_of e is < n, where n is either the normal number for comparable entities, or n is stated explicitly. This case includes the limit case, where the bearer lacks all parts of the specified type.
annotated property: IAO_0000115
annotated source: lacks parts or has fewer parts of type

lacks all parts of type
type: Class
subclass of: lacks parts or has fewer parts of type
IAO_0000115: A quality of physical entities inhering in a bearer by virtue of the bearer's lacking a physical part as specified by the additional entity.
comment: Example: [E=organism Q=lacks_all_parts_of_type E2=Wing] - applies to an organism. A relational quality in which the bearer entity has no parts of the specified type. The bearer of this quality has_part = 0 of the indicated entity type, where a comparable organism usually has at least 1 part of the same type. Note that the bearer of the quality is the whole, not the part. Formally: If a bearer entity e lacks all parts of type X at time t, then there exists no instances x of X at t such that x part_of e that has no wings, where wings are normally present in that organism type. In OWL this is equivalent to a restriction on the OBO_REL:has_part relation with cardinality=0, i.e has_part 0 E2.
database_cross_reference: OBO_REL:lacks_part
has_alternative_id: PATO:0001557
id: PATO:0002000
has_exact_synonym: lacks all physical parts of type
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: relational slim

Axiom
annotated target: A quality of physical entities inhering in a bearer by virtue of the bearer's lacking a physical part as specified by the additional entity.
database_cross_reference: PATOC:CJM
annotated property: IAO_0000115
annotated source: lacks all parts of type

has fewer parts of type
type: Class
equivalent class: Class
  intersection of: lacks parts or has fewer parts of type
  intersection of: Restriction
    on property: decreased_in_magnitude_relative_to
    some values from: normal
subclass of: lacks parts or has fewer parts of type
subclass of: decreased object quality
subclass of: Restriction
  on property: decreased_in_magnitude_relative_to
  some values from: normal
comment: Example: [E=hand Q=has_fewer_parts_of_type E2=digit] - applies to an organism that has no less fingers than is normal for organisms of that type.
has_alternative_id: PATO:0001569
id: PATO:0002001
IAO_0000115: The bearer of this quality has_part < n AND has_part > 0 of the indicated entity type, where n is the normal amount for a comparable organism. Note that the bearer of the quality is the whole, not the part. Formally: If a bearer entity e has fewer parts of type X at time t, then the number of instances x of X at t such that x part_of e is < n, where n is either the normal number for comparable entities, or n is stated explicitly.
has_exact_synonym: decreased number of
has_exact_synonym: has decreased number of
has_exact_synonym: has fewer physical parts of type
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: relational slim

Axiom
database_cross_reference: PATOC:CJM
annotated target: The bearer of this quality has_part < n AND has_part > 0 of the indicated entity type, where n is the normal amount for a comparable organism. Note that the bearer of the quality is the whole, not the part. Formally: If a bearer entity e has fewer parts of type X at time t, then the number of instances x of X at t such that x part_of e is < n, where n is either the normal number for comparable entities, or n is stated explicitly.
annotated property: IAO_0000115
annotated source: has fewer parts of type

has extra parts of type
type: Class
equivalent class: Class
  intersection of: altered number of
  intersection of: Restriction
    on property: increased_in_magnitude_relative_to
    some values from: normal
subclass of: altered number of
subclass of: increased object quality
subclass of: Restriction
  on property: increased_in_magnitude_relative_to
  some values from: normal
comment: In polydactyly, the bearer of the quality is the hand, and the entity type being counted is 'finger'. In EQ syntax, E=hand, Q=<this> E2=finger.
has_alternative_id: PATO:0001560
id: PATO:0002002
IAO_0000115: The bearer of this quality has_part > n of the indicated entity type, where n is the normal amount for a comparable organism. Note that the bearer of the quality is the whole, not the part.
has_exact_synonym: has extra parts of
has_exact_synonym: has increased number of
has_exact_synonym: having extra physical parts
has_exact_synonym: having supernumerary physical parts
has_exact_synonym: increased number of
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: relational slim

Axiom
database_cross_reference: PATOC:CJM
annotated target: The bearer of this quality has_part > n of the indicated entity type, where n is the normal amount for a comparable organism. Note that the bearer of the quality is the whole, not the part.
annotated property: IAO_0000115
annotated source: has extra parts of type

2-D shape
type: Class
subclass of: shape
has_related_synonym: 2-D projection
IAO_0000115: A shape that inheres in a 2 dimensional entity, such as a cross section or projection of a 3 dimensional entity.
id: PATO:0002006
has_related_synonym: cross-sectional
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: attribute slim

Axiom
annotated target: A shape that inheres in a 2 dimensional entity, such as a cross section or projection of a 3 dimensional entity.
database_cross_reference: PATOC:CJM
annotated property: IAO_0000115
annotated source: 2-D shape

increased occurrence
type: Class
equivalent class: Class
  intersection of: occurrence quality
  intersection of: Restriction
    on property: increased_in_magnitude_relative_to
    some values from: normal
subclass of: occurrence quality
subclass of: increased process quality
subclass of: Restriction
  on property: increased_in_magnitude_relative_to
  some values from: normal
creation date: 2009-03-26T11:10:11Z
IAO_0000115: An occurrence which is relatively high.
created by: George Gkoutos
id: PATO:0002051
has_exact_synonym: increased incidence
has_obo_namespace: quality
IAO_0000412: pato.owl

Axiom
annotated target: An occurrence which is relatively high.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: increased occurrence

decreased occurrence
type: Class
equivalent class: Class
  intersection of: occurrence quality
  intersection of: Restriction
    on property: decreased_in_magnitude_relative_to
    some values from: normal
subclass of: occurrence quality
subclass of: decreased process quality
subclass of: Restriction
  on property: decreased_in_magnitude_relative_to
  some values from: normal
creation date: 2009-03-26T11:12:35Z
IAO_0000115: An occurrence which is relatively low.
created by: George Gkoutos
id: PATO:0002052
has_exact_synonym: decreased incidence
has_obo_namespace: quality
IAO_0000412: pato.owl

Axiom
annotated target: An occurrence which is relatively low.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: decreased occurrence

increased area
type: Class
equivalent class: Class
  intersection of: area
  intersection of: Restriction
    on property: increased_in_magnitude_relative_to
    some values from: normal
subclass of: increased size
subclass of: area
subclass of: Restriction
  on property: increased_in_magnitude_relative_to
  some values from: normal
creation date: 2009-03-30T04:11:43Z
IAO_0000115: An area which is relatively high.
created by: George Gkoutos
id: PATO:0002057
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: value slim

Axiom
annotated target: An area which is relatively high.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: increased area

decreased area
type: Class
equivalent class: Class
  intersection of: area
  intersection of: Restriction
    on property: decreased_in_magnitude_relative_to
    some values from: normal
subclass of: decreased size
subclass of: area
subclass of: Restriction
  on property: decreased_in_magnitude_relative_to
  some values from: normal
creation date: 2009-03-30T04:12:11Z
IAO_0000115: An area which is relatively low.
created by: George Gkoutos
id: PATO:0002058
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: value slim

Axiom
annotated target: An area which is relatively low.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: decreased area

physical quality of a process
type: Class
subclass of: process quality
creation date: 2009-06-05T09:16:46Z
id: PATO:0002062
created by: george
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: attribute slim

star shaped
type: Class
subclass of: shape
creation date: 2009-07-01T01:48:19Z
IAO_0000115: A shape quality inhering in a bearer by virtue of the bearer's being arranged like rays or radii; radiating from a common center.
created by: George Gkoutos
id: PATO:0002065
has_obo_namespace: quality
has_exact_synonym: stellate
IAO_0000412: pato.owl
in_subset: cell quality
in_subset: mpath slim
in_subset: value slim

Axiom
annotated target: A shape quality inhering in a bearer by virtue of the bearer's being arranged like rays or radii; radiating from a common center.
database_cross_reference: PATOC:me
annotated property: IAO_0000115
annotated source: star shaped

altered number of
type: Class
subclass of: has number of
creation date: 2009-09-21T10:41:58Z
created by: George Gkoutos
IAO_0000115: Having extra or fewer parts.
id: PATO:0002083
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: attribute slim
in_subset: relational slim

Axiom
annotated target: Having extra or fewer parts.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: altered number of

peripheral
type: Class
subclass of: position
creation date: 2009-10-05T02:58:16Z
IAO_0000115: A positional quality inhering in a bearer by virtue of the bearer's being at the edge or boundary of a related entity.
id: PATO:0002107
created by: george
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: mpath slim
in_subset: relational slim
in_subset: value slim

Axiom
annotated target: A positional quality inhering in a bearer by virtue of the bearer's being at the edge or boundary of a related entity.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: peripheral

bilobed
type: Class
subclass of: lobed
creation date: 2010-07-08T01:54:08Z
IAO_0000115: A lobed quality inhering in a bearer by virtue of the bearer's being divided into or having two lobes.
id: PATO:0002214
created by: george
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: mpath slim
in_subset: value slim

Axiom
annotated target: A lobed quality inhering in a bearer by virtue of the bearer's being divided into or having two lobes.
database_cross_reference: thefreedictionary:http://www.thefreedictionary.com/bilobed
annotated property: IAO_0000115
annotated source: bilobed

fan-shaped
type: Class
subclass of: 2-D shape
creation date: 2010-07-09T01:43:42Z
IAO_0000115: A quality inhering in a bearer that is shaped in the form of a fan.
id: PATO:0002219
has_exact_synonym: fan-like
created by: george
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: value slim

Axiom
annotated target: A quality inhering in a bearer that is shaped in the form of a fan.
database_cross_reference: thefreedictionary:http://www.thefreedictionary.com/fan-shaped
annotated property: IAO_0000115
annotated source: fan-shaped

organization quality
type: Class
subclass of: structure
creation date: 2010-09-16T10:22:52Z
IAO_0000115: A structural quality inhering in a bearer by virtue of the bearer's being arranged in a systematic fashion.
id: PATO:0002264
created by: george
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: attribute slim

Axiom
annotated target: A structural quality inhering in a bearer by virtue of the bearer's being arranged in a systematic fashion.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: organization quality

centered
type: Class
subclass of: position
creation date: 2010-10-05T01:09:32Z
IAO_0000115: A positional quality inhering in a bearer by virtue of the bearer's being located in a position equidistant from edges.
id: PATO:0002268
created by: george
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: value slim

Axiom
annotated target: A positional quality inhering in a bearer by virtue of the bearer's being located in a position equidistant from edges.
database_cross_reference: PATOC:OREGON
annotated property: IAO_0000115
annotated source: centered

increased quality
type: Class
equivalent class: Class
  intersection of: quality
  intersection of: Restriction
    on property: increased_in_magnitude_relative_to
    some values from: normal
subclass of: deviation(from_normal)
subclass of: Restriction
  on property: increased_in_magnitude_relative_to
  some values from: normal
creation date: 2011-06-16T06:39:43Z
IAO_0000115: A quality that has a value that is increased compared to normal or average.
created by: George Gkoutos
id: PATO:0002300
has_obo_namespace: quality
IAO_0000412: pato.owl

Axiom
annotated target: A quality that has a value that is increased compared to normal or average.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: increased quality

decreased quality
type: Class
equivalent class: Class
  intersection of: quality
  intersection of: Restriction
    on property: decreased_in_magnitude_relative_to
    some values from: normal
subclass of: deviation(from_normal)
subclass of: Restriction
  on property: decreased_in_magnitude_relative_to
  some values from: normal
creation date: 2011-06-16T06:40:15Z
IAO_0000115: A quality that has a value that is decreased compared to normal or average.
created by: George Gkoutos
id: PATO:0002301
has_obo_namespace: quality
IAO_0000412: pato.owl

Axiom
annotated target: A quality that has a value that is decreased compared to normal or average.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: decreased quality

decreased process quality
type: Class
equivalent class: Class
  intersection of: process quality
  intersection of: Restriction
    on property: decreased_in_magnitude_relative_to
    some values from: normal
subclass of: process quality
subclass of: decreased quality
subclass of: Restriction
  on property: decreased_in_magnitude_relative_to
  some values from: normal
creation date: 2011-06-16T06:50:59Z
IAO_0000115: A quality of a process that has a value that is decreased compared to normal or average.
created by: George Gkoutos
id: PATO:0002302
has_obo_namespace: quality
IAO_0000412: pato.owl

Axiom
annotated target: A quality of a process that has a value that is decreased compared to normal or average.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: decreased process quality

decreased object quality
type: Class
equivalent class: Class
  intersection of: physical object quality
  intersection of: Restriction
    on property: decreased_in_magnitude_relative_to
    some values from: normal
subclass of: physical object quality
subclass of: decreased quality
subclass of: Restriction
  on property: decreased_in_magnitude_relative_to
  some values from: normal
creation date: 2011-06-16T06:51:54Z
IAO_0000115: A quality of an object that has a value that is decreased compared to normal or average.
created by: George Gkoutos
id: PATO:0002303
has_obo_namespace: quality
IAO_0000412: pato.owl

Axiom
annotated target: A quality of an object that has a value that is decreased compared to normal or average.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: decreased object quality

increased process quality
type: Class
equivalent class: Class
  intersection of: process quality
  intersection of: Restriction
    on property: increased_in_magnitude_relative_to
    some values from: normal
subclass of: process quality
subclass of: increased quality
subclass of: Restriction
  on property: increased_in_magnitude_relative_to
  some values from: normal
creation date: 2011-06-16T06:53:08Z
IAO_0000115: A quality of a process that has a value that is increased compared to normal or average.
created by: George Gkoutos
id: PATO:0002304
has_obo_namespace: quality
IAO_0000412: pato.owl

Axiom
annotated target: A quality of a process that has a value that is increased compared to normal or average.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: increased process quality

increased object quality
type: Class
equivalent class: Class
  intersection of: physical object quality
  intersection of: Restriction
    on property: increased_in_magnitude_relative_to
    some values from: normal
subclass of: physical object quality
subclass of: increased quality
subclass of: Restriction
  on property: increased_in_magnitude_relative_to
  some values from: normal
creation date: 2011-06-16T06:54:01Z
IAO_0000115: A quality of an object that has a value that is increased compared to normal or average.
created by: George Gkoutos
id: PATO:0002305
has_obo_namespace: quality
IAO_0000412: pato.owl

Axiom
annotated target: A quality of an object that has a value that is increased compared to normal or average.
database_cross_reference: PATOC:GVG
annotated property: IAO_0000115
annotated source: increased object quality

superelliptic
type: Class
subclass of: 2-D shape
creation date: 2011-10-12T12:45:16Z
IAO_0000115: A shape constituting a transition between a rectangle and a circle; a closed curve, of which the circle and ellipse are special cases, whose parametric equation is x = a.cos2/rt, y = b.cos2/rt
created by: George Gkoutos
has_exact_synonym: Lamé curve
id: PATO:0002318
has_obo_namespace: quality
IAO_0000412: pato.owl

Axiom
annotated target: A shape constituting a transition between a rectangle and a circle; a closed curve, of which the circle and ellipse are special cases, whose parametric equation is x = a.cos2/rt, y = b.cos2/rt
database_cross_reference: wiktionary:superellipse
annotated property: IAO_0000115
annotated source: superelliptic

temporal distribution quality
type: Class
subclass of: physical quality of a process
creation date: 2011-11-22T01:12:28Z
IAO_0000115: A temporal distribution pattern of process occurrences within a regulation/reference process.
created by: George Gkoutos
id: PATO:0002323
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: attribute slim

Axiom
annotated target: A temporal distribution pattern of process occurrences within a regulation/reference process.
database_cross_reference: PATOC:LC
annotated property: IAO_0000115
annotated source: temporal distribution quality

offset quality
type: Class
subclass of: temporal distribution quality
creation date: 2011-11-23T11:46:00Z
created by: George Gkoutos
id: PATO:0002324
IAO_0000115: The temporal relation between the end of the process with respect to a reference process.
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: attribute slim

Axiom
database_cross_reference: PATOC:LC
annotated target: The temporal relation between the end of the process with respect to a reference process.
annotated property: IAO_0000115
annotated source: offset quality

onset quality
type: Class
subclass of: temporal distribution quality
creation date: 2011-11-23T11:47:34Z
created by: George Gkoutos
id: PATO:0002325
IAO_0000115: The temporal relation between the start of the process with respect to a reference process.
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: attribute slim

Axiom
database_cross_reference: PATOC:LC
annotated target: The temporal relation between the start of the process with respect to a reference process.
annotated property: IAO_0000115
annotated source: onset quality

acinus
type: Class
subclass of: lobed
creation date: 2012-07-05T14:58:05Z
IAO_0000115: Having a shape that resembles a many-lobed "berry," such as a raspberry.
id: PATO:0002378
created by: gkoutos
has_obo_namespace: quality
IAO_0000412: pato.owl
in_subset: mpath slim
in_subset: value slim

Axiom
annotated target: Having a shape that resembles a many-lobed "berry," such as a raspberry.
database_cross_reference: wikipedia:https://en.wikipedia.org/wiki/Acinus
annotated property: IAO_0000115
annotated source: acinus

cell population
type: Class
equivalent class: Class
  intersection of: Restriction
    on property: has_part
    some values from: cto:cell
  intersection of: Restriction
    on property: has_part
    some values from: quality
subclass of: Restriction
  on property: has_part
  some values from: cto:cell
subclass of: Restriction
  on property: has_part
  some values from: quality
id: CMPO:0000002
IAO_0000115: A phenotype observation at the level of a population of cells
in_subset: cmpo

phenotype
type: Class
IAO_0000115: An observation where the phenotype is described in terms of a biological process, a cell population, a whole cell or a subcellular structure that bears a particular quality.
in_subset: cmpo

cell morphology phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: morphology
    intersection of: Restriction
      on property: RO_0000052
      some values from: cto:cell
subclass of: single cell phenotype
id: CMPO:0000005
IAO_0000115: A phenotype observation at the level of the whole cell relating to the cell's shape, size or structure
preferred label: cell morphology
in_subset: cmpo

cell process phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: process quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: biological_process
subclass of: phenotype
IAO_0000115: A phenotype observation at the level of a cellular process
id: CMPO:0000007
has_exact_synonym: cell physiology phenotype
in_subset: cmpo

cell component number phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: altered number of
    intersection of: Restriction
      on property: BFO_0000070
      some values from: cellular_component
    intersection of: Restriction
      on property: RO_0000052
      some values from: cto:cell
subclass of: single cell phenotype
IAO_0000115: An increase or decrease in the number of specified components within a cell
id: CMPO:0000008
preferred label: cell component number
in_subset: cmpo

cell component size phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: size
    intersection of: Restriction
      on property: RO_0000052
      some values from: cellular_component
subclass of: cell component morphology phenotype
id: CMPO:0000010
IAO_0000115: A phenotype observation at the level of a cellular component relating to the components size
preferred label: cell component size
in_subset: cmpo

cell component shape phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: shape
    intersection of: Restriction
      on property: RO_0000052
      some values from: cellular_component
subclass of: cell component morphology phenotype
IAO_0000115: A phenotype observation at the level of a cellular component relating to the components shape
id: CMPO:0000011
preferred label: cell component shape
in_subset: cmpo

cell component structure phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: structure
    intersection of: Restriction
      on property: RO_0000052
      some values from: cellular_component
subclass of: cell component morphology phenotype
IAO_0000115: A phenotype observation at the level of a cellular component relating to the components structure
id: CMPO:0000012
preferred label: cell component structure
in_subset: cmpo

cell viability phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: viability
    intersection of: Restriction
      on property: RO_0000052
      some values from: cto:cell
subclass of: single cell phenotype
id: CMPO:0000013
IAO_0000115: A phenotype relating to the ability of a cell survive or to develop normally
preferred label: cell viability
in_subset: cmpo

viable cell phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: viable
    intersection of: Restriction
      on property: RO_0000052
      some values from: cto:cell
subclass of: cell viability phenotype
id: CMPO:0000014
IAO_0000115: A cell phenotype where the cell is viable
preferred label: viable cell
in_subset: cmpo

inviable cell phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: lethal (sensu genetics)
    intersection of: Restriction
      on property: RO_0000052
      some values from: cto:cell
subclass of: cell viability phenotype
id: CMPO:0000015
IAO_0000115: A cell phenotype where the cell is not viable
preferred label: inviable cell
in_subset: cmpo

cell nucleation phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: nucleate quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: cto:cell
subclass of: single cell phenotype
id: CMPO:0000016
IAO_0000115: A phenotype observation at the level of the whole cell relating to the cell's nucleation
preferred label: cell nucleation
in_subset: cmpo

mononuclear cell phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: mononucleate
    intersection of: Restriction
      on property: RO_0000052
      some values from: cto:cell
subclass of: cell nucleation phenotype
id: CMPO:0000017
preferred label: mononuclear cell
in_subset: cmpo

multinucleated cell phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: multinucleate
    intersection of: Restriction
      on property: RO_0000052
      some values from: cto:cell
subclass of: cell nucleation phenotype
id: CMPO:0000018
IAO_0000115: A phenotype observation where a cell is multinucleate, e.g. have more than one nucleus per cell
has_exact_synonym: polynuclear cell
preferred label: multinucleated cell
in_subset: cmpo

cytoskeletal phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: cytoskeletal part
subclass of: phenotypes by organelle
subclass of: Restriction
  on property: part_of
  some values from: cytoskeletal part
IAO_0000115: A phenotype observation at the level of any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice.
id: CMPO:0000020
in_subset: cmpo

endoplasmic reticulum phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: Restriction
        on property: part_of
        some values from: endoplasmic reticulum part
subclass of: phenotypes by organelle
id: CMPO:0000021
IAO_0000115: A phenotype observation at the level of any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae.
in_subset: cmpo

golgi phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: Restriction
        on property: part_of
        some values from: Golgi apparatus part
subclass of: phenotypes by organelle
IAO_0000115: A phenotype observation at the level of any constituent part of the Golgi apparatus, a compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack
id: CMPO:0000022
in_subset: cmpo

mitochondrion phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: mitochondrial part
subclass of: phenotypes by organelle
IAO_0000115: A phenotype observation at the level of any constituent part of a mitochondrion, a semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells.
has_exact_synonym: mitochondrial part phenotype
id: CMPO:0000023
in_subset: cmpo

nuclear phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: Restriction
        on property: part_of
        some values from: nuclear part
subclass of: phenotypes by organelle
id: CMPO:0000024
IAO_0000115: A phenotype observation at the level of any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated.
in_subset: cmpo

organelle shape phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: shape
    intersection of: Restriction
      on property: RO_0000052
      some values from: organelle
subclass of: cell component shape phenotype
subclass of: phenotypes by organelle
id: CMPO:0000026
IAO_0000115: A phenotype observation at the level of a cellular organelle relating to the organelle's shape
preferred label: organelle shape
in_subset: cmpo

nucleus shape phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: shape
    intersection of: Restriction
      on property: RO_0000052
      some values from: nucleus
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: shape
    intersection of: Restriction
      on property: RO_0000052
      some values from: Restriction
        on property: part_of
        some values from: nuclear part
subclass of: organelle shape phenotype
subclass of: nuclear morphology phenotype
has_exact_synonym: nuclear shape
IAO_0000115: A phenotype observation at the level of the nucleus relating to the ratios of distances between its features (points, edges, surfaces and also holes etc).
in_subset: cmpo

cell adhesion phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: process quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: cell adhesion
subclass of: cell process phenotype
IAO_0000115: A phenotype where the attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules is observed
id: CMPO:0000028
in_subset: cmpo

cell cycle phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: process quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: Restriction
        on property: part_of
        some values from: cell cycle
subclass of: cell process phenotype
id: CMPO:0000029
IAO_0000115: A phenotype observation at the level of a cell cycle
in_subset: cmpo

cell death phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: process quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: cell death
subclass of: cell process phenotype
id: CMPO:0000030
IAO_0000115: A phenotype where the cell death process process is observed
definition source: PMID:20360735
in_subset: cmpo

cell membrane organisation phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: process quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: cellular membrane organization
subclass of: cell process phenotype
IAO_0000115: A phenotype observation of a process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
id: CMPO:0000032
in_subset: cmpo

cell migration phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: process quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: cell migration
subclass of: cell component movement phenotype
definition source: PMID:20360735
IAO_0000115: A phenotype of a cell involving its translation from one location to another
id: CMPO:0000033
in_subset: cmpo

cell growth phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: process quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: cell growth
subclass of: cell process phenotype
IAO_0000115: A phenotype observation of the process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.
id: CMPO:0000035
in_subset: cmpo

chromosome segregation phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: process quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: chromosome segregation
subclass of: cell process phenotype
IAO_0000115: A phenotype observation of the process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the alignment of chromosomes at the metaphase plate, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
id: CMPO:0000036
in_subset: cmpo

metabolic process phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: process quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: metabolic process
subclass of: cell process phenotype
id: CMPO:0000037
IAO_0000115: A phenotype observation of chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
in_subset: cmpo

organelle localization phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: process quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: organelle localization
subclass of: cell component localisation phenotype
IAO_0000115: A phenotype observations where any process in which an organelle is transported to, and/or maintained in, a specific location.
id: CMPO:0000038
in_subset: cmpo

regulation of metabolic process phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: process quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: regulation of metabolic process
subclass of: regulation of process phenotype
IAO_0000115: A phenotype observation where a process modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
id: CMPO:0000039
in_subset: cmpo

regulation of signal transduction phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: process quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: regulation of signal transduction
subclass of: regulation of process phenotype
IAO_0000115: A phenotype observation of a process that modulates the frequency, rate or extent of signal transduction.
id: CMPO:0000040
in_subset: cmpo

transport phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: process quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: transport
subclass of: cell process phenotype
IAO_0000115: A phenotype observation of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore.
id: CMPO:0000041
in_subset: cmpo

increased cell component number phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: has extra parts of type
    intersection of: Restriction
      on property: BFO_0000070
      some values from: cellular_component
    intersection of: Restriction
      on property: RO_0000052
      some values from: cto:cell
subclass of: cell component number phenotype
IAO_0000115: An increased number of specified cellular components relative to normal
id: CMPO:0000042
preferred label: increased cell component number
in_subset: cmpo

decreased cell component number phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: has fewer parts of type
    intersection of: Restriction
      on property: BFO_0000070
      some values from: cellular_component
    intersection of: Restriction
      on property: RO_0000052
      some values from: cto:cell
subclass of: cell component number phenotype
id: CMPO:0000043
IAO_0000115: A decrease in number of specified cellular components relative to normal
preferred label: decreased cell component number
in_subset: cmpo

apoptotic DNA fragmentation phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: process quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: apoptotic DNA fragmentation
subclass of: metabolic process phenotype
IAO_0000115: A phenotype observation where the cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments.
has_broad_synonym: apoptotic DNA
id: CMPO:0000047
preferred label: apoptotic DNA fragmentation
in_subset: cmpo

apoptotic cell shape phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: apoptotic
    intersection of: Restriction
      on property: RO_0000052
      some values from: cto:cell
subclass of: cell morphology phenotype
preferred label: apoptotic cell shape
comment: dispersed outline with blobby protrusions
id: CMPO:0000048
IAO_0000115: A phenotype observation at the level of the cell shape where the cell is apoptotic
in_subset: cmpo

aggregated cells in population
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: aggregated
    intersection of: Restriction
      on property: BFO_0000070
      some values from: cto:cell
subclass of: cell population
has_exact_synonym: cell aggregates
has_exact_synonym: cell islands
id: CMPO:0000049
has_exact_synonym: aggregated cells
IAO_0000115: Groups of cells gathered or tending to gather into a mass or whole.
has_exact_synonym: clustered cells
in_subset: cmpo

altered cell number in population
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: altered number of
    intersection of: Restriction
      on property: bearer of
      some values from: phenotype
subclass of: cell population
IAO_0000115: Number of cells in a population phenotype
id: CMPO:0000050
preferred label: cell number in population
in_subset: cmpo

increased cell numbers
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: has extra parts of type
    intersection of: Restriction
      on property: bearer of
      some values from: phenotype
subclass of: altered cell number in population
IAO_0000115: The population has an increased number of cells with respect to normal
id: CMPO:0000051
in_subset: cmpo

decreased cell numbers
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: has fewer parts of type
    intersection of: Restriction
      on property: bearer of
      some values from: phenotype
subclass of: altered cell number in population
id: CMPO:0000052
has_exact_synonym: reduced cell numbers
has_exact_synonym: decreased cells
has_exact_synonym: fewer cells
IAO_0000115: The population has a decreased number of cells with respect to normal
has_exact_synonym: less cells
in_subset: cmpo

more cells in S
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: has extra parts of type
    intersection of: Restriction
      on property: bearer of
      some values from: S phase mitotic phenotype
subclass of: increased cell numbers
id: CMPO:0000053
IAO_0000115: increased number of cells in S phase mitosis
in_subset: cmpo

cell population by process phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: quality
    intersection of: Restriction
      on property: BFO_0000070
      some values from: biological_process
subclass of: cell population
IAO_0000115: A population of cells where a specifcied biological process is occuring or is observed.
id: CMPO:0000054
preferred label: cell population process
in_subset: cmpo

more cells in G1
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: has extra parts of type
    intersection of: Restriction
      on property: bearer of
      some values from: G1 phase mitotic phenotype
subclass of: increased cell numbers
id: CMPO:0000055
IAO_0000115: increased cell numbers in G1
in_subset: cmpo

more cells in G2M
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: has extra parts of type
    intersection of: Restriction
      on property: bearer of
      some values from: G2/M transition phenotype
subclass of: increased cell numbers
IAO_0000115: increased number of cells in G2M
has_exact_synonym: increased mitotic index
id: CMPO:0000056
in_subset: cmpo

fewer cells in G1
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: has fewer parts of type
    intersection of: Restriction
      on property: bearer of
      some values from: G1 phase mitotic phenotype
subclass of: decreased cell numbers
id: CMPO:0000057
IAO_0000115: decreased number of cells in G1 phase
has_exact_synonym: less cells in G1
in_subset: cmpo

fewer cells in G2M
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: has fewer parts of type
    intersection of: Restriction
      on property: bearer of
      some values from: G2/M transition phenotype
subclass of: decreased cell numbers
has_exact_synonym: less cells in G2M
has_exact_synonym: decreased mitotic index
id: CMPO:0000058
IAO_0000115: decreased number of cells in G2M phase
in_subset: cmpo

fewer cells in S
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: has fewer parts of type
    intersection of: Restriction
      on property: bearer of
      some values from: S phase mitotic phenotype
subclass of: decreased cell numbers
IAO_0000115: decreased number of cells in S phase
id: CMPO:0000059
has_exact_synonym: decreased number of cells in S
has_exact_synonym: less cells in S
in_subset: cmpo

decreased number of focal adhesion phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: has fewer parts of type
    intersection of: Restriction
      on property: BFO_0000070
      some values from: focal adhesion
    intersection of: Restriction
      on property: RO_0000052
      some values from: cto:cell
subclass of: decreased cell component number phenotype
has_exact_synonym: decreased focal adhesion abundance
IAO_0000115: A phenotype observation at the level of focal adhesions where the components number has decreased.
id: CMPO:0000063
preferred label: decreased number of focal adhesion
in_subset: cmpo

centrally located focal adhesion phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: centered
    intersection of: Restriction
      on property: RO_0000052
      some values from: focal adhesion
subclass of: cell component position phenotype
definition source: PMID:19667130
id: CMPO:0000064
IAO_0000115: A phenotype observation where the focal adhesion is located in a position equidistant from the edges of the cell
preferred label: centrally located focal adhesion
in_subset: cmpo

cell component position phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: position
    intersection of: Restriction
      on property: RO_0000052
      some values from: cellular_component
subclass of: cellular component phenotype
id: CMPO:0000065
IAO_0000115: A phenotype observation at the level of a cellular component relating to the components position in the cell
preferred label: cell component position
in_subset: cmpo

peripheral focal adhesion phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: peripheral
    intersection of: Restriction
      on property: RO_0000052
      some values from: focal adhesion
subclass of: cell component position phenotype
id: CMPO:0000066
definition source: PMID:19667130
IAO_0000115: A phenotype observation where the focal adhesions's position is at the edge or boundary of a related entity.
preferred label: peripheral focal adhesion
in_subset: cmpo

decreased number of filopodia phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: has fewer parts of type
    intersection of: Restriction
      on property: BFO_0000070
      some values from: filopodium
    intersection of: Restriction
      on property: RO_0000052
      some values from: cto:cell
subclass of: decreased number of cell projections phenotype
IAO_0000115: A phenotype observation at the level of filopodia where the components number has decreased.
id: CMPO:0000067
preferred label: decreased number of filopodia
has_exact_synonym: fewer filopodia
in_subset: cmpo

decreased number of microtubules phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: has fewer parts of type
    intersection of: Restriction
      on property: BFO_0000070
      some values from: microtubule
    intersection of: Restriction
      on property: RO_0000052
      some values from: cto:cell
subclass of: decreased cell component number phenotype
has_exact_synonym: fewer microtubules
id: CMPO:0000068
IAO_0000115: A phenotype observation at the level of microtubules where the components number has decreased.
preferred label: decreased number of microtubules
in_subset: cmpo

decreased number of dendritic branches phenotyope
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: has fewer parts of type
    intersection of: Restriction
      on property: BFO_0000070
      some values from: dendritic branch
    intersection of: Restriction
      on property: RO_0000052
      some values from: cto:cell
subclass of: decreased cell component number phenotype
id: CMPO:0000069
IAO_0000115: A phenotype observation at the level of dendritic branches where the components number has decreased.
in_subset: cmpo

cells with projections
type: Class
subclass of: cell population
definition source: PMID:20531400
id: CMPO:0000071
has_exact_synonym: cells with protrusions
IAO_0000115: Population of cells with protrusions
in_subset: cmpo

increased number of cell projections phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: has extra parts of type
    intersection of: Restriction
      on property: BFO_0000070
      some values from: cell projection
    intersection of: Restriction
      on property: RO_0000052
      some values from: cto:cell
subclass of: increased cell component number phenotype
IAO_0000115: An increase in number of any cell projection relative to normal
id: CMPO:0000072
preferred label: increased number of cell projections
in_subset: cmpo

more cells with projections
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: has extra parts of type
    intersection of: Restriction
      on property: bearer of
      some values from: increased number of cell projections phenotype
subclass of: increased cell numbers
id: CMPO:0000073
IAO_0000115: increased number of cells in population with projections
in_subset: cmpo

decreased number of cell projections phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: has fewer parts of type
    intersection of: Restriction
      on property: BFO_0000070
      some values from: cell projection
    intersection of: Restriction
      on property: RO_0000052
      some values from: cto:cell
subclass of: decreased cell component number phenotype
IAO_0000115: A phenotype observation at the level of cell projections where the components number has decreased.
id: CMPO:0000074
preferred label: decreased number of cell projections
in_subset: cmpo

fewer cells with projections
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: has fewer parts of type
    intersection of: Restriction
      on property: bearer of
      some values from: increased number of cell projections phenotype
subclass of: decreased cell numbers
id: CMPO:0000075
IAO_0000115: decreased number of cells in population with projections
in_subset: cmpo

increased number of filopodia
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: has extra parts of type
    intersection of: Restriction
      on property: BFO_0000070
      some values from: filopodium
    intersection of: Restriction
      on property: RO_0000052
      some values from: cto:cell
subclass of: increased number of cell projections phenotype
id: CMPO:0000076
has_exact_synonym: more filopodia
IAO_0000115: A phenotype observation at the level of filopodia where the components number has increased.
in_subset: cmpo

elongated cell phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: elongated
    intersection of: Restriction
      on property: RO_0000052
      some values from: cto:cell
subclass of: cell morphology phenotype
IAO_0000115: A phenotype observation at the level of the cell shape where the cell is elongated, with a length notably greater than its width
id: CMPO:0000077
has_broad_synonym: bipolar cell
preferred label: elongated cell
in_subset: cmpo

elongated cells in population
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: has extra parts of type
    intersection of: Restriction
      on property: bearer of
      some values from: elongated cell phenotype
subclass of: increased cell numbers
subclass of: cell population by morphology
IAO_0000115: Cells in population with a length notably greater than their width
definition source: PMID:21893601; PMID:20531400
id: CMPO:0000078
in_subset: cmpo

increased number of lamellipodia phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: has extra parts of type
    intersection of: Restriction
      on property: BFO_0000070
      some values from: lamellipodium
    intersection of: Restriction
      on property: RO_0000052
      some values from: cto:cell
subclass of: increased number of cell projections phenotype
IAO_0000115: A phenotype observation at the level of lamellipodia where the components number has increased.
id: CMPO:0000080
preferred label: increased number of lamellipodia
has_exact_synonym: lamellipodium phenotype
in_subset: cmpo

decreased number of lamellipodia phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: has fewer parts of type
    intersection of: Restriction
      on property: BFO_0000070
      some values from: lamellipodium
    intersection of: Restriction
      on property: RO_0000052
      some values from: cto:cell
subclass of: decreased number of cell projections phenotype
IAO_0000115: A phenotype observation at the level of lamellipodia where the components number has decreased.
id: CMPO:0000081
preferred label: decreased number of lamellipodia
in_subset: cmpo

more lamellipodia cells
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: has extra parts of type
    intersection of: Restriction
      on property: bearer of
      some values from: increased number of lamellipodia phenotype
subclass of: more cells with projections
id: CMPO:0000083
IAO_0000115: increased lamellipodia cells in population phenotype
in_subset: cmpo

fewer lamellipodia cells
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: has fewer parts of type
    intersection of: Restriction
      on property: bearer of
      some values from: increased number of lamellipodia phenotype
subclass of: fewer cells with projections
id: CMPO:0000084
IAO_0000115: decreased lamellipodia cells in population phenotype
in_subset: cmpo

cell ploidy phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: ploidy
    intersection of: Restriction
      on property: RO_0000052
      some values from: cto:cell
subclass of: single cell phenotype
IAO_0000115: A phenotype observation at the level of the whole cell relating to the cell's ploidy
id: CMPO:0000085
preferred label: cell ploidy
in_subset: cmpo

polyploid cell phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: polyploid
    intersection of: Restriction
      on property: RO_0000052
      some values from: cto:cell
subclass of: cell ploidy phenotype
id: CMPO:0000086
IAO_0000115: A cell phenotype with more than two homologous sets of chromosomes.
preferred label: polyploid cell
in_subset: cmpo

S phase mitotic phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: process quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: S phase of mitotic cell cycle
subclass of: cell cycle phase phenotype
subclass of: mitotic process phenotype
id: CMPO:0000087
IAO_0000115: A phenotype observation at the level of athe S phase of the mitotic cell cycle
in_subset: cmpo

G1 phase mitotic phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: process quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: G1 phase of mitotic cell cycle
subclass of: cell cycle phase phenotype
subclass of: mitotic process phenotype
IAO_0000115: A phenotype observation at the level of a G1 phase of the mitotic cell cycle
id: CMPO:0000088
in_subset: cmpo

G2/M transition phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: process quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: G2/M transition of mitotic cell cycle
subclass of: mitotic process phenotype
id: CMPO:0000089
IAO_0000115: A phenotype observation at the level of the G2/M transition of the mitotic cell cycle
in_subset: cmpo

cell cycle phase phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: process quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: cell cycle phase
subclass of: cell cycle phenotype
IAO_0000115: A phenotype observation at the level of a cell cycle phase
id: CMPO:0000090
in_subset: cmpo

more polyploid cells
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: has extra parts of type
    intersection of: Restriction
      on property: bearer of
      some values from: polyploid cell phenotype
subclass of: increased cell numbers
id: CMPO:0000091
IAO_0000115: increased number of polyploid cells in population
in_subset: cmpo

increased number of focal adhesion phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: has extra parts of type
    intersection of: Restriction
      on property: BFO_0000070
      some values from: focal adhesion
    intersection of: Restriction
      on property: RO_0000052
      some values from: cto:cell
subclass of: increased cell component number phenotype
IAO_0000115: A phenotype observation at the level of focal adhesions where the components number has increased.
has_exact_synonym: increased focal adhesion abundance
id: CMPO:0000092
preferred label: increased number of focal adhesion
in_subset: cmpo

increased number of nucleoli phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: has extra parts of type
    intersection of: Restriction
      on property: BFO_0000070
      some values from: nucleolus
    intersection of: Restriction
      on property: RO_0000052
      some values from: cto:cell
subclass of: increased cell component number phenotype
id: CMPO:0000093
IAO_0000115: A phenotype observation at the level of nucleoli where the components number has increased.
preferred label: increased number of nucleoli
in_subset: cmpo

decreased number of nucleoli phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: has fewer parts of type
    intersection of: Restriction
      on property: BFO_0000070
      some values from: nucleolus
    intersection of: Restriction
      on property: RO_0000052
      some values from: cto:cell
subclass of: decreased cell component number phenotype
id: CMPO:0000094
IAO_0000115: A phenotype observation at the level of nucleoli where the components number has decreased.
preferred label: decreased number of nucleoli
in_subset: cmpo

more cells with decreased number of nucleoli
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: has extra parts of type
    intersection of: Restriction
      on property: bearer of
      some values from: decreased number of nucleoli phenotype
subclass of: increased cell numbers
id: CMPO:0000095
IAO_0000115: more cells with decreased number of nucleoli
in_subset: cmpo

more cells with increased number of nucleoli
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: has extra parts of type
    intersection of: Restriction
      on property: bearer of
      some values from: increased number of nucleoli phenotype
subclass of: increased cell numbers
id: CMPO:0000096
IAO_0000115: increased number of nucleoli in population phenotype
in_subset: cmpo

increased number of microtubules phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: has extra parts of type
    intersection of: Restriction
      on property: BFO_0000070
      some values from: microtubule
    intersection of: Restriction
      on property: RO_0000052
      some values from: cto:cell
subclass of: increased cell component number phenotype
IAO_0000115: A phenotype observation at the level of microtubules where the components number has increased.
has_exact_synonym: more microtubules
id: CMPO:0000097
preferred label: increased number of microtubules
in_subset: cmpo

phagosomes phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: quality
    intersection of: Restriction
      on property: BFO_0000070
      some values from: phagocytic vesicle
    intersection of: Restriction
      on property: RO_0000052
      some values from: cellular_component
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: phagocytic vesicle
subclass of: phenotypes by organelle
preferred label: phagosomes
has_exact_synonym: phagosomes present phenotype
IAO_0000115: A phenotype observation at the level of the phagosomes, a membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
id: CMPO:0000102
in_subset: cmpo

phagosomes absent phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: lacks all parts of type
    intersection of: Restriction
      on property: BFO_0000070
      some values from: phagocytic vesicle
    intersection of: Restriction
      on property: RO_0000052
      some values from: cto:cell
subclass of: absence of cellular component phenotype
IAO_0000115: A phenotype observation where phagosomes are absent
id: CMPO:0000103
preferred label: phagosomes absent
in_subset: cmpo

actin filament phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: actin filament
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: quality
    intersection of: Restriction
      on property: BFO_0000070
      some values from: actin filament
subclass of: cytoskeletal phenotype
IAO_0000115: A phenotype observation at the level of the actin filaments, a filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells.
id: CMPO:0000104
in_subset: cmpo

increased number of actin filament phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: has extra parts of type
    intersection of: Restriction
      on property: BFO_0000070
      some values from: actin filament
    intersection of: Restriction
      on property: RO_0000052
      some values from: cto:cell
subclass of: increased cell component number phenotype
subclass of: actin filament phenotype
IAO_0000115: A phenotype observation at the level of actin filaments where the components number has increased.
definition source: PMID:20531400
preferred label: increased number of actin filament
has_exact_synonym: more total actin
definition source: PMID: 21893601
has_exact_synonym: actin fiber cells
id: CMPO:0000105
has_exact_synonym: more actin
in_subset: cmpo

decreased number of actin filament phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: has fewer parts of type
    intersection of: Restriction
      on property: BFO_0000070
      some values from: actin filament
    intersection of: Restriction
      on property: RO_0000052
      some values from: cto:cell
subclass of: decreased cell component number phenotype
subclass of: actin filament phenotype
IAO_0000115: A phenotype observation at the level of actin filaments where the components number has decreased.
definition source: PMID: 21893601
id: CMPO:0000106
has_exact_synonym: less total actin
has_exact_synonym: less actin
preferred label: decreased number of actin filament
in_subset: cmpo

more actin filament cells
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: has extra parts of type
    intersection of: Restriction
      on property: bearer of
      some values from: increased number of actin filament phenotype
subclass of: increased cell numbers
id: CMPO:0000107
IAO_0000115: increased number of actin filament cells in population
in_subset: cmpo

fewer actin filament cells
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: has fewer parts of type
    intersection of: Restriction
      on property: bearer of
      some values from: actin filament phenotype
subclass of: decreased cell numbers
has_exact_synonym: decreased number of actin filament cells
id: CMPO:0000108
IAO_0000115: decreased number of actin filament phenotypes in population
in_subset: cmpo

centered cytoskeleton phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: centered
    intersection of: Restriction
      on property: RO_0000052
      some values from: cytoskeleton
subclass of: cytoskeletal phenotype
subclass of: cell component position phenotype
id: CMPO:0000109
IAO_0000115: A phenotype observation where the cytoskeleton is located in a position equidistant from the edges of the cell
preferred label: centered cytoskeleton
in_subset: cmpo

centered nucleus phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: centered
    intersection of: Restriction
      on property: RO_0000052
      some values from: nucleus
subclass of: nuclear phenotype
subclass of: cell component position phenotype
id: CMPO:0000110
IAO_0000115: A phenotype observation where the nucleus is located in a position equidistant from the edges of the cell
preferred label: centered nucleus
in_subset: cmpo

dispersed nucleus phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: dispersed
    intersection of: Restriction
      on property: RO_0000052
      some values from: nucleus
subclass of: nuclear phenotype
subclass of: cell component position phenotype
id: CMPO:0000111
IAO_0000115: A phenotype observation where the nucleus is distributed or spread over a considerable extent.
preferred label: dispersed nucleus
in_subset: cmpo

apoptopic nucleus phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: apoptotic
    intersection of: Restriction
      on property: RO_0000052
      some values from: nucleus
subclass of: cell component structure phenotype
subclass of: nuclear morphology phenotype
id: CMPO:0000112
IAO_0000115: A phenotype observation at the level of nucleus consisting of blebbing of the nucleus and DNA fragmentation due to the cell undergoing a specific form of programmed cell death termed apoptosis.
preferred label: apoptopic nucleus
in_subset: cmpo

deformed nucleus
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: deformed
    intersection of: Restriction
      on property: RO_0000052
      some values from: nucleus
subclass of: nuclear morphology phenotype
IAO_0000115: A phenotype observation where the nucleus is distorted in form
id: CMPO:0000113
in_subset: cmpo

peripheral nucleus phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: peripheral
    intersection of: Restriction
      on property: RO_0000052
      some values from: nucleus
subclass of: nuclear phenotype
subclass of: cell component position phenotype
IAO_0000115: A phenotype observation where the nucleus's position is at the edge or boundary of a related entity.
id: CMPO:0000114
preferred label: peripheral nucleus
in_subset: cmpo

peripheral cytoskeleton phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: peripheral
    intersection of: Restriction
      on property: RO_0000052
      some values from: cytoskeleton
subclass of: cytoskeletal phenotype
subclass of: cell component position phenotype
id: CMPO:0000115
IAO_0000115: A phenotype observation where the cytoskeleton's position is at the edge or boundary of a related entity.
preferred label: peripheral cytoskeleton
in_subset: cmpo

abnormal cell shape phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: shape
    intersection of: Restriction
      on property: RO_0000052
      some values from: cto:cell
    intersection of: Restriction
      on property: has qualifier
      some values from: abnormal
subclass of: cell morphology phenotype
id: CMPO:0000116
IAO_0000115: A phenotype observation at the level of the cell shape where the shape is abnormal
preferred label: abnormal cell shape
in_subset: cmpo

bilobed nucleus phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: bilobed
    intersection of: Restriction
      on property: RO_0000052
      some values from: nucleus
subclass of: nucleus shape phenotype
has_broad_synonym: bilobed
id: CMPO:0000117
IAO_0000115: A lobed quality inhering in a nucleus by virtue of the nucleus being divided into or having two lobes.
preferred label: bilobed nucleus
in_subset: cmpo

round cell phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: circular
    intersection of: Restriction
      on property: RO_0000052
      some values from: cto:cell
subclass of: cell morphology phenotype
has_exact_synonym: circular cell
definition source: PMID:21893601
comment: not spreading cell
id: CMPO:0000118
has_exact_synonym: spherical cell
IAO_0000115: A phenotype observation at the level of the cell shape where the cell is round
has_exact_synonym: low eccentricity cell
preferred label: round cell
in_subset: cmpo

elongated focal adhesion
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: elongated
    intersection of: Restriction
      on property: RO_0000052
      some values from: focal adhesion
subclass of: cell component shape phenotype
id: CMPO:0000119
IAO_0000115: A phenotype observation of the length of the focal adhesion is notably higher than the width.
has_broad_synonym: long focal adhesion
in_subset: cmpo

elongated nucleus
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: elongated
    intersection of: Restriction
      on property: RO_0000052
      some values from: nucleus
subclass of: nucleus shape phenotype
has_broad_synonym: long nucleus
IAO_0000115: A phenotype observation of the length of the nucleus is notably higher than the width.
id: CMPO:0000120
in_subset: cmpo

arrow shaped cell phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: arrow-shaped
    intersection of: Restriction
      on property: RO_0000052
      some values from: cto:cell
subclass of: cell morphology phenotype
id: CMPO:0000121
IAO_0000115: A phenotype observation at the level of the cell shape where the cell is arrow shaped, with a wide front and a sharp tail, displaying monopolar cell growth
has_exact_synonym: triangular shaped cell
in_subset: cmpo

triangular shaped cell phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: triangular
    intersection of: Restriction
      on property: RO_0000052
      some values from: cto:cell
subclass of: cell morphology phenotype
id: CMPO:0000122
IAO_0000115: A phenotype observation at the level of the cell shape where the cell has a triangular shape, with a wide front and a sharp tail, displaying cell motility
has_broad_synonym: arrow shaped cell
preferred label: triangular shaped cell
in_subset: cmpo

round nucleus phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: circular
    intersection of: Restriction
      on property: RO_0000052
      some values from: nucleus
subclass of: nucleus shape phenotype
has_exact_synonym: round nucleus
has_exact_synonym: circular nucleus
id: CMPO:0000123
IAO_0000115: A phenotype observation where the shape of the nucleus has every part of the surface or the circumference equidistant from the center.
preferred label: round nucleus
in_subset: cmpo

nuclear body phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: nuclear body
subclass of: nuclear phenotype
IAO_0000115: A phenotype observation at the level of the nuclear body, an extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
id: CMPO:0000125
preferred label: nuclear body
in_subset: cmpo

increased nuclear body size phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: increased size
    intersection of: Restriction
      on property: RO_0000052
      some values from: nuclear body
subclass of: nuclear body phenotype
subclass of: increased cell component size phenotype
subclass of: nuclear morphology phenotype
id: CMPO:0000126
IAO_0000115: A phenotype observation where the nuclear body size is relatively high.
definition source: PMID:22884692
preferred label: increased nuclear body size
in_subset: cmpo

decreased nuclear body size phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: decreased size
    intersection of: Restriction
      on property: RO_0000052
      some values from: nuclear body
subclass of: nuclear body phenotype
subclass of: decreased cell component size phenotype
subclass of: nuclear morphology phenotype
id: CMPO:0000127
definition source: PMID:22884692
IAO_0000115: A phenotype observation where the nuclear body size is relatively low.
preferred label: decreased nuclear body size
in_subset: cmpo

increased cell size phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: increased size
    intersection of: Restriction
      on property: RO_0000052
      some values from: cto:cell
subclass of: cell morphology phenotype
id: CMPO:0000128
IAO_0000115: A phenotype observation at the level of the cell size where a cell is larger with respect to normal/wild-type
has_exact_synonym: increased cell area
definition source: PMID:20531400
has_exact_synonym: large cell
has_exact_synonym: big cell
preferred label: increased cell size
in_subset: cmpo

decreased cell size phenoptype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: decreased size
    intersection of: Restriction
      on property: RO_0000052
      some values from: cto:cell
subclass of: cell morphology phenotype
id: CMPO:0000129
IAO_0000115: A phenotype observation at the level of the cell size where a cell is smaller with respect to normal/wild-type
has_exact_synonym: small cell
in_subset: cmpo

decreased golgi volume phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: decreased volume
    intersection of: Restriction
      on property: RO_0000052
      some values from: Golgi apparatus
subclass of: decreased cell component size phenotype
subclass of: golgi morphology phenotype
id: CMPO:0000130
IAO_0000115: A phenotype observation at the level of the golgi where the golgi's volume has decreased.
preferred label: decreased golgi volume
in_subset: cmpo

increased golgi volume phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: increased volume
    intersection of: Restriction
      on property: RO_0000052
      some values from: Golgi apparatus
subclass of: increased cell component size phenotype
subclass of: golgi morphology phenotype
IAO_0000115: A phenotype observation at the level of the golgi where the golgi's volume has increased.
id: CMPO:0000131
preferred label: increased golgi volume
in_subset: cmpo

decreased cilium length phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: decreased length
    intersection of: Restriction
      on property: RO_0000052
      some values from: cilium
subclass of: decreased cell component size phenotype
subclass of: cilium morphology phenotype
id: CMPO:0000132
IAO_0000115: A phenotype observation at the level of a cilium where the components length has decreased.
preferred label: decreased cilium length
in_subset: cmpo

increased cilium length phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: increased length
    intersection of: Restriction
      on property: RO_0000052
      some values from: cilium
subclass of: increased cell component size phenotype
subclass of: cilium morphology phenotype
IAO_0000115: A phenotype observation at the level of a cilium where the components length has increased.
id: CMPO:0000133
preferred label: increased cilium length
in_subset: cmpo

decreased size of focal adhesion phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: decreased size
    intersection of: Restriction
      on property: RO_0000052
      some values from: focal adhesion
subclass of: decreased cell component size phenotype
id: CMPO:0000134
IAO_0000115: A phenotype observation where the size of the focal adhesion has decreased.
preferred label: decreased size of focal adhesion
in_subset: cmpo

increased size of focal adhesion phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: increased size
    intersection of: Restriction
      on property: RO_0000052
      some values from: focal adhesion
subclass of: increased cell component size phenotype
IAO_0000115: A phenotype observation where the size of the focal adhesion has increased.
id: CMPO:0000135
preferred label: increased size of focal adhesion
in_subset: cmpo

decreased focal adhesion area phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: decreased area
    intersection of: Restriction
      on property: RO_0000052
      some values from: focal adhesion
subclass of: decreased size of focal adhesion phenotype
definition source: pmid:19667130
id: CMPO:0000136
has_exact_synonym: small focal adhesion
IAO_0000115: A phenotype observation where the area of the focal adhesion has decreased.
preferred label: decreased focal adhesion area
in_subset: cmpo

increased focal adhesion area phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: increased area
    intersection of: Restriction
      on property: RO_0000052
      some values from: focal adhesion
subclass of: increased size of focal adhesion phenotype
has_exact_synonym: large focal adhesion
IAO_0000115: A phenotype observation where the area of the focal adhesion has increased.
id: CMPO:0000137
definition source: pmid:19667130
preferred label: increased focal adhesion area
in_subset: cmpo

decreased focal adhesion length phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: decreased length
    intersection of: Restriction
      on property: RO_0000052
      some values from: focal adhesion
subclass of: decreased size of focal adhesion phenotype
id: CMPO:0000138
definition source: pmid:19667130
has_exact_synonym: short focal adhesion
IAO_0000115: A phenotype observation where the length of the focal adhesion has decreased.
preferred label: decreased focal adhesion length
in_subset: cmpo

increased focal adhesion length phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: increased length
    intersection of: Restriction
      on property: RO_0000052
      some values from: focal adhesion
subclass of: increased size of focal adhesion phenotype
IAO_0000115: A phenotype observation where the length of the focal adhesion has increased.
id: CMPO:0000139
preferred label: increased focal adhesion length
in_subset: cmpo

increased nucleus size phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: increased size
    intersection of: Restriction
      on property: RO_0000052
      some values from: nucleus
subclass of: increased cell component size phenotype
subclass of: nuclear morphology phenotype
has_exact_synonym: large nucleus
has_broad_synonym: increased DNA area
definition source: PMID:20531400
IAO_0000115: A phenotype observation where the size of the nucleus has increased
has_exact_synonym: large nuclei
definition source: PMID:20360735
id: CMPO:0000140
preferred label: increased nucleus size
in_subset: cmpo

decreased nucleus size phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: decreased size
    intersection of: Restriction
      on property: RO_0000052
      some values from: nucleus
subclass of: decreased cell component size phenotype
subclass of: nuclear morphology phenotype
definition source: PMID:21893601
id: CMPO:0000141
has_exact_synonym: small nucleus
has_broad_synonym: decreased DNA area
IAO_0000115: A phenotype observation where the size of the nucleus has decreased
definition source: PMID:20360735
preferred label: decreased nucleus size
in_subset: cmpo

increased nuclei size in G1 phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: increased nucleus size phenotype
    intersection of: Restriction
      on property: happens_during
      some values from: G1 phase mitotic phenotype
subclass of: increased nucleus size phenotype
IAO_0000115: A phenotype of a cell that has both an increased nuclei size phenotypes and a G1 phase phenotype
id: CMPO:0000143
preferred label: increased nuclei size in G1
in_subset: cmpo

decreased nuclei size in G1 phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: G1 phase mitotic phenotype
    intersection of: decreased nucleus size phenotype
subclass of: G1 phase mitotic phenotype
subclass of: decreased nucleus size phenotype
id: CMPO:0000144
IAO_0000115: A phenotype of a cell that has both a decreased nuclei size phenotypes and a G1 phase phenotype
preferred label: decreased nuclei size in G1
has_exact_synonym: small nuclei in G1
in_subset: cmpo

increased thickness of dendritic branches phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: increased thickness
    intersection of: Restriction
      on property: RO_0000052
      some values from: dendritic branch
subclass of: increased cell component size phenotype
IAO_0000115: A phenotype observation where the thickness of the dendritic branches has increased.
id: CMPO:0000145
preferred label: increased thickness of dendritic branches
in_subset: cmpo

decreased thickness of dendritic branches
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: decreased thickness
    intersection of: Restriction
      on property: RO_0000052
      some values from: dendritic branch
subclass of: decreased cell component size phenotype
id: CMPO:0000146
IAO_0000115: A phenotype observation where the thickness of the dendritic branches has decreased.
in_subset: cmpo

disorganized microtubules phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: disorganized
    intersection of: Restriction
      on property: RO_0000052
      some values from: microtubule
subclass of: cell component structure phenotype
subclass of: cytoskeletal phenotype
definition source: pmid:21893601
has_exact_synonym: microtubule disorganised
IAO_0000115: A phenotype observation where the microtublue structure is disorganised
id: CMPO:0000147
preferred label: disorganized microtubules
in_subset: cmpo

podosome phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: podosome
subclass of: cytoskeletal phenotype
IAO_0000115: A phenotype observation at the level of podosomes, an actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell.
id: CMPO:0000148
preferred label: podosome
in_subset: cmpo

radial cytoskeleton phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: radial symmetry
    intersection of: Restriction
      on property: RO_0000052
      some values from: cytoskeleton
subclass of: cytoskeletal phenotype
subclass of: cell component position phenotype
id: CMPO:0000149
IAO_0000115: A phenotype observation where the cytoskeleton is symmetric, having equal proportions around a central point or axis.
preferred label: radial cytoskeleton
in_subset: cmpo

phenotypes by organelle
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: organelle part
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: Restriction
        on property: part_of
        some values from: membrane-bounded organelle
subclass of: cellular component phenotype
IAO_0000115: Phenotype observation organised by specific named organelles.
id: CMPO:0000150
in_subset: cmpo

fragmented endoplasmic reticulum phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: broken
    intersection of: Restriction
      on property: RO_0000052
      some values from: endoplasmic reticulum
subclass of: cell component structure phenotype
subclass of: endoplasmic reticulum phenotype
has_exact_synonym: broken endoplasmic reticulum
IAO_0000115: A phenotype observation where the structure of the endoplasmic reticulum is fragmented or broken.
id: CMPO:0000151
preferred label: fragmented endoplasmic reticulum
in_subset: cmpo

fragmented golgi phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: broken
    intersection of: Restriction
      on property: RO_0000052
      some values from: Golgi apparatus
subclass of: cell component structure phenotype
subclass of: golgi morphology phenotype
has_exact_synonym: broken golgi
IAO_0000115: A phenotype observation at the level of the golgi where the golgi's structure is broken
id: CMPO:0000152
has_exact_synonym: broken golgi phenotype
preferred label: fragmented golgi
in_subset: cmpo

fragmented mitochondria phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: broken
    intersection of: Restriction
      on property: RO_0000052
      some values from: mitochondrion
subclass of: cell component structure phenotype
subclass of: mitochondrion phenotype
has_exact_synonym: broken mitochondria
IAO_0000115: A phenotype observation where the structure of the mitochondria is fragmented or broken.
id: CMPO:0000153
preferred label: fragmented mitochondria
in_subset: cmpo

bright nuclei phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: high brightness
    intersection of: Restriction
      on property: RO_0000052
      some values from: nucleus
subclass of: nuclear phenotype
definition source: PMID:20531400
id: CMPO:0000154
IAO_0000115: A phenotype observation where the nuclear's color brightness is relatively high.
preferred label: bright nuclei
in_subset: cmpo

fragmented nucleus phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: broken
    intersection of: Restriction
      on property: RO_0000052
      some values from: nucleus
subclass of: cell component structure phenotype
subclass of: nuclear morphology phenotype
IAO_0000115: A phenotype observation where the structure of the nucleus is fragmented or broken.
has_exact_synonym: broken nucleus
id: CMPO:0000155
preferred label: fragmented nucleus
in_subset: cmpo

graped micronucleus phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: acinus
    intersection of: Restriction
      on property: RO_0000052
      some values from: micronucleus
subclass of: polylobed nuclear phenotype
IAO_0000115: A phenotype observation where nuclear envelopes form around single chromosomes or small sets of chromosomes. Forming a grape like structure
id: CMPO:0000156
definition source: pmid:20360735
comment: Mitocheck Publication: http://www.ncbi.nlm.nih.gov/pubmed/20360735 Micronucleation, i.e. presumably nuclear envelopes around single chromosomes or small sets of chromosomes.
has_related_synonym: grape
preferred label: graped micronucleus
in_subset: cmpo

abnormal nucleus shape phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: shape
    intersection of: Restriction
      on property: RO_0000052
      some values from: nucleus
    intersection of: Restriction
      on property: has qualifier
      some values from: abnormal
subclass of: nucleus shape phenotype
has_exact_synonym: strange nuclear shape
has_exact_synonym: abnormal nuclear shape
definition source: PMID:20360735
IAO_0000115: A phenotype observation where the shape of the nucleus is abnormal
in_subset: cmpo

decreased nuclei size in G2/M phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: G2/M transition phenotype
    intersection of: decreased nucleus size phenotype
subclass of: G2/M transition phenotype
subclass of: decreased nucleus size phenotype
id: CMPO:0000158
IAO_0000115: A phenotype observation at the level of the G2/M transition of the mitotic cell cycle where the nuclei are decreased in size with respect to normal
preferred label: decreased nuclei size in G2/M
in_subset: cmpo

absence of cellular component phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: lacks all parts of type
    intersection of: Restriction
      on property: BFO_0000070
      some values from: cellular_component
    intersection of: Restriction
      on property: RO_0000052
      some values from: cto:cell
subclass of: cell component number phenotype
id: CMPO:0000159
IAO_0000115: A phenotype observation at the level of a cellular component where the cell component is absent
preferred label: absence of cellular component
in_subset: cmpo

cell viability in population phenotype
type: Class
label: cell population viability
subclass of: cell population
id: CMPO:0000160
IAO_0000115: A phenotype of a cell population relating to the ability of the cells to live and develop normally
in_subset: cmpo

increased cell viability in population
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: viability
    intersection of: Restriction
      on property: decreased_in_magnitude_relative_to
      some values from: normal
subclass of: cell viability in population phenotype
id: CMPO:0000161
IAO_0000115: increased number of viable cell phenotype in a population
in_subset: cmpo

decreased cell viability in population
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: viability
    intersection of: Restriction
      on property: increased_in_magnitude_relative_to
      some values from: normal
subclass of: cell viability in population phenotype
IAO_0000115: decreased number of viable cell phenotype in a population
id: CMPO:0000162
in_subset: cmpo

cell population by morphology
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: morphology
    intersection of: Restriction
      on property: BFO_0000070
      some values from: cto:cell
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: quality
    intersection of: Restriction
      on property: bearer of
      some values from: cell morphology phenotype
subclass of: cell population
id: CMPO:0000163
IAO_0000115: A population phenotype relating to the size, shape or structure of the cells within a population
preferred label: cell population morphology
in_subset: cmpo

absence of cytokinesis phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: lacking processual parts
    intersection of: Restriction
      on property: BFO_0000070
      some values from: cytokinesis
    intersection of: Restriction
      on property: RO_0000052
      some values from: cell division
subclass of: cytokinesis phenotype
subclass of: absence of cell process phenotype
id: CMPO:0000164
IAO_0000115: A phenotype that results in the absence of cytokinesis
preferred label: absence of cytokinesis
in_subset: cmpo

cytokinesis phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: process quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: cytokinesis
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: process quality
    intersection of: Restriction
      on property: BFO_0000070
      some values from: cytokinesis
subclass of: cell cycle phenotype
subclass of: cell population by process phenotype
subclass of: cell division phenotype
IAO_0000115: A phenotype observation at the level of cytokinesis
id: CMPO:0000165
in_subset: cmpo

cell division phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: process quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: Restriction
        on property: part_of
        some values from: cell division
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: process quality
    intersection of: Restriction
      on property: BFO_0000070
      some values from: Restriction
        on property: part_of
        some values from: cell division
subclass of: cell process phenotype
id: CMPO:0000166
IAO_0000115: A phenotype observation of the process resulting in the physical partitioning and separation of a cell into daughter cells.
in_subset: cmpo

increased rate of cell division phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: increased rate
    intersection of: Restriction
      on property: RO_0000052
      some values from: cell division
subclass of: cell division phenotype
has_exact_synonym: faster cell division
IAO_0000115: A phenotype where the cell division process occurs at a higher rate
id: CMPO:0000168
preferred label: increased rate of cell division
in_subset: cmpo

decreased rate of cell division phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: decreased rate
    intersection of: Restriction
      on property: RO_0000052
      some values from: cell division
subclass of: cell division phenotype
has_exact_synonym: slower cell division
IAO_0000115: A phenotype where the cell division process occurs at a lower rate
id: CMPO:0000169
preferred label: decreased rate of cell division
in_subset: cmpo

telomerase activity phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: process quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: telomerase activity
subclass of: cell process phenotype
id: CMPO:0000170
IAO_0000115: A phenotype observation of the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence.
in_subset: cmpo

decreased telomerase activity phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: decreased occurrence
    intersection of: Restriction
      on property: RO_0000052
      some values from: telomerase activity
subclass of: telomerase activity phenotype
IAO_0000115: A phenotype observation where the occurane of telomerase activity is decreased
id: CMPO:0000171
preferred label: decreased telomerase activity
in_subset: cmpo

increased telomerase activity phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: increased occurrence
    intersection of: Restriction
      on property: RO_0000052
      some values from: telomerase activity
subclass of: telomerase activity phenotype
IAO_0000115: A phenotype observation where the occurane of telomerase activity is increased
id: CMPO:0000172
preferred label: increased telomerase activity
in_subset: cmpo

G0/1 arrested phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: arrested
    intersection of: Restriction
      on property: RO_0000052
      some values from: G0 to G1 transition
subclass of: arrested process phenotype
id: CMPO:0000173
comment: (from GO) Under certain conditions, cells exit the cell cycle during G1 and remain in the G0 state as nongrowing, non-dividing (quiescent) cells.
IAO_0000115: A phenotype of a cell that is arrested at the G0/1 transition
preferred label: G0/1 arrested
in_subset: cmpo

polarized endoplasmic reticulum phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: position
    intersection of: Restriction
      on property: RO_0000052
      some values from: Class
        intersection of: endoplasmic reticulum
        intersection of: Restriction
subclass of: endoplasmic reticulum phenotype
subclass of: cell component position phenotype
has_exact_synonym: polarized endoplasmic reticulum
IAO_0000115: A phenotype observation where the endoplasmic reticulum is oriented in the cell with extremities at either end of the main axis.
id: CMPO:0000174
preferred label: polarized endoplasmic reticulum
in_subset: cmpo

molecular component phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: molecular entity
subclass of: phenotype
IAO_0000115: A phenotype observation at the level of a molecular component of a cell
id: CMPO:0000175
in_subset: cmpo

cell DNA phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: deoxyribonucleic acid
subclass of: molecular component phenotype
id: CMPO:0000176
IAO_0000115: A phenotype observation at the level of the cell DNA
in_subset: cmpo

misshapen DNA
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: shape
    intersection of: Restriction
      on property: RO_0000052
      some values from: deoxyribonucleic acid
    intersection of: Restriction
      on property: has qualifier
      some values from: abnormal
subclass of: cell DNA phenotype
IAO_0000115: A phenotyoe observation where the nucleus has an irregular shape that is not ovoid.
id: CMPO:0000177
in_subset: cmpo

site of double-strand break phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: site of double-strand break
subclass of: phenotypes by organelle
IAO_0000115: A phenotype observation at the level of the site of double-strand break, a region of a chromosome at which a DNA double-strand break has occurred.
id: CMPO:0000180
preferred label: site of double-strand break
in_subset: cmpo

decreased number of site of double-strand break phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: has fewer parts of type
    intersection of: Restriction
      on property: BFO_0000070
      some values from: site of double-strand break
    intersection of: Restriction
      on property: RO_0000052
      some values from: cto:cell
subclass of: decreased cell component number phenotype
IAO_0000115: A phenotype observation at the level of double strand breaks where the components number has decreased.
id: CMPO:0000181
preferred label: decreased number of site of double-strand break
in_subset: cmpo

increased number of site of double-strand break phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: has extra parts of type
    intersection of: Restriction
      on property: BFO_0000070
      some values from: site of double-strand break
    intersection of: Restriction
      on property: RO_0000052
      some values from: cto:cell
subclass of: increased cell component number phenotype
IAO_0000115: A phenotype observation where the number of double-strand breaks has increased
id: CMPO:0000182
preferred label: increased number of site of double-strand break
in_subset: cmpo

cell-matrix adhesion phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: process quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: cell-matrix adhesion
subclass of: cell adhesion phenotype
id: CMPO:0000185
in_subset: cmpo

increased cell component size phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: increased size
    intersection of: Restriction
      on property: RO_0000052
      some values from: cellular_component
subclass of: cell component size phenotype
id: CMPO:0000186
IAO_0000115: A phenotype observation at the level of a cellular component where the components size has increased.
preferred label: increased cell component size
in_subset: cmpo

decreased cell component size phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: decreased size
    intersection of: Restriction
      on property: RO_0000052
      some values from: cellular_component
subclass of: cell component size phenotype
id: CMPO:0000187
IAO_0000115: A phenotype observation at the level of a cellular component where the components size has decreased.
preferred label: decreased cell component size
in_subset: cmpo

cell spreading phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: process quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: substrate adhesion-dependent cell spreading
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: process quality
    intersection of: Restriction
      on property: BFO_0000070
      some values from: substrate adhesion-dependent cell spreading
subclass of: cell adhesion phenotype
subclass of: cell population by process phenotype
subclass of: cellular development phenotype
has_exact_synonym: substrate adhesion-dependent cell spreading phenotype
IAO_0000115: A phenotype observation where the morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate.
id: CMPO:0000188
in_subset: cmpo

cellular development phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: process quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: cellular developmental process
subclass of: cell process phenotype
id: CMPO:0000189
IAO_0000115: A phenotype observation of a biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.
in_subset: cmpo

decreased number of axons phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: has fewer parts of type
    intersection of: Restriction
      on property: BFO_0000070
      some values from: axon
    intersection of: Restriction
      on property: RO_0000052
      some values from: cto:cell
subclass of: decreased number of cell projections phenotype
IAO_0000115: A phenotype observation at the level of axons where the components number has decreased.
id: CMPO:0000190
preferred label: decreased number of axons
in_subset: cmpo

increased number of axons phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: has extra parts of type
    intersection of: Restriction
      on property: BFO_0000070
      some values from: axon
    intersection of: Restriction
      on property: RO_0000052
      some values from: cto:cell
subclass of: increased number of cell projections phenotype
IAO_0000115: A phenotype observation at the level of axons where the components number has increased.
id: CMPO:0000191
preferred label: increased number of axons
in_subset: cmpo

mitotic process phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: process quality
    intersection of: Restriction
      on property: BFO_0000070
      some values from: Restriction
        on property: part_of
        some values from: mitotic cell cycle
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: process quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: mitotic cell cycle
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: process quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: Restriction
        on property: part_of
        some values from: mitotic cell cycle
subclass of: cell cycle phenotype
id: CMPO:0000194
IAO_0000115: A phenotype observation at the level of the mitotic cell cycle
in_subset: cmpo

arrested process phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: arrested
    intersection of: Restriction
      on property: RO_0000052
      some values from: biological_process
subclass of: cell process phenotype
id: CMPO:0000195
IAO_0000115: A phenotype of a cell where a particular process is arrested, or ends earlier in time than expected
preferred label: arrested process
in_subset: cmpo

M phase arrested phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: arrested
    intersection of: Restriction
      on property: RO_0000052
      some values from: M phase of mitotic cell cycle
subclass of: M phase mitotic phenotype
subclass of: cell cycle arrested phenotype
has_exact_synonym: mitosis incomplete process phenotype
id: CMPO:0000196
has_exact_synonym: mitotic arrest
IAO_0000115: A phenotype of a cell where the M phase of mitotic cell cycle process is arrested, or ends earlier in time than expected
preferred label: M phase arrested
has_exact_synonym: m phase arrest
in_subset: cmpo

mitosis delayed phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: delayed
    intersection of: Restriction
      on property: BFO_0000070
      some values from: mitosis
    intersection of: Restriction
      on property: RO_0000052
      some values from: cell cycle
subclass of: mitotic process phenotype
subclass of: delayed process phenotype
id: CMPO:0000202
IAO_0000115: A phenotype observation where mitosis is delayed
definition source: PMID:20360735
has_exact_synonym: Mitotic delay
preferred label: mitosis delayed
in_subset: cmpo

G2 arrested phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: arrested
    intersection of: Restriction
      on property: RO_0000052
      some values from: G2 phase of mitotic cell cycle
subclass of: G2 phase mitotic phenotype
subclass of: cell cycle arrested phenotype
id: CMPO:0000203
IAO_0000115: A phenotype of a cell is arrested in G2 pahse of the cell cycle.
preferred label: G2 arrested
in_subset: cmpo

S phase arrested phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: arrested
    intersection of: Restriction
      on property: RO_0000052
      some values from: S phase of mitotic cell cycle
subclass of: S phase mitotic phenotype
subclass of: cell cycle arrested phenotype
id: CMPO:0000204
IAO_0000115: A phenotype of a cell where the S pahse process is arrested, or ends earlier in time than expected
preferred label: S phase arrested
in_subset: cmpo

increased duration of exit from mitosis phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: increased duration
    intersection of: Restriction
      on property: RO_0000052
      some values from: exit from mitosis
subclass of: exit from mitosis phenotype
definition source: PMID:20711181
preferred label: increased duration of exit from mitosis
has_exact_synonym: prolonged mitotic exit
IAO_0000115: A phenotype observation where the duration of the exit from mitosis is increased
id: CMPO:0000205
in_subset: cmpo

decreased duration of exit from mitosis phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: decreased duration
    intersection of: Restriction
      on property: RO_0000052
      some values from: exit from mitosis
subclass of: exit from mitosis phenotype
id: CMPO:0000206
preferred label: decreased duration of exit from mitosis
in_subset: cmpo

G2 phase mitotic phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: process quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: G2 phase of mitotic cell cycle
subclass of: cell cycle phase phenotype
subclass of: mitotic process phenotype
id: CMPO:0000207
IAO_0000115: A phenotype observation at the level of a G2 phase of the mitotic cell cycle
in_subset: cmpo

mitotic metaphase phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: process quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: mitotic metaphase
subclass of: cell cycle phase phenotype
subclass of: mitotic process phenotype
IAO_0000115: A phenotype observation at the level of the mitotic metaphase of the cell cycle
id: CMPO:0000208
in_subset: cmpo

more mitotic metaphase cells
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: has extra parts of type
    intersection of: Restriction
      on property: bearer of
      some values from: mitotic metaphase phenotype
subclass of: increased cell numbers
id: CMPO:0000210
IAO_0000115: increased number of mitotic metaphase cells in population phenotype
in_subset: cmpo

fewer mitotic metaphase cells
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: has fewer parts of type
    intersection of: Restriction
      on property: bearer of
      some values from: mitotic metaphase phenotype
subclass of: decreased cell numbers
id: CMPO:0000211
IAO_0000115: decreased number of mitotic metaphase cells in population phenotype
in_subset: cmpo

abnormal cell cycle phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: process quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: cell cycle
    intersection of: Restriction
      on property: has qualifier
      some values from: abnormal
subclass of: cell cycle phenotype
id: CMPO:0000212
IAO_0000115: A phenotype where the cell cycle is in some way abnormal
preferred label: abnormal cell cycle
in_subset: cmpo

binuclear cell phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: binucleate
    intersection of: Restriction
      on property: RO_0000052
      some values from: cto:cell
subclass of: multinucleated cell phenotype
id: CMPO:0000213
preferred label: binuclear cell
has_exact_synonym: nuclei stay close together
IAO_0000115: A phenotype observation where a cell is binucleate, e.g. have two nuclei per cell
in_subset: cmpo

increased duration of mitotic chromosome condensation phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: increased duration
    intersection of: Restriction
      on property: RO_0000052
      some values from: mitotic chromosome condensation
subclass of: mitotic chromosome condensation phenotype
id: CMPO:0000214
IAO_0000115: A phenotype observation where the duration of the mitotic chromosome condensation is increased
preferred label: increased duration of mitotic chromosome condensation
has_exact_synonym: longer mitotic chromosome condensation
in_subset: cmpo

decreased duration of mitotic chromosome condensation phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: decreased duration
    intersection of: Restriction
      on property: RO_0000052
      some values from: mitotic chromosome condensation
subclass of: mitotic chromosome condensation phenotype
id: CMPO:0000215
IAO_0000115: A phenotype observation where the duration of the mitotic chromosome condensation is decreased
preferred label: decreased duration of mitotic chromosome condensation
in_subset: cmpo

absence of mitotic chromosome decondensation phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: lacking processual parts
    intersection of: Restriction
      on property: BFO_0000070
      some values from: mitotic chromosome decondensation
    intersection of: Restriction
      on property: RO_0000052
      some values from: cell cycle
subclass of: mitotic process phenotype
subclass of: absence of cell process phenotype
id: CMPO:0000216
IAO_0000115: A phenotype resulting from the absence of mitotic chromosome decondensation
preferred label: absence of mitotic chromosome decondensation
has_broad_synonym: failure in decondensation
in_subset: cmpo

absence of mitotic process phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: lacking processual parts
    intersection of: Restriction
      on property: BFO_0000070
      some values from: mitotic cell cycle
    intersection of: Restriction
      on property: RO_0000052
      some values from: cell cycle
subclass of: mitotic process phenotype
subclass of: absence of cell process phenotype
id: CMPO:0000217
IAO_0000115: A phenotype resulting in the absence of mitotic process
preferred label: absence of mitotic process
in_subset: cmpo

mitotic chromosome condensation phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: process quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: mitotic chromosome condensation
subclass of: metabolic process phenotype
subclass of: mitotic process phenotype
id: CMPO:0000218
IAO_0000115: A phenotype observation at the level of mitotic chromosome condensation
in_subset: cmpo

mitotic chromosome decondensation phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: process quality
    intersection of: Restriction
      on property: BFO_0000070
      some values from: mitotic chromosome condensation
    intersection of: Restriction
      on property: RO_0000052
      some values from: cell cycle
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: process quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: mitotic chromosome decondensation
subclass of: cell population by process phenotype
subclass of: mitotic process phenotype
id: CMPO:0000219
IAO_0000115: A phenotype observation at the level of mitotic chromosome decondensation
preferred label: mitotic chromosome decondensation
in_subset: cmpo

cell apoptosis phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: process quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: apoptotic process
subclass of: cell death phenotype
IAO_0000115: A phenotype where the apoptosis process is observed
id: CMPO:0000220
in_subset: cmpo

more apoptosis in population
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: has extra parts of type
    intersection of: Restriction
      on property: bearer of
      some values from: cell apoptosis phenotype
subclass of: increased cell numbers
id: CMPO:0000221
IAO_0000115: increased number of apoptosis phenotypes in population
in_subset: cmpo

less apoptosis in population
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: has fewer parts of type
    intersection of: Restriction
      on property: bearer of
      some values from: cell apoptosis phenotype
subclass of: decreased cell numbers
id: CMPO:0000222
IAO_0000115: decreased number of apoptosis phenotypes in population
in_subset: cmpo

increased axon thickness phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: increased thickness
    intersection of: Restriction
      on property: RO_0000052
      some values from: axon
subclass of: increased cell component size phenotype
subclass of: cell projection phenotype
IAO_0000115: A phenotype observation where the thickness of the axon has increased.
id: CMPO:0000223
preferred label: increased axon thickness
in_subset: cmpo

decresed axon thickness phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: decreased thickness
    intersection of: Restriction
      on property: RO_0000052
      some values from: axon
subclass of: decreased cell component size phenotype
subclass of: cell projection phenotype
IAO_0000115: A phenotype observation where the thickness of the axon has decreased.
id: CMPO:0000224
preferred label: decresed axon thickness
in_subset: cmpo

increased axon length phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: increased length
    intersection of: Restriction
      on property: RO_0000052
      some values from: axon
subclass of: increased cell component size phenotype
subclass of: cell projection phenotype
IAO_0000115: A phenotype observation at the level of a axon where the components length has increased.
id: CMPO:0000227
preferred label: increased axon length
in_subset: cmpo

decreased axon length phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: decreased length
    intersection of: Restriction
      on property: RO_0000052
      some values from: axon
subclass of: decreased cell component size phenotype
subclass of: cell projection phenotype
id: CMPO:0000228
IAO_0000115: A phenotype observation at the level of a axon where the components length has decreased.
preferred label: decreased axon length
in_subset: cmpo

plasma membrane fusion occurance phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: occurrence quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: plasma membrane fusion
subclass of: cell membrane organisation phenotype
has_broad_synonym: cell fusion event
id: CMPO:0000229
preferred label: plasma membrane fusion occurance
in_subset: cmpo

increased rate of cell migration process phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: increased rate
    intersection of: Restriction
      on property: RO_0000052
      some values from: cell migration
subclass of: cell migration phenotype
definition source: PMID:20360735
id: CMPO:0000232
IAO_0000115: A phenotype where the cell migration process occurs at an increased rate, typically observed as a faster moving cell
preferred label: increased rate of cell migration process
in_subset: cmpo

decreased rate of cell migration process phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: decreased rate
    intersection of: Restriction
      on property: RO_0000052
      some values from: cell migration
subclass of: cell migration phenotype
IAO_0000115: A phenotype where the cell migration process occurs at an redcued rate, typically observed as a slower moving cell
id: CMPO:0000233
preferred label: decreased rate of cell migration process
has_narrow_synonym: decreased speed of cell migration
in_subset: cmpo

cell movement phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: movement quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: cto:cell
subclass of: single cell phenotype
IAO_0000115: A phenotype observation at the level of the whole cell relating to the cell's movement
id: CMPO:0000234
preferred label: cell movement
in_subset: cmpo

increased cell movement phenotype
type: Class
subclass of: cell movement phenotype
IAO_0000115: A phenotype observation at the level of the cell movement where cell movement is increased
id: CMPO:0000235
preferred label: increased cell movement
in_subset: cmpo

increased cell movement speed
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: increased speed
    intersection of: Restriction
      on property: RO_0000052
      some values from: cto:cell
subclass of: increased cell movement phenotype
has_exact_synonym: increased cell migration speed
id: CMPO:0000236
has_exact_synonym: cell moves faster
IAO_0000115: A phenotype observation at the level of the cell movement where the cell moves faster than normal/wild type.
in_subset: cmpo

increased cell movement distance
type: Class
subclass of: increased cell movement phenotype
id: CMPO:0000237
IAO_0000115: A phenotype observation at the level of the cell movement where the distance travelled by the cell is increased. The distance is measured as the euclidean distance between start and end point of the cell trajectory.
has_exact_synonym: increased cell migration distance
has_exact_synonym: cells cover a longer distance
in_subset: cmpo

decreased cell movement phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: Class
      intersection of: movement quality
      intersection of: Restriction
        on property: decreased_in_magnitude_relative_to
        some values from: normal
    intersection of: Restriction
      on property: RO_0000052
      some values from: cto:cell
subclass of: cell movement phenotype
IAO_0000115: A phenotype observation at the level of the cell movement where cell movement is decreased
id: CMPO:0000238
preferred label: decreased cell movement
in_subset: cmpo

decreased cell movement distance
type: Class
subclass of: decreased cell movement phenotype
has_exact_synonym: cells cover a shorter distance
id: CMPO:0000239
IAO_0000115: A phenotype observation at the level of the cell movement where the distance travelled by the cell is decreased. The distance is measured as the euclidean distance between start and end point of the cell trajectory.
in_subset: cmpo

decreased cell movement speed
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: decreased speed
    intersection of: Restriction
      on property: RO_0000052
      some values from: cto:cell
subclass of: decreased cell movement phenotype
id: CMPO:0000240
IAO_0000115: A phenotype observation at the level of the cell movement where the cell moves slower than normal/wild type.
has_exact_synonym: cell moves slower
in_subset: cmpo

proliferating cells
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: has extra parts of type
    intersection of: Restriction
      on property: bearer of
      some values from: cell division phenotype
subclass of: increased cell numbers
has_exact_synonym: high cell number in population
has_exact_synonym: increased proliferation
id: CMPO:0000241
IAO_0000115: increased number of cells in population phenotype
in_subset: cmpo

actin-mediated cell contraction phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: process quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: actin-mediated cell contraction
subclass of: cell component movement phenotype
id: CMPO:0000243
has_narrow_synonym: cell contraction
IAO_0000115: A phenotype of a cell contraction caused by an actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of all or part of the cell body.
preferred label: actin-mediated cell contraction
in_subset: cmpo

cell component movement phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: process quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: cellular component movement
subclass of: cell process phenotype
IAO_0000115: A phenotype where the directed, self-propelled movement of a cellular component without the involvement of an external agent such as a transporter or a pore is observed
id: CMPO:0000244
preferred label: cell component movement
in_subset: cmpo

cell secretion phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: process quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: secretion by cell
subclass of: transport phenotype
IAO_0000115: A phenotype observation of the controlled release of a substance by a cell.
id: CMPO:0000245
in_subset: cmpo

increased rate of protein secretion
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: increased rate
    intersection of: Restriction
      on property: RO_0000052
      some values from: protein secretion
subclass of: cell secretion phenotype
has_broad_synonym: enhanced protein secretion
definition source: PMID:22660414
id: CMPO:0000246
IAO_0000115: A phenotype observation where the rate of release of proteins from a cell is increased
in_subset: cmpo

decreased rate of protein secretion
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: decreased rate
    intersection of: Restriction
      on property: RO_0000052
      some values from: protein secretion
subclass of: cell secretion phenotype
has_broad_synonym: inhibition of protein secretion
IAO_0000115: A phenotype observation where the rate of release of proteins from a cell is decreased
id: CMPO:0000247
in_subset: cmpo

nuclear morphology phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: morphology
    intersection of: Restriction
      on property: RO_0000052
      some values from: Restriction
        on property: part_of
        some values from: nucleus
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: morphology
    intersection of: Restriction
      on property: RO_0000052
      some values from: nucleus
subclass of: nuclear phenotype
subclass of: cell component morphology phenotype
id: CMPO:0000249
IAO_0000115: A phenotype observation at the level of the nucleus relating to the nuclear morphology
preferred label: nuclear morphology
in_subset: cmpo

golgi morphology phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: morphology
    intersection of: Restriction
      on property: RO_0000052
      some values from: Golgi apparatus part
subclass of: golgi phenotype
subclass of: cell component morphology phenotype
id: CMPO:0000250
IAO_0000115: A phenotype observation at the level of the golgi relating to the golgi's morphology
preferred label: golgi morphology
in_subset: cmpo

cilium phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: Restriction
        on property: part_of
        some values from: cilium part
subclass of: phenotypes by organelle
IAO_0000115: A phenotype observation at the level of the cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface.
id: CMPO:0000251
in_subset: cmpo

cilium morphology phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: morphology
    intersection of: Restriction
      on property: RO_0000052
      some values from: cilium
subclass of: cilium phenotype
subclass of: cell projection phenotype
subclass of: cell component morphology phenotype
IAO_0000115: A phenotype observation at the level of a cilium relating to the components shape, size or structure
id: CMPO:0000252
preferred label: cilium morphology
in_subset: cmpo

single cell phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: cto:cell
subclass of: phenotype
id: CMPO:0000258
IAO_0000115: A phenotype observation at the level of a single or whole cell.
in_subset: cmpo

cellular component phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: cellular_component
subclass of: phenotype
IAO_0000115: A phenotype observation at the level of a cellular component
id: CMPO:0000259
in_subset: cmpo

geometric cell phenotype
type: Class
subclass of: cell morphology phenotype
id: CMPO:0000261
IAO_0000115: A phenotype observation at the level of the cell shape where the cell has a geometric shape with straight edges
definition source: PMID:21893601
preferred label: geometric cell
comment: request geometric shape in pato
in_subset: cmpo

apoptotic DNA
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: apoptotic
    intersection of: Restriction
      on property: RO_0000052
      some values from: deoxyribonucleic acid
subclass of: cell DNA phenotype
id: CMPO:0000262
IAO_0000115: Fragmented and condensed DNA during or following apoptosis
in_subset: cmpo

more cells in M phase
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: has extra parts of type
    intersection of: Restriction
      on property: bearer of
      some values from: M phase mitotic phenotype
subclass of: increased cell numbers
id: CMPO:0000263
IAO_0000115: Increased occurrence of mitotic cells
has_exact_synonym: increased number of mitotic cells
has_exact_synonym: increased occurrence of mitosis
in_subset: cmpo

fewer cells in M phase
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: has fewer parts of type
    intersection of: Restriction
      on property: bearer of
      some values from: M phase mitotic phenotype
subclass of: decreased cell numbers
has_exact_synonym: less cells in M phase
has_exact_synonym: decreased occurrence of mitosis
has_exact_synonym: decreased number of cell in mitosis
IAO_0000115: decreased occurrence of mitotic cells in population
id: CMPO:0000264
has_exact_synonym: decreased number of mitotic cells
in_subset: cmpo

M phase mitotic phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: process quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: M phase of mitotic cell cycle
subclass of: cell cycle phase phenotype
subclass of: mitotic process phenotype
id: CMPO:0000265
IAO_0000115: A phenotype observation at the level of the M phase of the mitotic cell cycle
in_subset: cmpo

asymmetric lamellipodia phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: asymmetrical
    intersection of: Restriction
      on property: RO_0000052
      some values from: lamellipodium
subclass of: cell component position phenotype
subclass of: lamellipodium phenotype
definition source: PMID:21893601
IAO_0000115: A phenotype observation where more lamellipoda is localised to one side of the cell with respect to the other
has_exact_synonym: asymmetric lamellae
id: CMPO:0000266
preferred label: asymmetric lamellipodia
in_subset: cmpo

star shaped cell phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: star shaped
    intersection of: Restriction
      on property: RO_0000052
      some values from: cto:cell
subclass of: cell morphology phenotype
definition source: PMID:21893601
id: CMPO:0000267
has_broad_synonym: spiky cell
IAO_0000115: A phenotype observation at the level of the cell shape where the cell has a star-like or bristly shape
preferred label: star shaped cell
in_subset: cmpo

spiny shaped cell phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: spiny
    intersection of: Restriction
      on property: RO_0000052
      some values from: cto:cell
subclass of: cell morphology phenotype
definition source: PMID:21893601
id: CMPO:0000268
IAO_0000115: A phenotype observation at the level of the cell shape where the cell has a star-like or bristly shape
preferred label: spiny shaped cell
in_subset: cmpo

increased variability of cell size in population
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: increased variability of size
    intersection of: Restriction
      on property: BFO_0000070
      some values from: cto:cell
subclass of: cell population by morphology
IAO_0000115: A population of cells where the cells exhibit a high variability of size
id: CMPO:0000269
has_exact_synonym: variable cell size
in_subset: cmpo

increased variability of cell shape in population
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: Class
      intersection of: variability of shape
      intersection of: Restriction
        on property: increased_in_magnitude_relative_to
        some values from: normal
    intersection of: Restriction
      on property: BFO_0000070
      some values from: cto:cell
subclass of: cell population by morphology
has_exact_synonym: variable cell shape
IAO_0000115: A population of cells where the cells exhibit a high variability of shape
id: CMPO:0000270
in_subset: cmpo

cortical actin cytoskeleton phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: cortical actin cytoskeleton
subclass of: cytoskeletal phenotype
definition source: A phenotype observation at the level of the cortical actin cytoskeleton, the portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane.
has_exact_synonym: peripheral actin phenotype
id: CMPO:0000271
in_subset: cmpo

increased cortical actin cytoskeleton mass phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: increased mass
    intersection of: Restriction
      on property: RO_0000052
      some values from: cortical actin cytoskeleton
subclass of: cortical actin cytoskeleton phenotype
IAO_0000115: A phenotype observation at the level of the cortical actin cytoskeleton where the components mass has increased.
has_exact_synonym: increased peripheral actin
definition source: PMID:21893601
id: CMPO:0000272
preferred label: increased cortical actin cytoskeleton mass
in_subset: cmpo

decreased cortical actin cytoskeleton mass phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: decreased mass
    intersection of: Restriction
      on property: RO_0000052
      some values from: cortical actin cytoskeleton
subclass of: cortical actin cytoskeleton phenotype
definition source: PMID:21893601
id: CMPO:0000273
IAO_0000115: A phenotype observation at the level of the cortical actin cytoskeleton where the components mass has decreased.
preferred label: decreased cortical actin cytoskeleton mass
has_exact_synonym: decreased peripheral actin
in_subset: cmpo

disorganised cortical actin cytoskeleton phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: disorganized
    intersection of: Restriction
      on property: RO_0000052
      some values from: cortical actin cytoskeleton
subclass of: cell component structure phenotype
subclass of: cortical actin cytoskeleton phenotype
definition source: PMID:21893601
id: CMPO:0000274
has_exact_synonym: disorganised peripheral actin phenotype
IAO_0000115: A phenotype observation at the level of the cortical actin cytoskeleton where the component shows an irregular organization
preferred label: disorganised cortical actin cytoskeleton
in_subset: cmpo

increased lamellipodia width phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: increased width
    intersection of: Restriction
      on property: RO_0000052
      some values from: lamellipodium
subclass of: increased cell component size phenotype
subclass of: lamellipodium phenotype
definition source: PMID:21893601
preferred label: increased lamellipodia width
has_exact_synonym: increased width of lamellae
id: CMPO:0000276
IAO_0000115: A phenotype observation at the level of a lamellipodia where the components width has increased.
in_subset: cmpo

decreased lamellipodia width phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: decreased width
    intersection of: Restriction
      on property: RO_0000052
      some values from: lamellipodium
subclass of: decreased cell component size phenotype
subclass of: lamellipodium phenotype
id: CMPO:0000277
IAO_0000115: A phenotype observation at the level of a lamellipodia where the components width has decreased.
definition source: PMID:21893601
preferred label: decreased lamellipodia width
has_exact_synonym: decreased width of lamellae
in_subset: cmpo

fan-shaped lamellipodia phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: fan-shaped
    intersection of: Restriction
      on property: RO_0000052
      some values from: lamellipodium
subclass of: cell component shape phenotype
subclass of: lamellipodium phenotype
id: CMPO:0000278
IAO_0000115: A phenotype observation where the lamellipodia is shaped in the form of a fan.
definition source: PMID:21893601
preferred label: fan-shaped lamellipodia
has_broad_synonym: motile lamellae
in_subset: cmpo

lamellipodium phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: lamellipodium
subclass of: cell projection phenotype
IAO_0000115: A phenotype observation at the level of a cell with an increased amount of lamellipodia.
id: CMPO:0000279
in_subset: cmpo

cell projection phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: cell projection
subclass of: cellular component phenotype
IAO_0000115: A phenotype observation at the level of a cellular component relating to a prolongation or process extending from a cell, e.g. a cilium, lamellipodium or axon.
id: CMPO:0000280
in_subset: cmpo

filopodium phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: filopodium
subclass of: cell projection phenotype
IAO_0000115: A phenotype observation at the level of the filopodium; a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast.
id: CMPO:0000281
preferred label: filopodium
in_subset: cmpo

layered cells in population
type: Class
subclass of: cell population by morphology
definition source: PMID:21893601
id: CMPO:0000282
has_broad_synonym: layered cells
IAO_0000115: Cells not stopping at confluence and growing on top of each other in layers
in_subset: cmpo

actin cytoskeleton phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: actin cytoskeleton
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: quality
    intersection of: Restriction
      on property: BFO_0000070
      some values from: actin cytoskeleton
subclass of: cytoskeletal phenotype
id: CMPO:0000283
IAO_0000115: A phenotype observation at the level of the actin cytoskeleton, the part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
preferred label: actin cytoskeleton
in_subset: cmpo

increased actin cytoskeleton mass phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: increased mass
    intersection of: Restriction
      on property: RO_0000052
      some values from: actin cytoskeleton
subclass of: actin cytoskeleton phenotype
id: CMPO:0000284
IAO_0000115: A phenotype observation at the level of a actin cytoskeleton where the components mass has increased
definition source: PMID:21893601
preferred label: increased actin cytoskeleton mass
in_subset: cmpo

decreased actin cytoskeleton mass phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: decreased mass
    intersection of: Restriction
      on property: RO_0000052
      some values from: actin cytoskeleton
subclass of: actin cytoskeleton phenotype
definition source: PMID:21893601
id: CMPO:0000285
IAO_0000115: A phenotype observation at the level of a actin cytoskeleton where the components mass has decreased.
preferred label: decreased actin cytoskeleton mass
in_subset: cmpo

aggregated microtubules phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: aggregated
    intersection of: Restriction
      on property: RO_0000052
      some values from: microtubule
subclass of: cytoskeletal phenotype
subclass of: cell component position phenotype
definition source: PMID:21893601
definition source: A phenotype observation where microtubules form clump-like structures as opposed to filaments
id: CMPO:0000286
preferred label: aggregated microtubules
has_exact_synonym: microtubule clumps
in_subset: cmpo

microtubules nuclear bracket phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: bilateral
    intersection of: Restriction
      on property: BFO_0000070
      some values from: nucleus
    intersection of: Restriction
      on property: RO_0000052
      some values from: microtubule bundle
subclass of: cytoskeletal phenotype
subclass of: cell component position phenotype
definition source: PMID:21893601
id: CMPO:0000287
IAO_0000115: A phenotype observation where the microtubules form two crescent shaped brackets around the nucleus
preferred label: microtubules nuclear bracket
in_subset: cmpo

microtubules nuclear ring phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: surrounding
    intersection of: Restriction
      on property: BFO_0000070
      some values from: nucleus
    intersection of: Restriction
      on property: RO_0000052
      some values from: microtubule bundle
subclass of: cytoskeletal phenotype
subclass of: cell component position phenotype
id: CMPO:0000288
definition source: PMID:21893601
has_exact_synonym: microtubule nuclear ring
IAO_0000115: A phenotype observation where the microtubules form a ring around the nucleus
preferred label: microtubules nuclear ring
in_subset: cmpo

increased amount of stress fibers phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: has extra parts of type
    intersection of: Restriction
      on property: BFO_0000070
      some values from: stress fiber
    intersection of: Restriction
      on property: RO_0000052
      some values from: cto:cell
subclass of: increased cell component number phenotype
IAO_0000115: A phenotype observation at the level of any stress fibers where the components number has increased.
id: CMPO:0000289
preferred label: increased amount of stress fibers
has_exact_synonym: more actin stress fibers
definition source: pmid:21893601
in_subset: cmpo

punctate actin foci phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: punctate
    intersection of: Restriction
      on property: RO_0000052
      some values from: actin filament
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: punctate
    intersection of: Restriction
      on property: BFO_0000070
      some values from: actin filament
subclass of: cell component position phenotype
subclass of: actin filament phenotype
has_exact_synonym: puncta actin filament phenotype
IAO_0000115: A phenotype observation where actin is observed as small patches or spots all over the cell
id: CMPO:0000290
preferred label: punctate actin foci
in_subset: cmpo

increased amount of punctate actin foci phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: has extra parts of type
    intersection of: Restriction
      on property: BFO_0000070
      some values from: Class
        intersection of: actin filament
        intersection of: Restriction
    intersection of: Restriction
      on property: RO_0000052
      some values from: cto:cell
subclass of: increased number of actin filament phenotype
has_exact_synonym: more actin puncta
id: CMPO:0000291
definition source: PMID:21893601
has_exact_synonym: increased actin puncta
IAO_0000115: A phenotype observation where a cell has an increased amount of actin observed as small patches or spots all over the cell
preferred label: increased amount of punctate actin foci
in_subset: cmpo

cell layer phenotype
type: Class
subclass of: cell population
definition source: http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20216
IAO_0000115: A phenotype of a culture in which cells grow as a monolayer that is attached to the culture substrate.
id: CMPO:0000292
in_subset: cmpo

loss of cell monolayer
type: Class
subclass of: cell layer phenotype
IAO_0000115: Loss of sheet like monolayer leading to empty patches
id: CMPO:0000293
has_exact_synonym: lost cell monolayer
in_subset: cmpo

increased actin localised to the nucleus
type: Class
equivalent class: Class
  intersection of: Restriction
    on property: has_part
    some values from: Class
      intersection of: increased rate
      intersection of: Restriction
        on property: RO_0000052
        some values from: Class
  intersection of: Restriction
    on property: has_part
    some values from: Class
      intersection of: has extra parts of type
      intersection of: Restriction
        on property: BFO_0000070
        some values from: actin filament
subclass of: actin filament phenotype
subclass of: cell component localisation phenotype
subclass of: Restriction
  on property: has_part
  some values from: Class
    intersection of: has extra parts of type
    intersection of: Restriction
      on property: BFO_0000070
      some values from: actin filament
subclass of: Restriction
  on property: has_part
  some values from: Class
    intersection of: increased rate
    intersection of: Restriction
      on property: RO_0000052
      some values from: Class
        intersection of: localization
        intersection of: Restriction
id: CMPO:0000294
has_exact_synonym: increased nuclear actin
IAO_0000115: A phenotype observation where many actin filaments are observed in or around the nucleus
definition source: PMID: 21893601
in_subset: cmpo

increased actin localised to the cytoplasm
type: Class
equivalent class: Class
  intersection of: Restriction
    on property: has_part
    some values from: Class
      intersection of: increased rate
      intersection of: Restriction
        on property: RO_0000052
        some values from: Class
  intersection of: Restriction
    on property: has_part
    some values from: Class
      intersection of: has extra parts of type
      intersection of: Restriction
        on property: BFO_0000070
        some values from: actin filament
subclass of: actin filament phenotype
subclass of: cell component localisation phenotype
subclass of: Restriction
  on property: has_part
  some values from: Class
    intersection of: increased rate
    intersection of: Restriction
      on property: RO_0000052
      some values from: Class
        intersection of: localization
        intersection of: Restriction
subclass of: Restriction
  on property: has_part
  some values from: Class
    intersection of: has extra parts of type
    intersection of: Restriction
      on property: BFO_0000070
      some values from: actin filament
definition source: PMID: 21893601
id: CMPO:0000296
has_exact_synonym: increased cytoplasmic actin
IAO_0000115: A phenotype observation where many actin filaments are observed in the cytoplasm
in_subset: cmpo

increased amount of stress fibers located in the cell cortex phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: has extra parts of type
    intersection of: Restriction
      on property: BFO_0000070
      some values from: Class
        intersection of: stress fiber
        intersection of: Restriction
    intersection of: Restriction
      on property: RO_0000052
      some values from: cto:cell
subclass of: increased amount of stress fibers phenotype
comment: Increased amount of actin stress fibers in the cortical area
has_broad_synonym: more cortical actin stress fibers
definition source: A phenotype observation at the level of stress fibers localized to the cell cortex where the components number has increased.
id: CMPO:0000297
preferred label: increased amount of stress fibers located in the cell cortex
definition source: pmid:21893601
in_subset: cmpo

increased amount of transverse stress fibers
type: Class
subclass of: increased amount of stress fibers phenotype
definition source: pmid:21893601
id: CMPO:0000298
comment: Increased amount of actin stress fibers, forming transverse arcs located in the cell cortex
has_exact_synonym: more transverse actin stress fibers
IAO_0000115: A phenotype observation at the level of stress fibers where the components number has increased and formed transverse arcs which are located in the cell cortex
in_subset: cmpo

increased amount of zig-zag stress fibers
type: Class
subclass of: increased amount of stress fibers phenotype
id: CMPO:0000299
has_exact_synonym: more zig-zag actin stress fibers
IAO_0000115: A phenotype observation at the level of stress fibers where the components number has increased and formed a zig zag pattern across the cell
comment: Increased amount of actin stress fibers, with zig-zag pattern across the cell
definition source: pmid:21893601
in_subset: cmpo

more multinucleate cells
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: has extra parts of type
    intersection of: Restriction
      on property: bearer of
      some values from: multinucleated cell phenotype
subclass of: increased cell numbers
id: CMPO:0000300
IAO_0000115: Increased cells that are multinucleated
in_subset: cmpo

no cells phenotype
type: Class
subclass of: cell population
id: CMPO:0000301
IAO_0000115: Absence of cells
definition source: PMID:21893601
preferred label: no cells
in_subset: cmpo

actin nuclear ring phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: surrounding
    intersection of: Restriction
      on property: BFO_0000070
      some values from: nucleus
    intersection of: Restriction
      on property: RO_0000052
      some values from: actin filament
subclass of: cell component position phenotype
subclass of: actin filament phenotype
has_exact_synonym: nuclear actin ring
definition source: PMID:21893601
IAO_0000115: A phenotype observation where the microtubules form a ring around the nucleus
id: CMPO:0000302
preferred label: actin nuclear ring
in_subset: cmpo

cell component morphology phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: morphology
    intersection of: Restriction
      on property: RO_0000052
      some values from: cellular_component
subclass of: cellular component phenotype
id: CMPO:0000303
IAO_0000115: A phenotype observation at the level of a cellular component relating to the components shape, size or structure
preferred label: cell component morphology
in_subset: cmpo

cell cycle arrested phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: arrested
    intersection of: Restriction
      on property: RO_0000052
      some values from: Restriction
        on property: part_of
        some values from: cell cycle process
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: arrested
    intersection of: Restriction
      on property: RO_0000052
      some values from: cell cycle phase
subclass of: cell cycle phase phenotype
subclass of: arrested process phenotype
IAO_0000115: A phenotype of a cell where a particular process is arrested, or ends earlier in time than expected
id: CMPO:0000304
preferred label: cell cycle arrested
in_subset: cmpo

metaphase arrested phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: arrested
    intersection of: Restriction
      on property: RO_0000052
      some values from: mitotic metaphase
subclass of: mitotic metaphase phenotype
subclass of: cell cycle arrested phenotype
has_exact_synonym: metaphase arrest
id: CMPO:0000305
definition source: PMID:20360735
IAO_0000115: A phenotype of a cell arrested in mitotic metaphase
preferred label: metaphase arrested
in_subset: cmpo

delayed process phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: delayed
    intersection of: Restriction
      on property: RO_0000052
      some values from: biological_process
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: delayed
    intersection of: Restriction
      on property: BFO_0000070
      some values from: biological_process
subclass of: cell process phenotype
subclass of: cell population by process phenotype
IAO_0000115: A phenotype of a cell where a particular process is delayed
id: CMPO:0000306
preferred label: delayed process
in_subset: cmpo

metaphase delayed phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: delayed
    intersection of: Restriction
      on property: RO_0000052
      some values from: mitotic metaphase
subclass of: mitotic metaphase phenotype
subclass of: delayed process phenotype
has_exact_synonym: metaphase delay
definition source: PMID:20360735
id: CMPO:0000307
IAO_0000115: A phenotype of a cell where mitotic metaphase is delayed
preferred label: metaphase delayed
in_subset: cmpo

impaired cell migration
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: process quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: cell migration
    intersection of: Restriction
      on property: has qualifier
      some values from: abnormal
subclass of: cell migration phenotype
has_exact_synonym: abnormal cell migration
id: CMPO:0000309
IAO_0000115: A phenotype where the cell migration is impaired
in_subset: cmpo

increased duration of cell migration process phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: increased duration
    intersection of: Restriction
      on property: RO_0000052
      some values from: cell migration
subclass of: cell migration phenotype
definition source: PMID:20360735
IAO_0000115: A phenotype where the cell migration process occurs for longer, typically observed as a cell moving a further distance
id: CMPO:0000312
preferred label: increased duration of cell migration process
in_subset: cmpo

decreased duration of cell migration process phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: decreased duration
    intersection of: Restriction
      on property: RO_0000052
      some values from: cell migration
subclass of: cell migration phenotype
id: CMPO:0000313
IAO_0000115: A phenotype where the cell migration process duration is reduced, typically observed as a cell moving a shorter distance
preferred label: decreased duration of cell migration process
in_subset: cmpo

exit from mitosis phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: process quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: exit from mitosis
subclass of: mitotic process phenotype
id: CMPO:0000314
IAO_0000115: A phenotype observation at the level of the exit from mitosis
preferred label: exit from mitosis
in_subset: cmpo

absence of cell process phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: lacking processual parts
    intersection of: Restriction
      on property: BFO_0000070
      some values from: biological_process
    intersection of: Restriction
      on property: RO_0000052
      some values from: biological_process
subclass of: cell process phenotype
subclass of: cell population by process phenotype
has_exact_synonym: cell physiology phenotype
IAO_0000115: A phenotype observation at the level of a cellular process where the cell process is absent
id: CMPO:0000315
preferred label: absence of cell process
in_subset: cmpo

abnormal cell growth phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: process quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: cell growth
    intersection of: Restriction
      on property: has qualifier
      some values from: abnormal
subclass of: cell growth phenotype
id: CMPO:0000316
IAO_0000115: A phenotype observation of the process in which the cell growth is abnormal
preferred label: abnormal cell growth
in_subset: cmpo

cell growth arrested phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: arrested
    intersection of: Restriction
      on property: RO_0000052
      some values from: cell growth
subclass of: cell growth phenotype
subclass of: arrested process phenotype
id: CMPO:0000317
IAO_0000115: A phenotype observation of the process in which the cell growth is arrested
preferred label: cell growth arrested
in_subset: cmpo

mild decrease in rate of protein secretion
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: decreased rate
    intersection of: Restriction
      on property: RO_0000052
      some values from: protein secretion
    intersection of: Restriction
      on property: has qualifier
      some values from: mild
subclass of: decreased rate of protein secretion
definition source: PMID:22660414
IAO_0000115: A phenotype observation where the rate of release of proteins from a cell is mildly decreased
id: CMPO:0000318
has_broad_synonym: mild inhibition of protein secretion
in_subset: cmpo

strong decrease in rate of protein secretion
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: decreased rate
    intersection of: Restriction
      on property: RO_0000052
      some values from: protein secretion
    intersection of: Restriction
      on property: has qualifier
      some values from: severe
subclass of: decreased rate of protein secretion
has_broad_synonym: strong inhibition of protein secretion
definition source: PMID:22660414
id: CMPO:0000319
IAO_0000115: A phenotype observation where the rate of release of proteins from a cell is severly decreased
in_subset: cmpo

increased cell spreading phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: increased occurrence
    intersection of: Restriction
      on property: RO_0000052
      some values from: substrate adhesion-dependent cell spreading
subclass of: cell spreading phenotype
id: CMPO:0000320
IAO_0000115: A phenotype observation where there is an increased occurance of cell spreading
preferred label: increased cell spreading
in_subset: cmpo

mild increase of cell spreading phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: increased occurrence
    intersection of: Restriction
      on property: RO_0000052
      some values from: substrate adhesion-dependent cell spreading
    intersection of: Restriction
      on property: has qualifier
      some values from: mild
subclass of: increased cell spreading phenotype
IAO_0000115: A phenotype observation where there is a mild increase of cell spreading
definition source: PMID:19667130
id: CMPO:0000321
has_broad_synonym: moderate cell spreading
preferred label: mild increase of cell spreading
in_subset: cmpo

strong increase of cell spreading phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: increased occurrence
    intersection of: Restriction
      on property: RO_0000052
      some values from: substrate adhesion-dependent cell spreading
    intersection of: Restriction
      on property: has qualifier
      some values from: severe
subclass of: increased cell spreading phenotype
IAO_0000115: A phenotype observation where there is a severe increase in cell spreading
id: CMPO:0000322
has_broad_synonym: extensive cell spreading
preferred label: strong increase of cell spreading
in_subset: cmpo

decreased cell spreading phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: decreased occurrence
    intersection of: Restriction
      on property: RO_0000052
      some values from: substrate adhesion-dependent cell spreading
subclass of: cell spreading phenotype
has_broad_synonym: poor cell spreading
IAO_0000115: A phenotype observation where there is a decreased occurance of cell spreading
id: CMPO:0000323
definition source: PMID:19667130
preferred label: decreased cell spreading
in_subset: cmpo

absence of cell spreading phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: lacking processual parts
    intersection of: Restriction
      on property: BFO_0000070
      some values from: substrate adhesion-dependent cell spreading
    intersection of: Restriction
      on property: RO_0000052
      some values from: biological_process
subclass of: cell spreading phenotype
subclass of: absence of cell process phenotype
IAO_0000115: A phenotype observation where cell spreading is absent
preferred label: absence of cell spreading
has_exact_synonym: no spreading cells
id: CMPO:0000324
in_subset: cmpo

spread cell morphology phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: morphology
    intersection of: Restriction
      on property: RO_0000052
      some values from: Class
        intersection of: cto:cell
        intersection of: Restriction
subclass of: cell morphology phenotype
id: CMPO:0000325
IAO_0000115: A phenotype observation where a cell shows a thin and large projected areas, with developed matrix adhesions at the cell periphery, as opposed to round cells with no or few adhesion sites
preferred label: spread cell morphology
has_exact_synonym: spreading cell shape
in_subset: cmpo

abnormal chromosome segregation phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: process quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: chromosome segregation
    intersection of: Restriction
      on property: has qualifier
      some values from: abnormal
subclass of: chromosome segregation phenotype
has_broad_synonym: segregation problems
id: CMPO:0000326
preferred label: abnormal chromosome segregation
has_broad_synonym: lagging chromosomes
has_broad_synonym: chromatin bridges
definition source: PMID:20360735
IAO_0000115: A phenotype observation of the process in which the chromosome segregation is abnormal
has_broad_synonym: multiple DNA masses
in_subset: cmpo

mitotic prophase phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: process quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: mitotic prophase
subclass of: cell cycle phase phenotype
subclass of: mitotic process phenotype
IAO_0000115: A phenotype observation at the level of the mitotic prophase of the cell cycle
id: CMPO:0000327
in_subset: cmpo

increased duration of mitotic prophase phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: increased duration
    intersection of: Restriction
      on property: RO_0000052
      some values from: mitotic prophase
subclass of: mitotic prophase phenotype
IAO_0000115: A phenotype observation where the duration of the mitotic prophase of the cell cycle is increased
id: CMPO:0000328
preferred label: increased duration of mitotic prophase
in_subset: cmpo

decreased duration of mitotic prophase phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: decreased duration
    intersection of: Restriction
      on property: RO_0000052
      some values from: mitotic prophase
subclass of: mitotic prophase phenotype
id: CMPO:0000329
IAO_0000115: A phenotype observation where the duration of the mitotic prophase of the cell cycle is decreased
preferred label: decreased duration of mitotic prophase
in_subset: cmpo

decreased frequency of negative regulation of NF-kappaB transcription factor activity phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: decreased frequency
    intersection of: Restriction
      on property: RO_0000052
      some values from: negative regulation of NF-kappaB transcription factor activity
subclass of: regulation of metabolic process phenotype
IAO_0000115: A phenotype observation where the frequency of a process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB is decreased.
IAO_0000116: decreased number of oscillations; the amplitude of the first peak is comparable to control, although the duration may be increased; the time of the second and third peaks is delayed, due to greater interval times between termination and initiation of nuclear translocation responses
id: CMPO:0000330
has_related_synonym: decreased NF-kB oscillation
definition source: PMID:23300644
preferred label: decreased frequency of negative regulation of NF-kappaB transcription factor activity
in_subset: cmpo

increased frequency of negative regulation of NF-kappaB transcription factor activity phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: increased frequency
    intersection of: Restriction
      on property: RO_0000052
      some values from: positive regulation of NF-kappaB transcription factor activity
subclass of: regulation of metabolic process phenotype
IAO_0000115: A phenotype observation where the frequency of a process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB is increased.
id: CMPO:0000331
definition source: PMID:23300644
has_related_synonym: increased NF-kB oscillation
preferred label: increased frequency of negative regulation of NF-kappaB transcription factor activity
IAO_0000116: increased number of oscillations; the amplitude of the second and third peak is increased and nuclear translocation responses occur at increased intervals.
in_subset: cmpo

cytoplasmic sequestering of NF-kappaB phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: continuous
    intersection of: Restriction
      on property: RO_0000052
      some values from: cytoplasmic sequestering of NF-kappaB
subclass of: regulation of signal transduction phenotype
definition source: PMID:23300644
IAO_0000116: increased number of oscillations; the amplitude of the second and third peak is increased and nuclear translocation responses occur at increased intervals.
has_related_synonym: no NF-kB oscillation phenotype
IAO_0000115: A phenotype observation where the frequency of a process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB is increased.
id: CMPO:0000332
preferred label: cytoplasmic sequestering of NF-kappaB
in_subset: cmpo

abnormal release of cytoplasmic sequestered NF-kappaB phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: process quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: release of cytoplasmic sequestered NF-kappaB
    intersection of: Restriction
      on property: has qualifier
      some values from: abnormal
subclass of: regulation of signal transduction phenotype
IAO_0000115: A phenotype observation where the release of NF-kappaB from specific molecules in the cytoplasm to which it was bound, thereby allowing its translocation into the nucleus, is abnormal.
IAO_0000116: contains all cases that are significantly different from the rest, but don't share any clear commonalities. NF-kB oscillation patterns are not synchronized within a cell population, oscillation amplitude and frequency follow erratic patterns
has_related_synonym: different NF-kB oscillation phenotype
definition source: PMID:23300644
id: CMPO:0000333
preferred label: abnormal release of cytoplasmic sequestered NF-kappaB
in_subset: cmpo

regulation of process phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: process quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: regulation of biological process
subclass of: cell process phenotype
id: CMPO:0000334
IAO_0000115: A phenotype observation where any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
in_subset: cmpo

bright nuclear body phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: high brightness
    intersection of: Restriction
      on property: RO_0000052
      some values from: nuclear body
subclass of: nuclear body phenotype
IAO_0000115: A phenotype obervation where the nuclear body's color brightness is relatively high.
definition source: pmid:22884692
has_related_synonym: increased intensity of nuclear body
id: CMPO:0000335
preferred label: bright nuclear body
in_subset: cmpo

round focal adhesion
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: circular
    intersection of: Restriction
      on property: RO_0000052
      some values from: focal adhesion
subclass of: cell component shape phenotype
id: CMPO:0000337
IAO_0000115: A phenotype observation where the shape of the focal adhesion has every part of the surface or the circumference equidistant from the center.
in_subset: cmpo

mitosis arrested
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: arrested
    intersection of: Restriction
      on property: RO_0000052
      some values from: mitosis
subclass of: mitotic process phenotype
subclass of: cell cycle arrested phenotype
id: CMPO:0000338
IAO_0000115: A phenotype of a cell that is arrested at mitosis
definition source: PMID:20360735
has_exact_synonym: mitotic arrest
in_subset: cmpo

increased cell size in population
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: has extra parts of type
    intersection of: Restriction
      on property: bearer of
      some values from: increased cell size phenotype
subclass of: increased cell numbers
subclass of: cell population by morphology
has_exact_synonym: large cells
id: CMPO:0000340
IAO_0000115: A population of cells where there is an increased number of large cells in the population
in_subset: cmpo

pyknotic nuclear phenotype
type: Class
subclass of: nuclear phenotype
id: CMPO:0000341
IAO_0000115: A phenotype observation at the level of the nucleus underoging Pyknosis, or karyopyknosis, consisting of the irreversible condensation of chromatin in the nucleus of a cell undergoing necrosis or apoptosis.
has_exact_synonym: pyknotic nucleus
has_broad_synonym: pyknotic cell
in_subset: cmpo

prometaphase arrested phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: arrested
    intersection of: Restriction
      on property: RO_0000052
      some values from: mitotic prometaphase
subclass of: cell cycle arrested phenotype
has_exact_synonym: prometaphase arrest
id: CMPO:0000343
IAO_0000115: A phenotype of a cell arrested in mitotic prometaphase
preferred label: prometaphase arrested
in_subset: cmpo

prometaphase delayed phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: delayed
    intersection of: Restriction
      on property: RO_0000052
      some values from: mitotic prometaphase
subclass of: cell cycle phase phenotype
subclass of: delayed process phenotype
IAO_0000115: A phenotype of a cell where mitotic prometaphase is delayed
id: CMPO:0000344
has_exact_synonym: prometaphase delay
preferred label: prometaphase delayed
in_subset: cmpo

increased variability of nuclear shape in population
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: Class
      intersection of: variability of shape
      intersection of: Restriction
        on property: increased_in_magnitude_relative_to
        some values from: normal
    intersection of: Restriction
      on property: BFO_0000070
      some values from: nucleus
subclass of: cell population by morphology
id: CMPO:0000345
IAO_0000115: A population of cells where the nuclei exhibit a high variability of shape
has_exact_synonym: variable cell shape
in_subset: cmpo

decreased rate of intracellular protein transport phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: decreased rate
    intersection of: Restriction
      on property: RO_0000052
      some values from: intracellular protein transport
subclass of: transport phenotype
IAO_0000115: A phenotype observation where the rate of intracellular protein transport is decreased
id: CMPO:0000346
definition source: pmid:21795383
preferred label: decreased rate of intracellular protein transport
in_subset: cmpo

absence of mitotic metaphase process phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: lacking processual parts
    intersection of: Restriction
      on property: BFO_0000070
      some values from: mitotic metaphase
    intersection of: Restriction
      on property: RO_0000052
      some values from: cell cycle
subclass of: mitotic process phenotype
subclass of: absence of cell process phenotype
IAO_0000115: A phenotype resulting in the absence of mitotic metaphase process
id: CMPO:0000347
preferred label: absence of mitotic metaphase
in_subset: cmpo

mitotic metaphase plate congression phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: process quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: mitotic metaphase plate congression
subclass of: mitotic process phenotype
has_broad_synonym: metaphase alignment problem
id: CMPO:0000348
IAO_0000115: A phenotype observation at the level of the cell cycle process in which chromosomes are aligned at the metaphase plate, a plane halfway between the poles of the mitotic spindle, during mitosis.
preferred label: mitotic metaphase plate congression
in_subset: cmpo

increased substrate-dependent cell migration, cell extension phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: increased occurrence
    intersection of: Restriction
      on property: RO_0000052
      some values from: substrate-dependent cell migration, cell extension
subclass of: cell migration phenotype
id: CMPO:0000349
IAO_0000115: A phenotype where an increased formation of a cell surface protrusion, such as a lamellipodium or filopodium, at the leading edge of a migrating cell is observed.
has_exact_synonym: increased protrusive activity
preferred label: increased substrate-dependent cell migration, cell extension
in_subset: cmpo

increased substrate-dependent cell migration
type: Class
label: increased substrate-dependent cell migration phenotype
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: increased occurrence
    intersection of: Restriction
      on property: RO_0000052
      some values from: substrate-dependent cell migration
subclass of: cell migration phenotype
id: CMPO:0000350
has_exact_synonym: increased directional cell migration
IAO_0000115: A phenotype where an increased occurrence of the orderly movement of a cell from one site to another along a substrate such as the extracellular matrix is observed.
in_subset: cmpo

increased microtubule-based processes phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: increased occurrence
    intersection of: Restriction
      on property: RO_0000052
      some values from: microtubule-based process
subclass of: cell process phenotype
IAO_0000115: A phenotype where an increased occurance of any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins, is observed.
preferred label: increased microtubule-based processes
has_exact_synonym: microtubule processes
id: CMPO:0000351
in_subset: cmpo

increased monopolar cell elongation phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: increased occurrence
    intersection of: Restriction
      on property: RO_0000052
      some values from: monopolar cell growth
subclass of: cell growth phenotype
subclass of: cellular development phenotype
id: CMPO:0000353
IAO_0000115: A phenotype observation of the process in which a cell increases in size due to polarized growth from one end of a cell.
preferred label: increased monopolar cell elongation
has_exact_synonym: increased polar cell elongation
in_subset: cmpo

decreased monopolar cell elongation phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: decreased occurrence
    intersection of: Restriction
      on property: RO_0000052
      some values from: monopolar cell growth
subclass of: cell growth phenotype
subclass of: cellular development phenotype
has_exact_synonym: decreased polar cell elongation
id: CMPO:0000354
IAO_0000115: A phenotype observation of the process in which a cell decreases in size due to polarized growth from one end of a cell.
preferred label: decreased monopolar cell elongation
in_subset: cmpo

mild actin-mediated cell contraction phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: occurrence quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: actin-mediated cell contraction
    intersection of: Restriction
      on property: has qualifier
      some values from: mild
subclass of: actin-mediated cell contraction phenotype
IAO_0000115: A phenotype of a cell contraction caused by an actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in mild contraction of all or part of the cell body.
id: CMPO:0000355
preferred label: mild actin-mediated cell contraction
in_subset: cmpo

cell component localisation phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: process quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: localization
subclass of: cell process phenotype
has_exact_synonym: cell component localization
IAO_0000115: A phenotype where any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location is observed
id: CMPO:0000356
preferred label: cell component localisation
in_subset: cmpo

polylobed nuclear phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: acinus
    intersection of: Restriction
      on property: RO_0000052
      some values from: nucleus
subclass of: nucleus shape phenotype
id: CMPO:0000357
has_exact_synonym: acinus nuclear phenotype
IAO_0000115: A phenotype observation where the shape of the nucleus resembles a many-lobed berry, such as a raspberry.
in_subset: cmpo

increased rate of DNA amplification
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: increased rate
    intersection of: Restriction
      on property: RO_0000052
      some values from: DNA amplification
subclass of: metabolic process phenotype
IAO_0000115: A phenotype of a cell where the rate of DNA amplification is increased
id: CMPO:0000358
in_subset: cmpo

increased amount of DNA
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: has extra parts of type
    intersection of: Restriction
      on property: BFO_0000070
      some values from: deoxyribonucleic acid
    intersection of: Restriction
      on property: RO_0000052
      some values from: cto:cell
subclass of: increased cell component number phenotype
subclass of: Restriction
  on property: has_part
  some values from: Class
    intersection of: has extra parts of type
    intersection of: Restriction
      on property: BFO_0000070
      some values from: cellular_component
    intersection of: Restriction
      on property: RO_0000052
      some values from: cto:cell
id: CMPO:0000359
IAO_0000115: A phenotype observation where a cell has an increased amount of DNA
in_subset: cmpo

centriole replication phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: process quality
    intersection of: Restriction
      on property: RO_0000052
      some values from: centriole replication
subclass of: cell cycle phenotype
id: CMPO:0000360
IAO_0000115: A phenotype of a cell in which the biological process resulting in a doubling of the number of centrioles in the cell is affected
definition source: pmid:18620859
has_exact_synonym: centriole duplication phenotype
preferred label: centriole replication
in_subset: cmpo

increased centriole replication phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: increased occurrence
    intersection of: Restriction
      on property: RO_0000052
      some values from: centriole replication
subclass of: increased microtubule-based processes phenotype
subclass of: centriole replication phenotype
has_exact_synonym: centriole amplification phenotype
id: CMPO:0000361
IAO_0000115: A phenotype of a cell in which the biological process resulting in a the number of centrioles is increased
preferred label: increased centriole replication
in_subset: cmpo

decreased centriole replication phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: decreased occurrence
    intersection of: Restriction
      on property: RO_0000052
      some values from: centriole replication
subclass of: centriole replication phenotype
id: CMPO:0000362
IAO_0000115: A phenotype of a cell in which the biological process resulting in a the number of centrioles is decreased
has_exact_synonym: centriole underduplication phenotype
preferred label: decreased centriole replication
in_subset: cmpo

protein localization to cellular component phenotype
type: Class
equivalent class: Restriction
  on property: has_part
  some values from: Class
    intersection of: occurrence quality
    intersection of: Class
      intersection of: Restriction
        on property: RO_0000052
        some values from: protein localization to organelle
      intersection of: Restriction
        on property: transports or maintains localization of
        some values from: polypeptide
subclass of: cell component localisation phenotype